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Hiroaki Kato,Takuhiro Shida,Yoshibumi Komeda,Tamao Saito,Atsushi Kato 한국식물학회 2011 Journal of Plant Biology Vol.54 No.3
The protein encoded by the activated disease resistance 1-like1 (ADR1-L1) gene (locus name, At4g33300)belongs to the activated disease resistance 1 (ADR1) family of coiled-coil nucleotide-binding site leucine-rich repeat-type disease resistance proteins. This family contains four proteins and they have specific features in their amino acid sequences. It has been reported that ADR1 protein belongs to the ADR1family, which is related to not only defense response but also drought tolerance. We found that transgenic plants overexpressing the ADR1-L1 gene showed a dwarf phenotype and morphological change in leaves. The expression levels of defense-related genes and the resistance to Pseudomonas syringae pv. tomato DC3000 were increased in transgenic plants. However, enhancement of drought tolerance and activation of abiotic response genes were not observed. When the growth temperature was changed from 22°C to 28°C, the expression of defense-related genes and the enhancement of resistance to a bacterial pathogen were suppressed and the dwarf phenotype and morphological change of leaves recovered.
Atsushi Kato,Hiroaki Kato,Takuhiro Shida,Tamao Saito,Yoshibumi Komeda 한국식물학회 2009 Journal of Plant Biology Vol.52 No.6
Comparative analysis of nucleotide sequences of the genomic region located around 100 map unit of chromosome 1 using two accessions, Columbia (Col) and Landsberg erecta (Ler), of Arabidopsis thaliana was performed. High divergence was detected between them, and the length of the Ler sequence was half of corresponding sequence of Col. This divergence occurred by tandem duplication, deletion of large regions, and insertion of unrelated sequences. These events led to the high polymorphism of plant disease resistant genes, which are located in the analyzed region. It is highly probable that two-round duplication occurred, and the insertion sequences are transposable elements. The data suggest that the analyzed region had been evolving until quite recently.
( Motoyasu Kato ),( Yuta Arai ),( Hiroaki Motomura ),( Issei Sumiyoshi ),( Yusuke Ochi ),( Junko Watanabe ),( Hiroaki Ihara ),( Shinsaku Togo ),( Shinichi Sasaki ),( Kazuhisa Takahashi ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Acute exacerbation of chronic fibrotic idiopathic interstitial pneumonia (AE-IIP) is associated with a high mortality rate. In 2016, the International Working Group classified the etiology of AE-IIP into idiopathic and triggered. Several factors can trigger AE-IIP; however, the triggers associated with the worst prognosis have not been identified. The aim of this study was to investigate the prognosis of patients with various types of AE-IIP, particularly infection-triggered, non-infection-triggered, and idiopathic AE-IIPs. Methods: We retrospectively collected data for 128 patients with chronic fibrotic IIP (CF-IIP) who were hospitalized because of respiratory failure during the period between April 2009 and March 2019 at Juntendo University Hospital. There were 79 patients who developed AE-IIP, and 21 patients who developed bacterial pneumonia combined with CF-IIP. AE-IIP was classified into idiopathic, infection-triggered, and non-infection-triggered. We analyzed differences in patient characteristics, examination findings, and prognosis among the types. Finally, we evaluated risk factors for early death due to AE-IIPs. Results: Idiopathic, infection-triggered, and non-infection-triggered AE-IIPs were diagnosed in 34, 25, and 20 patients, respectively. The survival time was significantly longer for bacterial pneumonia combined with IIP than for AE-IIP. Moreover, the survival time was significantly longer for infection-triggered AE-IIP than for idiopathic or non-infection-triggered AE-IIP. The mortality rate was significantly lower with infection-triggered AEIIP than with other types of AE-IIP. Finally, a multivariate analysis revealed that radiological findings at the time of onset of AE-IIPs and AE-IIP patterns were independent risk factors for early death. Conclusion: Our results suggest that patients with infection-triggered AE-IIP may have a better prognosis than those with other types of AE-IIP.
