심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이

남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.

R.C.造에서 超音波速度에 미치는 鐵1筋의 影響 : 길이방향鐵筋을 중심으로 On the longitudinal Steel bar

윤석천,정수영,연길환 忠南大學校 産業技術硏究所 1988 산업기술연구논문집 Vol.3 No.2

Ultrasonic testing of a reinforced concrete member by means of the ultrasonic testing apparatus is affected by the steel bar embedded in concrete. A test location avoid the zone of steel effect when selecting test location in reinforced concrete member. But if it is impossible, it is necessary to make a correction to the measured value to provide an estimate of the velocity of the pulse in the plain concrete. The purpose of this study is to analyze the effect of steel bar on ultrasonic pulse velocity and the evaluate optimum correction formular by means of comparison between pulse velocity in concrete and effective pulse velocity according to steel bar diameters. Concrete mixes having water cement ratio of 0.4 and 0.6 by weight and slump values of 18㎝ in fresh concrete were used to make 20×30×60㎝ cubes for pulse velocity in concrete and effective pulse velocity. The diameters of the plain bars were 6, 9, 12, 19, 25, 32, 38 and 50㎜.

Asphalt로 피복된 Portland Cement를 使用한 Concrete의 諸性質

尹錫天,李昌甲,洪元杓,鄭秀永,南宰鉉 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1

The construction works with concrete has the potential problems of water tightness. The conventional treatments for water-tight concrete are not satisfactory in terms of strength and water tightness. This study was to investigate the effects and application of the asphalt-coated portland cement on water-proof of the concrete and its influences on the physical properties of the concrete. The asphalt-coated portland cement, which is hereafter referred to as ACPC, was made by coating ordinary portland cement with asphalt in the rate of weight ranging from 0.5 to 1.0 percent. In this process, Calcium Chloride and Sodium Silicate were tried as the hardening time accelerator for producing ACPC, and carbon black, talc and other materials were tested for their effectiveness as pore filler. The specimens were prepared and tested with the various amounts of additives as a variable factor to find the optimum material. The analysis was mainly focused at water tightness, physical properties of the concrete and working conditions. The major findings of this experiment are as follows ; 1) Water-proof Test ① The specimens of ACPC and ordinary portland cement(OPC) were tested under the pressures of 3 and 9 kilograms per square centimeter per 24hours respectively and compared. The OPC specimens showed considerable amount of leakaged water while the ACPC specimens were rated lower permeabilities of 89%/28days, 40%/56days and21%/84days under the abovementioned pressure conditions. The most successful composition for water-proof was identified as ACPC added with Calcium Chloride and carbon black. ② The ACPC demonstrated its superiority in absorption test. The absorption amount of OPC for l hour was greater than that of ACPC for 24hours. 2) Compressive Strength Test Four kinds of specimens of ACPC aging 7, 28, 56 and 84days were tested and compared for their respective results of OPC. The ACPC added with carbon black was lower than OPC in compressive strength in the case of curing ages of 7 and 28days but ACPC was superior to the OPC in the specimens aging 56 and 84days. The ACPC added with others except carbon black exposed their lower compressive strength in all circumstances compared with the OPC specimens. 3) Slump Test The slump of ACPC with various additives such as carbon black, talc or clay was 21.6 centimeter which was higher than the OPC of 18.4centimeter slump. This result concluded that ACPC was much favorable in workability in comparison with that of the OPC. The conclusions are summarized as follows; 1) The optimum mixture for water tightness and compressive strength of concrete was found at 0.5% of SACPC, Calcium Chloride and carbon black respectively at the rate of the weight of cement.

