정보통신산업의 국민경제적 위상과 전망

김용규,문석웅,홍동표 한양대학교 디지털경제연구소 2003 디지털경제연구 Vol.8 No.-

호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

SF-36을 이용한 농촌 노인들의 건강상태 평가

전진용,김상아,박웅섭,오미경,홍윤미 관동대학교 의과학연구소 2001 關東醫大學術誌 Vol.5 No.1

This study was conducted to understand health status by general characteristic, and to find out relationship between the general characteristics and rural elderly's health status. Health status was measured using SF-36(Medical Outcome Study Short From 36). The finding of this study were as follow; Mean scores of health status by sex were higher in male on physical function, social function and role limitation-emotion. The elderly educated more reported good health on physical function, role limitation-physical, vitality, bodily pain and general health than did the elderly educated less. The elderly who have disease reported bad health on social function, mental health and general health. Therefore we reviewed the evidence that sex, education and illness are associated with health status in the elderly, and that specific public health service that related such condition should be considered for the rural elderly.

經驗生命表의 作成을 위한 補整模型의 硏究

권용만,장덕준,홍연웅 國立 昌原大學校 基礎科學硏究所 1993 基礎科學硏究所論文集 Vol.4 No.-

This paper presents a general law of mortality that is equal to a mixture of Greville's nonparametric graduation model(difference order 3) and Gompertz parametric survival function. Using crude death rates for constructing Korea experience life table (male, 1991), we know that Greville's model including a samll number of weighted moving average terms graduates well up to age 10, but there is no significant difference above age 60. And we propose a revised King-Hardy method for estimating parameters of Gompertz, and show that the revised method performs well in terms of bias and mean square error. Finally, a numerical example is given.

電氣火災와 部品鑑識에 關한 硏究

金容柱,洪眞雄 충주대 산업과학기술연구소 1994 産業科學論文集 Vol.2 No.-

Identification of the cause of electrically related fire accident may be approached either by studying accident related electric properties or by investigating power instruments at the site of the accident. In the present paper, the former approach is taken especially on investigating the consequences of excessive current induced by eletric short circuiting of high power instruments which is reported as the primary cause electricity related fire accidents. In order to provide reliability of the identification method, we used electric part of glass type fuse, consent and plug.

비뇨기과 입원환자에서 진통이 미치는 Nabumetone(Unimetone^(�))의 임상적 효과

이홍우,김세웅,이광돈,조용현,윤문수 최신의학사 1994 最新醫學 Vol.37 No.6

효과적인 하중운반체계의 동역학적 연구

서국웅,양점홍,윤양진,황영성,이중숙,김용재,유경복 釜山大學校 附設 體育科學硏究所 1994 體育科學硏究所 論文集 Vol.10 No.-

The purpose of this study was to get the quantitative data of effect of two different load carrying system on Kinematics and Kinetics. The subjects for the research were 2-adults. The mechanism of each load carrying pattern was measured by a motion analylizer, a forceplatform and EMG system. The conclusions were get from Kinematics variables and Kinetics variables. 1. It was not effected at the vertical reaction force(Fz) of left, right foot according to the big value the 1st peack of 10kg, 15kg fore, back-pack carrying system, 20 kgw, 30 kgw back-pack carrying system in walking. But it was effected at the vertical reaction force(Fz) on 30 kgw back-pack carrying system in walking. 2. It was not effected at the Anterior-Posterior reaction force(Fx) of left, right foot according to high value of the 1st peack on 10 kgw, 15 kgw fore, back-pack carrying in walking. But, it was effected on the 20 kgw, 30 kgw only back-pack carrying in walking. 3. It was effected at the left-right reaction force(Fy) of left-right foot according to the big value of the 2nd peak on 10 kgw, 15 kgw fore-backpack carrying system in walking. It was more effective than 20 kgw, 30 kgw back-pack carrying system in walking. There was not disorder force(Fx) on 10 kgw, 15 kgw fore-backpack carrying system in walking. 4. Analysis of computer graphic, on the pack carrying system in walking. It was efficient in 10 kgw, 15 kgw fore-backpack carrying system in walking. But, it was efficient on 20 kgw, 30 kgw backpack carrying in walking. Castrocnemius, Tibialis anterior, Vastus lateralis, Vastus medialis, are stressed to bend their body foreward. So it occurred fatigue fast, injured muscles and joints. 5. Extension anyles and flection angles of the knee joint and the hip joint on 10 kgw, 15 kgw fore-backpack carrying system in walking showed less than those on 20 kgw, 30 kgw backpack carrying system in walking. It was efficient on the 10 kgw, 15 kgw fore-backpack carrying system in walking. 6. Magnitudes of EMG of Castrocnemius, Tibialis anterior, Vastus lateralis, Vastus medialis, were increased according to increasing weight road and were decreased on the 20 kgw, 30 kgw back-pack carrying system in walking.

