폴리메타크릴레이트를 이용한 케토로락 트로메타민 서방성 정제의 제조와 용출평가

전일순,윤재남,이은미,박용근,김동우,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

To improve administration of ketolorac tromethamine, we prepared matrix tablets with Eudragit (RS 100 or 30D), diluents (avicel:lactose=l:l or Ca phosphate) and Mg stearate using wet-granulation method. Sustained release matrix tablets using Eudragit® RS 100 7 and 10% decreased dissolution rate at pH 1.2 and 68 Ca. phosphate as diluents showed more decreased dissolution rate than that of avicel:lactose (1:l). Sustained release matrix tablets using Eudragit® RS 30D also showed very effective sustained release of KT.

지역별 건설업 인력수급 현황 분석에 관한 연구

전찬민,전용일,황찬수,박태근 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In currency crisis(IMF relief loan), the construction industry has prepared a foundation for existence by taking such desperate countermeasure as reducing a lot of construction companies and readjusting the their structure. Even though a number of employee of construction industry came to a million in 1996, it reduced to 980 thousand in 1997 and 710 thousand in 1998. After 1998, there was the trend about reducing a number of employee every year. The final goals of this study have inquired into the current situation of manpower supply and demand per region, compared and analyzed the circumstance of manpower supply and demand, and utilized references in decision-making between construction companies and students.

교정용 스테인리스강 선재의 내식성에 미치는 응력 제거 열처리 조건의 영향

오근택,전용석,황충주,김경남 대한치과기재학회 2001 대한치과재료학회지 Vol.28 No.2

Heat treatment is applied to orthodontic wires in order to relieve the stress that results from cold working and the orthodontists manipulations. In this study, 4 types of wires were heat-treated in an air, argon or vacuum environment, and were either cooled in a furnace or a water bath. Corrosion properties of the heat-treated wires were investigated by potentiodynamic method. The difference of corrosion resistance between the wires heat-treated in an ambient according to cooling methods was not significant. After heat-treated in an ambient, both water-cooled and furnace-cooled wires had a similar and low corrosion resistance. The difference of corrosion resistance between the wires heat-treated n a vacuum environment with cooling methods was significant. After heat-treated in a vacuum, the furnace-cooled wires had high corrosion resistance, but the water-cooled wires low. After heat-treated in a vacuum, argon, or air environments, the water-cooled wires had low corrosion resistance. It was considered because the irregular and unstable film was formed on the surface of the wires when cooled in a water bath. The control wires showed a low current density and high pitting potential, but most of the heat-treated wires did high current density and low pitting potential except for the wire heat-treated in vacuum and then cooled in a furnace. Conclusively, orthodontic wires are considered to have to be heat treated in vacuum condition or inert gas environment and then to be cooled in a furnace in order to inhibit surface oxidation, minimize the decrease of corrosion resistance and improve the mechanical properties.

회맹장 및 대장을 침범한 장 결핵에 있어서 바륨을 이용한 방사선 이중조영촬영 소견에 대한 연구

진용현,전혜정,이용근,강철호,조성범,김윤환,박철민,차상훈,김일영,이혜경 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

To determine the characteristic double contrast barium enema findings of ileo-cecal and colonic tuberculosis and to make differential diagnosis from other bowel inflammatory disease. Sixty-seven patients confirmed as ileo-cecal and/or colonic-tuberculosis in six hospitals were evaluated retrospectively. The diagnosis was proven by endoscopic biopsy, surgery, and clinical follow up. Nine of 67 patients were excluded because radiologic findings were normal though endocopic biopsy examinations resulted in tuberculosis. Histopathological diagnosis were madein 58 cases as follows: endoscopic biopsy(n=29), operation(n=12), follow up examination(n=14), tissue culture(n=1), laparoscopic biopsy(n=2). There were 30 men and 28 females. The mean age were 36 yrs(range:16-67), 34 patients were in the second and third decade. The distribution of lesions, morphological characteristics, mucosal changes, ulcer shape and depth, associated with other tuberculous lesion, multiplicity were retrospectively analyzed in the findngs of double contrast barim enema. The commonest clinical symptoms were abdominal pain(n=35, 60%) and diarrhea(n=18, 31%). The chest radiography revealed association of pulmonary tuberculosis in 39 cases. Tuberculous lesions of other organs except chest were present in five cases. Double contrast barium enema findings showed a thickening and irregularity of intestinal mucosal fold(n=29, 50%), bowel contraction and/or shortening(n=26, 45%). There were small, nodular, superficial ulcers in the case of ulcer depth less than 2 mm in the depth. As many as 39 cases(67%) in this series had two or more lesions in the intestinal tuberculosis. The involved segment revealed symmetrical feature(n=21, 36%). Inflammatory pseudopolypoid lesions were noted in 30 cases(52%). The ileo-cecal region was involved in 38 cases(66%). The ascending colon(n=25, 43%) was the second commonest site with or without contiguous cecal involvement. Lesions in terminal ileum, ileo-cecal valve, transverse colon, descending colon and appendix were seen in 19, 18, 18, 12 and seven cases, respectively. Among 18 cases of ileo-cecal valve lesions, there were incompetency in nine cases(16%) and wide gapping in four cases(7%). In 14 cases, tuberculous enterocolitis was diagnosed by clinical follow-up and double contrast barium enema study. 12 out of 14 cases, the findings of double contrast barium enema of tuberculous enterocolitis were normalized after anti-tuberculous medication. However, two cases showed more aggravated state than before due to inappropriate treatment. Double contrast barium enema plays an important role in the diagnosis of tuberculous enterocolitis, determines the type, site and extent of the involvement and helps in treatment guide by using sequential studies.

