위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

총체적 학습법을 통한 취업 대비 기사 자격증 취득을 위한 특별 학습 지도

육 철,노용택,김대유,이상희 永同工科大學校 1996 硏究論叢 Vol.2 No.1

본 연구는 생명공학부 유전공학전공 2, 3학년을 대상으로 진행된 특별 학습 program으로 취업 대비 목적의 국가 기술 자격증 취득을 위한 특별 학습 지도와 산업 현장 이해를 돕기 위한 현장 교육을 목적으로 추진되었다. 본 연구의 주요 추진 상황으로는 정규 강의와 별도로 소규모 grouping을 통한 특별 학습 실시, 산업체 현장 견학 및 실습, 기사 시험을 대비한 집중 학습 program실시, 하계 방학 특강, 취업에 필요한 제반 교육 등을 실시하였다. 주요 실적으로는 식품 제조 기사 1차시험에서 60%의 합격률을 보였으며 6회에 걸친 산업체 현장 견학과 1회의 산업체 실습을 통하여 현장에 대한 이해도를 높임과 동시에 관련 산업체에 영동공대의 인지도를 높여 주었다. 그리고 본 연구의 가장 중요한 성과로는 목표 설정과 동기 부여를 통하여 학생들 스스로가 학습 성취감을 느낄 수 있었던 점이라 생각된다. This research is of a special topics course(STC) prepared for the sophomore and junior students of the Faculty of Life Science and Engineering(majoring in genetic engineering). It consists of two major programs to improve opportunities for employment of students after graduation: one is a special study program for national technical qualification certification and the other is a field trip and practical experience to learn about industry firsthand. This course included special programs such as special group study in small-sized groups of 2-5 persons, tours and practice at industrial plants and laboratories, intensive study programs prepared for the national technical qualification examination, special lectures during the summer vacation and general education designed to increase opportunities for employment of the students after graduation, in addition to the normal lectures. With the fulfillment of this special topics course, 60% of students who participated in the program succeeded in the national technical qualification examination for food processing, and the students 'understanding about processing and facilities at plants was increased through a total of 7 plant tours and practice which also helped the acknowledgement of YIT to the relevant industries.

STS 학습 지도법에 의한 유전공학 전공의 취업률 향상에 관한 연구

김대유,노용택,육철,이상희 永同大學校 1997 硏究論叢 Vol.3 No.1

STC 교육은 학생들이 학교를 떠나 장차 사회에서 유용하게 쓸 수 있는 경험을 쌓게 하는 방법으로서, 본 연구는 이와 같은 STC 학습법을 활용하여 생명공학부 유전공학전공 2, 3, 4학년 학생들을 대상으로 진행된 취업 대비 기사 자격증 취득을 위한 특별 학습 지도와 산업 현장 이해를 돕기 위한 현장 교육을 목적으로 추진되었다. 본 연구의 주요 추진 상황으로 정규 강의와 별도로 소규모 grouping을 통한 특별 학습 실시, 산업체 견학 및 대학원 실험실 실습, 기사 시험을 대비한 집중 학습 program실시, 하계 방학 특강, 취업에 필요한 제반 교육 들을 실시하였다. 주요 실적으로는 식품 제조 기사2급 2차 시험에 생명공학부 유전공학전공 4학년 학생 5명이 응시하여 5명 전원이 합격한 것을 비롯하여 총 8명이 기사 자격증을 취득하였고, 여러 차례 현장 학습을 통하여 현장에 대한 감각과 이해력을 높였던 점을 들 수 있다. 그리고 본 연구의 가장 중요한 성과로는 목표 설정과 동기 부여 및 목표달성을 통하여 학생들 스스로가 학습 성취도를 고취시킬 수 있었던 점이라 생각된다. STC program is a strategy of preparatory educations for students to gain useful experiences for social activities after graduation. In this STC study, special programs to pass the national technical qualification certification and field trips and practical experiments to understand the actual conditions of industry and society first-hand, are carried out through STS education method. This course included special programs besides the regular lectures such as special group study in small-sized group, tours at industrial plants and laboratories, practical experiments in graduate school, intensive study programs prepared for the national technical qualification examination, special lectures during the summer vacation and general educations for employment after graduation. In this program, it was achieved that 5 senior students passed the national technical qualification examination of food manufacturing, totally 8 students aquired the national technical qualification certification and students majoring in genetic engineering of the faculty of life science and engineering learned the feeling and appreciations of industry and society through several field learning. Conclusively, the main achievement of STS program is that students for themselves developed the learning activity through setting the goals, giving incentives, and reaching the goals voluntarily.

