보육시설 과학 특별활동 프로그램의 개발과 적용

조복희,곽혜경,한유미,양연숙,손경화 한국영유아보육학회 2003 한국영유아보육학 Vol.0 No.32

The purpose of this study was to develop early childhood science activities, which could be utilized as an extracurricular program in the day-care center. The program is based on the Constructivist theory(Piaget and Vygotsky) and the nation-wide survey data on the extracurricular programs and science activities in the day-care center. After the manuals for the program was monitored and corrected by the professionals, the application of each activities was empirically tested by the teachers in the day-care setting. The effects of the sample program(6 activities) were conducted using Tegano, Sawyers & Moran(1989)'s Scientific problem-solving scale and Lee(2001)'s Scientific attitude scale. Subject of thirty nine children were administered by the pre-test and post-test and experimental group participated the program for six weeks. The results showed that the program was effective for enhancement of scientific problem-solving ability and scientific attitude of young children in day-care setting.

고립성 직장결핵 3예

이동수,정강욱,황도연,이형화,김대현,김영성,곽동협 대한내과학회 2003 대한내과학회지 Vol.64 No.1

저자들은 장결핵 중 발생 부위상 드문 곳으로 알려진 직장에 발생한 고림성 결핵을 3예 경험하였기에 문헌고찰과 함께 보고하는 바이다. Isolated rectal tuberculosis commonly involves sigmoid, ascending, or transverse colon. Rectal involvement in tuberculosis is uncommon and poorly characterized. Isolated rectal tuberculosis was defined as focal lesions of rectum in the abscence of demonstrable lesions in the small and large bowel. Diagnosis of rectal tuberculosis was based on characteristic endoscopic appearance of lesions, histopathologic feature of tuberculosis in biopsy material and response to antitubercular therapy. Three patients with isolated rectal tuberculosis were seen at Kwak's hospital. The lesions observed was classified according to macroscopic morphology as follows: ulcerative, hypertrophic and ulcero-hypertrophic. Clinical manifestations were non-specific and consists of rectal bleeding, fever, weight loss, constipation and abdominal pain. One of the three patients had coexisting tuberculous pleurisy. Response to antitubercular chemotherapy was good. (Koeran J Med 64:96-100, 2003)

Sleep monitoring sensor using flexible metal strain gauge

Kwak, Yeon Hwa,Kim, Jinyong,Kim, Kunnyun IOP Publishing 2018 Japanese journal of applied physics Vol.57 No.5

Flexible heartbeat sensor for wearable device

Kwak, Yeon Hwa,Kim, Wonhyo,Park, Kwang Bum,Kim, Kunnyun,Seo, Sungkyu Elsevier Applied Science 2017 Biosensors & bioelectronics Vol. No.

<P><B>Abstract</B></P> <P>We demonstrate a flexible strain-gauge sensor and its use in a wearable application for heart rate detection. This polymer-based strain-gauge sensor was fabricated using a double-sided fabrication method with polymer and metal, i.e., polyimide and nickel-chrome. The fabrication process for this strain-gauge sensor is compatible with the conventional flexible printed circuit board (FPCB) processes facilitating its commercialization. The fabricated sensor showed a linear relation for an applied normal force of more than 930 kPa, with a minimum detectable force of 6.25Pa. This sensor can also linearly detect a bending radius from 5mm to 100mm. It is a thin, flexible, compact, and inexpensive (for mass production) heart rate detection sensor that is highly sensitive compared to the established optical photoplethysmography (PPG) sensors. It can detect not only the timing of heart pulsation, but also the amplitude or shape of the pulse signal. The proposed strain-gauge sensor can be applicable to various applications for smart devices requiring heartbeat detection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We demonstrate a flexible heartbeat sensor for wearable device. </LI> <LI> The proposed sensor showed a linear relation for an applied normal force of more than 930 kPa, with a minimum detectable force of 6.25 Pa. </LI> <LI> The sensor can detect a bending radius from 5 mm to 100 mm. </LI> <LI> It can analyze not only the timing of heart pulsation, but also the amplitude or shape of the pulse signal. </LI> </UL> </P>

