실험계획법을 이용한 나노 결정 소석회 합성

김진성,김정우,이희수,김용남,신현규,김환,Kim, Jin-Seong,Kim, Jung-Woo,Lee, Hee-Soo,Kim, Yong-Nam,Shin, Hyun-Gyoo,Kim, Hwan 한국결정성장학회 2008 한국결정성장학회지 Vol.18 No.4

본 연구에서는 균일침전법으로 합성된 $CaCO_3$를 하소한 후 수화시키는 방법을 이용하여 소석회를 제조하였다. 소석회를 제조하기 위하여, 염화칼슘$(CaCl_2)$과 우레아(Urea)가 출발 물질로 사용되었으며 염화칼슘 수용액과 우레아 수용액을 혼합하여 가열하는 동안 반응용기 내에서 탄산칼슘이 합성되었다. 침전물들을 여과하고 증류수와 에탄올로 수 차례 세척하였으며 건조시켰다. 소석회는 하소된 탄산칼슘의 수화과정을 통하여 합성되었다. 최적의 합성조건을 선정하는데 있어 실험의 잡음인자를 최소화하고 결과를 통계적으로 추론할 수 있는 실험계획법(다구치 실험계획법)을 이용하였다. 제조된 탄산칼슘을 $1000^{\circ}C$에서 30분 동안 하소시킨 후 에탄올 및 옥살산이 첨가된 증류수로 수화시킴으로써 결정입자 크기가 약 50 nm인 소석회를 제조할 수 있었다. Nano-crystalline slaked lime was synthesized using design of experiment. In order to synthesize slaked lime, calcium chloride $(CaCl_2)$ and urea were used as starting materials. Calcium chloride solution and urea solution were mixed and heated in vessel that calcium carbonate was precipitated during heating. Precipitates were filtered, washed several times using D.I.water and ethanol and finally dried in oven. Slaked lime $(Ca(OH)_2)$ has been fabricated by the hydration of calcined $CaCO_3$. Design of experiment (Taguchi method) was used to optimize parameter, to minimize noise factors of experiment and to statistically analyze the results. Slaked lime having about 50 nm in optimized crystallite size could be obtained by calcination of $CaCO_3$ at $1000^{\circ}C$ for 0.5 h and hydration with D.I water containing ethanol and oxalic acid.

간과 비장의 체적을 구하기 위한 3차원 영역 확장 기반 자동 영상 분할 알고리즘의 동물팬텀을 이용한 성능검증

김진성,조준식,신경숙,김진환,전호상,조규성,Kim, Jin-Sung,Cho, June-Sik,Shin, Kyung-Sook,Kim, Jin-Hwan,Jeon, Ho-Sang,Cho, Gyu-Seong 한국의학물리학회 2008 의학물리 Vol.19 No.3

간경변 및간암 환자의 증가로 간이식술의 필요성이 점점 증가되고 있고, 특히 공여자의 생체 간이식은 간이식술의 주된 분야를 차지하고 있으며 간이식 수술 전 공여자에서 간체적의 정확한 측정은 수술 후 공여자와 수여자의 간기능을 예측하는데 있어 중요한 자료가 되며, 성공적인 수술과 환자의 예후에 밀접한 영향을 미친다. 그러나 현재 환자의 간체적을 구하는 과정은 환자의 모든 CT 영상위의 간을 수작업을 통해 영상분할한 후에 3차원 간체적을 구하고 있으며 많은 시간과 노력이 필요한 작업이다. 이러한 문제를 해결하기 위해서 본 논문에서는 자동으로 간과 비장을 문턱값처리, 형태학적 영상처리, 3차원 영역확장법등의 기법을 이용하여 분할하는 알고리즘을 개발하여 체적을 구하는 시간을 단축하였다. 이러한 알고리즘의 정확성을 평가하기 위해서 동물의 실제 간과 비장을 팬텀으로 제작하여 실제 측정한 체적과 알고리즘으로 분할된 영상의 결과를 비교 평가하였다. 문턱치값의 설정에 따라 다른 결과를 보이는 특성이 있지만 자동으로 문턱치를 결정했을 때 비장과 간의 체적측정 오차는 9.27%, -4.52%이었으며, 수동으로 문턱치를 결정했을 때 최소 오차가 각각 0.2%, 0.17%의 결과를 보였다. 이러한 팬텀 연구를 통해 자동 분할 알고리즘으로 얻은 체적의 결과가 정확성과 재현성을 보여주어 추후 간체적을 구하는 보조수단으로 활용될 수 있을 것이라 예상된다. Living donor liver transplantation is increasingly performed as an alternative to cadaveric transplantation. Preoperative screening of the donor candidates is very important. The quality, size, and vascular and biliary anatomy of the liver are best assessed with magnetic resonance (MR) imaging or computed tomography (CT). In particular, the volume of the potential graft must be measured to ensure sufficient liver function after surgery. Preoperative liver segmentation has proved useful for measuring the graft volume before living donor liver transplantations in previous studies. In these studies, the liver segments were manually delineated on each image section. The delineated areas were multiplied by the section thickness to obtain volumes and summed to obtain the total volume of the liver segments. This process is tedious and time consuming. To compensate for this problem, automatic segmentation techniques have been proposed with multiplanar CT images. These methods involve the use of sequences of thresholding, morphologic operations (ie, mathematic operations, such as image dilation, erosion, opening, and closing, that are based on shape), and 3D region growing methods. These techniques are complex but require a few computation times. We made a phantom for volume measurement with pig and evaluated actual volume of spleen and liver of phantom. The results represent that our semiautomatic volume measurement algorithm shows a good accuracy and repeatability with actual volume of phantom and possibility for clinical use to assist physician as a measuring tool.

