Significance of Thrombocytosis in Clinicopathologic Characteristics and Prognosis of Gastric Cancer

Li, Fang-Xuan,Wei, Li-Juan,Zhang, Huan,Li, Shi-Xia,Liu, Jun-Tian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Purpose: We aimed to study the relationship between thrombocytosis and clinical features of gastric cancerfocussing on platelet counts and gastric cancer progression through different TNM stages. Methods: According to the normal range of platelet count in our institution, 1,596 patients were divided to two groups: a thrombocytosis group (120 patients, > $400{\times}1000/{\mu}L$) and a control group (1,476 patients, ${\leq}400{\times}1000/{\mu}L$). Results: The incidence of thrombocytosis was 7.5%. Higher platelet counts were observed in patients with older age, larger tumor size, deeper invasion, lymph node metastasis, distant metastasis and advanced TNM stage. In multivariate logistic regression, tumor size, depth of tumor invasion, lymph node metastasis and TNM stage were independent risk factors for thrombocytosis of gastric cancer patients. On prognostic analysis, age, tumor size, tumor location, histologic type, depth of tumor invasion, lymph node metastasis, distant metastasis and TNM stage and platelet count were important factors. Tumor size, invasion depth, lymph node metastasis, TNM stage and the platelet count were independent prognostic factors. Conclusion: Thrombocytosis is associated with clinical features of gastric cancer patients and correlates with a poor prognosis.

DIETARY SUPPLEMENTAL EFFECTS OF Gracilaria lemaneiformis ON GROWTH PERFORMANCE, HAEMATOLOGICAL PARAMETERS AND SALINITY STRESS OF JUVENILE PACIFIC WHITE SHRIMP (Litopenaeus vannamei)

Li-xia Tian,Ying-ying Yu,Yong-jian Liu,Jin Niu,Wen-dong Chen,Hui-jun Yang,Gui-ying Liang 한국수산과학회 양식분과 2015 한국수산과학회 양식분과 학술대회 Vol.2015 No.5

Asymmetric selenophene-based non-fullerene acceptors for high-performance organic solar cells

Li, Chao,Xia, Tian,Song, Jiali,Fu, Huiting,Ryu, Hwa Sook,Weng, Kangkang,Ye, Linglong,Woo, Han Young,Sun, Yanming The Royal Society of Chemistry 2019 Journal of materials chemistry. A, Materials for e Vol.7 No.4

<P>Compared to thiophene-based non-fullerene acceptors (NFAs), selenophene-based NFAs have received much less attention. And organic solar cells (OSCs) based on selenophene-containing NFAs typically exhibit relatively low power conversion efficiency (PCE < 12%) and fill factor (FF < 70%). In this contribution, we have designed and synthesized two asymmetric selenophene-based NFAs, named SePTT-2F and SePTTT-2F, which possess the same end-capping group but different selenophene-containing conjugated backbones. On comparing the two NFAs, SePTTT-2F with more extended conjugation in the backbone was found to have almost the same maximum absorption peak and optical bandgap in film as SePTT-2F but an up-shifted lowest unoccupied molecular orbital (LUMO) energy level and higher electron mobility. By pairing the NFAs with the polymer donor PBT1-C, the resultant blend film based on SePTTT-2F exhibited higher and more balanced charge mobilities and more efficient exciton dissociation and charge collection in comparison with the SePTT-2F-based blend film. As a result, OSCs based on SePTTT-2F delivered an impressively high PCE of 12.24% with an outstanding FF of 75.9%, much higher than those of the SePTT-2F-based OSCs. To the best of our knowledge, the PCE of 12.24% and FF of 75.9% are among the highest values reported in the literature so far for both the parameters amongst selenophene-containing NFA-based OSCs. Our results demonstrate that extending the conjugation in the selenophene-containing backbone is an effective strategy to design highly efficient selenophene-based NFAs.</P>

Knockdown of GCF2/LRRFIP1 by RNAi Causes Cell Growth Inhibition and Increased Apoptosis in Human Hepatoma HepG2 Cells

Li, Jing-Ping,Cao, Nai-Xia,Jiang, Ri-Ting,He, Shao-Jian,Huang, Tian-Ming,Wu, Bo,Chen, De-Feng,Ma, Ping,Chen, Li,Zhou, Su-Fang,Xie, Xiao-Xun,Luo, Guo-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: GC-binding factor 2 (GCF2) is a transcriptional regulator that represses transcriptional activity of the epidermal growth factor receptor (EGFR) by binding to a specific GC-rich sequence in the EGFR gene promoter. In addition to this function, GCF2 has also been identified as a tumor-associated antigen and regarded as a potentially valuable serum biomarker for early human hepatocellular carcinoma (HCC) diagnosis. GCF2 is high expressed in most HCC tissues and cell lines including HepG2. This study focused on the influence of GCF2 on cell proliferation and apoptosis in HepG2 cells. Materials and Methods: GCF2 expression at both mRNA and protein levels in HepG2 cells was detected with reverse transcription (RT) PCR and Western blotting, respectively. RNA interference (RNAi) technology was used to knock down GCF2 mRNA and protein expression. Afterwards, cell viability was analyzed with a Cell Counting Kit-8 (CCK-8), and cell apoptosis and caspase 3 activity by flow cytometry and with a Caspase 3 Activity Kit, respectively. Results: Specific down-regulation of GCF2 expression caused cell growth inhibition, and increased apoptosis and caspase 3 activity in HepG2 cells. Conclusions: These primary results suggest that GCF2 may influence cell proliferation and apoptosis in HepG2 cells, and also provides a molecular basis for further investigation into the possible mechanism at proliferation and apoptosis in HCC.

