정상 임부 및 정상 산욕부에 있어서 뇨중 Pregnanendiol 배설량에 관하여

이수월(SW Lee) 대한산부인과학회 1962 Obstetrics & Gynecology Science Vol.5 No.1

Evaluation of the urinary pregnandiol in the urine obtained from six cases of normal gravida and nine cases of normal puerpera were performed by Guterman and Schraeder`s method. Results are shown below. 1) The urinary pregnandiol levels in the normal gravida present the gradual increase in amount from 4th week of gestation to 20th week and reach the highest level at about 32nd ~ 36th week of gestation, however, gradual decrease are observed thereafter. 2) The urinary pregnandiol level in the urine obtained from women in the puerperium present adrupt falls immediately after the delivery and become negligible on fifth post-partum day thereafter.

인삼(人蔘)의 중추신경(中樞神經)에 대(對)한 작용(作用)

이수월(Lee, S.W.) 대한약리학회 1974 대한약리학잡지 Vol.10 No.2

Results of an experiment on the general behavior of rats in order to explore the possible pharmacological actions of Panax Ginseng upon the central nervous system can be summarized as follows: 1) The rats treated with Ginseng-saponin intraperitoneally with the doses of 50 or 100 mg/kg show the decreased sleeping component and increase in lying and grooming component and walking and rearing component of general behavior. 2) There are no difference between control group and saline treated group in pattern of general behavior components. 3) In the Ginseng-saponin treated groups, the amphetamine stimulated walking and rearing component of genenarl behavior are reduced but lying and grooming component are elevated. 4) Ginseng-saponin shows very low acute toxicity in mice. The LD₅₀ in mice of 24 hours after intraperitoneal injection was 795 mg/kg. From the above findings, it is to suggest that the Ginseng saponin might stimulate the central nervous system but its mode of action appears to be different from that of amphetamine. And the effects of Ginseng saponin may be varied depending on various experimental situation or condition of animals.

KIKO 거래기업의 사전 위험성 인지 여부에 관한 연구

정태영,이수월 경성대학교 산업개발연구소 2014 산업혁신연구 Vol.30 No.2

본 연구에서는 최근 KIKO(Knock-In, Knock-Out) 거래와 관련하여 제기되고 있는 여러 가지 논점 중에서 거래기업의 사전 위험성 인지 여부에 초점을 맞추고, 과연 거래기업들이 KIKO 거래의 높은 위험성을 사전에 충분하게 인지하고 있었는지에 대해 탐험적인 분석을 실시해 보았다. 이를 위해 KIKO 거래 이전에 외환파생금융상품을 거래한 경험이 있는 기업은 KIKO 거래의 위험성을 인지할 수 있는 능력이 있으며, 외환파생금융상품을 거래한 경험이 없는 기업들은 KIKO 거래의 위험성을 인지할 수 있는 능력이 부족하였을 것으로 가정하고, 과거 수년간의 외환파생금융상품 거래 여부가 KIKO 거래 여부에 미치는 영향을 분석해 봄으로써 KIKO 거래기업의 사전 위험성 인지 여부를 추정해 보았다. 분석 결과 외환파생금융상품 거래 경험이 있는 기업일수록 KIKO 거래 가능성이 높은 것으로 나타나 거래기업들은 KIKO 거래의 높은 위험성을 사전에 인지하고 있었던 것으로 판단된다. 이러한 분석 결과는 KIKO 거래기업들이 위험성을 제대로 인지하지 못하였다는 피해기업들의 주장과는 차이점을 보이고 있다. 오히려 거래기업이 KIKO 거래의 위험성은 인지하고 있었지만, 당시 환율이 지속적으로 하락하는 상황에서 어느 정도 위험을 감수하더라도 선물환율보다 유리한 약정환율로 달러를 매도하기 위해(투기적인 목적으로) 거래를 하였을 개연성이 높다는 것을 시사하고 있다. This paper investigates whether KIKO traded firms properly perceived the risks inherent in KIKO before signing KIKO contracts. We first assume firms with prior experience of foreign exchange risk hedging using financial derivatives were well aware of the risks inherent in KIKO contracts while firms with no prior foreign exchange risk hedging experience were not aware of the risks properly. Under this somewhat strong assumption, we test whether there is any relationships between prior foreign exchange risk hedging experience with financial derivatives and KIKO transactions. Empirical results show that firms with prior experience of foreign exchange risk hedging are more likely to enter into KIKO contracts vis-a-vis firms with no prior experience of foreign exchange risk hedging, which implies that firms with prior foreign exchange risk hedging experience may have been well aware of high risks inherent in KIKO contracts. This paper is an exploratory study to find out whether firms properly recognized the risks inherent in KIKO contracts. We expect more rigorous empirical studies on this issue.

