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Human HS1BP3 induces cell apoptosis and activates AP-1
( Tai Ping Shi ),( Jie Shi Xie ),( Ying Xiong ),( Wei Wei Deng ),( Jin Hai Guo ),( Feng Wang ),( Da Long Ma ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.6
In the present study, we characterized the function of HS1-binding protein 3 (HS1BP3), which is mutated in essential tremor and may be involved in lymphocyte activation. We found that HS1BP3 localized to the mitochondria and endoplasmic reticulum partially. Overexpression of HS1BP3 induced apoptosis in HEK293T and HeLa cell lines. When these cell lines were transfected with HS1BP3, they exhibited nuclear DNA condensation, externalization of phosphatidylserine (PS), and cleavage of poly ADP ribose polymerase (PARP). Furthermore, suppression of HS1BP3 or HS1 expression attenuates HS1BP3 induced apoptosis. In addition, HS1BP3 enhanced activator protein 1 (AP-1)-mediated transcription in a dose-dependent manner. Therefore, we conclude that HS1BP3 regulates apoptosis via HS1 and stimulates AP-1-mediated transcription. [BMB reports 2011; 44(6): 381-386]
Enzymatic Determination of Somatic Cells by Using Transparisation in Raw Milk
Bou-Oung Lee,Wen-Ying Xu,Oun-Ki Chang,Tai-Hua Jin 한국축산식품학회 2004 한국축산식품학회지 Vol.24 No.4
The transparisation technology for milk and milk products could be applied widely and very importantly to various determination because transparisation can economize the cost and increase with precision in the milk payment system. Component of butanone or Triton in transparisation solvent would inhibit the growth of bacteria and method. Enzymatic determination of leucocytes were proposed to evaluate milk quality as mastitis in the milk payment system, this can be easily applied to simplify automation of the determation with the lowest investment cost in milk pay system. The significance of this technique, it can be used in the quality control of raw milk and milk products, milk payment system, and programming of national dairy project. Transparisation technology is used in somatic cell counting by enzymic methods. The range of deviation for this method is 16% in 74 samples. But the deviation is increased to 20% when the Infoss method is used. It is affected by the percentage of epithelial cells and white blood cells in somatic cells from different animals and the stages of aging. NAgase activity has an obvious correlation with white - blood cells in milk. In the case of mastitis the white-blood cells is 90~95% in somatic cells in milk, it is showing greater precision in measuring the state of mastitis. In conclusion the enzymic method of somatic cell counting is a relatively simple and easy method of measurement and can be easily practiced. And the importance of this method is also worth utilizing for indirect counting of Somatic cells by use of synthetic substrates to NAgase. In the future, with the further development of the research in this field, it will be possible to automatize the measurement.
김연희(Yeon-Hee Kim),정태영(Tai-Ying Zheng),이진식(Jin-Shik Lee),강용철(Yong-Cheol Kang) 대한전기학회 2011 대한전기학회 학술대회 논문집 Vol.2011 No.10
This paper assumes that a wind mast (WM) is installed several kilometers from a wind power plant (WPP) to collect the direction and the speed of wind. The distance between the WM and the WPP is determined based on the expected storm speed to meet the ramp rate requirement of a grid code. This paper proposes a supervised shutdown algorithm of a large off-shore WPP in a heavy storm situation. Based on the information on the direction and the speed of wind measured at a WM, a sequence of wind generator group is generated. Each group is shut down with the required maximum ramp-down rate in the order of wind arriving time. The shutdown start/end times of each group may be re-scheduled to avoid superposition between adjacent two groups. If the wind speed exceeds the expected speed, the ramp rate is unable to meet the required grid code. In this case, the minimum number of the wind generator groups rate is decided, which are shut down with the twice the required ramp rate. The performance of the proposed supervised shutdown algorithm is verified considering various heavy storm scenarios. The results show that the proposed algorithm can protect the large WPP from various heavy storm situations, generating energy as much as possible with the minimal adverse effects on the power system stability.
Enzymatic Determination of Somatic Cells by Using Transparisation in Raw Milk
Lee, Bou-Oung,Xu, Wen-Ying,Chang, Oun-Ki,Jin, Tai-Hua Korean Society for Food Science of Animal Resource 2004 한국축산식품학회지 Vol.24 No.4
The transparisation technology for milk and milk products could be applied widely and very importantly to various determination because transparisation can economize the cost and increase with precision in the milk payment system. Component of butanone or Triton in transparisation solvent would inhibit the growth of bacteria and method. Enzymatic determination of leucocytes were proposed to evaluate milk quality as mastitis in the milk payment system, this can be easily applied to simplify automation of the determation with the lowest investment cost in milk pay system. The significance of this technique, it can be used in the quality control of raw milk and milk products, milk payment system, and programming of national dairy project. Transparisation technology is used in somatic cell counting by enzymic methods. The range of deviation for this method is 16% in 74 samples. But the deviation is increased to 20% when the Infoss method is used. It is affected by the percentage of epithelial cells and white blood cells in somatic cells from different animals and the stages of aging. NAgase activity has an obvious correlation with white-blood cells in milk. In the case of mastitis the white-blood cells is 90-95% in somatic cells in milk, it is showing greater precision in measuring the state of mastitis. In conclusion the enzymic method of somatic cell counting is a relatively simple and easy method of measurement and can be easily practiced. And the importance of this method is also worth utilizing for indirect counting of Somatic cells by use of synthetic substrates to NAgase. In the future, with the further development of the research in this field, it will b possible to automatize the measurement.