Acupuncture for Osteoporosis: a Review of Its Clinical and Preclinical Studies

Tian Yimiao,Wang Lili,Xu Tianshu,Li Rui,Zhu Ruyuan,Chen Beibei,Zhang Hao,Xia Bingke,Che Yiwen,Zhao Dandan,Zhang Dongwei 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.5

Acupuncture has gained growing attention in the management of osteoporosis (OP). However, a comprehensive review has not yet been conducted on the efficacy and challenges of acupuncture in preliminary research and clinical trials. Therefore, an extensive literature search was conducted using electronic databases, including PubMed (www.ncbi.nlm.nih.gov/pubmed), CNKI (www.cnki.net), and Web of Science, for studies published from the beginning of 2000 to the end of May 2022. Combinations of synonyms for OP, acupuncture, traditional Chinese medicine, clinical trial, preclinical study, and animal experiments were searched. A total of 290 papers were consulted, including 115 reviews, 109 clinical observations, and 66 preclinical studies. There is accumulating evidence to support the beneficial role of acupuncture in preserving bone quality and relieving clinical symptoms based on clinical and preclinical investigations. The top ten most commonly used acupoints are BL23, ST36, BL20, BL11, CV4, GV4, SP 6, KI3, BL18, and GB39. The underlying mechanisms behind the benefits of acupuncture may be linked with the regulation of the hypothalamic-pituitary-gonadal (adrenal) axis and activation of the Wnt/β-catenin and OPG/RANKL/RANK signaling pathways. In summary, strong evidence may still come from prospective and well-designed clinical trials to shed light on the potential role of acupuncture in preserving bone loss. Future investigations are needed to explore the potential underlying mechanisms, long-term clinical efficacy, and compliance of acupuncture in OP management.

Effects of PTTG Down-regulation on Proliferation and Metastasis of the SCL-1 Cutaneous Squamous Cell Carcinoma Cell Line

Xia, Yong-Hua,Li, Min,Fu, Dan-Dan,Xu, Su-Ling,Li, Zhan-Guo,Liu, Dong,Tian, Zhong-Wei Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

Aims: To study effects of down-regulation of pituitary tumor-transforming gene (PTTG) on proliferation and metastasis ability of the SCL-1 cutaneous squamous cell carcinoma (CSCC) cell line and explore related mechanisms. Methods: SCL-1 cells were divided into 3 groups (untreated, siRNA control and PTTG siRNA). Cell proliferation assays were performed using a CCK-8 kit and proliferation and metastasis ability were analyzed using Boyden chambers. In addition, expression of MMP-2 and MMP-9 was detected by r-time qPCR and Western blotting. Results: Down-regulation of PTTG could markedly inhibit cell proliferation in SCL-1 cells, compared to untreated and control siRNA groups (P < 0.05). Real-time qPCR demonstrated that expression levels of PTTG, MMP-2 and MMP-9 in the PTTG siRNA group were 0.8%, 23.2% and 21.3% of untreated levels. Western blotting revealed that expression of PTTG, MMP-2 and MMP-9 proteins in the PTTG siRNA group was obviously down-regulated. The numbers of migrating cells ($51.38{\pm}4.71$) in the PTTG siRNA group was obviously lower than that in untreated group ($131.33{\pm}6.12$) and the control siRNA group ($127.72{\pm}5.20$) (P < 0.05), suggesting that decrease of proliferation and metastasis ability mediated by PTTG knock-down may be closely correlated with down-regulation of MMP-2 and MMP-9 expression. Conclusion: Inhibition of PTTG expression may be a new target for therapy of CSCC.

A study of P release from Fe-P and Ca-P via the organic acids secreted by Aspergillus niger

Tian Da,Wang Liyan,Hu Jun,Zhang Liangliang,Zhou Ningning,Xia Jingjing,Xu Meiyue,Yusef Kianpoor Kalkhajeh,Wang Shimei,Li Zhen,Gao Hongjian 한국미생물학회 2021 The journal of microbiology Vol.59 No.9

Phosphate solubilizing fungi (PSF) have been widely applied to dissolve insoluble phosphates (IPs). However, the PSF usually demonstrates a different phosphate solubilizing capacity for various IPs. This study explored the mechanisms of Aspergillus niger for the dissolution of ferric phosphate (FePO4, Fe-P), and tricalcium phosphate (Ca3[PO4]2, Ca-P) regarding the tricarboxylic acid (TCA) cycle. Aspergillus niger has higher phosphorus (P) content released from Ca-P, reached the maximum value of 861 mg/L after seven days of incubation, compared with the 169 mg/L from Fe-P. Oxalic acid promoted the release of P from Ca-P through the formation of calcium oxalate. The presence of Fe-P can stimulate A. niger to secrete large amounts of citric acid, confirmed by the enhancement of citrate synthase (CS) activity. However, citric acid only promotes 0.5% of P released from Fe-P. Meanwhile, although oxalic acid still dominates the release of P from Fe-P, its abundance was significantly declined. In contrast, oxalic acid also shows a higher P release ratio in Ca-P than citric acid, i.e., 36% vs. 22%. This study points to the future usage of A. niger to dissolve IPs in soil required to enhance oxalic acid secretion.

