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- 저자 : Youn Kyoung Son (검색결과 81 건)
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Son, Youn Kyoung,Yoon, So Ra,Bang, Woo Young,Bae, Chang-Hwan,Yeo, Joo-Hong,Yeo, Rimkyo,An, Juhyun,Song, Juhyun,Kim, Oh Yoen The Korean Nutrition Society 2019 Nutrition Research and Practice Vol.13 No.4
BACKGOURND/OBJECTIVES: Vascular inflammation is an important feature in the atherosclerotic process. Recent studies report that leaves and branches of Carpinus turczaninowii (C. turczaninowii) have antioxidant capacity and exert anti-inflammatory effects. However, no study has reported the regulatory effect of C. turczaninowii extract on the arterial inflammatory response. This study therefore investigated modulation of the arterial inflammatory response after exposure to C. turczaninowii extract, using human aortic vascular smooth muscle cells (HAoSMCs). MATERIALS/METHODS: Scavenging activity of free radicals, total phenolic content (TPC), cell viability, mRNA expressions, and secreted levels of cytokines were measured in LPS-stimulated (10 ng/mL) HAoSMCs treated with the C. turczaninowii extract. RESULTS: C. turczaninowii extract contains high amounts of TPC ($225.6{\pm}21.0mg$ of gallic acid equivalents/g of the extract), as well as exerts time-and dose-dependent increases in strongly scavenged free radicals (average $14.8{\pm}1.97{\mu}g/mL$ $IC_{50}$ at 40 min). Cell viabilities after exposure to the extracts (1 and $10{\mu}g/mL$) were similar to the viability of non-treated cells. Cytokine mRNA expressions were significantly suppressed by the extracts (1 and $10{\mu}g/mL$) at 6 hours (h) after exposure. Interleukin-6 secretion was dose-dependently suppressed 2 h after incubation with the extract, at $1-10{\mu}g/mL$ in non-stimulated cells, and at 5 and $10{\mu}g/mL$ in LPS-stimulated cells. Similar patterns were also observed at 24 h after incubation with the extract (at $1-10{\mu}g/mL$ in non-stimulated cells, and at $10{\mu}g/mL$ in the LPS-stimulated cells). Soluble intracellular vascular adhesion molecules (sICAM-1) secreted from non-stimulated cells and LPS-stimulated cells were similarly suppressed in a dose-dependent manner after 24 h exposure to the extracts, but not after 2 h. In addition, sICAM-1 concentration after 24 h treatment was positively related to IL-6 levels after 2 h and 24 h exposure (r = 0.418, P = 0.003, and r = 0.524, P < 0.001, respectively). CONCLUSIONS: This study demonstrates that C. turczaninowii modulates the arterial inflammatory response, and indicates the potential to be applied as a therapeutic use for atherosclerosis.
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Youn Kyoung Son,Sora Yoon,Woo Young Bang,Chang Hwan Bae,Joo Hong Yeo,Rimkyo Yeo,Juhyun An,Juhyun Song,Oh Yoen Kim 한국영양학회 2019 Nutrition Research and Practice Vol.13 No.4
BACKGOURND/OBJECTIVES: Vascular inflammation is an important feature in the atherosclerotic process. Recent studies report that leaves and branches of Carpinus turczaninowii (C. turczaninowii) have antioxidant capacity and exert anti-inflammatory effects. However, no study has reported the regulatory effect of C. turczaninowii extract on the arterial inflammatory response. This study therefore investigated modulation of the arterial inflammatory response after exposure to C. turczaninowii extract, using human aortic vascular smooth muscle cells (HAoSMCs). MATERIALS/METHODS: Scavenging activity of free radicals, total phenolic content (TPC), cell viability, mRNA expressions, and secreted levels of cytokines were measured in LPS-stimulated (10 ng/mL) HAoSMCs treated with the C. turczaninowii extract. RESULTS: C. turczaninowii extract contains high amounts of TPC (225.6 ± 21.0 mg of gallic acid equivalents/g of the extract), as well as exerts time-and dose-dependent increases in strongly scavenged free radicals (average 14.8 ± 1.97 μg/mL IC50 at 40 min). Cell viabilities after exposure to the extracts (1 and 10 μg/mL) were similar to the viability of non-treated cells. Cytokine mRNA expressions were significantly suppressed by the extracts (1 and 10 μg/mL) at 6 hours (h) after exposure. Interleukin-6 secretion was dose-dependently suppressed 2 h after incubation with the extract, at 1-10 μg/mL in non-stimulated cells, and at 5 and 10 μg/mL in LPS-stimulated cells. Similar patterns were also observed at 24 h after incubation with the extract (at 1-10 μg/mL in non-stimulated cells, and at 10 μg/mL in the LPS-stimulated cells). Soluble intracellular vascular adhesion molecules (sICAM-1) secreted from non-stimulated cells and LPS-stimulated cells were similarly suppressed in a dose-dependent manner after 24 h exposure to the extracts, but not after 2 h. In addition, sICAM-1 concentration after 24 h treatment was positively related to IL-6 levels after 2 h and 24 h exposure (r = 0.418, P = 0.003, and r = 0.524, P < 0.001, respectively). CONCLUSIONS: This study demonstrates that C. turczaninowii modulates the arterial inflammatory response, and indicates the potential to be applied as a therapeutic use for atherosclerosis.
