蒼耳子의 IC - 2 細胞에 대한 抗알러지 效果에 關한 硏究 ( 2 )

徐榮培,崔永奉,李龍求,李永喆 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

This study was carried out for the purpose of knowing the effect from anti-allergic action of B cells and the IC-2 mast cells the extraction from Xanthii Fructus(EXF). In order to know the effect of the cytotoxicity from extraction of Xanthii Fructus, we had to examine the safe density of EXF on lung fibroblast cells of the mouse (mLPCs). We also attempted to resolve the relationship cytotoxicity. The effect was on the organization of cytokine gene expression from the increas and divorce of the B cells and allergic acting by EXF, we found it necessary to examine the IC-2 cells and B cells. We examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of EXF on the increase and divorce of the B cells by ^3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and nitric oxide (NO). The results are as follows : 1. EXF did not show cytotoxicity against mLFCs. 2. According to the inspection on the effect on IC-2 cells gene expression by EXF, we found out the following results: EXF reduced IL-4, IL-6, GM-CSF, TNF-α gene expression and histamine release of IC-2 cells. The EXF inhibited signs of inflammation IC-2 cells.

고성능 BiCMOS의 전기적 특성에 관한 연구

구용서 서경대학교 1994 論文集 Vol.22 No.2

이중 매몰층, 1.5㎛ 에피두께, 이중 well, LOCOS 소자격리, LDD MOS 소자와 이중 다결정실리콘 전극을 갖는 바이폴라 소자에 의하여 구성된 BiCMOS 소자를 설계, 제작하였다. 제작된 소자를 측정 및 분석한 결과, 31단 CML 바이폴라(A_E=2×8μ㎡)링 발진기와 31단 CMOS(A_E=1.25×5μ㎡) 인버터 링 발진기로부터 94㎰/5V와 330㎰/12V의 게이트 전달지연시간/소자 강복전압을 갖는 바이폴라 및 MOS 소자특성을 얻을 수 있었다. 또한 BiCMOS 소자의 경우, 31단 BiCMOS 링 발진기로부터 약 700㎰의 게이트 전달 지연시간을 얻었으며, 출력부하의 증가에 따른 속도의 감속비가 완만한 전기적 특성을 얻을 수 있었다.

CALPUFF model과 ISCST3 model을 이용한 악취모델링 기법 연구

구윤서,김성태,김용규,송선호 안양대학교 산업기술연구소 2002 自然科學硏究 Vol.9 No.-

악취는 인간의 후각기관에 의해 감지되기 때문에, 대상 지역의 평균농도(Average Concentration) 보다는 악취의 특성상 순간적인 농도인 첨두농도(Peak Concentration)가 중요한 의미를 갖는다. 따라서 이것을 모델링에 적용하기에는 많은 어려움이 있다. 이를 해결하는 것이 이 연구의 주된 과제라 할 수 있다. 현재 국내에서 환경영향평가에 많이 사용되고 있는 ISCST3 Model (Industrial Source Complex Short Term 3 Model)과 CALPUFF Model (California Puff Model)을 사용하여 첨두농도(Peak Concentration)를 고려한 관능악취도(Odor Intensity)를 두 가지 방법으로 산정 하였다. 첫 번째로는 오염원에서 배출되는 물질의 농도를 이용하는 방법과 다른 하나는 종합악취도 개념으로 악취농도(Odor Concentration)를 이용하여 관능악취도를 산정하는 것이다. 위의 두 가지 방법을 ISCST3 Model과 CALPUFF Model에 적용하여 모델링을 수행한 후 나온 기여농도를 첨두농도로 환산한 후 관능악취도를 계산하였다. 이와 같은 이론 배경을 바탕으로 현장 적용성을 파악하기 위해서 수도권매립장의 한 지점에서 가상의 가스배제공이 있다고 가정하고, ISCST3 Model과 CALPUFF Model에 동일한 조건으로 모델링을 수행하여 매립장 주변에 미치는 관능악취도를 각각 산출해 비교 검토하였다. 그 결과 두 모델에서의 차이는 크지 않았으나 기여농도와 첨두농도 사이에는 상당한 차이를 보였다. 결과적으로 악취모델링을 수행함에 있어서 기여농도만을 고려하는 것은 관능악취도를 과소평가 할 우려가 있으므로 배출원 특성을 고려한 첨두농도로 관능악취도를 평가하는 것이 타당하다고 판단된다. In order to manage the odor related public complains effectively, the estimation of peak ground-level concentration which is capable of predicting the intermittent maximum response less than 10 seconds is very important. However, peak rather than 3 minute or 1 hour average concentrations are not easily predicted by current air dispersion models such as SCST3 (Industrial Source Complex Short Term - version 3) and CALPUFF (CALifornia Puff) models. According to the field and wind tunnel measurements, the intensity of the peak concentration depends on the emission source type, downwind distance and atmospheric stability. The odor modeling methods to predict the peak concentration were reviewed and the detailed procedure for the odor modeling was explained in this study. In order to compare the conventional air dispersion models with the oder models, the odor concentrations with various modeling techniques under the identical emission and meterological conditions were calculated. The peak concentration shows highest value than the 3 minutes or 1 hour average concentrations. The predicted odor concentrations by the CALPUFF model are higher than those predicted by the ISCST3 model since the CALPUFF model reflects the time-dependent movement of the plume. It is recommended that using the peak concentration with the CALPUFF model rather than 3 minutes or 1 hour average concentrations is more reasonable approaches to manage the odor problems.