Hiroaki Kawanishi,Katsuhiro Ito,Satoshi Kamido,Yuka Kohno,Toshihiro Uemura,Keiji Kato,Hirotsugu Uetsuki,Hitoshi Ohno,Kazuhiro Okumura 대한비뇨의학회 2016 Investigative and Clinical Urology Vol.57 No.6
Purpose: Laparoscopic urologists are familiar with both transperitoneal and retroperitoneal approaches. That experience is an advantage when devising a strategy for intra-abdominal lymph node biopsy. We report the feasibility and effectiveness of laparoscopic biopsy using a urological laparoscopic technique for the treatment of patients with clinically suspected intra-abdominal lymphoma. Materials and Methods: From October 2010 to April 2015, a total of 22 patients underwent laparoscopic biopsy for suspected intra-abdominal lymphoma. We adopted a retroperitoneal approach for paraaortic or paracaval masses, whereas we used a transperitoneal approach for mesenteric, iliac, or obturator masses. Whenever possible, an entire node was removed; otherwise, the biopsy consisted of wedge resection sized at least 1 cm3. Results: Biopsy specimens were obtained from the following lymph node sites: 10 paraaortic, 5 paracaval, 3 mesenteric, 2 obturator, 1 common iliac, and 1 perinephric fat. Laparoscopic lymph node biopsy was completed in all patients, and there were no conversions to open surgery. The median operating time was 97 minutes (range, 62–167 minutes). The estimated blood loss was <50 mL in all cases. Postoperatively, one patient (4.5%) had symptomatic chylous lymphocele that required surgical intervention. Precise diagnosis was established for all patients: malignant lymphoma in 20 patients and metastatic urothelial carcinoma and squamous cell carcinoma of unknown origin in 1 patient each. All lymphomas could be fully subclassified. Conclusions: Appropriate use of the transperitoneal or retroperitoneal approach is safe and effective for laparoscopic lymph node biopsy in patients with suspected intra-abdominal lymphoma.
Tatsuji Enoki,Hiromu Ohnogi,Hiroaki Sagawa,Ikunoshin Kato 한국식품영양과학회 2004 한국식품영양과학회 학술대회발표집 Vol.55 No.-
The number of diabetic patients is increasing especially in Asia according to change of life habits (1). In mild case of diabetes, many patients are left without medical treatments and the long period of none treatment causes serious complications that impair the quality of life of the patients (2). Diabetes is a chronic disease that is characterized by hyperglycemia caused by insufficiency of the insulin action (3). So, we considered that edible ingredients which can complement insulin action are useful to prevent and cure diabetes and complications associated with the disease.<br/> We tried to find the insulin mimic compounds from edible plants. We investigated the two insulin mimic activities of edible plant materials; (a) adipocyte differentiation activity and (b) enhancement activity of glucose uptake, using pre-adipocyte cell line 3T3-L1 (4,5). As a result, we found that ethanol extract of Angelica keiskei, a dropwort indigenous to Japan and called “Ashitaba”, has both activities (6). We tried to isolate active compounds from the extract, and we found that two major chalcons peculiar to Angelica keiskei, xanthoangelol (XA) and 4-hydroxyderricin (4HD) have both activities (a) and (b). Regarding adipocyte differentiation, XA and 4HD have the similar level of activities. On the other hand, regarding enhancement of glucose uptake, the activity of 4HD is several times as high as that of XA. Furthermore, the combination of XA and 4HD could complement insulin action (induction of adipocyte differentiation and enhancement of glucose uptake) in in vitro assay.<br/> Taking the results of in vitro assay into consideration, we investigated each anti-diabetic activity of XA and 4HD using KKAy mice that develop diabetes and shows hyperglycemia by aging (7). To investigate the preventive activity against diabetes, we administered oral dose of XA or 4HD for several weeks to KKAy mice that had not showed symptoms of diabetes. As a results, both oral dose of XA and 4HD suppressed the increase of blood sugar. Namely, oral dose of XA and 4HD suppressed the development of diabetes. To investigate the curing activity of XA and 4HD against diabetes, we administered oral dose of XA or 4HD for several days to KKAy mice that had showed hyperglycemia, and observed oral dose of XA and 4HD decreased the blood sugar respectively. These results suggested that XA and 4HD have anti-diabetic activities.<br/> On the other hand, we had already found that some coumarins and a chroman contained in Ashitaba can induce nerve growth factor (NGF) that has preventive and curing activity of peripheral nerve disease caused by diabetic hyperglycemia. Also founded is that many chalcones contained in Ashitaba have aldose reductase inhibition activity that is effective to prevent complications caused by diabetic hyperglycemia.<br/> Our research results mentioned above strongly suggest that daily ingestion of Ashitaba may be able to prevent and cure diabetes and complications by synergistic effect of each biological activity of Ashitaba.
Evaluation of Interlayer Exchange Coupling in α-Fe(100)/Nd2Fe14B(001) Films
Daisuke Ogawa,Kunihiro Koike,Hiroaki Kato,Shigemi Mizukami,Takamichi Miyazaki,Mikihiko Oogane,Yasuo Ando 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
We fabricated α-Fe(100)/Nd2Fe14B(001) bilayer films with different thicknesses values of the-Fe layer on MgO(100) substrates by using an ultra-high-vacuum (UHV) magnetron sputteringsystem. The exchange coupling constant at the heterointerfaces of α-Fe(100)/Nd2Fe14B(001) wasevaluated by analyzing the magnetization curves and the ferromagnetic resonance (FMR) spectra. We observed a significant lower shift of the α-Fe resonance field compared to that of the α-Fe singlelayer irrespective of the Fe-layer thickness, which suggests the existence of an internal field owingto a positive exchange coupling between the -Fe(100) and the Nd2Fe14B(001) layers.