변연성 발육성 치아종 : A Case of Peripheral Developing Odontoma

윤정훈,임경수,손홍범 조선대학교 구강생물학연구소 2003 Oral Biology Research (Oral Biol Res) Vol.27 No.1

A peripheral odontoma is a relatively rare lesion and is thought to represent the soft tissue counterpart of the central or intraosseous odontoma. Although several odontogenic tumors can occur peripherally, only a few cases of peripheral odontomas involving the gingival tissues have been reported. No earlier stage of peripheral odontoma or peripheral developing odontoma has been described. Here, we report a case of a peripheral developing odontoma occurring in the gingiva of a 4-rear-old Korean boy. Microscopic sections showed several nodules of developing rudimentary tooth germ-like structures in the gingival tissue. It seems likely that this case arise from remnants of the dental lamina located in the gingiva, since the clinical and histologic presentation lends support to the peripheral origin of this tumor.

대학생의 상담에 대한 태도

김범선,전윤경,전진실 西江大學校 學生生活相談硏究所 2008 人間理解 Vol.29 No.-

본 연구는 성별, 연령 등의 인구학적 변인과 이전 상담 경험여부가 상담에 대한 태도에 어떠한 영향을 미치는 가를 알아보기 위해 실시되었다. 이를 위해 서울시내 S 대학에 재학 중인 528명의 학생들에게 상담에 대한 태도와 이전 상담 경험, 그리고 인구학적 특성들을 알아보는 설문지에 응답하게 한 후 그 결과를 통계적으로 분석하였다. 상담에 대한 태도는 Fisher 와 Turner(1975)의 상담태도에 관한 질문지로 측정되었다. 그 결과, 인구학적 변인 중 성별, 학년, 소속 학과, 재수 여부, 종교, 그리고 이전 상담 경험이 상담에 대한 태도에 영향을 미치는 것으로 나타났다. 즉, 여성이 남성에 비해, 천주교 집단이 다른 종교 집단에 비해 전문가에 대한 신뢰와 상담 욕구 면에서 유의미하게 높게 나타났고, 4학년 집단이 1학년에 비해, 문학부가 다른 학부에 비해 전문가에 대한 신뢰의 측면에서 유의미하게 높은 점수를 보였다. 재수를 하지 않은 집단이 삼수이상 집단에 비해 오점수용에서 더 유연한 것으로 나타났으며, 이전에 상담을 해 본 사람일수록 상담에 대한 태도도 더 긍정적이고, 상담전문가를 더 신뢰하며, 오점 수용에 유연하고, 상담 욕구도 높은 것을 알 수 있었다. 마지막으로 이를 통해 얻을 수 있는 논의점과 본 연구의 제한점, 후속 연구를 위한 제안점을 기술하였다. This study investigated college students' attitude toward counseling according to gender, age, and other demographic variables. Research participants were 528 S college students in Seoul. They filled out the Attitude Toward Seeking Professional Help Scale(Fisher & Turner, 1975) and demographic guestionnaire. To analyze data, correlation analysis and ANOVA were conducted. As results, gender, grade, major failure in previous college entrance exam, religion and previous counseling experience had significant influence on attitude toward counseling. Results indicated that women and catholic groups showed more positive attitude in Confidence and Need of seeking attitude toward counseling than other groups. The college seniors and the departs of literature groups showed more positive tendency in Confidence of seeking attitude toward counseling than others. Students who had not repeated a college entrance exam had more flexible attitude in Stigma. Students with previous counseling experience showed more positive tendency in Need, Stigma, Confidence and the whole attitude toward counseling. Discussions and limitations on this study were described.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

HCC : PE-054 ; Prospective comparison of prognostic values of modified recist with EASL criteria in hepatocellular carcinoma following chemoembolization