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Direct effect of protein kinase C inhibitors on cardiovascular ion channels
( Youn Kyoung Son ),( Da Hye Hong ),( Dae Joong Kim ),( Amy L Firth ),( Won Sun Park ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.9
Protein kinase C (PKC) is a central enzyme that modulates numerous biological functions. For this reason, specific PKC inhibitors/activators are required to study PKC-related signaling mechanisms. To date, although many PKC inhibitors have been developed, they are limited by poor selectivity and nonspecificity. In this review, we focus on the nonspecific actions of PKC inhibitors on cardiovascular ion channels in addition to their PKC-inhibiting functions. The aim of this paper is to urge caution when using PKC inhibitors to block PKC function. This information may help to better understand PKC-related physiological/biochemical studies. [BMB reports 2011; 44(9): 559-565]
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Son, Seon Kyoung,Kim, Youn-Su,Son, Hae Jung,Ko, Min Jae,Kim, Honggon,Lee, Doh-Kwon,Kim, Jin Young,Choi, Dong Hoon,Kim, Kyungkon,Kim, BongSoo American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.5
<P>We synthesized four polymers (pT3DPP-HD, pT3DPP-OD, pT2TTDPP-HD, and pT2TTDPP-OD) and characterized their photovoltaic properties as a function of the backbone planarity, alkyl side chain length, and film morphology. The polymers were donor–acceptor type low-band-gap (1.2–1.3 eV) polymers employing terthiophene (T3) or thiophene–thieno[3,2-<I>b</I>]thiophene–thiophene (T2TT) as the donor and 2,5-bis(2-hexyldecyl)pyrrolo[3,4-<I>c</I>]pyrrole-1,4-(2<I>H</I>,5<I>H</I>)-dione (DPP-HD) or 2,5-bis(2-octyldodecyl)pyrrolo[3,4-<I>c</I>]pyrrole-1,4-(2<I>H</I>,5<I>H</I>)-dione (DPP-OD) as the acceptor. The T2TT moiety in the polymer backbone is more planar than the T3; the OD moiety as the alkyl side chain ensured a higher solubility than the HD moiety. Polymer solar cells (PSCs) were fabricated, and their properties were characterized. The photoactive layer consisted of one of the four polymers and one of the fullerene derivatives (PC<SUB>70</SUB>BM or PC<SUB>60</SUB>BM). For a given fullerene derivative, the PCEs prepared with each of the four polymers were ordered according to pT3DPP-OD, pT2TTDPP-HD, pT3DPP-HD, and pT2TTDPP-OD. Studies on the morphologies of the polymer:fullerene layers revealed that the pT3DPP-OD:PC<SUB>70</SUB>BM blend exhibited an optimal degree of phase separation between the polymer and the fullerene, while retaining a high degree of interconnectivity, thereby yielding the highest PCE measured in this series. By contrast, the pT2TTDPP-OD:fullerene yielded the lowest PCE because of too high crystalline fibrous polymer domains. In conclusion, we demonstrate that minute variations in the polymer chemical structure strongly affects both (i) the nanoscale miscibility between the polymers and fullerenes and (ii) the interconnectivity of the polymer chains, and these properties are tightly correlated with the solar cell performance.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-5/jp405744d/production/images/medium/jp-2013-05744d_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp405744d'>ACS Electronic Supporting Info</A></P>
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중환자실 간호사의 의사소통 능력, 소진이 간호업무성과에 미치는 영향
손연정(Son, Youn-Jung),이연아(Lee, Youn A),심경란(Sim, Kyoung Nan),공성숙(Kong, Seong Sook),박영수(Park, Young-Su) 기본간호학회 2013 기본간호학회지 Vol.20 No.3
Purpose: The purpose of this study was to investigate the influence of communication competence and burnout on nursing performance in intensive care units (ICU). Method: The participants were 209 nurses from four university hospitals. Measurements included a socio-demographic and job related survey, communication competence inventory, the Maslach burnout inventory and a nursing performance scale. Data were collected from February 6 to 24, 2012, with a self-report questionnaire. The statistical analyses were performed with SPSS 18.0 software. Results: The mean scores for communication competence, burnout and nursing performance were 50.49, 84.72, and 62.18, respectively. Communication competence (r=.44, p<.001) and burn out (r=-.32, p<.001) were significantly correlated with nursing performance. In the multiple linear regression, factors influencing nursing performance were communication competence, age and burnout. These variables explained about 46% of the total variance of nursing performance. Communication competence (β=.34, p<.001) was the most influential factor. Conclusion: Nurses’ poor communication skills and burnout can influence the occurrences of medical errors in ICU nursing performance. The results suggest that good communication and burnout resolution skills programs should be implemented to improve nursing performance efficiency.
