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      • 요로 결석의 체외 충격파 쇄석술 : 단순 복부 사진을 이용한 성공률 예측의 효율성 Efficacy of the KUB in Predicting the Success Rate

        이연희,김유미 단국대학교 1998 論文集 Vol.33 No.-

        Background: To evaluate the efficacy of KUB according to size, location, shape of urinary stones in ESWL. Methods: In 149patients with urinary stones, we retrospectively reviewed KUB findings of stone size, location, shape and analyzed success rate of ESWL. Results: The overall success rate of ESWL in 149 cases was 89.9%. And the sucess rates of renal and ureter stones were 81.4% & 93.4% respectively. It was more successfully treated by ESWL when stone showed size below 2㎝, round shape and ureteropelvic junction(UVJ) location. Conclusions: The KUB is a useful imaging modality in evaluating the efficacy of ESWL of urinary stone.

      • KCI등재

        옥외광고의 도시 공간 구성 양상에 대한 연구 : 새로운 매체형식의 재현 공간 실천 분석을 위한 이론적 접근

        이유연 한국방송광고공사 2007 광고연구 Vol.0 No.77

        디지털 미디어 기술과 광고환경의 변화에 따른 새로운 옥외매체의 적용은 도시의 일상공간을 현실적 이미지와 동영상으로 채우며 공간을 의미와 소통, 관계의 복잡하고 중층적인 구조로 생성해 낸다. 본고는 옥외광고가 일상적 공간에 위치하며 공간을 전유하고 환경과 소통하는 양상을 문화, 사회학적 관점에서 살펴보았으며 그러한 탐구의 출발점으로서 옥외광고의 공간 실천을 설명할 수 있는 이론적 틀의 탐색과 구축을 목표로 하였다. 따라서 옥외광고의 실천 맥락으로서 도시 공간을 이해하였으며, 특히‘재현의 공간’에서의 옥외광고의 공간 실천 양상을 문화 지리, 건축 공간, 문화 연구의 담론을 통해 숙고, 이를 기반으로 옥외광고의 재현 공간 실천의 분석 틀을 도출하였다. 이 과정에서 옥외광고가 공간의 전유를 통해 재현의 공간을 확보하며 이를 통해 새로운 공간의 의미를 생산하고 통제하여, 정서적으로 차별적인 거리감을 생성하고 있음을 다각적인 사례를 통해 제시하였다. Out-of-home advertising, especially with the development of digital technology and the change of marketing environment, is one of the crucial constituents which make urban space in modern age a competitive field of representations and symbols. Hereupon, it is suggested to investigate on out-of-home advertising in the perspective of cultural sociology to describe the phase where it appropriates, communicates with, and influences on daily space. This article, as the starting point of the inquiry, searches and constructs the analytical frame which explains the process of spatial practice by out-of-home advertising. For this object, it suggests to understand urban space as the context of out-of-home advertising, focusing on the“ space of representation”. In this process, this article argues that out-of-home advertising occupies the space of representation, creates and controls the meaning of the represented place, and develops the emotionally differentiated distances. The analytical frame suggested here, can be used for development of theory by field research and analysis while assumed as variable one which can be adjusted and proceeded through review on ongoing facts and situations.

