성인 엉덩관절을 이루는 구조에 대한 형태학적 연구

원예연,장준섭,정인혁,한대용,한창동,서진석 아주대학교 의과학연구소 1999 아주의학 Vol.4 No.1

With 77 hip joints of Korean adults available, anatomical study was carried out to clarify morphological variations of the acetabular labrum, the acetabular articular cartilage, the penetrating sites, the purchasing lengths of transacetabular screws including dangerous neurovascular structures, and the theoretical safe space of the acetabular fossa. The results were as follows; 1. The posterior superior region of the acetabulum through which the screw could be inserted more than 50 ㎜ in length was the safest region. However, depending on the insertion angle, the screw could penetrate the psoas muscle with an average 30 ㎜ of intervening space. 2. The average purchasing length of the screws penetrating the mid point (B) of the articular surface which was located on the inferior portion of the line (AB) connecting the anterior superior iliac spine and the center of the acetabulum: the mid points (C and D) of the articular surface which was located on the anterior and posterior portion of the line (CD) perpendicular to the line AB; and the mid point (G) of the articular surface which was located on the posterior inferior portion of the acetabular articular surface, was more than 20 ㎜. The screws penetrating the point "C" had a risk to damage the bladder and the screws penetrating the points "D" and "G" had a risk to endanger gluteal neurovascular bundles. 3. The screw placed in the anterior superior region of the acetabulum could be directed toward the external iliac vessels. The perpendicular bony thickness of this region averaged 13 ㎜. The topographical relationship of the external iliac artery and vein was variable and classified into 6 types. 4. At the center of the acetabulum, the most vulnerable structure was the obturator neurovascular bundle and the average thickness of bone at this point was measured as 6.5 ㎜. 5. The thickness of the compact bone became wider from the inner side to the outer side of the lunate surface. 6. The posterior inferior portion of the acetabular fossa would be a danger area when we used the screws for infernal fixation of the acetabular fracture through the acetabular fossa. 7. The morphological variations of the acetabular labrum which were measured differently at different locations should be considered during reading magnetic resonance images. 8. The anterior, anterosuperior and posterosuperior portion of the acetabular labrum might be easily torn because the labrum was attached to the bone-like "seating on a flat bony surface." 9. The shape of the articular cartilage was classified into 5 types according to the position of both ends. The above data in this study revealed new findings which should be considered at the times of diagnosis and operation of the hip joint together with morphological characteristics of Korean adult hips.

사무직 근로자의 수면의 질 및 직무스트레스와 우울과의 관련성

강미나,강수영,권수정,김현주,배재원,이보연,이예진,임의롬,정다영,조한솔 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to understand the degree of depression, sleep quality, job stress and their association among office workers. Method: A self-administered questionnaire was distributed to 147 workers employed in 5 big enterprises, and 5 small and medium enterprises from October 21 to November 21, 2012. The questionnaires included socio-demographic and health-related characteristics, job-related characteristics, sleep quality, job stress (KOSS) and depression (CES-D). Result: Among all subjects, 23.1% was in the depression group (21 points and over in the CES-D score). Depressive level was positively correlated with job stress and quality of sleep. The adjusted odd ratio for the effects of sleep quality and job stress on depression significantly increased in the depression group compared to that of the normal group. Multiple regression analysis revealed that the following factors of influence had combined explanatory powers on depression: BMI, life satisfaction, quality of sleep, and job stress. Conclusion: The study revealed that complicated influences were exerted on the level of depression by variable factors, as well as socio-demographic characteristics, health-related characteristics, quality of sleep, and job stress. Specifically, the level of depression was influenced by the quality of sleep and job stress.

Patient and Surgeon Specific Arthroplaty

Ye Yeon Won(원예연) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.04

Peripheral and Central Metabolites Affecting Depression, Anxiety, Suicidal Ideation, and Anger in Complex Regional Pain Syndrome Patients Using a Magnetic Resonance Spectroscopy

Ye-Ha Jung,Hyeonjin Kim,So Yeon Jeon,Jeong Min Kwon,Won Joon Lee,Joon Hwan Jang,Dasom Lee,Yoonji Lee,Do-Hyung Kang 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.9

ObjectiveaaThis study investigated peripheral and central metabolites affecting depression, anxiety, suicidal ideation, and anger in complex regional pain syndrome (CRPS) patients. MethodsaaMetabolite levels were determined in the right and left thalamus and insula, in 12 CRPS patients using magnetic resonance spectroscopy (MRS). ResultsaaThere were positive correlations between valine (Val)/tNAA (N-acetylaspartate+N-acetylaspartylglutamate) and the anxiety, and a negative correlation between glutamine (Gln)/NAA and the depression. There were positive correlations between alanine (Ala)/Gln and the depression and suicidal ideation, between glutamate (Glu)/Gln and the depression and suicidal ideation, between N-acetylaspartylglutamate (NAAG)/Gln and the depression. There was a positive correlation between Ala/NAAG and the trait anger and a negative correlation between creatine (Cr)/N-acetylaspartate (NAA) and the trait anger. There was a negative correlation between Cr/Glx (Glu+Gln) and the trait anger. High hemoglobin and alkaline phosphatase were associated with low pain levels, but CO2 and chloride showed positive correlations with pain levels in CRPS patients. Peripheral glucose, CO2 and chloride were associated with depression, anxiety, anger and suicidal ideation. ConclusionaaThe specific central and peripheral metabolites were associated with psychological disorders including depression, anxiety, suicidal ideation and anger in CRPS patients, showing pathological interactions between a painful body and mind.