Molecular Engineering of Blue Fluorescent Molecules Based on Silicon End-Capped Diphenylaminofluorene Derivatives for Efficient Organic Light-Emitting Materials

Lee, Kum Hee,Kang, Lee Kyung,Lee, Jin Yong,Kang, Sunwoo,Jeon, Soon Ok,Yook, Kyoung Soo,Lee, Jun Yeob,Yoon, Seung Soo WILEY-VCH Verlag 2010 Advanced Functional Materials Vol.20 No.8

<P>Blue fluorescent materials based on silicone end-capped 2-diphenylaminofluorene derivatives are synthesized and characterized. These materials are doped into a 2-methyl-9,10-di-[2-naphthyl]anthracene host as blue dopant materials in the emitting layer of organic light-emitting diode devices bearing a structure of ITO/DNTPD (60 nm)/NPB (30 nm)/emitting layer (30 nm)/Alq<SUB>3</SUB> (20 nm)/LiF (1.0 nm)/Al (200 nm). All devices exhibit highly efficient blue electroluminescence with high external quantum efficiencies (3.47%–7.34% at 20 mA cm<SUP>−2</SUP>). The best luminous efficiency of 11.2 cd A<SUP>−1</SUP> and highest quantum efficiency of 7.34% at 20 mA cm<SUP>−2</SUP> are obtained in a device with CIE coordinates (0.15, 0.25). A deep-blue OLED with CIE coordinates (0.15, 0.14) exhibits a luminous efficiency of 3.70 cd A<SUP>−1</SUP> and quantum efficiency of 3.47% at 20 mA cm<SUP>−2</SUP>.</P> <B>Graphic Abstract</B> <P>Highly efficient blue organic light-emitting diodes are developed using dopant materials based on a 2-diphenylaminofluoren-7-yl-vinylarene core with various silicon-substituted end-capping groups. The best luminous efficiency of 11.2 cd A<SUP>−1</SUP> and highest quantum efficiency of 7.34% at 20 mA cm<SUP>−2</SUP> are obtained in a device with CIE coordinates (0.15, 0.25). A deep-blue OLED with CIE coordinates (0.15, 0.14) exhibits a luminous efficiency of 3.70 cd A<SUP>−1</SUP> and a quantum efficiency of 3.47% at 20 mA cm<SUP>−2</SUP>. <img src='wiley_img_2010/1616301X-2010-20-8-ADFM200901895-content.gif' alt='wiley_img_2010/1616301X-2010-20-8-ADFM200901895-content'> </P>

<i>tert</i>-Butylated spirofluorene derivatives with arylamine groups for highly efficient blue organic light emitting diodes

Lee, Kum Hee,Kim, Seul Ong,You, Jae Nam,Kang, Sunwoo,Lee, Jin Yong,Yook, Kyoung Soo,Jeon, Soon Ok,Lee, Jun Yeob,Yoon, Seung Soo The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.11