      • KCI등재후보

        카드뮴에 폭로되지 않은 일부 한국인의 혈중, 요중 카드뮴 농도

        연유용,안규동,이병국 大韓産業醫學會 1992 대한직업환경의학회지 Vol.4 No.1

        In order to identify the normal range of blood and urine cadmium levels in Korean, blood cadmium (Cd-B) and creatinine adjusted urine cadmium (Cd-U (Cr)) and specific gravity adjusted urine cadmium (Cd-U (SG)) were analized in 403 Koreans (male : 160, female : 243) who were not occupationally exposed to cadmium by atomic absorption spectrophtometry using Zeeman effect background correction. The summarized results were as follows : 1. Sample distribution patterns of blood and urine cadmium levels in 403 who were not occupationally exposed to cadmium were log-normal distribution. 2. While the Cd-B, Cd-U(Cr) and Cd-U(SG) of males were 0.18±0.10(GM : 0.16)ug/dl of Cd-B, 1.56±1.26 (GM : 1.19) ug/g creatinine of Cd-U(Cr), 1.60±1.20(GM : 1.28) ug/l of Cd-U (SG), those of females were 0.15±0.07 (GM : 0.14) ug/dl of Cd-B, 2.68±2.19(GM : 1.87) ug/g creatinine of Cd-U(Cr), 1.95±1.42(GM : 1.48) ug/l of Cd-U(SG), respectively. There was a statistically significant difference of three indices between sexes (p<0.01). 3. Cd-B, Cd-U(Cr), and Cd-U (SG) of both sexes were increased with increase of age. There were significant increase of Cd-B, Cd-U (Cr) and Cd-U (SG) by the increase of age. 4. While Cd-B (GM) and Cd-U (Cr) (GM) in smoker and nonsmoker of males were 0.17ug/dl, 1.21ug/g creatinine and 0.13ug/dl, 1.14ug/g creatinine, those of females were 0.18ug/dl, 3.79ug/g creatinine 0.14ug/dl, 1.71ug/dl. 1.71ug/g creatinine. There was statistically significant difference of theree indices between sexes(p<0.001). 5. There was significant increase of Cd-B, Cd-U (Cr) and Cd-U (SG) in smoking males by the increase of calculated pack year. 6. In stepwise multiple regression analysis, using Cd-B, Cd-U (Cr) and Cd-U (SG) as a dependent variables and age, sex, smoking and blood pressure as an independent variables, smoking habits, age and sex were contributed to Cd-B, significantly(p<0.001), age and sex were contributed to Cd-U(Cr) and Cd-U(SG) significantly(p<0.001).

      • KCI등재

        고등학교 교사의 전문적 자본이 교직만족도에 미치는 영향 : 학교장 지도성과 학교풍토의 직렬다중매개효과 분석을 중심으로

        한유경,설가인,이은지,김하영 이화여자대학교 사범대학 교과교육연구소 2022 교과교육학연구 Vol.26 No.6

        This study examined the structural relationship between professional capital and teacher satisfaction of high school teachers. For the analysis, data from 3,614 high school teachers who responded to the 9th year of the GEPS were used, and the serial multiple mediation effect of principal leadership and school climate was analyzed in the relationship between professional capital and teacher satisfaction. The result of the analysis showed that, human capital, a sub-element of professional capital, had a positive effect on principal leadership and teacher satisfaction, and social capital had a positive effect on the school climate. Decision capital had a positive effect on all of principal leadership, school climate, and teacher satisfaction. Principal leadership significantly increased the vitality of the school climate, and principal leadership and school climate had a positive effect on teacher satisfaction. In mediation effect, principal leadership showed significant mediation effect between mediated human capital and teacher satisfaction, and between decision capital and teacher satisfaction. The school climate had a significant indirect effect on the relationship between social capital and teacher satisfaction, decision capital and teacher satisfaction. In addition, the effect mediated by school principal leadership through the school climate was significant in the relationship between human capital and teacher satisfaction, decision capital and teacher satisfaction. Based on the above results, implications for improving teacher satisfaction were drawn. 이 연구는 고등학교 교사의 전문적 자본과 교직만족도 간의 구조적 관계를 검증하고자 하였다. 이를 위해 경기종단연구 9차년도 조사에 응답한 고등학교 교사 중 3,614명을 대상으로 전문적 자본과 교직만족도의 관계에서 학교장 지도성과 학교풍토의 직렬다중매개효과를 분석하였다. 분석 결과, 전문적 자본의 하위요소인 인적 자본은 학교장 지도성과 교직만족도에, 사회적 자본은 학교풍토에 긍정적인 영향을 미쳤다. 의사결정적 자본은 학교장 지도성, 학교풍토, 교직만족도 모두에 정적인 효과를 지니는 것으로 나타났다. 학교장 지도성은 학교풍토의 활력을 유의하게 높였고, 학교장 지도성과 학교풍토는 교직만족도에 긍정적인 영향을 주었다. 매개효과를 검증한 결과, 학교장 지도성은 인적 자본과 교직만족도, 의사결정적 자본과 교직만족도를 유의하게 매개하였다. 학교풍토는 사회적 자본과 교직만족도, 의사결정적 자본과 교직만족도 간의 관계에 있어 간접효과가 유의하였다. 또한, 학교장 지도성이 학교풍토를 거쳐 매개한 효과는 인적 자본과 교직만족도, 의사결정적 자본과 교직만족도 간의 관계에서 유의하였다. 이상의 결과를 토대로 교직만족도 제고를 위한 시사점을 도출하였다.

