DNA 감지를 위한 MOSFET형 전하검출센서의 제작 및 특성

정용택,김동선,류홍근,박혜정,신장규,최평,이종현,임근배 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

내시경으로 확인된 상부소화관 용종의 임상적 고찰

김영건,김병호,성자원,이기천,허승식,이종선,정현용,이헌영 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.2

From January 1987 to October 1991, we performed 14,333 cases of upper gastrointestinal endoscopy and diagnosed 527 cases with U.G.I polyp. We assesed these 527 cases and obtained following results: 1) The overall incidence of U.G.I. polyps was 3.6%, and there was no sexual difference. The peak incidence was in 6th decades(32.4%). 2) The U.G.I. polyps were located chiefly at stomach(415 cases, 78.7%), among which antrum occupied antrum 43.5%, body 24.0% and funds 5.1%. And the others were esophagus(6.5%) and duodenum(12.3%). 3) The size of U.G.I. polyp was below 1cm in 72.3%, from 1cm to 1.9cm in 20.7% and above 2cm in 7.0%. According to Yamada' classification, type Ⅰ, Ⅱ, Ⅲ and Ⅳ was 31.9%, 51.3%, 13.7% and 3.0%. 4) Histological nature of U.I.G. polyp were hyperplastic polyp(85.8%), adenomatous polyps(9.3%), carcinomatous polyps(3.3%) and etc. The size of neoplastic polyp such as adenomatous polyps(mean 1.0±0.7cm) and carcinomatous polyps(niean 2.0±1.8) were larger man hyperplastic polyp(mean 0.6±0.4) (p<0.05) 5) The gastric polyps were associated with peptic ulcer(7.5%), gastric cancer(3.2%), other malignancy(3.5%), hepatobiliary disease(5.5%), post subtotal gastrectomy(5.5%). And others(75%) werenot associated with specific disease.

유기성 폐기물과 알칼리 안정화제가 첨가된 연안 양식장 퇴적물 조비료의 영양성분 조성

김정배,강창근,이근섭,박정임,이필용 한국환경과학회 2002 한국환경과학회지 Vol.11 No.12

To utilize coastal aquaculture ground bottom sediment in which concentrations of harmful pollutants are low and organic content is high as an organic fertilizer alkaline stabilizers such as CaO, Oyster shell, Mg(OH)_2 were added to the bottom sediment organic additives of livestock or food wastes. Nutritive qualities of crude fertilizers were measured to examine effects of alkaline stabilizers and organic waste additions. The Mg(OH)_2-added crude fertilizer had significantly lower total carbon(T-C) and nitrogen(T-N) content, reflecting the dilution effect due to great amount of Mg(OH)_2 addition. However, the addition of oyster shell had no significant effect on the T-C and T-N content of the fertilizer. P_2O_5 and K_2O content was considerably higher in the mixed of aquaculture ground bottom sediment and livestock wastes than in the mixture of the sediments and food wastes, resulting from higher P_2O_5 and K_2O content in livestock wastes. Addition of Mg(OH)_2 increased the content of MgO in the crude fertilizer but significantly reduced the content of other nutritive elements such as P_2O_5, K_2O and CaO. Addition of oyster shell as an alkaline stabilizer seemed to have the advantage of saving time and expenses for dryness due to role as a modulator of water content. Moreover, additions of effect Mg(OH)_2 decreased the concentrations of heavy metals in the fertilizer by the dilution while additions of oryster shell had no influence on heavy metal concentrations in the fertilizer.

소화성 궤양에 대한 Nizatidine의 임상효과

안정기,이기천,허승식,이종선,정현용,이헌영,김영건 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

Nizatidine is a newly introduced potent H2-receptor antagonist of acid secretion with long duration of action. For evaluation of clinical efficancy and safety, twenty one patients with endoscopically proved thirteen gastric ulcers and eight duodenal ulcers were treated with nizatidine 300mg at bed time via per os for 6 weeks. The results were as follows 1. The rate of complete endoscopic healing of duodenal ulcer 92.3% and 87.5% after 6 weeks. The overall healing rate of peptic ulcer was achieved in 89.9% at 6 weeks. 2. Clinical symptoms disappeared in 84.6%, 92.3% and 100% of patients with duodenal ulcer and 75.0%, 87.5% and 87.5% patients with gastric ulcer at 2, 4 and 6 weeks respectively. 3. There were not developed any symptoms and signs suggesting side effect of drug. In conclusion, data from this study suggest that nizatidine 300mg p.o. at sleeping time is effective and safe in treatment of peptic ulcer disease, and is well tolerated on a short-term basis.