사람폐암세포주 (PC-14)에서 Cyclosporin A에 의한 Adriamycin 내성의 극복

김영환,홍원선,송재관,강윤구,이진오,강태웅,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3

Cyclosporin A and verapamil were tested using MTT assay to evalute the modification effect on the resistance to adriamycin in a human lung cancer cell line(PC-14) and its resistant subline(PC-14/A). PC-14/A was derived by the continuous exposure of PC-14 to incremental concentrations of adriamycin. PC-14/A was 2.5 times more resistant to adriamycin in terms of ICso than PC-14. Cyclosporin A alone, at a concentration of 2.5㎍/㎖, inhibited the growth of PC-14 to 68.3%. 2.5㎍/ ㎖ and 5.0㎍/㎖ of cyclosporin A showed an increase in the cytotoxicity of adriamycin (p<0.01) with 5.0㎍/㎖ being greater than 2.5㎍/㎖(p<0.01). Excluding the direct cytotoxic effect, however, cyclosporin A did not increase in the sensitivity of PC-14 to adriamycin but only showed an additional cytotoxic effect with adriamycin. Verapamil (up to 6.0㎍/㎖) did not inhibit the growth of PC-14. 3.0㎍/㎖ of verapamil did not increase the cytotoxic effect of adriamycin. The combination of cyclosporin A and verapamil with adriamycin enhanced the cytotoxicity of adriamycin, but the result was similar to that of cyclosporin A with adriamycin. 5.0㎍/㎖ of cyclosporin A modified the adriamycin resistance of PC-14/A(SR, 3.2). However, 3.0㎍/㎖ of verapamil did not significantly reverse the adriamycin resistance of PC-14/A. The modified effect of the combination of 5.0㎍/㎖ of cyclosporin A and 3.0㎍/㎖ of verapamil was similar to that of 5.0㎍/㎖ of cyclosporin A alone in PC-14/A. These results demonstrate that cyclosporin A has an additional cytotoxic effect with adriamycin in PC-14 and PC-14/A and has overcome the acquired resistance to adriamycin in PC-14/A. They also suggest that cyclospoin A may have the therapeutic potential in the treatment of human lung cancer.

가토에 있어서 편측 요관 폐색시 환측, 반대측 요관에 대한 변화 : 조직학적 소견을 중심으로

설종구,김용웅,육승모,노안식,김홍식,김상현,이충식 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

This study was designed to clarify histological changes in the experimental rabbit ureter after unilateral prartial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, partial obstruction followed by 4 weeks, complete obstruction followed by 2 weeks, complete obstruction followed by 4 weeks. The normal control group consisted of 5 adult white rabbits. The H & E stain. light microscopy were used. Abnormal histological fingings were showed in ipsilateral ureter of all subgroups; dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis, interstitial inflammation. These findings were most severe in the complete-obstructed ureter for 4 weeks. There were no significant changes in contralateral ureter of all subgroups. Despite of progressive histological changes in ipsilateral ureter no abnormal findings were showed in contralateral ureter. We suggest that long term experimental investigation for histological changes in ipsilateral ureter and compensatory changes in contralateral ureter should be done.

가토에서 일측 요관 부분 및 완전폐색시 신장과 요관의 조직학적 변화

김상현,김용웅,육승모,한동석,노안식,임재성,김홍식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

This study was designed to clarify histologic changes in the experimental rabbit kidney and ureter after unilateral partial or complete ureteral obstruction. A total of 20 adult white rabbits were divided into 4 subgroups in the partial obstruction followed by 2 weeks, the partial obstruction followed by 4 weeks, the complete obstruction followed by 2 weeks, and the complete obstruction followed by 4 weeks. The normal control group was consisted of 5 adult white rabbits. The kidneys and ureters for light microscopy were fixed in 10% neutral formalin, embedded in paraffin and stained with hematoxylin and eosin. Abnormal histologic fingings showed in ipsilateral kidney and ureter of all subgroups(such as dilatation of uriniferous tubule, focal necrosis and desquamation of epithelium, interstitial fibrosis, glomerular congestion, widening of Bowman's space, dilatation of ureter, epithelial cell atrophy or loss, interstitial fibrosis and interstitial inflammation). These findings were most severe in the group of the complete-obstructed ureter for 4 weeks. No significant changes showed in contralateral ureter of all subgroups. The degree of obstruction was severe and period of obstruction was long, the histological changes in ipsilateral side were severe. Despite of changes in ipsilateral side no abnormal findings showed in contralateral side. We suggest that long term experimental investigation of histologic changes in ipsilateral side and compensatory changes in contralateral side have to be studied.