( Beom Kyung Kim ),( Kyung Ah Kim ),( Jun Yong Park ),( Sang Hoon Ahn ),( Chae Yoon Chon ),( Kwang Hyub Han ),( Myeong Jin Kim ),( Seung Up Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background/Aims: European Association for the Study of the Liver (EASL) and modified Response Evaluation Criteria in Solid Tumors (mRECIST) guidelines, which measure changes in arterialized hepatocellular carcinoma (HCC), differ in terms of number of target lesions (all vs. ≤2) and calculation method (bidimensional vs. unidimensional). We compared prognostic values of mRECIST for predicting overall survival (OS) with reference to EASL criteria in patients with treatment-naive HCC undergoing trans-arterial chemoembolization (TACE). Methods: Ability to predict OS during longitudinal follow-up was expressed as C-index, and a sample size of 292 patients was required to validate its equivalence between each criteria. Treatment responses were assessed using both guidelines 4 weeks after the first TACE, using dynamic computed tomography or magnetic resonance imaging. Kaplan-Meier and Cox regression analyses were used to explore differences in OS between responders (complete or partial) and non-responders (stable or progressive disease), defined by each method. Results: C-index for EASL and mRECIST guidelines were 0.753 and 0.759, respectively, demonstrating equivalence between two methods. Differences in median OS between responders and non-responders reached statistical significance for both EASL (30.1 vs. 18.7 months, p<0.001) and mRECIST (33.8 vs. 17.1 months, p<0.001) guidelines. In addition, α -fetoprotein (p<0.001), tumor number (p<0.001) and tumor size (p=0.048) were significant predictors of OS. In subsequent multivariate analysis, response to each radiologic criteria, tumor number, and α-fetoprotein were identified as independent predictors (all p<0.05). Conclusion: mRECIST, as a simpler method, provided equivalent prognostic values for predicting OS to EASL criteria in patients with HCC undergoing TACE as an initial treatment modality.

HCC : PE-054 ; Prospective comparison of prognostic values of modified recist with EASL criteria in hepatocellular carcinoma following chemoembolization

( Beom Kyung Kim ),( Kyung Ah Kim ),( Jun Yong Park ),( Sang Hoon Ahn ),( Chae Yoon Chon ),( Kwang Hyub Han,),( Myeong Jin Kim ),( Seung Up Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background/Aims: European Association for the Study of the Liver (EASL) and modified Response Evaluation Criteria inSolid Tumors (mRECIST) guidelines, which measure changes in arterialized hepatocellular carcinoma (HCC), differ in terms of number of target lesions (all vs. ≤2) and calculation method (bidimensional vs. unidimensional). We compared prognostic values of mRECIST for predicting overall survival (OS) with reference to EASL criteria in patients with treatment-naive HCC undergoing trans-arterial chemoembolization (TACE). Methods: Ability to predict OS during longitudinal follow-up was expressed as C-index, and a sample size of 292 patients was required to validate its equivalence between each criteria. Treatment responses were assessed using both guidelines 4 weeks after the first TACE, using dynamic computed tomography or magnetic resonance imaging. Kaplan?Meier and Cox regression analyses were used to explore differences in OS between responders (complete or partial) and non-responders (stable or progressive disease), defined by each method. Results: C-index for EASL and mRECIST guidelines were 0.753 and 0.759, respectively, demonstrating equivalence between two methods. Differences in median OS between responders and non-responders reached statistical significance for both EASL (30.1 vs. 18.7 months, p<0.001) and mRECIST (33.8 vs. 17.1 months, p<0.001) guidelines. In addition, α -fetoprotein (p<0.001), tumor number (p<0.001) and tumor size (p=0.048) were significant predictors of OS. In subsequent multivariate analysis, response to each radiologic criteria, tumor number, and α-fetoprotein were identified as independent predictors (all p<0.05). Conclusion: mRECIST, as a simpler method, provided equivalent prognostic values for predicting OS to EASL criteria in patients with HCC undergoing TACE as an initial treatment modality.

