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안병준,이유희,김신일 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-
We have prepared 5 solvent fractions from red ginseng; petroleum ether(GP), diethyl ether (PE), ethyl acetate(GA), n-butanol(GB) and water(GW) fractions, and isolated three polyacetylenes from GP and GE; panaxynol(PN), panaxydol(PD) and panaxytriol(PT). GP, GE and PN potentiated the cytotoxicity of fluorouracil(5-FU) against A549 by 33%, 36% and 29%, respectively. The cytotoxicity of tamoxifen(TMX) against the same was enhanced by GP and PT by 46% and 27%, PN, PD and PT increase the cytotoxicity of mitomycin C by 20%, 18% and 28%, respectively. GP, GE and PD potentiated the cytotoxicity of adriamycin by 27%, 29% and 22%, respectively. GE and PD increased the cytotoxicity of tamoxifen against SK-OV-3 by 25% and 17%. There was evidence that other cytotoxicity-potentiating substances exist in GP and GE.
Lee, Dong-Hyeon,Jeon, Hui-Kyung,You, Ji-Han,Park, Mi-Yeon,Lee, Seung-Jae,Kim, Sung-Sik,Shim, Byung-Joo,Choi, Yun-Seok,Shin, Woo-Seung,Lee, Jong-Min,Park, Chul-Soo,Youn, Ho-Joong,Chung, Wook-Sung,Kim, The Korean Society of Cardiology 2010 Korean Circulation Journal Vol.40 No.8
<P><B>Background and Objectives</B></P><P>Pentraxin 3 (PTX3) was shown to be elevated in the acute phase of acute myocardial infarction (AMI) and to have prognostic significance in AMI patients. The aim of this study was to estimate whether the value of PTX3 could be used as a prognostic biomarker, with the global registry of acute coronary events (GRACE) risk assessment tool, in patients with acute coronary syndrome (ACS).</P><P><B>Subjects and Methods</B></P><P>Between July 2007 and June 2008, 137 patient subjects (mean age : 61±12 years, M : F=108 : 29) with ACS who underwent coronary intervention, but did not have a prior percutaneous coronary intervention (PCI) and/or follow-up coronary angiogram, were enrolled. We estimated the all-cause mortality or death/MI, in-hospital and to 6 months, using the GRACE risk scores and compared these estimates with serum PTX3 concentrations.</P><P><B>Results</B></P><P>The serum PTX3 concentration showed a significant increase in ST segment elevation myocardial infarction (STEMI) greater than the unstable angina pectoris (UAP) group (2.4±2.1 ng/mL vs. 1.3±0.9 ng/mL, p= 0.017, respectively), but did not show a significant difference between non-ST segment elevation myocardial infarction (NSTEMI) and the UAP group (1.9±1.4 ng/mL vs. 1.3±0.9 ng/mL, p=0.083, respectively). The serum PTX3 concentration was closely related to death/MI in-hospital (r=0.242, p=0.015) and death/MI to 6 months (r=0.224, p=0.023), respectively. The serum PTX3 concentration was not related to all-cause mortality in-hospital (r=0.112, p=0.269) and to 6 months (r=0.132, p=0.191), respectively. Among the parameters determining the GRACE risk scores, the degree of Killip class in congestive heart failure (CHF) was independently associated with the supramedian PTX3 concentration [odds ratio: 2.229 (95% confidence interval: 1.038-4.787), p=0.040].</P><P><B>Conclusion</B></P><P>The serum PTX3 level provides important information for the risk stratification of CHF among the parameters determining the GRACE risk scores in subjects with ACS.</P>
항암성 천연물 및 그 유사체(X) L1210 및 S-180에 대한 하늘타리의 항암성
이유희(You Hui Lee),강석균(Suck Kyun Kang),안병준(Byung Zoon Ahn) 대한약학회 1986 약학회지 Vol.30 No.4
A strongly cytotoxic fraction (Fc-2, ED50=0.0003mcg/ml) against L1210 cell was obtained from the root, seed and fruit of Trichosanthes kirilowii. Administration of Fc-2 prolonged the life span of the BDF1 mice bearing L1210 and the ICR mice bearing S-180 by 135% and 130%, respectively. The Fc-2 affected L1210 cells were enlarged in their diameters two or three times in comparison with the untreated ones. When 20mg/kg of Fc-2 was administered, intraperitoneally, all the mice were killed.