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Exploiting Multi-Hop Relaying to Overcome Blockage in Directional mmWave Small Cells
Yong Niu,Chuhan Gao,Yongliang Ma,Li Su,Depeng Jin 한국통신학회 2016 Journal of communications and networks Vol.18 No.3
With vast amounts of spectrum available in themillimeter wave (mmWave) band, small cells at mmWave frequenciesdensely deployed underlying the conventional homogeneousmacrocell network have gained considerable interest fromacademia, industry, and standards bodies. Due to high propagationloss at higher frequencies, mmWave communications are inherentlydirectional, and concurrent transmissions (spatial reuse)under low inter-link interference can be enabled to significantlyimprove network capacity. On the other hand, mmWave linksare easily blocked by obstacles such as human body and furniture. In this paper, we develop a multi-hop relaying transmission(MHRT) scheme to steer blocked flows around obstacles by establishingmulti-hop relay paths. In MHRT, a relay path selectionalgorithm is proposed to establish relay paths for blocked flowsfor better use of concurrent transmissions. After relay path selection,we use a multi-hop transmission scheduling algorithm to computenear-optimal schedules by fully exploiting the spatial reuse. Through extensive simulations under various traffic patterns andchannel conditions, we demonstrate MHRT achieves superior performancein terms of network throughput and connection robustnesscompared with other existing protocols, especially under seriousblockage conditions. The performance ofMHRT with differenthop limitations is also simulated and analyzed for a better choiceof the maximum hop number in practice.
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Yong Chun Li,Fan Rong Meng,Chun Yan Zhang,Ning Zhang,Ming Shan Sun,Jiang Ping Ren,Hong Bin Niu,Xiang Wang,Jun Yin 한국식물학회 2012 Journal of Plant Biology Vol.55 No.5
To understand better the mechanisms that regulate the water stress response in wheat, we conducted a comparative analysis of transcript profiles in roots from two wheat genotypes -- drought-tolerant ‘Luohan No. 2’ (LH)and drought-susceptible ‘Chinese Spring’ (CS). In LH roots,3831 transcripts displayed changes in expression of at least two-fold over the well-watered control when drought treatment was applied. Of these, 1593 were induced while 2238 were repressed. Relatively fewer transcripts were drought-responsive in CS; i.e., 1404 transcripts were induced and 1493 were repressed. In common between LH and CS,569 transcripts were induced and 424 transcripts were repressed. In all, 689 transcripts (757 probe sets) identified from LH and 537 transcripts (575 probe sets) from CS were annotated and classified into 10 functional categories. Among those annotated transcripts from LH and CS that had fold-change ratios of at least 4, 92 induced transcripts were common to both, while 23 transcripts were specifically induced in LH. Gene ontology analysis of these induced genes showed highly significant enrichment for multiple terms related to abiotic stimuli, organic acid biosynthesis,and lipid metabolism. This suggests that these gene groups play important roles during the stress response in LH and CS, and might also be responsible for differences in drought tolerance between those genotypes.
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Psychosocial Response and Symptom Burden for Male Smokers with Lung Cancer
Niu, Zhi-Min,Liang, Chun-Shui,Yu, Min,Wang, Yong-Sheng,Yu, Hai-Xia,Zhang, Qiong-Wen,Wei, Yu-Quan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Purpose: Cigarette smoking causes many kinds of cancer, and it is more closely related with lung cancer, rather than other cancers. Smoking is the leading cause of lung cancer and ninety percent of the smokers are male in China, but there is little published data concerning the psychological responses in the male smokers with lung cancer and its influence on the symptom burden. The aim of the study was to verify the hypothesis that male smokers with lung cancer have more positive attitude and less symptom burden, comparing to male non-smokers. Methods: A total of 194 men with cancer in West China Hospital, Sichuan, China, were assessed by self-administered questionnaire. Psychological response was measured by the Chinese version of Mini-Mental Adjustment to Cancer scale (Mini-MAC), and symptom burden was measured by the physical symptom distress scale from the Rotterdam Symptom Checklist (RSCL). Results: We found that smokers with lung cancer got higher scores in positive attitude and a smaller symptom burden than non-smokers. Patients with education lower than high school got higher scores of positive attitude compared to college graduate patients (p=0.038). Smokers with lung cancer who knew the potential carcinogenicity of cigarette showed less negative emotions (p=0.011). The psychological response was not affected by age, clinical stage, cell type, smoking duration and amount. Conclusions: Male smokers with lung cancer have a more positive attitude and fewer symptoms, comparing to male non-smokers. Appropriate psychological intervention for non-smokers with lung cancer deserves more attention.
