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( Song I Bae ),( You Sun Kim ),( Jong Pil Im ),( Jae Hee Cheon ),( Byong Duk Ye ),( Ji Won Kim ),( Young Ho Kim ),( Kang Moon Lee ),( Joo Sung Kim ),( Dong Soo Han ),( Won Ho Kim ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Anti-tumor necrosis factor-alpha (anti-TNF-a) agents have been known to alter the natural course of Crohn`s disease (CD). Therefore, we aimed to compare the changes in clinical features and disease course according to the time of introduction of anti-TNF-a agent in Korea. Methods: We performed a retrospective analysis on 1,382 Korean CD patients diagnosed between 1982 and 2008 who were enrolled in the retrospective cohort of CrOhn`s disease cliNical NEtwork and CohorT (CONNECT) study. The anti-TNF-a agent has been applied to national medical insurance in 2005, and more widely used since 2007 in Korea. Accordingly the patients were divided into 3 groups [Group A (1981-2004): 656 patients, Group B (2005-2006): 282 patients, Group C (2007-2008): 362 patients]. Results: The average age (p=0.251), disease location (p=0.941) and behavior (p=0.813) at the time of diagnosis were not different among 3 groups. The anti-TNF-a agent was administered in a total of 31.0% of the patients (n=403), and showed no difference among groups (p=0.124). However, the 3- and 5-year cumulative probabilities of administration of anti-TNF-a agent were significantly higher in group C (p Conclusions: After the introduction of anti-TNF-a agent to the treatment of Korean CD patients, natural history of the CD has been changed. We found that early administration of an anti-TNF-a agent can help delay the occurrence of perianal fistula and the need for surgery in Korean CD patients.
( Min Song ),( Miri Hong ),( Min Yong Lee ),( Jun Goo Jee ),( You Mie Lee ),( Jong Sup Bae ),( Tae Cheon Jeong ),( Sangkyu Lee ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Hyperoside, quercetin-3-O-galactoside, is a flavonoid isolated from Oenanthe javanica. In the present study, we investigated potential herb-drug inhibitory effects of hyperoside on nine cytochrome P450 (CYP) isoforms in pooled human liver microsomes (HLMs) and human recombinant cDNA expressed CYP using a cocktail probe assay. Hyperoside strongly inhibited CYP2D6-catalyzed dextromethorphan O-demethylation, with IC values of 1.2 and 0.81 μM after 0 and 15 min of preincubation, and a Ki value of 2.01 μM in HLMs, respectively. Hyperoside strongly decreased CYP2D6 activity dose-, but not time-, dependently in HLMs. In addition, the Lineweaver-Burk and Secondary plots for the inhibition of CYP2D6 in HLMs fitted a competitive inhibition mode. Furthermore, hyperoside decreased CYP2D6-catalyzed dextromethorphan O-demethylation activity of human recombinant cDNA-expressed CYP2D6, with an IC value of 3.87 μM. However, other CYPs were not inhibited significantly by hyperoside. In conclusion, our data demonstrate that hyperoside is a potent selective CYP2D6 inhibitor in HLMs, and suggest that hyperoside might cause herb-drug interactions when co-administrated with CYP2D substrates.ⓒ2013 Elsevier Ltd. All rights reserved.
유혜진(You, Hye Jin),송용관(Song, Yong Gwan),김승재(Kim, Seung Jae),천승현(Cheon, Sung Hyeon) 한국체육교육학회 2017 한국체육교육학회지 Vol.22 No.2
본 연구에서는 Neff(2003b)가 개발한 자기자비심 척도가 국내의 여자 학생운동선수들에게서도 적합한 요인구조와 타당성을 지니고 있는지를 검증하였다. 한국형 스포츠 자기자비심 척도는 제안된 번역과정에 따라 번역과 역번역 과정을 거쳐 최종 문항을 확정하였다. 척도의 타당성을 확인하기 위해 국내 중,고,대학교에 재학 중인 여자 학생운동선수 310명을 대상으로 설문조사가 진행되었고, 수집된 자료를 토대로 스포츠 자기자비심 척도의 요인 및 문항 적합성을 검증하였다. 통계적 검증 과정에서 낮은 요인 부하량을 지닌 3요인이 삭제되었으나, 원척도와 동일한 6요인 23문항이 국내 여자 학생운동선수들에게서 타당한 것으로 확인되었다. 부가적으로 스포츠 자기자비심 척도의 준거타당도, 판별타당도, 개념타당도와 예측타당도를 검증한 결과 모든 타당도가 입증되었다. 이러한 결과는 스포츠 상황에서 자기자비심 척도가 운동선수들에게 적합하게 사용될 수 있다는 것을 보여주며, 특히 여자 학생운동선수들의 자기자비심을 구체적으로 파악하는데 유용한 정보를 제공해 줄 것으로 생각된다. Objective: The purpose of this study was to validate self-compassion scale (SCS) developed by Neff (2003a) suitably for Korean women’s student-athletes. Method: For this, SCS went through the process of translation-back translation by three bilingual persons, and verified its internal-validity through the experts. The final korea version scale was composed of 26 items of completed SCS. Ten items of self-esteem expected to be correlated with positive factors of SCS, 3 items of physical self-description, 4 items of amotivation expected to be negatively correlated, and 5 items of athlete burnout questionnaires. Woman athlete-students’ (n=310) were asked to complete questionnaires to assess the perceptions of SCS. Results: As results, based on confirmatory factor analyses (CFA), the results supported the initial validity and reliability of the korean version of SCS in Sport Setting. That is, 3 items (self-judgement) were eliminated of the original SCS 6 factor 23 items, SCS was verified through CFA. Korea version of SCS also demonstrated good factorial and predictive validity in Sport field. Conclusion: In overall, Korean SCS for sport players will be useful for sport setting and can be applied for SCS of athlete.