      • 초기계태에서 valproic acid에 의한 신경관 기형 : 입체현미경적 관찰

        김동호,조무연,정유남,최영주,이종선,민경수,이무섭 충북대학교 의학연구소 2000 忠北醫大學術誌 Vol.10 No.1

        연구목적 ' 항경련제인 valproic acid가 초기계태의 신경관 형성에 영향을 주는 기형유발에 대해 입체현미경하에서 관찰하였다 연구재 료 및 방법 : 백색의 Leghorn의 신선한 수정란을 30-35시간 동안 배양하여 Hamburger & Hamilton 기 5-10기의 초기 계태를 천공 필터를 이용하여 분리하여 6-30시간 동안 CO2 세포 배양기에서 배양하였고 무작위로 대조군과 실험군을 분류하였다. 실험군은 valproic acid 의 RPMI culture media 의 농도에 따라 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ 네가지 군으로 분리하였다. 각각의 대조군과 valproic acid를 처치한 실험군에서 입체 현미경하에서 초기계태의 신경관 형성의 형태학적인 특징과 기형형성의 빈도를 비교하였다. 결과: valproic acid가 없는 RPMI media에서 배양된 대조군은 24개의 계태는 22(91.7%)개는 정상으로 자랐으며 2(8.3%)개는 비정상으로 자랐다 이에 반하여 valproic acid가 처치된 RPMI media에서 배양된 72개의 계태는 42(58.3%)개가 비정상으로 자랐다. 주로 확인된 이상 형태는 신경주름의 변형. 신경관 폐쇄부전, 체절의 장애 및 발육 정지 등 이었다. 계태의 기형 형성은 valproic acid의 농도에 비례하여 증가하였다. valproic acrid 의 농도가 100 ㎍/㎖인 경우 18개 계태 중 2(11.1%)개에서 경미한 신경관 기형이 나타났으며 200 ㎍/㎖인 경우 18개 계태 중 11(61,1%)개는 정상, 7(38.9%)개는 명백한 신경관 기형이 나타났으며 500 ㎍/㎖인 경우 18개의 계태 중 5(27.8%)개는 정상. 13(72.2%)개는 명백한 신경관 기형을 나타냈다. 1000 ㎍/㎖인 경우 18(100%)개 모두 심한 신경관 기형이 나타났다. 결론: valproic acid는 초기계태에서 신경관 기형을 유발 했는데 저농도에서는 일부 경미한 신경관 이상을 보였고 고농도에서는 대부분 심한 신경관 손상을 동반하고 성장 속도가 둔화되어 약 용량의 증가에 따라 기형이 증가되는 dose-dependent manner 로 그 영향이 나타났다. Purpose : The teratogeruc effects of valproic acid widely used as anticonvulsant on the neurulation of the explanted eraly chick embryos were observed by the stereoscope. Materials and Methods: Fresh fertilized white leghorn hen eggs were incubated for 30-35 hours in an e99 incubator. The Hamburger and Hamilton stage 5-10 chick embryos were explanted using the punched-out filter paper explantation technique and cultured in the CO2 cell culture incubator for 6-30 hours. They were randomly divided into a control group and an experimental group. The experimental group was divided into four subgroups according to the valproic acid concentrations of 100 ㎍/㎖, 200 ㎍/㎖, 500 ㎍/㎖, 1000 ㎍/㎖ with which the RPMI culture media were treated. The morphological characteristics and the incidences of teratogenic effects on the neurulation of early chick embryos in the control and experimental groups were compared with each other using the stereomicroscope. Results : Of the 24 chick embryos cultured in the RPMI media without valproic acrid, 22 embryos(91.7%) developed normally, and 2 embryos (8.3%) developed abnormally, in contrast, among 72 embryos cultured in the valproic acrid-treated media, 42 embryos(58.3%) developed abnormally. The frequent anomalous features were deformities of the neural folds, failure of neural tube closure, derangement of somites, and developmental arrest. Of 18 embryos cultured in the media treated each with 100㎍/㎖ of valproic acid, 2 embryos(11.1%) showed mild abnormality of neural tube defect on stereoscopic examination. Of 18 embryos cultured 7l the media treated each with 200㎍/㎖ of valproic acid, 11 embryos(61.1%) developed normally for 20 hours and 7 embryos (38.9%) showed definite neural tube defect. Of 18 embryos cultured in the media 7reated each with 500㎍/㎖ of vaIprolc acid, 5 embryos(27.8%) developed normally (or 20 hours and 13 embryos (72.2% ) showed definite neural tube defect. Of 18 embryos cultured in the media treated each with 1000㎍/㎖ of valproic acid, 1 embryo developed normally for 4 hours but all embryos (100%) showed severe neural tube defect on whole brain after 8 hours of culture. Conclusion : Valproic acid induced mild neural tube defects in low concentration and in high concentration of valproic acid, most chick embryos developed slowly and showed severe neral tube defects. The frequency and severity of abnormal embryos ulcreased in dose-dependent manner.