Anatomic Assessment of the Acetabular Fossa for Screw Fixation in Acetabular Fracture

Ye Yeon Won(원예연),Dae Yong Han(한대용),Byung Woo Min(민병우),In Hyuk Chung(정인혁),Man Kyung Kim(김만경) 대한정형외과학회 2004 대한정형외과학회지 Vol.39 No.5

목적: 비구골절에서 비구의 사각형면에 평행하면서 비구와를 관통하는 나사못을 삽입하는 경우에 알아야 할 비구와의 공간적 정보를 알아보고자 하였다. 대상 및 방법: 성인 사체의 반쪽 골반 25쪽을 8토막으로 절단하여 절단선들이 비구와의 가장자리를 따라 만나는 7개의 측정점을 얻었다. 사각형면으로부터 이들 점들까지의 수직선상에서 연골 및 뼈의 두께를 측정하고 비교하였다. 결과: 비구와 바닥의 두께가 가장 얇은 부위의 평균 두께는 3.9±1.9 ㎜이었다. 사각형면으로부터 수직으로 측정한 뼈 및 연골의 총 두께의 평균은 12.7±2.1 ㎜에서 17.8±3.8 ㎜의 범위에 있었다. 비구와의 안전 공간이 제일 작은 부위는 후하방 지역으로 평균 4.8±1.6 ㎜ (p<0.05)이었으며 다른 부위에서는 평균 8.3-10.0 ㎜이었다. 결론: 본 연구의 형태학적 계측자료에 의하면 비구와의 안전 공간이 제일 작은 부위는 후하방 구역이었으므로 이 구역을 피하여 나사못을 삽입하는 것이 안전하다고 사료된다. Purpose: To obtain spatial information on the acetabular fossa concerning ‘transacetabular screw’ insertion through the acetabular fossa parallel to the quadrilateral surface for fixing an acetabular fracture. Materials and Methods: Each hemipelvis harvested from 25 adult fresh frozen cadavers was sectioned into eight segments. This resulted in seven measuring points located along the outer margin of the acetabular fossa. At these points, we measured and compared the vertical thicknesses of cartilage and bone from the quadrilateral surface. Results: The average thickness of the thinnest portion of the acetabular fossa floor was 3.9±1.9 ㎜. The entire thickness of the bone and cartilage measured vertically from the quadrilateral surface at the 7 points ranged from 12.7±2.1 ㎜ to 17.8±3.8 ㎜. The thinnest safe space of exposed threads of the ‘transacetabular screw’ inserted through the acetabular fossa was consistently just below the posterior conus of the lunate surface, measuring 4.8±1.6 mm (p<0.05). At the other points, it measured 8.3-10.8 ㎜. Conclusion: We suggest that ‘transacetabular screws’ can be inserted safely if due consideration is paid to the spatial characteristics of on the acetabular fossa. Screw insertion into the postero-inferior portion of the acetbular fossa should be done carefully.

Street Tree Management Strategies for Different Special-Purpose Areas: Using Citizen Science Data

Ye Inn Kim,Ji Yeon Park,Won Seok Jang,Woo Hyeon Park,최윤의 인간식물환경학회 2023 인간식물환경학회지 Vol.26 No.6

Background and objective: This study investigated the occurrence characteristics of street tree management factors basedon different special-purpose areas with emphasis on citizen participation in data collection. Methods: We collected growth and management data of street tree sections and individual trees within sections using amonitoring form developed for street trees in four special-purpose areas in the urban area of Chuncheon. We used a binarylogistic regression model to analyze the probability of occurrence for each management factor (pruning traces, signblocking, disease and pest, felled trees, piled objects, and broken branches). Results: The probability of occurrence of management factors varied by special-purpose area, which was related to thecharacteristics of each area. Conclusion: This study suggests the need to develop efficient street tree management strategies by prioritizingmanagement factors in consideration of differences in special-purpose areas

Repofix 외고정 기구를 이용한 제 3형 개방성 경골 골절의 치료

원예연,전창훈 대한골절학회 1995 대한골절학회지 Vol.8 No.4

We reviewed 18 patients with type III open tibial fracture from February 1992 to June 1995(mean follow-up period 56.7 weeks) treated with Repofix external fixator. There were 16 men and 2 wemen. According to the Gustilo's classification, there were type IIIa in ll cases and type IIIb in 7 cases. Mean period of removal of external fixator was 19.3 weeks and after removal of external fixator, cast immobillization was performed in 4 cases. Among them, bony unions were noted in 15 cases and there were nonunion in 2 cases and malunion in 1 case. The causes of nonunion were failure of accurate reduction in I cases and severe initial comminuted fracture in 1 case. Complications were nerve injury, pin site infection and ring-type osteomyelitis. After removal of external fixator, nerve injuries were recovered and pin site infections except l case were healed. Ring-type osteomylitis was occurred in 1 case after removal of external fixator and osteomyelitis was dured after curettage. When type E open tibial fractures were treated with Repofix external fixator, there were advantages of 1) early weight bearing, 2) sagittal and coronal reduction of fracture and 3) correction of rotation. With advantages, this external fixator was appropriate for the treatment of type g open tibial fractures.