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음식물 비료 처리 및 경작지에 따른 인삼의 페놀릭 대사체 예비연구
Kyoung Jin Youn,Na Young Son,Taek Jun Lee,Seung Hyun Kim,Ill Min Chung 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.10
Background : Despite the presence of various bioactive compounds in ginseng, there is lack of study about the phenolic metabolites in ginseng especially depending on the cultivation soil and the fertilizer types. Therefore, this study aims to develop an (-)ESI-LC-MS/MS analytical method for the measurement of selected phenolic compounds in the ginseng root. Methods and Results : Total phenol content in ginseng root was measured with the Folin-Ciocalteau method using UV/Vis spectrophotometer. Then, the 56 selected phenolic metabolites in ginseng root were measured with the (-)ESI-LC-MS/MS. The brief LC-MS/MS analytical conditions were as follows; Thermo Scientific Syncronis C18 HPLC Column (250 × 4.6 mm, 5 μm) was used. Optimized instrument settings were as follows: Curtain gas 20 psi, collision gas 2 psi, ion spray voltage –4500 V, nebulizer gas 40 psi, heating gas 70 psi, and its temperature 350℃. Total phenol content was higher in the ginseng cultivated in the paddy-converted field than that in upland. In particular, the total phenol content was about 6% decreased in the ginseng root cultivated with the food waste fertilizer compared to the control (p < 0.05). Six phenolic constituents including caffeic, chlorogenic, p-coumaric, ferulic, gentisic, and salicylic acids were found in the ginseng root by using the LC-MS/MS in MRM (multiple reaction monitoring) Mode. These six phenolic compounds occupied approximately 20% of the total phenol content measured in the corresponding ginseng root. The chlorogenic acid was the most abundant phenolic metabolite found in the ginseng root, accounting for ≥ 95% of the sum of six phenolic compounds, in this study. Conclusion : This preliminary study can be useful for the study on content and composition of phenolic metabolites in ginseng root with the aspect of metabolomics. We plan to further optimize the LC-MS/MS analytical method and then provide the extended understanding on the phenolic metabolism in the ginseng root with respect to the ginseng cultivation conditions.
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Long-term RF exposure on behavior and cerebral glucose metabolism in 5xFAD mice
Son, Yeonghoon,Kim, Jin Su,Jeong, Ye Ji,Jeong, Youn Kyoung,Kwon, Jong Hwa,Choi, Hyung-Do,Pack, Jeong-Ki,Kim, Nam,Lee, Yun-Sil,Lee, Hae-June Elsevier 2018 Neuroscience Letters Vol.666 No.-
<P><B>Abstract</B></P> <P>Given the increased public concern about the deleterious biological consequences of radiofrequency electromagnetic fields (RF-EMFs), the involvement of RF-EMFs in neurodegenerative diseases, especially Alzheimer’s disease (AD), has received increased consideration. To investigate the effect of long-term RF-EMF exposure on AD progression, we exposed 5xFAD mice to 1950 MHz RF-EMF at a specific absorption rate of 5.0 W/kg for 2 h/day and 5 days/week for 8 months. Behavioral changes were assessed by an open field test and an object recognition memory task after RF exposure was terminated. In addition, cerebral glucose metabolism was analyzed in the brains of the 5xFAD mice using 18F-deoxyglucose positron emission tomography. The hyperactivity-like and anxiolytic behaviors of the 5xFAD mice in open field tests were rescued by RF exposure. Furthermore, long-term RF-EMF exposure improved the cognitive deficits of 5xFAD mice that were observed in the object recognition memory test. Consistent with the behavioral changes, glucose metabolism in the hippocampus and amygdala regions of the brains of 5xFAD mice following RF exposure was significantly increased compared to glucose metabolism in the brains of sham-exposed mice. These data suggest that long-term exposure to RF-EMF might exert beneficial effects on AD in 5xFAD mice.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Chronic RF-EMF exposure improved cognitive deficits in 5xFAD mice. </LI> <LI> Chronic RF-EMF exposure rescued locomotor defects in AD-transgenic mice. </LI> <LI> Glucose metabolism was increased in the brains of 5xFAD mice after RF-EMF. </LI> </UL> </P>
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손경희(Kyoung Hee Son),신윤숙(Youn Sook Shin) 한국가정과학회 1999 한국가정과학회지 Vol.2 No.1
Tencel fabrics were treated with cellulase after mechanical prefibrillation treatment. SEM analysis was carried out to study morphological change of the treated fabric. The cellulase-treated Tencel fabrics were evaluated for weight loss and tensile strength. X-ray diffraction method, moisture regain, and K/S value were used to elucidate crystalline structural changes occurred by cellulase treatment. Degree of polymerization and copper number of the cellulase-treated fabrics were also measured to estimate effect of hydrolysis. SEM analysis indicated that with treatment of prefibrillation and cellulase, fibrils were produced and damage occurred deep into the fiber. Increases in concentration and time of cellulase treatment increased weight loss and decreased tensile strength retention of the treated fabrics. As cellulase hydrolysis progressed, degree of crystallinity, moisture regain and K/S value were not much changed.(Korean J Human Ecology 2(1):142∼148. 1999)
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