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Yanmei Zhou,Yue Li,Shujie Liu,Enyou Li 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
Sevoflurane, one of the most commonly used inhalation anesthetics, induces apoptosis and oxidative stress in lymphocytes. Propofol, an intravenous anesthetic, exhibits antiapoptotic and antioxidative activities. Therefore, the present study aimed to investigate whether propofol attenuates sevoflurane-induced cellular injury in human peripheral lymphocytes. Lymphocytes harvested from healthy volunteers were assigned to treatments with different concentrations of propofol, or 8% sevoflurane, or their combination. Propofol at concentrations of 5, 10 or 25 μg/mL had little effect, but 50 μg/mL propofol or 8% sevoflurane significantly reduced cell viability and mitochondrial membrane potential (ΔΨm), and increased cell apoptosis, activation of caspase-3 and the production of intracellular reactive oxygen species, compared with untreated cells. Five and ten μg/mL propofol attenuated the impact of sevoflurane on cell viability, apoptosis and ΔΨm, and 5, 10 and 25 μg/mL propofol inhibited the production of intracellular reactive oxygen species stimulated by sevoflurane. However, a combination of 50 μg/mL propofol and 8% sevoflurane led to more severe cellular injury than sevoflurane alone. The results suggest that propofol can attenuate sevoflurane-induced cellular injury of human peripheral lymphocytes in a concentration-dependent manner, providing a rational for the clinical use of sevoflurane combined with appropriate doses of propofol.
Chengru Li,Xiaolin Li,Yanmei Li,Xiangtao Deng,Zhaodong Wang 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.11
Oxidation is an inevitable problem and accelerates the wear of materials under high temperature wear conditions. To enhancethe oxidation resistance of TiC particle–reinforced steel matrix composites (TiC-SMCs), the role of Cr on the oxidationmechanism of TiC-SMCs at 600 °C was investigated through experimentation and first-principles calculations in this work. The results indicated that the addition of 3 wt% Cr could induce a transformation from internal oxidation to external oxidationbecause the diffusion energy barrier of O atoms was increased from 0.66 to 0.91 eV. Furthermore, The adsorption ofthe Fe and O atoms was reduced via Cr addition. Consequently, the oxidation resistance of TiC-SMCs was improved andinternal oxidation was inhibited with increasing Cr content, where the oxidation rate coefficients of TiC-SMCs with 3 wt%and 0.3 wt% Cr content were 3.79 × 10−4 and 4.84 × 10−1 mg2cm−4 h−1, respectively. The present study would not onlyprovide the basic understanding for the role of Cr on oxidation behavior, but also contribute to the design of TiC reinforcedsteel matrix composites with excellent oxidation resistance.
UPF Tracking Method Based on Color and SIFT Features Adaptive Fusion
Yibo Li,Xuezheng Zhuang,Yanmei Liu 보안공학연구지원센터(IJSIP) 2014 International Journal of Signal Processing, Image Vol.7 No.6
Based on the problems that target appears rotation and noise interference in complex environment, an improved multi-feature adaptive fusion tracking method is proposed. The algorithm adopts unscented Kalman particle filter (UPF) to update the measurement information in the sample particles, better overcome the problem of the particle weight degradation. In addition, in order to overcome the defects of additive and multiplicative fusion algorithm in the feature selection, the multiple adaptive fusion characteristics method that target color distribution and scale invariance feature (SIFT) are used as complementary information. Experimental results show that the proposed method is superior to the traditional methods which are based on fixed weight or standard particle filter.
Xihong Zhao,Li Wang,Jin Chu,Yanmei Li,Yanyan Li,Zhenbo Xu,Lin Li,Mark E. Shirtliff,Xiaowei He,Yao Liu,Jihua Wang,Liansheng Yang 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.6
A loop-mediated isothermal amplification (LAMP) method for rapid detection of the food-borne Salmonella strains had been developed and evaluated in this study. The optimal reaction condition was found to be 65℃ for 45 min, with the detection limit as 1 pg DNA/tube and 100 CFU/reaction. Application of LAMP assays was performed on 214 food-borne Salmonella strains using a rapid procedure and easy result confirmation, where the specificity of LAMP and polymerase chain reaction (PCR)assays was 97.7% (209/214) and 91.6% (196/214),respectively; with a 100% specificity for both assays.
Xihong Zhao,Li Wang,Jin Chu,Yanyan Li,Yanmei Li,Lin Li,Mark E. Shirtliff,Xiaowei He,Yao Liu,Jihua Wang,Liansheng Yang,Zhenbo Xu 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.5
A loop-mediated isothermal amplification (LAMP) method for rapid detection of the foodborne Vibrio parahaemolyticus strains and related virulent factors had been developed and evaluated in this study. Six primers, including outer primers, inner primers, and loop primers, were specially designed for recognizing 8 distinct sequences on 3 target genes, which were tlh, tdh, and trh. The detection limits were found to be 100, 100 fg, and 1 pg DNA/tube for tlh, tdh, and trh, respectively. Application of LAMP assays were performed on 368 foodborne V. parahaemolyticus strains, the sensitivities of LAMP assays for the tlh, tdh, and trh were 100, 95.6, and 96.4%, and the negative predictive values (NPV) were 100, 84.7, and 93.1%, respectively; with a 100% specificity and positive predictive value (PPV) for all 3 target genes.
