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Interface State and Coercivity in Nd-Fe-B/Dy Films
Jin Umezawa,Yoshiki Sakai,Kunihiro Koike,Daisuke Ogawa,Yoshiyuki Mizuno,Hiroaki Kato,Takamichi Miyazaki,Yasuo Ando 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We fabricated a model interface system, which consised of a Nd2Fe14B layer with Dy overlayers,in order to study the relationship between the microstructure near the interface and the coercivity. The coercivity Hc of the 1-µm-thick Nd-Fe-B films with a Dy overlayer was enhanced by thermaldiffusion of Dy atoms from the film’s surface into the Nd-Fe-B layer. The Nd-Fe-B/Dy films annealedat 700℃ showed a significant increase in the Hc of up to about 17 kOe. The maximum increasein the value of the coercivity ΔHc of the annealed films with a Dy overlayer was approximately 13kOe. The XRD measurement suggested the existence of rare-earth oxides (NdO and Dy2O3) in theDy-coated films with high value of the ΔHc.
Complications Related to Gastric Endoscopic Submucosal Dissection and Their Managements
Itaru Saito,Yosuke Tsuji,Yoshiki Sakaguchi,Keiko Niimi,Satoshi Ono,Shinya Kodashima,Nobutake Yamamichi,Mitsuhiro Fujishiro,Kazuhiko Koike 대한소화기내시경학회 2014 Clinical Endoscopy Vol.47 No.5
Endoscopic submucosal dissection (ESD) for early gastric cancer is a well-established procedure with the advantage of resection in an en bloc fashion, regardless of the size, shape, coexisting ulcer, and location of the lesion. However, gastric ESD is a more difficult and meticulous technique, and also requires a longer procedure time, than conventional endoscopic mucosal resection. These factors naturally increase the risk of various complications. The two most common complications accompanying gastric ESD are bleeding and perforation. These complications are known to occur both intraoperatively and postoperatively. However, there are other rare but serious complications related to gastric ESD, including aspiration pneumonia, stenosis, venous thromboembolism, and air embolism. Endoscopists should have sufficient knowledge about such complications and be prepared to deal with them appropriately, as successful management of complications is necessary for the successful completion of the entire ESD procedure.
Yoshihide Kanno,Tetsuya Ohira,Yoshihiro Harada,Yoshiki Koike,Taku Yamagata,Megumi Tanaka,Tomohiro Shimada,Kei Ito 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.3
Afferent loop syndrome is often difficult to resolve. Among patients with afferent loop syndrome whose data were extracted fromdatabases, 5 patients in whom metal stent placement was attempted were included and evaluated in this study. The procedure wastechnically successful without any adverse events in all patients. Metal stent(s) was placed with an endoscope in the through-the-scopemanner in 4 patients and via a percutaneous route in 1 patient. Obvious clinical efficacy was observed in all patients. Adverse eventsrelated to the procedure and stent occlusion during the follow-up period were not observed. Metal stent placement for malignantobstruction of the afferent loop was found to be safe and feasible.
Yoshihide Kanno,Tetsuya Ohira,Yoshihiro Harada,Shinsuke Koshita,Takahisa Ogawa,Hiroaki Kusunose,Yoshiki Koike,Taku Yamagata,Toshitaka Sakai,Kaori Masu,Keisuke Yonamine,Kazuaki Miyamoto,Megumi Tanaka,T 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.3
Background/Aims: The aim of this study was to evaluate the safety of sedation with propofol as an alternative to benzodiazepinedrugs in outpatient endoscopy. Methods: In this prospective study, examinees who underwent outpatient endoscopy under propofol sedation and submitted a nextdayquestionnaire with providing informed consent were evaluated. Periprocedural acute responses, late adverse events within 24hours, and examinee satisfaction were evaluated. Results: Among the 4,122 patients who received propofol in the 17,978 outpatient-based endoscopic examinations performedbetween November 2016 and March 2018, 2,305 eligible examinees (esophagogastroduodenoscopy for 1,340, endoscopicultrasonography for 945, and total colonoscopy for 20) were enrolled, and their responses to a questionnaire were analyzed. Themean propofol dose was 69.6±24.4 mg (range, 20–200 mg). Diazepam, midazolam, and/or pentazocine in combination withpropofol was administered to 146 examinees. Mild oxygen desaturation was observed in 59 examinees (2.6%); and mild bradycardia,in 2 (0.09%). Other severe reactions or late events did not occur. After eliminating 181 invalid responses, 97.7% (2,065/2,124) of thepatients desired propofol sedation in future examinations. Conclusions: Propofol sedation was found to be safe-without severe adverse events or accidents-for outpatient endoscopy on thebasis of the patients’ next-day self-evaluation. Given the high satisfaction level, propofol sedation might be an ideal tool for painlessendoscopic screening.
Shiho Kuji,Akira Endo,Manabu Kubota,Atsushi Uekawa,Fumi Kawakami,Yoshiki Mikami,Junki Koike,Nao Suzuki 대한부인종양학회 2023 Journal of Gynecologic Oncology Vol.34 No.1
Objective: Previously, we reported that insulinoma-associated protein 1 (INSM1) immunohistochemistry (IHC) showed high sensitivity for neuroendocrine carcinoma of the uterine cervix and was an effective method for histopathological diagnosis, but that its specificity remained to be verified. Therefore, the aim was to verify the specificity of INSM1 IHC for a large number of non-neuroendocrine neoplasia (NEN) of the cervix. Methods: RNA sequences were performed for cell lines of small cell carcinoma (TCYIK), squamous cell carcinoma (SiHa), and adenocarcinoma (HeLa). A total of 104 cases of formalin-fixed and paraffin-embedded specimens, 16 cases of cervical NEN and 88 cases of cervical non-NEN, were evaluated immunohistochemically for conventional neuroendocrine markers and INSM1. All processes without antigen retrieval were performed by an automated IHC system. Results: The transcripts per million levels of INSM1 in RNA sequences were 1505 in TCYIK, 0 in SiHa, and HeLa. INSM1 immunoreactivity was shown only in the TCYIK. Immunohistochemical results showed that 15 cases of cervical NEN showed positive for INSM1; the positivity score of the tumor cell population and the stain strength for INSM1 were high. Two of the 88 cases of cervical non-NENs were positive for INSM1 in one case each of typical adenocarcinoma and squamous cell carcinoma. The sensitivity of INSM1 for cervical NEN was 94%; specificity, 98%; the positive predictive value, 88%; and the negative predictive value, 99%. Conclusion: INSM1 is an adjunctive diagnostic method with excellent specificity and sensitivity for diagnosing cervical NEN. Higher specificity can be obtained if morphological evaluation is also performed.