Design and fabrication of the MMIC frequency doubler for 29 GHz local oscillator application

김진성,이성대,이복형,김성찬,설우석,임병옥,김삼동,박현창,박형무,이진구,Kim, Jin-Sung,Lee, Seong-Dae,Lee, Bok-Hyoung,Kim, Sung-Chan,Sul, Woo-Suk,Lim, Byeong-Ok,Kim, Sam-Dong,Park, Hyun-Chang,Park, Hyung-Moo,Rhee, Jin-Koo The Institute of Electronics and Information Engin 2001 電子工學會論文誌-TC (Telecommunications) Vol.38 No.11

밀리미터파 대역에서 안정적이고 경제적인 local oscillator (LO) 신호를 생성하기 위한 주파수 체배기를 설계 및 제작하였다. 주파수 체배기는 14.5 GHz를 입력받아 29 GHz를 생성하도록 설계되었으며, 측정 결과 14.5 GHz에서 S11이 -9.2 dB, 29 GHz에서 S22가 -18.6 dB 로 입력 측은 14.5 GHz에, 출력 측은 29GHz에 매칭이 되었다. 변환손실의 경우 14.5 GHz에서 입력전력 6 dBm일 때 최소 값인 18.2 dB를 보였으며, 출력 단에서의 주파수 스펙트럼 특성은 14.5 GHz에서 15.2dB의 값을 나타내었다. 또한 입력신호의 isolation특성은 10.5 GHz에서 18.5GHz까지 주파수 범위에서 30 dB이상의 값을 보였다. 제작된 MMIC(Microwave monolithic integrated circuits) 주파수 체배기의 칩 사이즈는 $1.5{\times}2.2\;mm^2$이다. We demonstrate the MMIC (monolithic microwave integrated circuit) frequency doublers generating stable and low-cost 29 GHz local oscillator signals from 14.5 GHz input signals. These devices were designed and fabricated by using the M MIC integration process of $0.1\;{\mu}m$ gate-length PHEMTs (pseudomorphic high electron mobility transistors) and passive components. The measurements showed S11 or -9.2 dB at 145 GHz, S22 of -18.6 dG at 29 GHz and a minimum conversion loss of 18.2 dB at 14.5 GHz with an input power or 6 dBm. Fundamental signal of 14.5 GHz were suppressed below 15.2 dBe compared to the second harmonic signal at the output port, and the isolation characteristics of fundamental signal between the input and the output port were maintained above :i0 dB in the frequency range 10.5 GHz to 18.5 GHz. The chip size of the fabricated MMIC frequency doubler is $1.5{\times}2.2\;mm^2$.

전형 대상자와 방법의 수정, 개선을 바란다

김진성,Kim, Jin-Seong 한국대학교육협의회 2001 大學敎育 Vol.113 No.-

Tm₂O₃ 첨가가 MLCC용 $BaTiO₃ 유전특성에 미치는 영향

김진성,이희수,강도원,김정욱,Kim, Jin-Seong,Lee, Hee-Soo,Kang, Do-Won,Kim, Jeong-Wook 한국결정성장학회 2010 한국결정성장학회지 Vol.20 No.1