Preparation of Co₃O₄/NF Anode for Lithium-ion Batteries

Tian, Shiyi,Li, Botao,Zhang, Bochao,Wang, Yang,Yang, Xu,Ye, Han,Xia, Zhijie,Zheng, Guoxu The Korean Electrochemical Society 2020 Journal of electrochemical science and technology Vol.11 No.4

Due to its characteristics of light weight, high energy density, good safety, long service life, no memory effect, and environmental friendliness, lithium-ion batteries (LIBs) are widely used in various portable electronic products. The capacity and performance of LIBs largely depend on the performance of electrode materials. Therefore, the development of better positive and negative materials is the focus of current research. The application of metal organic framework materials (MOFs) derivatives in energy storage has attracted much attention and research. Using MOFs as precursors, porous metal oxides and porous carbon materials with controllable structure can be obtained. In this paper, rod-shaped Co-MOF-74 was grown on Ni Foam (NF) by hydrothermal method, and then Co-MOF-74/NF precursor was heat-treated to obtain rodshaped Co₃O₄/NF. Ni Foam was skeleton structured, which effectively relieved. The change of internal stress changes and destroys the structural volume of the electrode material and reduces the capacity attenuation. Co₃O₄/NF composite material has a specific discharge capacity of up to 1858 mA h/g for the first time, and a reversible capacity of up to 902.4 mA h/g at a current density of 200 mA/g, and has excellent rate and impedance performance. The synthesis strategy reported in this article opens the way to design high-performance electrodes for energy storage and electrochemical catalysis.

Microstructure characteristics and hydrogen storage kinetic of nano MgNi‑REO alloys

Hongxiao Tian,Xinghu Yan,Xia Li,Feng Hu,Yongzhi Li,Zengwu Zhao 한국탄소학회 2023 Carbon Letters Vol.33 No.7

Mg81Ni19-8wt.% REO (oxides of Lanthanum and Cerium) alloys were successfully prepared using mechanical alloying method with Mg-Ni alloy and REO powder. Phase analysis, structural characterization, and microstructure imagine of the alloys were conducted using X-ray diffraction (XRD), metallurgical microscope, and transmission electron microscopy (TEM) methods. Multi-phase structures, including the primary phase of Mg2Ni and several secondary phases of Mg + Mg2Ni, MgNi-LaO, and MgNi-CeO, were found in in the as-cast Mg81Ni19- 8wt.% REO alloys. XRD and TEM results showed that Ce exhibits variable valence behavior at various stages, and the addition of REO promotes the nanocrystalline of the alloy. The hydrogen absorption capacity of ball-milled Mg81Ni19 and Mg81Ni19- 8wt.%REO alloy for 2 h at 343 K is 1.34 wt.% and 1.83 wt.%, which are much larger than 0.94 wt.% of as-cast Mg81Ni19 alloy. The addition of REO led to a decrease of the thermal decomposition temperature of the alloy hydride by approximately 20 K and a reduction of the activation energy of the hydrogen desorption reaction by 10% and 13%, respectively.

Unsupervised one-class classification for condition assessment of bridge cables using Bayesian factor analysis

Lingfang Li,Xiaoyou Wang,Wei Tian,Yao Du,Rong-rong Hou,Yong Xia 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.29 No.1

Cables are critical components of cable-stayed bridges. A structural health monitoring system provides real-time cable tension recording for cable health monitoring. However, the measurement data involve multiple sources of variability, i.e., varying environmental and operational factors, which increase the complexity of cable condition monitoring. In this study, a one-class classification method is developed for cable condition assessment using Bayesian factor analysis (FA). The singlepeaked vehicle-induced cable tension is assumed to be relevant to vehicle positions and weights. The Bayesian FA is adopted to establish the correlation model between cable tensions and vehicles. Vehicle weights are assumed to be latent variables and the influences of different transverse positions are quantified by coefficient parameters. The Bayesian theorem is employed to estimate the parameters and variables automatically, and the damage index is defined on the basis of the well-trained model. The proposed method is applied to one cable-stayed bridge for cable damage detection. Significant deviations of the damage indices of Cable SJS11 were observed, indicating a damaged condition in 2011. This study develops a novel method to evaluate the health condition of individual cable using the FA in the Bayesian framework. Only vehicle-induced cable tensions are used and there is no need to monitor the vehicles. The entire process, including the data pre-processing, model training and damage index calculation of one cable, takes only 35 s, which is highly efficient.