대량 출혈로 발현한 원발성 위장관 말초 T세포 림프종 1예
김유선,송인성,정현채,김상균,김우호,김정룡,김주성,천재희,서승오,박규주 대한소화기학회 2000 대한소화기학회지 Vol.36 No.2
Most primary gastrointestinal lymphomas are B-cell origin. T-cell lymphomas of the intestine comprise the small portion of gastrointestinal lymphomas. Peripheral T-cell lymphomas (PTCL) rarely affect the gastrointestinal tracts at their initial presentation and the majority of primary gastrointestinal PTCL involve the small intestine. There has been few reports about the diffuse and extensive involvement of gastrointestinal tracts by PTCL. In Korea, there has been no report of a primary gastrointestinal PTCL so far. The common manifestations of PTCL involving the gastrointestinal tracts are abdominal pain, gastrointestinal bleeding, perforation, and diarrhea. However, these are not sufficient for the correct diagnosis. Several other gastrointestinal diseases may mimic PTCL. Its low incidence and clinical similarity to other gastrointestinal diseases make a correct diagnosis difficult. We report a case of primary gastrointestinal PTCL involving the whole gastrointestinal tracts, which rarely casuses massive bleeding, with a review of literatures.
Case Study of Deep Borehole Drilling by Rock Types for Deep Geological Disposal of HLW
Dae-Sung Cheon,Jai-Yong Park,Wonkyong Song,You Hong Kim,Ki Seog Kim,Seong-Chun Jun 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2
Deep borehole drilling is essential not only to select the host rock type for deep geological disposal of high-level radioactive waste (HLW), but also to identify the characteristics of the disposal site during the site selection process. In particular, since the disposal depth of HLW is considered to be over 300 m, deep borehole drilling must be performed. In deep borehole drilling, drilling design, excavation, and operation may vary depending on the rock type, drilling depth, and drilling purpose etc. This study introduced cases in which Korea was divided into four geotectonic structures and four representative rock types and conducted with a goal of 750 m drilling depth. Prior to this, a review of deep drilling cases conducted at domestic and abroad was presented. If sufficient time and cost are available, several drilling holes can be excavated for various purposes, but if not, one or two drilling holes should be used to achieve the objectives of various fields related to HLW disposal. The presence of bedding, strata or fault zones depending on the type of rock, etc. may affect drilling deviation or circulating water management. In addition, unlike drilling in general geotechnical investigation drilling, the use of polymers or grouting agents is limited to determine hydraulic and geochemical characteristics. This report introduces the experience considered during the design and drilling process of deep drilling in granite, gneiss, sedimentary rock, volcanic rock, etc., and is expected to be used as basic data when carrying out future HLW projects.
Evaluation of Deep Geological Characteristics Using Deep Boreholes
Dae-Sung Cheon,You Hong Kihm,Kwangmin Jin,Wonkyong Song,Seong Kon Lee,Sung Phil Hyun,Heejun Suk 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.2
The depth of geological disposal of high-level radioactive waste (HLW) varies from country to country, but it is generally considered below 300 m underground. As one of the reliable methods to understand the geological characteristics of these deep areas, the site investigation through drilling is recommended. This paper deals with multidisciplinary research that evaluates the geological characteristics of the site using deep drilling. The deep drilling is 750 m, which is higher than the planned disposal depth. Prior to drilling, literature and surface geological surveys of the target area were conducted, and during drilling, real-time measurement of excavated information for obtaining drilling information, circulating water management and chemical composition through a closed system were monitored. After drilling, field tests such as geophysical borehole logging, deep groundwater sampling, constant pressure injection test, and hydraulic fracturing test were performed. Analysis of the recovered drilling core from a geological point of view such as age dating, rock formation and structural geological analysis, and from geochemical perspectives such as concentration of major/ minor cationic elements, major anions, and trace elements along with the water quality parameters pH, DO, Ec, Eh, etc., from geothermal perspective such as thermal conductivity and coefficient of thermal expansion, from rock mechanical aspects such as physical and mechanical properties of intact rocks and joints, joint distribution, etc. Deep drilling has been completed with 2 holes for granite and 2 holes for sedimentary rocks, and further drilling for gneiss and sedimentary rocks is in progress.