山茱萸의 抗알러지 效果에 關한 硏究

徐榮培,吉基正,李龍求,李永喆 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

In order to investigate the anti-allergic effects of Corni Fructus extract(CFE) and about the expression of CD23, IgE, it was necessary for it to be activated by anti-CD40, rHRF. We then analyzed it from the flow cytometer. 1. CFE significantly decreased the expression of anti-CD23, IgE. 2. According to inspection of the inhibitory effect of CFE on the cell proliferation of B cells, IgE, IL-4, histamine release of B cells, we found out the following results: CFE reduced cell proliferation of B cells significantly, and reduced the immunoreaction directly in the B cells by the inhibitory effects on the IgE release of B cells. And CFE reduced the immunoreaction directly in the B cells by inhibitory effects on IL-4, histamine release of B cells.

紅花의 造血作用에 對한 實驗的 硏究

徐榮培,李龍求,李永喆,閔平基 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

In order to investigate the haematopoietic effects of Carthami Flos on various experiments were studied. The results were obtained as follows: 1. In the proliferous effect of bone marrow cells, water extracts of Carthami Flos played an important role on the proliferating bone marrow cells compared with control group at low density. 2. The water extracts of Carthami Flos promoted the proliferation of the bone marrow cells into cluster, BFU-E, CFU-GEMM and colony. 3. In the bone marrow cells treated with CTX, the water extracts of Carthami Flos promoted the SCF, EPO, IL-4, IL-6 gene expression, but gene expression of its receptors, c-kit, EPO-R, TPO, c-mpl, EKLF, GATA-1 were not promoted significantly. According to the above results, water extracts of Cathami Flos promoted not only the differentiation

太子蔘의 造血作用에 對한 實驗的 硏究

徐榮培,李龍求,李永喆,李太元 대한본초학회 2002 大韓本草學會誌 Vol.17 No.1

In order to investigate the hematopoietic effects of Pseudostellariae Radix various experiment about hematopoiesis were studied. The results were obtained as follows: 1. In the proliferous effect of bone marrow cells, water extracts of Pseudostellariae Radix played an important role on the proliferating bone marrow cells compared with control group. 2. The water extracts of Pseudostellariae Radix activated the bone marrow cells. 3. The water extracts of Pseudostellariae Radix promoted the proliferation of the bone marrow cells into cluster, BFU-E, CFU-GEMM. 4. In the bone marrow cells treated with CTX, the water extracts of Pseudostellariae Radix promoted the SCF, EPO, IL-4, IL-6 gene expression, but gene expression of its receptors, c-kit, EPO-R, TPO, c-mpl, EKLF, GATA-1 were not promoted significantly. According to the above results, water extracts of Pseudostellariae Radix promoted not only the differentiation of the bone marrow cells into CFU-GEMM which mother cell of erythrocytes, thrombocytes, monocytes and macrophages, but also the differentiation of the bone marrow cells into BFU-E. On the other hand, in the gene expression that have a lot of hematopoietic effects in the early differentiation of haematopoietic stem cells by promoting the gene expression of SCF, EPO, IL-4, IL-6 and so forth. Above results also demonstrates that the water extracts of Pseudostellariae Radix have somewhat meaningful effects in hematogenesis but not sufficient to explain its mechanisms about hematogenesis, therefore further deep studies should be accomplished about its mechanisms.