해조류 NDF에 결합된 주요 무기질(Ca, P, Mg)의 함량 분석 및 추정 이용률

곽연화(Yeon Hwa Kwak),배승철(Sung Chul Bai),김대진(Dae Jin Kim) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.7

해조류는 다당류인 수용성 식이섬유와 무기질의 공급원으로 그 필요성이 증대되고 있다. 그러나 인간이나 단위 동물에 있어서는 해조류의 세포벽물질을 분해할 수 있는 효소를 갖고 있지 않은 것으로 알려져 있어 이에 결합된 무기질은 인체 내 소화가 대부분 되지 않는다. 따라서 본 연구는 해조류의 무기질 함량을 측정하고, 해조류 다당류인 세포벽 물질(NDF, netural detergent fiber)에 결합된 다량 무기질인 Ca, P, Mg을 측정하여, 원래 해조류에 함유되어 있던 무기질 함량에서 NDF에 결합된 무기질의 함량을 감한 후 계산하여 실질적인 해조류의 무기질 추정 이용률을 산정하였다. Ca과 Mg의 경우, NDF에 결합된 무기질의 평균 함량은 각각 77.59, 45.62 ㎎/100 g NDF로 모두 96% 이상의 높은 추정 이용률을 보였고, P의 경우에는 NDF에 결합된 무기질의 함량이 많아 그 추정 이용률은 73.24%로 비교적 낮았다. P의 경우, NDF에 결합된 함량이 비교적 높았지만 70% 이상이 실질적으로 소화되어 이용가능하며, Ca과 Mg은 모두 96%이상의 높은 추정 이용률을 보여 대부분의 무기질이 실질적으로 소화되어 이용되는 것으로 보인다. 따라서 해조 다당류인 수용성 식이섬유와 무기질의 급원으로 알려진 해조류는 인체 내의 소화율을 고려한다고 하더라도 무기질의 높은 이용률을 보일 것으로 판단되어 무기질의 급원으로 그 이용이 기대된다. 더욱이 해조류는 한국인에게 부족한 영양소로 주목 받는 Ca을 가장 많이 함유하고 있으며 동시에 그 추정이용률이 90% 이상으로 높아 Ca의 공급원으로써 해조류의 이용을 기대하며, 추후 추정 이용률을 토대로 소화율을 고려한 무기질의 생체이용률에 관한 연구가 활발히 진행되어야 한다고 사료된다. This study was aimed to evaluate the estimated availabilities and contents of major minerals (Ca, P, and Mg) in seven different seaweeds using the neutral detergent fiber (NDF) which could bind minerals. The estimated availability was calculated by subtracting the NDF-bound major mineral contents from the total major mineral contents of seaweeds. Average estimated availability of Ca, P, and Mg contents of seven seaweeds were 96.31, 73.24, and 96.79%, respectively. These results may suggest that seaweeds could be one of the good sources of major minerals for human nutrition because of their high average estimated availabilities of Ca, P, and Mg.

문자입력에 초점을 둔 터치 리모콘

곽연화(Yeon Hwa Kwak),김원효(Wonhyo Kim),박광범(Kwang Bum Park),김건년(Kunnyun Kim) 한국HCI학회 2014 한국HCI학회 학술대회 Vol.2014 No.12

스마트폰 기반 감성분석용 인터페이스 장치 개발

곽연화(Yeon Hwa Kwak),김원효(Wonhyo Kim),박광범(Kwang Bum Park),김건년(Kunnyun Kim) 한국HCI학회 2013 한국HCI학회 학술대회 Vol.2013 No.1

7종 해조류 NDF에 결합된 미량무기질(Fe, Zn, Cu, Mn) 함량 및 추정 이용률

곽연화(Yeon Hwa Kwak),김형수(Hyeong Soo Kim),최수진(Su Jin Choi),김대진(Dae Jin Kim) 한국식품영양과학회 2010 한국식품영양과학회지 Vol.39 No.7