<P>A series of <I>tert</I>-butylated spirofluorene derivatives incorporating a diphenylaminoaryl-vinyl group was synthesized <I>via</I> the Horner–Wadsworth–Emmons olefination and a Suzuki cross-coupling reaction. To examine the electroluminescent properties of these materials, multilayered OLEDs were fabricated into the following device structure: ITO/DNTPD/NPB/MADN:blue dopant materials <B>1–14</B>/Alq<SUB>3</SUB>/Liq/Al. All devices showed efficient blue emission. In particular, one device exhibited highly efficient sky blue emission with a maximum luminance of 25 100 cd m<SUP>−2</SUP> at 8.5 V, as well as luminous, power and external quantum efficiencies of 9.5 cd A<SUP>−1</SUP>, 5.1 lm W<SUP>−1</SUP> and 6.7% at 20 mA cm<SUP>−2</SUP>, respectively. The peak wavelength of electroluminescence was 458 and 484 nm with CIE<SUB><I>x</I>,<I>y</I></SUB> coordinates of (0.14, 0.21) at 8.0 V. In addition, a deep blue device with CIE<SUB><I>x</I>,<I>y</I></SUB> coordinates of (0.15, 0.15) at 8.0 V showed a luminous efficiency and external quantum efficiency of 3.8 cd A<SUP>−1</SUP> and 3.3% at 20 mA cm<SUP>−2</SUP>, respectively.</P> <P>Graphic Abstract</P><P>A series of <I>tert</I>-butylated spirofluorene derivatives incorporating a diphenylaminoaryl-vinyl group was synthesized and their photophysical and electroluminescent properties examined. In the case of devices <B>10A</B>, using <B>10</B> as a dopant in the emitting layer, exhibited efficient blue emission with CIE coordinates of (0.15, 0.15). <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm14869b'> </P>

Proteomic Analysis of Biomarker Candidates for Biological Effects by Korean Red Ginseng

Yong Yook Lee 한국식품영양과학회 2019 한국식품영양과학회 학술대회발표집 Vol.2019 No.10

Proteomic studies of putative molecular signatures for biological effects by Korean Red Ginseng

Yong Yook Lee,Hwi Won Seo,Jong-Su Kyung,Sun Hee Hyun,Byung Cheol Han,Songhee Park,Seung-Ho So,Seung Ho Lee,Eugene C. Yi 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4

Background: Korean Red Ginseng (KRG) has been widely used as an herbal medicine to normalize andstrengthen body functions. Although many researchers have focused on the biological effects of KRG,more studies on the action mechanism of red ginseng are still needed. Previously, we investigated theproteomic changes of the rat spleen while searching for molecular signatures and the action mechanismof KRG. The proteomic analysis revealed that differentially expressed proteins (DEPs) were involved inthe increased immune response and phagocytosis. The aim of this study was to evaluate the biologicalactivities of KRG, especially the immune-enhancing response of KRG. Methods: Rats were divided into 4 groups: 0 (control group), 500, 1000, and 2000 mg/kg administrationof KRG powder for 6 weeks, respectively. Isobaric tags for relative and absolute quantitation was performedwith Q-Exactive LC-MS/MS to compare associated proteins between the groups. The putativeDEPs were identified by a current UniProt rat protein database search and by the Gene Ontologyannotations. Results: The DEPs appear to increase the innate and acquired immunity as well as immune cell movement. These results suggest that KRG can stimulate immune responses. This analysis refined our targetsof interest to include the potential functions of KRG. Furthermore, we validated the potential moleculartargets of the functions, representatively LCN2, CRAMP, and HLA-DQB1, by Western blotting. Conclusion: These results may provide molecular signature candidates to elucidate the mechanisms ofthe immune response by KRG. Here, we demonstrate a strategy of tissue proteomics for the discovery ofthe molecular function of KRG.