Pyrantel Pamoate (Combantrin)에 依한 蛔蟲 및 鉤蟲感染의 集團治療

徐丙卨,朴定圭,趙昇烈,姜信榮,魚光本,康世喆,李源宰,李正雨,黃邱一 中央醫學社 1972 中央醫學 Vol.23 No.6

The mass treatment trial of pyrantel pamoate on Ascaris lumbricoides and Ancylostoma duodenale infections was carried out to school-children and inhabitants in rural areas in the central part of Korea. Pyrantel pamoate ("Combantrin") tablet (123 mg base) was administered as a single dose of 10. 0 mg per kg. body weight to a total of 4,198 Ascaris infected cases selected out of 4,436 (41. 6%) positives, who were screened from the total 10,660 collected stool specimens. Of these, only 3,169. cases were followed up after treatment to provide an analysis in this study. Incidentally 161 cases with concomittently infected hookworm were also subjected to assess the efficacy of pyrantel pamoate against A. duodenale. The egg negative conversion rate on A. lumbricoides was 95.3%, and on A. duodenale, 97.5% four weeks following treatment. In failed cases, the egg reduction rates on both of the infections were 97.6% and 97.3% respectively. No side effects and no problem in drug administration were demonstrated. It is concluded that this study confirms the high efficacy of pyrantel pamoate in the treatment of Ascaris lumbricoides and Ancylostoma duodenale infections and also proves the acceptability and safety of this drug in the mass treatment of ascariasis in a population with relatively high worm burden.

Pyrantel Pamoate(Combantrin)에 依한 蛔蟲症의 減量療法

徐丙卨,李純炯,趙昇烈,姜信榮,梁龍石,黃邱一,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea. A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of' pyrantel pamoate. A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen. For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll's Egg Counting Technique). The results obtained were; 1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6). 2. The reduction rates were also obtained just as the same order of the above results. 3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1). 4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5). 5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics. From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.

표재성 방광암에서 Bacillus Calmette-Guerin 방광 내 주입요법 : 장기적 추적결과 Long-term Follow up Results

김용웅,왕세환,육승모,한동석,노안식,나용길,설종구 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

To evaluated the results of long-term follow up of superficial bladder cancer patients who were treated with transurethral resection and intravesical BCG therapy. Between April 1989 and December 1997, 65 patients with superficial bladder cancer were treated with TUR-B(Transurethral resection of bladder tumor) and intravesical BCG instillation, and follow-up was performed for 5 years longer, and the mean follow-up duration was 82 months. Of 65 patients, pathologic stage were Ta in 17 cases and T1 in 48 cases and grade were G Ⅰ in 22 cases, G Ⅱ in 35 cases and G Ⅲ in 8 cases. The tumor recurred in 22(33.8%) at the median of 21.8 months and the tumor progressed in 9(13.8%) at the median of 20.8 months. Most of the recurrences and progression were within 3 year(838 and 77%). Progression is more likely in higher grade(G Ⅱ, G Ⅲ) and higher stage(T1). The complete response rate after first and second courses of BCG therapy were 53% and 73% and the 5 and 10 year disease specific survival rates were 89.5 and 78% respectively. The complete response rate after first and second courses of BCG therapywere 53% and 73%. Most of recurrences and progressions were within 3 years of the BCG therapy, but some cases occured after 5 years. Therefore, close long-term follow up is needed.

표면 조도의 변화에 따른 마찰 및 마멸 특성

조용주,이상욱,구영필,서만식 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.56 No.-

마찰과 미끄럼 마멸에서 표면 거칠기의 특성에 대한 효과는 실험적으로 볼-디스크 마멸 시험기를 가지고 연구되어졌다. 실험은 서로 다른 하중, 미끄럼 속도, 그리고 윤활유 점도 조건하에서 산술평균값, skewness, kutosis를 변화시켜 수행되었다. 음의 값을 가지는 더 낮은 skewness 또는 더 높은 kutosis의 표면조도를 가진 같은 상술평균 값에 대하여 더 낮은 마찰을 가지는 경향이 있다. The effect of characteristic of surface roughness on friction and sliding wear was studied experimentally with ball-on-disk type wear tester. The test was conducted with specimens those have varying arithmetic mean value, skewness and durtosis under the condition of different load, sliding speed and lubricant viscosity. The surface of the lower skewness in negative value or the higher kurtosis tends to have low friction for the same arithmetic mean value.