Micronucleus test를 이용한 수종 결합용레진과 상아질결합제의 돌연변이 유발에 관한 연구

이용근,전혜림,김철위,윤숙진 大韓齒科器材學會 1992 대한치과재료학회지 Vol.19 No.1

The purpose of this study was to evaluate the mutagenicity of the bonding resins of dental composites and the dentin bonding agents. Eight bonding resins, six dentin bonding agents and distilled water (negative control) were administered orally and cyclophosphamide (positive control) was administered intraperitoneally to the mice. The mice were killed by cervical dislocation at 24 hours after administration and the femurs were removed and dissected. The bone marrow cells were collected and smeared on glass slides and stained with haematoxylin-eosin staining method and were observed with light microscope(X450). The following results can be drawn: 1. The bonding resins of dental composites and the dentin bonding agents were tested in this study seemed to be non-mutagenic. 2. The numbers of micronucleated polychromatic erythrocytes were similar both in the bonding resins of dental composites and the dentin bonding agents. 3. In the case of some products(AP, SC' and AA), the number of micronucleated polychromatic erythrocs was high beyond other products.

Liver-Fluke의 寄生이 山羊의 繁殖障害와 乳肉生産에 미치는 影響에 관한 硏究

金敎準,田暢淇,金容國,金相根 충남대학교 농업과학연구소 1979 農業技術硏究報告 Vol.6 No.1

These studies were carried out to investigate the effects of liver-fluke infection on the reproductive disorder and milk and meat production in Korea Native Goat. A survey of infected goat in Chungnam district was conducted with 474 head by interdermal reaction and also a clinical observation was founded. A experiment was carried out to determine the effects of liver fluke extract on the reproductive disorder by subcutaneous injection and milk and meat yield were measured from treated goats. The results obtained were summarized as follows. 1. The rate of positive goat was 71.3% among the surveyed goat and the highest rate was appeared at 3∼4 years old goats as 81.4%. 2. The treated goats lost condition and failed to thrive, and became progressive weaker. 3. In hemogram observation, the rate of eosinophil leucocyte was increased significantly by extract treated. 4. It was appeared the pathogenic signs such symptoms poisoning liver function disturbance and reproductive disorder from treated goats with liver fluke extract. 5. In milking goat the milk yield droped significantly and fattening goat did not fatten. 6. The gross income value per capita was lower from infected goat and it was analysed more sensitivly in net income value.

분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계

윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-

Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.

Effects of Samreungjeon on the Proliferation of Transplanted-L1210 Cells in Mice

Yong Keun Jeon,Jae Yoon Leem,Jung Mo Song,Jae Soon Eun 한의병리학회 2005 대한동의병리학회 학술대회논문집 Vol.2005 No.8

Reinforced nitrogen oxide gas adsorption by sulfur ionic treatment

Jeon Young Pyo,Lee Sang-hwa,Song Jun Yong,Park Yong Yeol,Lee Eun Jung,Jeon Ok Sung,Kang Sung Ho,Byun Chang Woo,Kim Jinpyung,Park Sang Yoon,Yoo Young Joon,Yang Keun–Hyeok 한국물리학회 2021 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.79 No.11

To obtain a material that adsorbs nitrogen oxide (NOx) gas with high efficiency, we used sulfuric acid ( H2SO4)-treated activated carbon (AC). The proposed H2SO4- treated AC was treated by dipping and spray coating in a H2SO4 solution. For structural analysis, scanning electron microscopy and Brunauer–Emmett–Teller measurements were performed on general and H2SO4- treated ACs. The composition of the atoms on the surface and inner pore structure of both ACs was confirmed through energy dispersive X-ray spectroscopy measurements. From the structural analysis, it was confirmed that the structure of H2SO4- treated AC was similar to that of general AC, indicating that it was not affected by the H2SO4 solution. There was no significant difference in the inner pore structures of general and H2SO4- treated ACs through specific surface area analysis, which indicates that the physical adsorption of NOx gas for the H2SO4- treated AC is similar to that of general AC. Based on the atomic composition analysis, it was confirmed that sulfur ions were largely present on the inner pore structure than the surface of H2SO4- treated AC. These results indicate that the chemical adsorption of sulfur ions and NOx gas in the inner pore structure occurred rather than physical adsorption. The results of this study are expected to be applicable to the field of materials that remove harmful gases.

빌딩 Emergency 서비스를 위한 WoO(Web-of-Object) 플랫폼 구조

전용근(Yong Keun Jeon),정광현(Kwang Hyeun Jeong),정일영(Ilyoung Chong) 한국통신학회 2014 한국통신학회 학술대회논문집 Vol.2014 No.1