      • KCI등재

        Microarray Analysis of Thyroid Stimulating Hormone, Insulin-Like Growth Factor-1, and Insulin-Induced Gene Expression in FRTL-5 Thyroid Cells

        Lee, You Jin,Park, Do Joon,Shin, Chan Soo,Park, Kyong Soo,Kim, Seong Yeon,Lee, Hong Kyu,Park, Young Joo,Cho, Bo Youn The Korean Academy of Medical Sciences 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22 No.5

        <P>To determine which genes are regulated by thyroid stimulating hormone (thyrotropin, TSH), insulin and insulin-like growth factor-1 (IGF-1) in the rat thyroid, we used the microarray technology and observed the changes in gene expression. The expressions of genes for bone morphogenetic protein 6, the glucagon receptor, and cyclin D1 were increased by both TSH and IGF-1; for cytochrome P450, 2c37, the expression was decreased by both. Genes for cholecystokinin, glucuronidase, beta, demethyl-Q 7, and cytochrome c oxidase, subunit VIIIa, were up-regulated; the genes for ribosomal protein L37 and ribosomal protein L4 were down-regulated by TSH and insulin. However, there was no gene observed to be regulated by all three: TSH, IGF-1, and insulin molecules studied. These findings suggest that TSH, IGF-1, and insulin stimulate different signal pathways, which can interact with one another to regulate the proliferation of thyrocytes, and thereby provide additional influence on the process of cellular proliferation.</P>

      • Fine mapping of <i>qBK1</i> , a major QTL for bakanae disease resistance in rice

        Lee, Sais-Beul,Kim, Namgyu,Hur, Yeon-Jae,Cho, Su-Min,Kim, Tae-Heon,Lee, Ji-youn,Cho, Jun-Hyeon,Lee, Jong-Hee,Song, You-Chun,Seo, Young-Su,Ko, Jong-Min,Park, Dong-Soo Springer US 2019 Rice Vol.12 No.-

        <P><B>Background</B></P><P>Bakanae disease is an important fungal disease caused by <I>Gibberella fujikuroi</I>. Incidence of rice bakanae disease creates serious problems in the foremost rice growing countries, and no rice variety has been found to be completely resistant to this disease. However, breeding rice varieties resistant to bakanae disease may be a cost-saving solution preferable to the application of fungicides. In this study, we aimed to determine the exact position and the candidate gene for <I>qBK1</I>, a major resistant quantitative trait locus (QTLs) for bakanae disease.</P><P><B>Results</B></P><P>The genotypes/phenotypes of recombinants selected from backcrossed recombinant inbred lines of two rice varieties, Shingwang (resistant) and Ilpum (susceptible), indicated that the locus <I>qBK1</I>, conferring resistance to bakanae disease in Shingwang, was delimited to a 35-kb interval delimited by InDel 18 (23.637 Mbp) and InDel 19–14 (23.672 Mbp). Sequence analysis of this 35-kb region revealed four candidate genes, LOC_Os01g41770, LOC_Os01g41780, LOC_Os01g41790, and LOC_Os01g41800. There were many non-synonymous SNPs in LOC_Os01g41770 and the transcript of LOC_Os01g41790 was early terminated in Shingwang, whereas there were no differences in both LOC_Os01g41780 and LOC_Os01g41800 sequences between Ilpum and Shingwang. Expression profiling of the four candidate genes showed the up-regulation of LOC_Os01g41770, LOC_Os01g41780, and LOC_Os01g41790 in Ilpum and of LOC_Os01g41800 in Shingwang after inoculation of <I>G. fujikuroi.</I></P><P><B>Conclusion</B></P><P>Utilization of marker-assisted selection (MAS) with a precise molecular marker on <I>qBK1</I> could provide an effective tool for breeding rice varieties resistant to bakanae disease. To our knowledge, this is the first report on fine mapping and candidate gene approaches for identifying the gene for <I>qBK1</I>.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (10.1186/s12284-019-0295-9) contains supplementary material, which is available to authorized users.</P>

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