페로브스카이트 구조를 갖고 $Tm_2O_3$가 첨가된 MLCC용 $BaTiO_3$ 유전체를 제조하기 위하여 환원분위기, $1320^{\circ}C$의 온도조건에서 2시간 동안 소결하였다. 유전특성 측정과 미세구조 관찰을 통하여, $Tm_2O_3$ 첨가에 따라 $BaTiO_3$ 세라믹의 유전특성에 미치는 영향에 대해 연구하였으며 각 유전체의 상분석을 통하여 이차상 유무를 확인하였다. 1 mol%의 $Tm_2O_3$를 첨가한 유전체 시편이 유전특성이 가장 우수한 반면에 2 mol% 이상의 $Tm_2O_3$를 첨가한 시편의 유전상수는 1 mol%를 첨가한 시편에 비해 낮은 값을 보였다. 유전특성에 영향을 미치는 grain 크기 및 pyrochlore 이차상 형성은 미세구조분석과 결정구조분석에 의해 조사되었다. 또한, 이들 데이터를 대표적 희토류인 $Er_2O_3$를 첨가한 유전체 시편과 비교하였고 유전특성과 관련이 있는 pyrochlore상의 형성을 상분석으로써 확인하였으며 이 결과는 세라믹 커패시터의 유전특성이 도핑에 따른 이차상과 $BaTiO_3$ tetragonality의 변화와 관련되어있다고 판단된다. Thulium oxide-doped barium titanate ceramics for MLCCs with perovskite structure were prepared by a sintering process at $1320^{\circ}C$ for 2 h in a reduced atmosphere. The effect of $Tm_2O_3$ addition on dielectric property of barium titanate ceramics has been studied in terms of their microstructures. Moreover, the phase identification of the dielectric specimens was conducted to define the secondary phase (pyrochlore). The specimen doped with 1 mol% $Tm_2O_3$ exhibited the highest dielectric constant. However, the dielectric constants of specimens with more than 2 mol% $Tm_2O_3$ to $BaTiO_3$ were the lower values than that of 1 mol% doped one. The grain size and the formation of pyrochlore phase associated with the dielectric properties were examined through morphology development and the structural analysis. Furthermore, these data were compared with the property of the dielectric material doped with $Er_2O_3$. It could be concluded that the dielectric property of ceramic capacitors were attributed to the change of pyrochlore phase and the tetragonality of $BaTiO_3$ with doping.

수종 한약제의 위암세포에 대한 항암작용 효능 검색 및 약리작용에 관한 분자생물학적 연구

김진성,이지향,류봉하,박재훈,지성길,유진화,Kim, Jin-Seong,Lee, Ji-Whyang,Ryu, Bong-Ha,Park, Jae-Hoon,Ji, Sung-Gil,Yoo, Jin-Hwa 대한암한의학회 1999 大韓癌韓醫學會誌 Vol.5 No.1

Traditional oriental medicines have been used for treatment of various kinds of human cancers for long times and some of them proven to be effective clinically. However, the pharmacological actions and mechanisms related to cancer treatment are generally unknown. In an effort to clarify the action mechanisms of several oriental medicines used for cancer treatments, we planned this experimental procedures. We selected Cordyceps sinensis (冬蟲下草), Punellae Herba (夏枯草), Rehmanniae Radix (熟地黃), Paeoniae Radix (白芍藥), Oldenlandiae Herba (白花蛇舌草), Partulaceae Herba (馬齒? ), Scdopendra subspinipes mutilans (蜈蚣), Mylabris Phalerara (班蟄), Phellinus igniarius(桑黃), Ganodermae Lignum(靈芝) for evaluation, which have been used for patients of gastric cancers. The twenty grams of medicines were boiled in 100ml of water for 1 hour and filtered with $0.2\;{\mu}m$ pore-sized filter unit to remove insoluble particles. Initially we evaluated the effects oriental medicines on growth inhibition in stomach cancer cells. The gastric cancer cell line, AGS, was cultured in RPMI 1640 supplemented with l0% heat-inactivated fetal bovine serum and treated with $10{\mu}l$ oriental medicines per 1ml of medium up to 48 hours. The specimens were subjected to MTT assay for evaluation of growth inhibition. We found mat Mylabris phalerata (班蟄) markedly suppressed the growth of cancer cells as shown in results. Next, we checked the effects of oriental medicines on cancer on cell cycles and apptosis. Mylabrls phalerata (班蟄) inhibited cell cycle progression of cancer cells a compared with control cells and cells treated with other medicines. In addition, Mylabri phalerata (班蟄) induced apoptosis in 30-40% of stomch cancer cells within 24 hours. Other oriental medicines used for this experiments did not show apoptosis-inducing effects on cancer cells. Finally, we determined the expression levels of genes associated with cell cycle and apoptosis. The expressions of Bcl-2 and bcl-XL were downregulated by the treatment of Mylabris phalerata (班蟄). However, the expression levels of genes related to cell cycles were not altered significantly. In conclusion, we found that Mylabris phalerata (班蟄) has in vivo gowth-inhibiting and apptosis-inducing effects on stomach cancer cells. However, we think that at least animal experiments are necessay for evduations.