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Effect of TLR4 and B7-H1 on Immune Escape of Urothelial Bladder Cancer and its Clinical Significance
Wang, Yong-Hua,Cao, Yan-Wei,Yang, Xue-Cheng,Niu, Hai-Tao,Sun, Li-Jiang,Wang, Xin-Sheng,Liu, Jing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background/Aim: Toll-like receptor 4 (TLR4) and B7-H1, both normally expressed restricted to immune cells, are found to be aberrantly expressed in a majority of human tumors and may play important roles in regulation of tumor immunity. It has been shown that urothelial bladder cancer (UBC) patients can manifest tumoral immune escape which may be a potential critical factor in tumor pathogenesis and progression. However, so far, the mechanisms of UBC-related immune escape have not been clarified. The aim of this study was to investigate the effect of TLR4 and B7-H1 on immune escape of UBC. Methods: Bladder cancer T24 cells were pre-incubated with LPS and co-cultured with tumor specific CTLs. CTL cytotoxicity and apoptosis rates were measured by MTT assay and flow cytometry, respectively. The effects of an ERK inhibitor on B7-H1 expression and CTL cytotoxicity against T24 cells were also evaluated. In addition, TLR4, B7-H1 and PD-1 protein expression was analyzed by immunohistochemistry in 60 UBC specimens and 10 normal urothelia. Results: TLR4 activation protected T24 cells from CTL killing via B7-H1 overexpression. However PD98059, an inhibitor of ERK, enhanced CTL killing of T24 cells by reducing B7-H1 expression. TLR4 expression was generally decreased in UBC specimens, while B7-H1 and PD-1 were greatly overexpressed. Moreover, expression of both B7-H1 and PD-1 was significantly associated with UICC stage and WHO grade classification. Conclusions: TLR4 and B7-H1 may contribute to immune escape of UBC. Targeting B7-H1 or the ERK pathway may offer new immunotherapy strategies for bladder cancer.
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Detection and Monitoring of Potential Geological Disaster Using SBAS-InSAR Technology
Wei Niu,Xiaonong Hu,Bo Lin,Fanqi Meng,Yong Zhang,Jin Zhao 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.11
As a global geological environment problem, geological disasters are more likely to induce severe geological disasters and cause loss of personnel and property due to their suddenness and concealment, frequent heavy rainfall and regular extreme weather. In this paper, Sentinel-1A data and DEM data combined with short baseline synthetic aperture interferar (SBAS-InSAR) technology are used to analyze and calculate the spatial-temporal evolution characteristics of surface deformation in Zibo-Weifang area of Shandong Province during 2016-2019. Linear fitting of InSAR monitoring deformation results is performed using level monitoring data to verify the accuracy of the results. The findings indicate that surface deformation in most of the study area is relatively stable, but in some areas, especially near Lucun Town, the maximum negative deformation rate exceeds 80mm/a. Based on the surface deformation results, a total of 377 potential geological disasters are identified using an integrated multi-source stereo observation system of the sky and ground. This identification is done by observing optical remote sensing images and taking the absolute value of surface deformation rate greater than 10 mm/a as the judgment basis, along with ground investigation and review. Several typical geological disaster sites are screened and they are found to be in unstable state. The research results can provide scientific support for geological disaster prevention and control in Shandong Province.