HBV : The Fate of Chronic Hepatitis B in the Era of Antiviral Therapy

( Yoon Hea Park ),( Beom Kyung Kim ),( Jun Yong Park ),( Seung Up Kim ),( Do Young Kim ),( Ja Kyung Kim ),( Kwan Sik Lee ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Sang Hoon Ahn ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Chronic hepatitis B (CHB) can progress to cirrhosis and hepatocellular carcinoma (HCC), either of which can lead to a liver-related death. The progression of liver disease in hepatitis B virus (HBV) infection is fostered by active virus replication. Recently, antiviral therapy with minimal side effects have become available to achieve sustained suppression of HBV replication, thereby preventing cirrhosis, hepatic failure, and, ultimately, HCC. The aim of this study is to reappraise the clinical courses regarding disease progression in the era of antiviral therapy for Korean CHB patients who were potential candidates for antiviral therapy. Methods: Between 2001 and 2005, treatment-naive CHB patients without cirrhosis were enrolled and followed-up for at least 5years. During follow-up period, patients have received antiviral therapy according to the Korean Association for the Study of the Liver guideline, if indicated. Ultrasonography and laboratory assessment were performed regularly. Primary endpoints were development of cirrhosis, or hepatic decompensation, HCC, or liver-related deaths, which were examined using Kaplan-Meier method. Results: Of 360 patients, 323 (89.7%) received antiviral therapy such as lamivudine (70.6%), entecavir (8.7%), or telbivudine (6.5%). During a median follow-up period of 94 months, cirrhosis developed in 29 (8.1%) patients, hepatic decompensation in 4 (1.1%) patients, and HCC in 15 (4.2%) patients. The annual incidence of cirrhosis, hepatic decompensation, and HCC were 1.05%, 0.14%, and 0.53% per person-year, respectively. Age was an independent prognostic factor for developing cirrhosis (hazard ratio [HR] 1.075; 95% confidence interval [CI] 1.037-1.116), whereas those for developing HCC were age (HR 1.060, 95% CI 1.012-1.111) and progression to cirrhosis (HR 17.470, 95% CI 5.081-60.063). Conclusions: In the era of antiviral therapy, the overall clinical courses of patients with CHB in Korea have been much improved since the introduction of lamivudine in 1999. However, older age and cirrhosis still remain risk factors for HCC.

The accuracy and prognostic value of radiological tumor staging compared with pathological staging in hepatocellular carcinoma

( Beom Kyung Kim ),( Young Nyun Park ),( Kwang Hyub Han ),( Do Young Kim ),( Young Han Paik ),( Kyung Sik Kim ),( Jin Sub Choi ),( Kwan Sik Lee ),( Byung Soo Moon ),( Chae Yoon Chon ),( Young Myoung M 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.3(S)

Study on inverse estimation of radiative reflection properties in mid-wavelength infrared region by using the repulsive particle swarm optimization algorithm

Yoon, Kyung-Beom,Park, Sang-Joon,Kim, Tae-Kuk The Optical Society 2013 Applied optics Vol.52 No.22

HCC : O-011 ; Optimal number of target lesions for EASL and modified recist guidelines concerning survivals for hepatocellular carcinoma treated with transarterial chemoembolization

( Beom Kyung Kim ),( Myeong Jin Kim ),( Kyung A Kim ),( Jun Yong Park ),( Sang Hoon Ahn ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Seung Up Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1

Background/Aims: To date, most studies regarding optimal number of target lesions for enhancement criteria for hepatocellular carcinoma (HCC) have focused on cross-sectional analyses of concordance. We aimed to determine optimal number of target lesions for EASL and mRECIST guidelines in predicting overall survival (OS). Methods: We analyzed 254 consecutive treatment-naive HCC patients having at least two measurable target lesions undergoing trans-arterial chemoembolization (TACE). Kappa-values for inter-method agreement of treatment responses were calculated for comparisons between use of maximum of one, two, three, or four targets versus use of all target lesions. Prognostic values of radiological assessments according to number of target lesions for predicting OS were expressed as C-index. Results: By EASL and mRECIST guidelines, kappa-values between responses assessing the longest two, three, or four targets and assessing all target lesions were 0.924, 0.977, or 1.000 and 0.907, 0.959, or 1.000, respectively, whereas those between responses assessing only one target and assessing all target lesions were 0.723 and 0.666, respectively. C-index when measuring the longest one, two, three, four, and all target lesions was similar, ranging from 0.739 to 0.749 for EASL criteria and from 0.750 to 0.759 for mRECIST. From Cox regression analyses, radiological response from each calculation method demonstrated independently significant effects on OS for both guidelines, regardless of number of target lesions. Conclusions: Prognostic values for predicting OS were similar regardless of number of target lesions. Evaluating at least the largest two lesions rather than only one lesion should be recommended considering high concordances from crosssectional analyses.