Yanmei Feng,Zhiqiang Wang,Yunfeng Yang,Xiang-Feng Wu,Xiaodong Gong,Yajian Liu,Yufei Li,Zuo-Lin Cao,Chao Wang,Xin Tong 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.7
The Ag2SO3/NaNbO3 hybrids have been fabricated via a facile method at room temperature. Several methods such as X-ray diffraction, UV-Vis diffuse reflectance spectroscopy, scanning electron microscopy, electrochemical impedance spectroscopy and X-ray photoelectron spectroscopy were used to characterize the samples. Moreover, the photocatalytic activity of the samples was assessed by degradation of rhodamine B and methyl orange under the visible light illumination. Experimental results indicated the photocatalytic degradation efficiency of the as-fabricated hybrids was first increased and then decreased with increasing the dosage of NaNbO3. When the molar ratio of Ag2SO3 to NaNbO3 was 1:0.7, the as-fabricated composites had the best photodegradation efficiency of 96.4% in 30 min for rhodamine B and 97.1% in 60 min for methyl orange, respectively. These were obviously higher than that of pure samples. Furthermore, Ag2SO3 was conjugated with NaNbO3 via chemical-bonds rather than physical contact. In addition, the possible photocatalytic degradation mechanism was also provided and the main roles during the process of photocatalytic degradation were played by holes.
Vaginal Microbiome Dysbiosis is Associated with the Different Cervical Disease Status
Ma Yingying,Li Yanpeng,Liu Yanmei,Cao Le,Han Xiao,Gao Shujun,Zhang Chiyu 한국미생물학회 2023 The journal of microbiology Vol.61 No.4
Vaginal microbiome composition was demonstrated to be associated with cervical disease. The colonization characteristics of vaginal microbes and their association with the different cervical disease status, especially cervical cancer (CC), are rarely investigated. In this cross-sectional study, we characterized the vaginal microbiome of women with different status of cervical diseases, including 22 NV + (normal tissue with HPV infection), low-grade squamous intraepithelial lesion (LSIL, n = 45), high-grade squamous intraepithelial lesion (HSIL, n = 36) and CC (n = 27) using bacterial 16S DNA sequencing. Thirty HPV-negative women with normal tissue were used as the control group. We found that higher diversity of microbiome with gradual depletion of Lactobacillus, especially L. crispatus, was associated with the severity of cervical disease. High-risk HPV16 infection was associated with higher microbiome diversity and depletion of Lactobacillus in high-grade cervical diseases (i.e. HSIL and CC). The CC group was characterized by higher levels of Fannyhessea vaginae, Prevotella, Bacteroides, Finegoldia, Vibrio, Veillonella, Peptostreptococcus, and Dialister. Co-occurrence network analyses showed that negative correlations were exclusively observed between Lactobacillus and other bacteria, and almost all non-Lactobacillus bacteria were positively correlated with each other. In particular, the most diverse and complex co-occurrence network of vaginal bacteria, as well as a complete loss of L. crispatus, was observed in women with CC. Logistic regression model identified HPV16 and Lactobacillus as significant risk and protective factors for CC, respectively. These results suggest that specific Lactobacillus species (e.g. L. crispatus and L. iners) can be used as important markers to target prevention measures prioritizing HPV16-infected women and other hrHPV-infected women for test, vaccination and treat initiatives.
Youyang Qu,Yu Liu,Yanmei Zhu,Li Chen,Wei Sun,Yulan Zhu 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.11
As a component of the neurovascular unit, cerebral smooth muscle cells (CSMCs) are an important mediator in the development of cerebral vascular diseases such as stroke. Epoxye-icosatrienoic acids (EETs) are the products of ara-chidonic acid catalyzed by cytochrome P450 epoxygenase. EETs are shown to exert neuroprotective effects. In this article, the role of EET in the growth and apoptosis of CSMCs and the underlying mechanisms under oxygen glucose deprivation (OGD) conditions were addressed. The viability of CMSCs was decreased significantly in the OGD group, while different subtypes of EETs, especially 14,15-EET, could increase the viability of CSMCs under OGD conditions. RAPA (serine/threonine kinase Mammalian Target of Rapamycin), a specific mTOR inhibitor, could elevate the level of oxygen free radicals in CSMCs as well as the anti-apoptotic effects of 14,15-EET under OGD conditions. However, SP600125, a specific JNK (c-Jun N-terminal protein kinase) pathway inhibitor, could attenuate oxygen free radicals levels in CSMCs as well as the anti-apoptotic effects of 14,15-EET under OGD conditions. These results strongly suggest that EETs exert protective functions during the growth and apoptosis of CSMCs, via the JNK/c-Jun and mTOR signaling pathways in vitro. We are the first to disclose the beneficial roles and underlying mechanism of 14,15-EET in CSMC under OGD conditions.