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Increased Frequency of Foxp3+ Regulatory T Cells in Mice with Hepatocellular Carcinoma
Du, Yong,Chen, Xin,Huang, Zhi-Ming,Ye, Xiao-Hua,Niu, Qing Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
The CD4+CD25+ regulatory T cell (Treg) is a special kind of T cell subset. Studies have showed that Treg cells are involved in a number of physiological processes and pathologic conditions such as autoimmune diseases, transplantation tolerance and cancer. Tregs with unique capacity for immune inhibition can impair anti-tumour immunity and help tumor cells to escape from immune surveillance. The aim of our study was to investigate whether Tregs are involved in hepatocellular carcinoma (HCC). A BABL/C mouse with HCC in situ model was established to evaluate the Treg existence in carcinoma tissues and the changes of Tregs in spleen using flow cytometry and immunohistochemistry methods. Granzyme B expression in carcinoma tissues was analyzed by immunohistochemistry to investigate the tumor local immune status.The proportion of CD4+CD25+/CD4+ spleen lymphocytes of tumor bearing mice ($18.8%{\pm}1.26%$) was found to be significantly higher than that in normal mice ($9.99%{\pm}1.90%$) (P<0.01 ). Immunohistochemistry of spleen tissue also confirmed that there was an increase in Treg in tumor-bearing mice, while in carcinomas it showed Treg cells to be present in tumor infiltrating lymphocyte areas while Granzyme B was rarely observed. Anti-tumour immunity was suppressed, and this might be associated with the increase of Tregs. Our observations suggest that the CD4+CD25+Treg/CD4+ proportion in spleen lymphocytes can be a sensitive index to evaluate the change of Tregs in hepatocellular carcinoma mice and the Treg may be a promising therapeutic target for cancer.
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Zhou Yong,Dong Qi,Niu Xiao-Jun,Xu Hong,Xiong Qi,Su Hao,Zheng Jun 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.6
A 2 MW direct-drive (DD) high temperature superconducting (HTS) wind power generator with HTS wires in the rotor fi eld windings and copper transposed conductor in the stator coils was explored for the wind turbine application in this study. An oil-cooling air-core stator with non-magnetic teeth of the 2 MW DD HTS generator was designed because the high fl ux density generated by the HTS wires wound result in larger dissipation in iron teeth, and the process of that could be summarized as follows. First, a 2 MW DD HTS wind power generator was designed, and the electromagnetic (EM), loss, EM force, and insulation of the DD HTS generator were analyzed and developed, respectively. Second, the thermal and mechanical of the one pole pair oil-cooling air-gap armature was analyzed by the fi nite element analysis. Then, a pole pair segment of the oil-cooling air-core stator with the same structure as the 2 MW generator was designed and manufactured to identify potential challenges, obtain practical knowledge before production, and then reduce the development risk of the 2 MW DD HTS generator. Furthermore, a test system with converter, oil-cooling system, and data acquisition equipment was developed simultaneously to test the temperature distribution of the slotless stator. The performance test results show that the maximum temperature rise of the one pole pair oil-cooling stator under rated conditions is about 81.4 K, which satisfi es the design requirements of the 2 MW DD HTS generator.
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( Xue Liang Niu ),( Xiao Ran Hao ),( Zhang Yong Hong ),( Long Fei Chen ),( Xi Yu ),( Xu Dong Zhu ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.5
Fungi of the genus Pestalotiopsis have drawn attention for their capability to produce an array of bioactive secondary metabolites that have potential for drug development. Here, we report the determination of a polyketide derivative compound, pestalotiollide B, in the culture of the saprophytic fungus Pestalotiopsis microspora NK17. Structural information acquired by analyses with a set of spectroscopic and chromatographic techniques suggests that pestalotiollide B has the same skeleton as the penicillide derivatives, dibenzodioxocinones, which are inhibitors of cholesterol ester transfer protein (CETP), and as purpactins A and C’, inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT). Strain NK17 can make a fairly high yield of pestalotiollide B (i.e., up to 7.22 mg/l) in a constitutive manner in liquid culture. Moreover, we found that a putative histone deacetylase gene, designated as hid1, played a role in the biosynthesis of pestalotiollide B. In the hid1 null mutant, the yield of pestalotiollide B increased approximately 2-fold to 15.90 mg/l. In contrast, deletion of gene hid1 led to a dramatic decrease of conidia production of the fungus. These results suggest that hid1 is a modulator, concerting secondary metabolism and development such as conidiation in P. microspora. Our work may help with the investigation into the biosynthesis of pestalotiollide B and the development for new CETP and ACAT inhibitors.
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