급성심근경색증의 조기진단에 있어서 Myoglobin의 진단적 의의

이정헌,김종근,정병천,서강석,박정배,조용근,류재근,전재은,채성철,박의현 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: Exact and early diagnosis of acute myocardial infarction (AMI) is essential for the subsequent routine management of this frequent cardiovascular disease. Currently, AMI has been diagnosed using the combination of the history, electrocardiogram(ECG), and biochemical markers of myocardial necrosis. At present, many biochemical markers are used to diagnose AMI. In this study, the predictive values of serum myoglobin and creatine kinase-MB(CK-MB) were compared in the emergency department. Methods: Fifty-four consecutive patients who presented within 12 hours from onset of chest pain of presumed cardiac origin were enrolled into the study. Patients with trauma or renal failure were excluded. The serial serum myoglobin and CK-MB levels were obtained prospectively at admission and 2, 4, 6, 12, 24 and 48 hours after admission. We compare the levels of serum myoglobin and CK-MB within 2, 4, 6, 8, 10, 12, 24, and 48 hours after symptom onset respectively. And we compare the sensitivity, specificity, positive predictive value, and negative predictive value of myoglobin and CK-MB. Results: using World Health Organization criteria, 28 AMI patients were identified. Mean time from symptom onset to presentation was 4.1±1.3 hours. The predictive values of serum myoglobin were better than those of CK-MB within 6 hours after symptom onset. But, 6 hours after symptom onset, the predictive values of CK-MB were better than those of serum myoglobin. The false positive cases of serum myoglobin were 3-one was lung cancer with pleural effusion and the others were unstable angina. The false positive cases of CK-MB were 6-one case was viral myocarditis and the ohters were unstable angina. Conclusion: To compare the serum myoglobin and CK-MB in the diagnosis of AMI, serum myoglobin had better predictive values than CK-MB within 6 hours after symptom onset and useful in the early diagnosis of AMI. But, 6 hours after symptom onset, CK-MB had better predictive values than serum myoglobin and useful in following up.

7두의 개에서 배설성 요로조영술을 통한 신장 기능 평가

최윤정,이기자,최형준,이용진,박성준,송근호,정성목,최호정,이영원 忠南大學校 獸醫科大學 動物醫科學硏究所 2005 動物醫科學硏究誌 Vol.13 No.-

Excretory urography is a type of contrast study used to verify and localize upper urinary tract disease. It is an inexpensive and easy way to visualize of anatomic and functional status of the kidney and has been used as a primary imaging modality for the evaluation of urinary tract abnormalities. We describe urological signs of 7 dogs who examined with excretory urography and ultrasonography. Six cases were referred to veterinary medical teaching hospital. Chungnam national university (VMTH, CNU) to evaluate renal function after the treatment for renal failure and one case was referred showing hematuria. In case 1, 2 and 4, blood test and urinalysis was normal and the results of excretory urography presented that renal function were normal range. In case 3, the results of urinalysis, ultrasonography, and excretory urography except blood test presented abnormal kidney and hydronephrosis was diagnosed. In case 5 and 6, blood test, urinalysis, ultrasonography and excretory urography indicated renal failure. In case 7, blood test, urinalysis and ultrasonography presented partially abnormal signs, however, the results of excretory urography was normal range.