Screening Tool for Anxiety Disorders: Development and Validation of the Korean Anxiety Screening Assessment

Ye-seul Kim,Yeon-soo Park,Gyeong-cheol Cho,Ki-ho Park,Shin-Hyang Kim,Seung Yeon Baik,Cho Long Kim,Soo-yun Jung,Won-Hye Lee,Youn-young Choi,Seung-Hwan Lee,Kee-Hong Choi 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.11

Objective This study evaluated the psychometric properties of the Korean Anxiety Screening Assessment (K-ANX) developed for screening anxiety disorders. Methods Data from 613 participants were analyzed. The K-ANX was evaluated for reliability using Cronbach’s alpha, item-total correlation, and test information curve, and for validity using focus group interviews, factor analysis, correlational analysis, and item characteristics based on item response theory (IRT). The diagnostic sensitivity and specificity of the K-ANX were compared with those of the Beck Anxiety Inventory (BAI) and Generalized Anxiety Disorder 7-item scale (GAD-7). Results The K-ANX showed excellent internal consistency (α=0.97) and item-total coefficients (0.92–0.97), and a one-factor structure was suggested. All items were highly correlated with the total scores of the BAI, GAD-7, and Penn State Worry Questionnaire. IRT analysis indicated the K-ANX was most informative as a screening tool for anxiety disorders at the range between 0.8 and 1.6 (i.e., top 21.2 to 5.5 percentiles). Higher sensitivity (0.795) and specificity (0.937) for identifying anxiety disorders were observed in the K-ANX compared to the BAI and GAD-7. Conclusion The K-ANX is a reliable and valid measure to screen anxiety disorders in a Korean sample, with greater sensitivity and specificity than current measures of anxiety symptoms.

다발성 골절 치료시 발생한 지연성 용혈성 수혈 부작용

원예연,이원익,민병현,송명렬 대한골절학회 1998 대한골절학회지 Vol.11 No.3

This is a case report of delayed hemolytic transfusion reaction due to Anti-Le*b and Anti- Jk*b in treatment of multiple fracture. The patient was a 14 year-old boy and had no history of transfusion or blood products. The patient underwent open reduction and internal fixation for fracture of supracondyle of femur with massive blood transfusion. Abnormal finding of ABO incompatibility was not found as usual method. The patient developed a marked fall in hemoglobin and hematocrit value and a marked hyperviliruvinemia at 8 day after surgery, which suggested hemolytic anemia and jaundice. After the evaluation of this hemolytic anemia and jaundice, we found the Anti-Le*b antibody and Anti-Jk*b antibody. A delayed hemolytic transfusion reaction represents an infrequent, but potentially hazardous complication of blood transfusion. The phenomenon usually originates from exposure to a blood group antigen by prior transfusion or pregnancy. Delayed appearance of isoantibodies, first detected 4 to 14 days after the transfusion of apparently compatible blood, has bee detected by the authors.

Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson’s disease therapy

Yeon, Seul Ki,Choi, Ji Won,Park, Jong-Hyun,Lee, Ye Rim,Kim, Hyeon Jeong,Shin, Su Jeong,Jang, Bo Ko,Kim, Siwon,Bahn, Yong-Sun,Han, Gyoonhee,Lee, Yong Sup,Pae, Ae Nim,Park, Ki Duk Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.1

<P><B>Abstract</B></P> <P>Benzyloxyphenyl moiety is a common structure of highly potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B), safinamide and sembragiline. We synthesized 4-(benzyloxy)phenyl and biphenyl-4-yl derivatives including halogen substituents on the terminal aryl unit. In addition, we modified the carbon linker between amine group and the biaryl linked unit. Among synthesized compounds, <B>12c</B> exhibited the most potent and selective MAO-B inhibitory effect (hMAO-B IC<SUB>50</SUB>: 8.9 nM; >10,000-fold selectivity over MAO-A) as a competitive inhibitor. In addition, <B>12c</B> showed greater MAO-B inhibitory activity and selectivity compared to well-known MAO-B inhibitors such as selegiline, safinamide and sembragiline. In the MPTP-induced mouse model of Parkinson’s disease (PD), <B>12c</B> significantly protected the tyrosine hydroxylase (TH)-immunopositive DAergic neurons and attenuated the PD-associated behavioral deficits. This study suggests characteristic structures as a MAO-B inhibitor that may provide a good insight for the development of therapeutic agents for PD.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>