尋常性좌창(Acne Vulgaris)에 對한 Vibramycin의 臨床的效果

洪起煥,安順姬,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

尋常性?瘡이 顔面에 甚한 女高生 40名을 double-blind試驗에 依하여 Vibramycin(Vibramyin 100mg을 1日 1回 經口的으로 投與)을 投與하여 다음의 結果를 얻었다. 1) Vibramycin 4週間 投與하였을 때 治癒率 은 80.0%이고 placebo를 投與時는 29.3%를 나타내었다. 그리고 治療效果는 投藥 3週에 顯著이 나타나기 始作하였다. 2) 投藥中止後 3週에는 治癒率이 Vibramycin 投藥群에서 減少를 보였으며 2名은 再發되었다. 3) 投藥 4週동안 治療效果가 不充分한 患者에게 3週間 더 延長하였을 때는 더욱 顯著한 效果를 볼 수 있었다. Forty high school girls with acne vulgaris were included in a double-blind trial to assess the tLapeu tic effect of Vibramycin (100 mg Vibramycin capsule, orally, once daily). The results, assessed clinically are as follows; 1. When Vibramycin was administered for 4 weeks, the cure rate showed 80. 0% and in the case of placebo, 29.3%, and the effectiveness was significantly appeared at 3 weeks of treatment. 2. In follow-up study, at 3 weeks after cessation of Vibramycin treatment, the cure rate decreased in Vibramycin group, and especially, in two girls, rashes like as inflammatory papules and pustules was reappeared. 3. When Vibramycin was administered another 3 weeks in addition, to those whom the effectiveness was insufficient in spite of 4 week-treatment, it had showed significantly beneficial effect.

"Tinidazole"(Fasigyn)에 依한 Giardia Lamblia의 驅蟲效果

崔源永,李玉蘭,李元求,이규면,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

"Tinidazole a new antiflagellate drug, was given orally for 3-7 days to 99 children infected with G.lamblia. Stool examination for detection and evaluation of therapeutic on giardiasis were made by formaline-ether concentration techniques. The children were grouped according to doses and the duration of administration of the drug. The results were summarized as follows; 1) Except 1 case out of 99 children, none of the children showed G. lamblia in the stool examination 2 weeks after administration of the drug, regardless of groups. 2) 4 weeks after administration of the drug, group A (10 mg per kg for 7 days) and group B (5 mg per kg for 7 days) children showed 100% of negative conversion, but group C (10 mg per kg for 5 days) children revealed 84.6% of negatives. 3) 6 months later, the negative conversion rates in groups A, B and C were reduced to 54.5%, 57. 1% and 50. 0% respectively. 4) Mild or transient side effects-nausea, abdominal pain, headache or fever and diarrhea were noted in 16 cases (27. 1%) out of 59 cases.

Pyrantel Pamoate(Combantrin)에 依한 蛔蟲症의 減量療法

徐丙卨,李純炯,趙昇烈,姜信榮,梁龍石,黃邱一,朴定圭,李水月 中央醫學社 1973 中央醫學 Vol.25 No.4

The mass treatment trial with low dosage of pyrantel pamoate against Ascaris lumbricoides infection was conducted to school children in rural areas of Korea. A comparative trial in the use of piperazine salt, santonin-kainic acid complex in the treatment of ascariasis was also attempted to evaluate the efficacy of' pyrantel pamoate. A total of 804 Ascaris infected school children selected out of 822-positives, who were screened from the total 1, 699 collected specimens, were classified into 7 groups. One of the three kinds of anthelmintics, i.e., pyrantel pamoate, piperazine adipate and santonin-kainic acid complex was administered to each group according to the planned regimen. For the evaluation, the egg negative conversion rate(cure rate) and egg reduction rate were calculated 4 weeks after treatment on 623 follow-up cases with the obtained results from the stool examinations (Cellophane Thick Smear Method and Stoll's Egg Counting Technique). The results obtained were; 1. The egg negative conversion rate was the highest in pyrantel treated groups (Group 1, 2, 3), santonin-kainic acid complex treated group (Group 7) coming next, and the lowest in piperazine treated groups (Group 4, 5, 6). 2. The reduction rates were also obtained just as the same order of the above results. 3. Among the pyrantel pamoate treated groups, the low dosage groups (Group 2 8: 3) showed 90.6% and 85.7% of negative conversion rate, and 99. 2% and 98. 2% of reduction rate respectively, while 94.1% of negative conversion rate and 97.9% of reduction rate were obtained in the conventional dosage group (Group 1). 4. On the analysis of efficacy in the groups treated with piperazine adipate, the best results were. shown in 2 or 3 consecutively treated groups (Group 4 &.- 6) under the supervision of qualified doctors, and the worst was in the group treated with 2 consecutive administration by teachers without supervision (Group 5). 5. The side reactions were so negligible in all the trial groups that none of the treated cases complained about the known side effect of those anthelmintics. From the present study, it can be suggested that the pyrantel pamoate is the most effective among three drugs, and also be recommended to apply the low dosage schedule of pyrantel pamoate in the masstreatment of ascariasis to reduce the expense of masstreatment.

Glycyrrhizin이 Liver Glycogen Storage에 미치는 영향(影響)

한평희(Han, P.H.),이동열(Lee, D.Y.),홍석영(Hong, S.Y.),정규화(Chung, K.H.),이수월(Lee, S.W.) 대한약리학회 1967 대한약리학잡지 Vol.3 No.1

Many investigators reported the mineral corticoid hormon-like action of Glycyrrhizin. The other investigators suggested concerning the glucocorticoid hormon-like action. Authors had been observed the glycogen content of the liver to make sure the relationship between glucocorticoid like action of Glycyrrhizin and glucose metabolism in the liver. There was significant increase in the liver glycogen content in rat fed Glycyrrhizin for two weeks, however it was confirmed that Glucuronic acid combined with Glucuronic was unable to make any influence to glycogen content. The relation concerning the effect of Glycyrrhizin on liver glycogen and its mechanism of action might be needed followup study.