Proteomic studies of putative molecular signatures for biological effects by Korean Red Ginseng

Lee, Yong Yook,Seo, Hwi Won,Kyung, Jong-Su,Hyun, Sun Hee,Han, Byung Cheol,Park, Songhee,So, Seung Ho,Lee, Seung Ho,Yi, Eugene C. The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.4

Background: Korean Red Ginseng (KRG) has been widely used as an herbal medicine to normalize and strengthen body functions. Although many researchers have focused on the biological effects of KRG, more studies on the action mechanism of red ginseng are still needed. Previously, we investigated the proteomic changes of the rat spleen while searching for molecular signatures and the action mechanism of KRG. The proteomic analysis revealed that differentially expressed proteins (DEPs) were involved in the increased immune response and phagocytosis. The aim of this study was to evaluate the biological activities of KRG, especially the immune-enhancing response of KRG. Methods: Rats were divided into 4 groups: 0 (control group), 500, 1000, and 2000 mg/kg administration of KRG powder for 6 weeks, respectively. Isobaric tags for relative and absolute quantitation was performed with Q-Exactive LC-MS/MS to compare associated proteins between the groups. The putative DEPs were identified by a current UniProt rat protein database search and by the Gene Ontology annotations. Results: The DEPs appear to increase the innate and acquired immunity as well as immune cell movement. These results suggest that KRG can stimulate immune responses. This analysis refined our targets of interest to include the potential functions of KRG. Furthermore, we validated the potential molecular targets of the functions, representatively LCN2, CRAMP, and HLA-DQB1, by Western blotting. Conclusion: These results may provide molecular signature candidates to elucidate the mechanisms of the immune response by KRG. Here, we demonstrate a strategy of tissue proteomics for the discovery of the molecular function of KRG.

Inhibitory activity of ginsenosides isolated from processed ginseng on platelet aggregation.

Lee, Jin Gyun,Lee, Yong Yook,Wu, Bo,Kim, Sun Young,Lee, Yong Jae,Yun-Choi, Hye Sook,Park, Jeong Hill Govi-Verlag Pharmazeutischer Verlag [etc.] ; Verla 2010 PHARMAZIE Vol.65 No.7

<P>Seven ginsenosides, namely Rg6 (1), F4 (2), Rk3 (3), Rh4 (4), Rs3 (5), Rs4 (6) and Rs5 (7) isolated from processed ginseng were evaluated for their effects on platelet aggregation induced by adenosine diphosphate (ADP), collagen, arachidonic acid (AA) and U46619 (thromboxane A2 mimetic drug). Ginsenosides Rg6, F4 and Rk3 showed inhibitory activity (IC50 = 76 microM, 114 microM and 128 microM, respectively) on AA-induced platelet aggregation. The corresponding IC50 values were comparable to that of acetylsalicylic acid (ASA) (63 microM). Compared to ASA (IC50 = 468 microM) ginsenosides Rg6, F4, Rk3 and Rh4 were found to be more inhibitive (IC50 = 286 microM, 87 microM, 187 microM and 119 microM, respectively) against U46619-induced aggregation. On the other hand, most of the ginsenosides (Rg6, F4, Rh4, Rs3, Rs5) showed negligible effects on ADP and collagen-induced platelet aggregation. The acetylated ginsenosides (Rs3, Rs4 and Rs5) had only mild effects on aggregation induced by four stimulators.</P>

Platelet Anti-Aggregatory Effects of Coumarins from the Roots of Angelica genuflexa and A. gigas

Lee, Yong-Yook,Lee, Sang-Hyun,Jin, Jing-Ling,Yunchoi, Hye-Sook The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.9

Five coumarins, isoimperatorin (1), pabulenol (2), isooxypeucedanin (3), oxypeucedanin hydrate (4) and osthol (5) were isolated from the MeOH extract of Angelica genuflexa in the course of searching for anti-platelet and anti-coagulant components from plants. Pabulenol (2) was isolated from A. genuflexa for the first time. The five compounds isolated from A. genuflexa, together with decursinol angelate (6), decursin (7) and nodakenin (8) from A. gigas were evaluated for their effects on platelet aggregation and blood coagulation. Compounds 2, 5, 6 and 7 were observed to be either equally effective or 2∼4 times more inhibitory than ASA in both arachidonic acid and U46619 ($TXA_2$ mimetic) induced platelet aggregations.