임신 40주와 출산 후 6주에 있는 20대 임산부 보행의 역학적 특성 비교

윤희중,문동안,정남주,금명숙,이경식,유실,김영란,한윤수 한국운동역학회 2000 한국운동역학회지 Vol.10 No.1

본 연구는 임신 40주와 출산후 6주간에 있는 임산부의 보행 동작의 특정을 규명함으로써 이와 관련된 연구자들에게 기초자료를 제공하고자 실시하였다. 이를 위해 임신 4주에 있는 임산부를 대상으로 1차 실험을 실시하였으며 동일한 대상자를 출산후 6주에 2차로 실험하여 자료를 수집하였다. 디지타이징 시 오차를 최소화하고 인체관절점의 분별을 위해 21개의 반사마커를 부착하였다. 10m의 보행주로를 걷는 동안 두 대의 비디오카메라를 이용하여60Hz로 자료를 수집하였으며 동시에 100Hz 지면반력자료를 수집하였다.수집되어진 자료는 DLT 방법을 사용하여 분석하였으며 이의 분석에 Kwon3d 프로그램을 활용하였다. 분석결과 다음과 같은 결론을 얻었다. 1. 임신 40주와 출산 후 6주의 보행 시 지지시간과 스윙시간의 비율이 다르게 나타났으며 보폭과 보간, 활보장은 임신 40주에서 더 큰 값을 보였다. 상체 전경각 역시 임신 40주에서 더 큰 값을 보였다. 힙관절, 무릎관절, 발목관절각도는 S1이 출산후 6주에서 큰 값을 보인반면 S2는 출산전후에 큰 변화를 보이지 않다. 2. 상하지면반력의 경우 FP1과 FP2는 임신 40주보다는 출산 6주에서 큰값을 보였지만 FP3는 임신 40주에서 보다 큰값을 보이고 있었다. 전후지면반력의 경우 출산전과 후 모두 Fy2에서 보다 큰 값을 보이고 있었다. This Study was to investigate kinematical characteristic comparison of the gait pregnant 40weeks and after delivery 6weeks 20´s women and provide the basic data. To accomplish this study, in the first, carry out an experiment with the pregnant women in the pregnant 40weeks on the videotape, and than the second, make an experiment with the kinematic data. Kinematic data were filtered with a low-pass, fourth-order Butterworth filter with an effective cut off frequency of 6Hz. The conclusions were drawn as follows; 1. Floor contact Periods(stance and swing rate) were differed from before and after the delivery and a pregnant 40 weeks was greater than after delivery 6 weeks in the step, width, stride. Also, a pregnant 40 weeks was greater than after delivery 6 weeks in the front angular. And the other angular components were represented similar pattern. 2. In the vertical load, delivery 6 weeks was grater than a pregnant 40 weeks in the FP1(first peak) and FP2(valley). And FP3(second peak)was represent that a pregnant 40 weeks was greater than delivery 6 weeks. Also, in the horizontal shear, Fy2(progressional force)was greater than Fy1(breaking force) about time of the delivery.

신장이식에서의 전해질 이상

윤영석 대한신장학회 1993 대한신장학회잡지 Vol.12 No.부록7

마이크로 프로세서에 의한 自己制御형 永久磁石 同期 電動機의 驅動 및 運轉 特性의 改善

윤병도,김윤호,김일환,이용석 중앙대학교 기술과학연구소 1989 기술과학연구소 논문집 Vol.19 No.-

전력 전자 공학의 발달에 의해 영구자석 동기전동기의 운전 분야가 대단히 진보되고 있음이 최근 논문을 통해서 보고 되고 있다. 영구자석 동기전동기는 크기와 중량의 감소로 인한 장점, 회전자의 동손이 없으므로 효율이 높다는 장점이 있어 각종 분야의 응용에 유리하다. 본 연구는 마이크로프로세서와 전압원 인버터를 사용한 자기제어형 영구자석 동기전동기의 구동장치를 제안한다. 영구자석 동기전동기의 운전은 고정자 전류와 역기전력을 동기화 시킴으로서 가능하게 한다. 고 분해능의 인크리멘탈 엔코더를 사용하여 영구자석 동기전동기에 적합한 자기제어형 PWM. 인버터 설계를 가능하게 하였다. 저속 영역에서 토오크 리플을 감소 시키기 위해 펄스 수를 제어하였으며 운전중 최적 부하각의 제어는 토오크-속도 특성을 개선시킴을 검토 하였다. Recent research has indicated that the permanent magnet synchronous motor(PMSM) drives are considerably improved by the development of power electronics. The PMSMs are favoured in many applications as there are advantages in size and weight reduction, and in efficiency due to elimination of the field copper losses. This paper presents a Self-Controlled PMSM, fed by voltage suource inverter based on the microprocessor. The proper operation of the PMSM can be ensured only if the stator current is always synchronized with is Back-EMF. The use of incremantal encoder with high resolution makes it possible to design a Self-Controlled PWM inverter for a PMSM. The pulse ratios are controlled to reduce the torque ripple in the low-speed drive region. In addition, torque-speed characteristics are improved by the control of optimal load angle.

Filter pressing이 마그마에 분화에 미치는 영향

윤동숙,이영조 慶北大學校 自然科學大學 地質學科 地質學硏究會 1989 伏賢地質 Vol.- No.11

ZrO₂- 8m/ oY₂O₃- Bi₂O₃3성분계의 분말특성 및 소결체특성

윤종석,이희수,오영제 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.2

The properties of the powder and the sintered body of ZrO₂- 8m/ oY₂O₃- Bi₂O₃prepared by copreciptitation method were investigated. The crystallization temperatures of the powder were increased with increasing of amount of bismuth, and the agglomeration was developed by the increasing of calcination temperatures. The sinterability was increased with the amount of Bi₂O₃added which caused liquid phase, and the deterioration of the thermal expansions and the electrical properties were happened. The electrical properties of 8YZB system were that the electrical conductivity was from ?? and the oxygen ion transference number was from 0.75 to 0.92.