마이크로 유체 채널 내 응용을 위한 3차원 구조의 FET형 센서 제작

류홍근,김동선,정용택,박혜정,신장규,박진성,임근배 경북대학교 센서기술연구소 2002 센서技術學術大會論文集 Vol.13 No.1

화살나무 추출물에 의한 Doxorubicin-유도 조직손상의 억제

이정호,신숙정,문용,이동근 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.2

Doxorubicin(DR), a potent antineoplastic drug, is effective in adult and childhood solid tumors and hematologic cancer. However, it has minor(mucositis, nausea, vomiting and alopecia) and major(myelosuppression, cumulative dose-related cardiomyopathy, and skin and subcutaneous ulcers) clinical toxic effects. Accidental subcutaneous DR-extravasation may provoke a prolonged and severe cutaneous inflammatory reaction for which there is currently no simple and effective treatment method. Because of this, apart from measures to prevent paravenous extravasation, many methods of preventing these ulcers have been tried clinically or experimentally, but the efficacy is uncertain. The present study was undertaken to exploit Euonymus alatus extract(EA) as an antidote for DR-induced skin ulceration, using animal model, and to evaluate the effects of EA on the pharmacological activity of DR. Sprague-Dawley rats and ICR mice were intradermally injected DR(0.5 mg/rat and 0.2 mg/ mouse) with or without EA(10 mg/rat and 5 mg/mouse). In rat model, intradermal injection of DR alone produced predictable uniform skin necrosis and ulceration involving the deep dermis. These ulcers developed within 3-7 days, remained stable for 2-4 weeks, and all rats died in 55 days of observation. However, intradermal injection of DR plus EA into rat developed only minor transient edema, erythema and mild inflammation involving the superficial dermis, which healed quickly, and all rats survived throughout the experimental periods. In mouse model, intradermal injection of DR alone produced an ulcer approximately 15.2 mm2 at 5 days. This ulcer was progressively aggravated in size until 15 days, and regressed and healed after that. But, when mice were intradermally injected DR plus EA, the ulcers were reduced in size and healed quickly. These results suggest significant efficacy for EA as a DR-extravasation antidote. B16 cells, 3LL cells and human tonsillar lymphocytes were cultured in the presence of DR with or without EA, and the proliferation responses of these cells were evaluated. DR alone de-creased remarkably the proliferation of malignant cells as well as normal cells, in a dose-dependent fashion. On the other hand, the EA itself reduced weakly the responses of tumor cells but increased those of normal cells. And EA also slightly enhanced the DR- induced inhibition of the tumor cell-proliferation, but it restored the DR-derived decrease of the lymphocyte-prol-iferation. These results suggest that EA itself has no side effects, and also suggest that EA may possibly diminish the systemic toxic effects of DR-administration. Taken together, the present study reveals that EA has an antidotic activity against DR-ex-travasations and systemic DR. And these results suggest the possibility that EA could be developed and used in a form of DR-annex as an antidotic and reinforcing agent of DR.

골프지도자의 직무특성이 직무만족도에 미치는 영향

이종근,지용석,정희석 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

The purpose of this study is to examine the job satisfaction of the job characteristics of golf instructors and to investigate the important factors affected by that. To achieve this purpose, 300 leaders who are certified semi-pro among golf leaders throughout the country are selected as the population, but the questionnaires from 274 subjects are adopted for the data of the final analysis. And this thesis attempts to use the way of Correlation Analysis and Covariance Structure Analysis using LISREL, as a statistical method to verify an established hypothesis. The results have processed through the analysis are summarized as follows. First, the determinative variables, such as the challenge for job, the suitableness for job, the security for work, the utility expected for job and the variables satisfying expectation have had a positive influence on the occupational commitment of golf instructors, but job challenge, amount of duty, and the need for achievement have had a negative effect on that. Second, the determinative variables, such as job suitableness, job security and expected utility, and the variables satisfying expectation have had a positive influence on the occupational contentment, but job challenge, amount of duty, and the need for achievement have not affected on that. On the other hand, the control variable which is their marital status also has been exercised a positive influence on the job satisfaction.

Sarcoma 180 이식마우스에서 Interleukin-2, 4 10의 변화

김광혁,박건영,정영기,이원기 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

Experiments were undertaken to investigate the effect of cancer cell, sarcoma 180 (S180) on production of interleukin(IL)-2, 4, and 10 in BALB/c mice. Splenocytes of normal mice were incubated with S 180 cells. The culture supernatants were collected at 2, 4, 6, 24, and 72 hr and assessed for IL-2, 4, and IL-10 production by enzyme-linked immunosorbent assay. The production of IL-2 in the culture supernatant of adherent cells exposed with S 180 was not detected, but it increased at 24 and 72 hr in culture with non-adherent or whole splenocyte. The production of IL-4 in the culture supernatant of S 180, adherent, non-adherent or whole splenocyte was detected, but by co-culture with S 180 it showed significant increase at 72 hr. Also, the production of IL-10 in the culture supernatant of S 180, adherent, non-adherent, or whole splenocytes was detected. By exposure with S 180 it increased to 10-80 times in comparison with the control. Normal mice were transplanted with S 180 into peritoneum. Sera and peritoneal fluids(PF) were collected at 2, 4, 6, and 24 hr. The production of IL-2 in sera was not detected, but in PF it was a little. The production of IL-4 in sera or PF was detected, but it showed the significant decrease in comparison with the control. The production of IL-10 in sera was detected in transplantation or control group, and it increased in transplantation group. The production of IL-10 in PF showed the increase at 24 hr. By exposure of S 180 tumor cells in immuno-competent cells or transplantation with S 180 into mouse, IL-4 decreased in sera and PF, but IL-10 showed the remarkable increase in the culture supernatant of splenocytes and in sea. These data suggest that the unbalanced conditions such as suppression of IL-4 production and overproduction of IL-10 in vivo may be responsible for dysfunction of immune system.