본 연구는 해조류 세포벽에 결합된 무기질은 모두 이용되지 않는다는 전제하에 해조류의 세포벽물질(중성세제불용 성섬유: neutral detergent fiber, NDF)을 측정하고 이에 결합된 미량 무기질 Fe, Cu, Zn, Mn의 함량을 조사하여 해조류 내에 함유되어 있는 무기질 함량에서 빼줌으로써 계산하여 해조류의 무기질 이용률을 추정하였다. 해조류 총 7종에 대해, 해조류 100 g당 NDF에 결합된 무기질 Zn, Cu, Mn의 평균 함량은 각각 1.78, 0.43, 0.23 ㎎으로 그에 따른 이용률이 각각 90.56, 85.43, 87.26%로 모두 85% 이상의 높은 이용률을 나타냈다. 반면, Fe은 NDF에 결합된 무기질 함량이 22.42 ㎎/100 g으로 비교적 많은 양이 결합되어 있어 그 이용률은 68.36%로 낮은 이용률을 보였다. Fe이 NDF에 가장 많이 결합한다는 보고와 같이 해조류에서도 식이섬유인 NDF에 결합된 Fe의 함량이 많아 그 이용률은 상대적으로 낮았다. 하지만 그 외 Zn, Cu, Mn의 이용률은 85% 이상으로 높아 인체 내의 소화율을 고려한다 하더라도 이들 무기질은 높은 추정 이용률을 보일 것으로 판단되어 인체 영양상 미량 무기질의 좋은 식품자원으로써 그 이용을 기대해 본다. The substantial trace mineral usabilities of seven seaweeds for nutrient evaluation have been studied. As the neutral detergent fiber (NDF) bound trace minerals have been known to be indigestible, these contents were excluded in the digestible trace mineral contents evaluation. Therefore, those four trace mineral contents in seven seaweeds and their NDF-bound contents were estimated. Consequently, the NDF-bound Zn, Cu and Mn contents, except Fe, in seven seaweeds were between 10 and 20% of total trace mineral contents, thus 80~90% of seaweeds trace minerals were observed to be substantially digestible. Although the average estimated availability of Fe in the seaweeds were relatively low, those Zn, Cu and Mn were high in relative to those total contents. Thus, even with consideration of their digestibility, seaweeds could be one of good sources of trace minerals for human nutrition because of their high availabilities of Zn, Cu and Mn.

Detection of Aspergillus, Penicillium, and Fusarium Species by Sandwich Enzyme-Linked Immunosorbent Assay Using Mixed Monoclonal Antibodies

KWAK, BO-YEON,KWON, BYUNG-JOON,KWEON, CHANG-HEE,SHON, DONG-HWA 한국미생물 · 생명공학회 2004 Journal of microbiology and biotechnology Vol.14 No.2

The antibody-mix sandwich enzyme-linked immunosorbent assay (Ab-mix sELISA) system was developed in order to simultaneously detect the extracellular polysaccharide (EPS) of Aspergillus, Penicillium, or Fusarium species using one detection system. The detection limit and detection range of the Ab-mix sELISA towards EPS of Penicilliun citrinum were not changed, and those towards Fusarium moniliforme EPS were changed a little compared to that of individual sandwich ELISA [9, 10]. The fungal culture filtrates of Aspergillus and Penicillium species showed nearly similar reactivity towards Ab-mix sELISA as that of sELISA using the MAb lGll alone [9]. Also, the fungal culture filtrates of Fusarium species showed nearly the same reactivity towards Ab-mix sELISA as that of sELISA using the MAb lB8 alone [10]. Thus, this ELISA system showed that the three genera of molds, Aspergillus, Penicillium, or Fusarium, which are three major important molds producing mycotoxins in food or agricultural commodities, could be detected at the same time, using one detection system.

Analyses of methionine sulfoxide reductase activities towards free and peptidyl methionine sulfoxides

Kwak, Geun-Hee,Hwang, Kwang Yeon,Kim, Hwa-Young Elsevier 2012 Archives of biochemistry and biophysics Vol.527 No.1