빙축ㆍ수축기술의 보급 확산을 기대하며

김진성,Kim, Jin-Seong 한국설비기술협회 1989 설비 : 공조ㆍ냉동ㆍ위생 Vol.6 No.11

Rambus DRAM실장용 ${mu}!$BGA (Ball Grid Array) 및 ${mu}!$Spring 패키지와 전기적 특성

김진성,유영갑,Kim, Jin-Seong,Yu, Yeong-Gap 대한전자공학회 2001 電子工學會論文誌-SD (Semiconductor and devices) Vol.38 No.4

본 논문에서는 μspring 패키지의 구조와 제조공정을 소개하고, 전기적 특성을 μBGA와 비교 분석한 결과를 제시하였다. μBGA에서와 같이 μSpring 패키지의 연결선 인덕턴스 값은 기존의 TSOP 패키지의 반 이하로서 월등한 고속 신호 전달 특성을 제공하게 된다. 또한 μSpring CSP 패키지의 경우 가장 열악한 substrate trace를 가진 핀에서도 2.9nH로 평가되어, Rambus DRAM module의 인덕턴스 규격 상한 값 4nH에 비하여, 약 25% 정도의 margin을 제공한다. μSpring CSP패키지는 μBGA의 약 50%의 제조 비용으로서 μBGA가 만족시키지 못하는 JEDEC Level 1 규격을 충족시킬 뿐만 아니라, thermal cycle 1000회를 통과하는 높은 신뢰성을 제공하여 강력한 경쟁력을 가진다. This paper presents the structure of a $\mu$Spring package, its fabrication process and an analysis of its electrical characteristics compared to that of a $\mu$BGA. It was found that both $\mu$BGA and $\mu$Spring packages provide with outstanding high speed signal transmission characteristics due to their lower inductance of package interconnection lines, smaller than half of inductance of TSOP package lines. Even the worst case substrate trace of a Rambus DRAM $\mu$Spring package yields the line inductance of 2.9nH, which provides with 25% margin compared to the Rambus DRAM specification of 4nH. The fabrication cost of $\mu$Spring package is lower than that of $\mu$BGA by 50%, passes 1000 thermal cycles, meets JEDEC Level 1 specification whereas $\mu$BGA does not, and thereby yields high reliability and strong competing power.

도시계획과 지가변동에 대한 고찰

김진성,Kim, Jin-Seong 대한건축사협회 1969 建築士 Vol.4 No.12

추출방법(抽出方法)에 따른 내소화중탕(內消和中湯)의 효능(效能)에 대(對)한 연구(硏究)

김진성,류봉하,박동원,류기원,윤주호,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won,Yoon, Joo-Ho 대한한방내과학회 2001 大韓韓方內科學會誌 Vol.22 No.1

When I evaluated the component variation of Naesowhajung-tang by the three types of extraction method, and each type's effects on the gastrointestinal tract, I got the following results. 1. The output ratio of extracts made out of Naesowhajung-tang were not significantly different among 13.8% of water extract(Sample-I), 13.5% of 50% ethanol extract(Sample-II), and 15.6% of water extract by spray dryer(Sample-III). 2. magnolol, honokiol, hesperidin, naringin, poncirin and glycyrrhizin Sample II had the largest amount of the following contents: magnolol, honokiol, hesperidin, naringin, poncirin and glycyrrhizin. 3. All the extracts of Naesowhajung-tang showed the inhibitory effect on the smooth muscle contraction of the isolated ileum in mice and fundus-strip in rats induced by acetylcholine chloride and barium chloride. 4. High concentration Sample-II was recognized to be effective in preventing gastric ulcers in Shay's rats. but not in the other rat group. 5. All the extracts of Naesowhajung-tang were recognized to be effective in preventing gastric ulcers induced by Ethanol-HCl in rats. 6. The increase of transport ability in the small intestine was recognized only when the concentration of all the samples was doubled, but not in the other concentrations. 7. The increase of transport ability in the large intestine was recognized only when the concentration of Sample-II was doubled, but not in other concentration. Using the results mentioned above, I suggest that Sample-II has more significant effects on the gastrointestinal tract than the others.