Methylation Status and Expression of E-cadherin in Oral Squamous Cell Carcinomas Compared to Benign Oral Epithelial Lesions

Son, Hyun-Jin,Chu, Jung-Youb,Cho, Eui-Sic,Lee, Dong-Geun,Min, Myung-Gee,Lee, Suk-Keun,Cho, Nam-Pyo The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Expression of invasion/metastasis suppressor, E-cadherin, is reduced in many types of human carcinomas. Although somatic and germline utations in the CDH1, which encodes the human E-cadherin, have frequently been reported in cases with diffuse gastric and lobular breast ancers, irreversible genetic inactivations are rare in other human carcinomas. Recently, it has been well documented that some genes in human cancers may be inactivated by altered CpG methylation. Herein, we determined the expression and methylation status of E-cadherin in oral squamous cell carcinoma (SCC) by immunohistochemistry and methylation-specific PCR. The expression of E-cadherin was significantly higher in the well-differentiated oral SCCs than the moderately or poorly differentiated ones. None of eight tested benign pithelial hyperplasias showed aberrant methylation, whereas five of 12 oral squamous cell carcinomas showed aberrant methylation. When we compared E-cadherin expression with methylation status, oral SCCs with normal methylation showed a higher expression of E-cadherin than those with methylation. These findings suggest that aberrant CpG methylation of CDH1 promoter region is closely associated with transcriptional inactivation and might be involved in tumor progression of the oral mucosa.

水稻의 基肥 水準과 栽植密度가 生育 및 收量에 미치는 影響

安元燮,金鎭雨,崔周鎬 진주산업대학교 1987 論文集 Vol.25 No.-

1986年 4月부터 10月까지 晋州農林專門大學 實習團場에서 供試品種 東津(Dong jin)을 N의 基肥 水準 및 栽植 密度에 미치는 影響에 관하여 試驗한 結果를 要約하면 다음과 같다. 1. 分蘗數는 N 18㎏區가 높았고 72株區가 가장 많았다. 2. 穗長은 N 18㎏區와 72株區 다른區에 비하여 약간 길었다. 3. 粒數는 N 18㎏區가 가장 많았으며 栽植密度間에는 高度의 有意性이 認定되었다. 4. 登熟比率은 基??水準間에 有意性이 認定되었고 72株區가 높았으며 N 18㎏區가 가장 낮았다. 5. 千粒量은 施肥量間에 有意性이 認定되었으나 栽植 密度間에는 차가 거의 없었다. 6. 收量은 栽植 密度間에는 有意性이 認定되었으며 施肥量에는 認定되지 않았지만 N 18㎏區에서 약간 높은 傾向을 보였다. This experiment was conducted in the experimental field of Chinju National Agricultural and Forestry Junior College from April to October, 1986. The purpose of this experiment was to investigate the effect of basic nitrogen, fertilization level and planting density on the growth and yield of rice cultivar, Dong jin,. The results obtained are as follows : 1. The number of tilers was largest at the level 18㎏ N ad in the spacing of 72 plants. 2. The panicle lengh was a little longer then any other group at the level of 18㎏ N and in the spacing of 72 plants. 3. The grain number was largest at the level of 18㎏ N and highly significant difference in the grain number was confirmed among the different planting density. 4. The percentage of ripeness showed significant differences among the levels of basic fertilization. It was high in the spacing of 72 plants and lowest at the level of 18㎏ N. 5. The 1000 grain weght revealed a significant difference among the fertilization levels, but it showed little difference among the plant density. 6. The difference of yield showed significance among the planting density, but it showed little significance among the levels of fertilization. Only the yield of 18㎏ N level tended to be a little large.

LPCD법에 의한 Tin박막의 전계 에미터 어레이 제작

조경제,이상윤,류정탁,김연보,이진호 大邱大學校 科學技術硏究所 2001 科學技術硏究 Vol.8 No.2

Using low pressure chemical vapor deposition (LPCVD), TiN thin films as field emitter array were fabricated. In this Work, a method was transfered to a substrate and the wet-etching of the silicon substrate instead of fabricated method of mold shape was using in generally but we have fabricated gated field emitter tips as using mold shape of the new method that using a side wall space structure. Following sequences such as LPCVD method of a gate electrod and gate oxide on a silicon substrate and defesited BPSG thin film as a high temperature was flowed by the mold shape of a sharpen, the TiN as a materials of emitter tips was deposited after was bounded by anodic bonding and the wet-etching of the silicon substrate by using KOII solution, the last have fabricated a gated field emitter arrays of a sharpen. These emitters were estmated by scanning electron microscopy and X-ray diffraction.

터널 콘크리트 벽체의 건전도 평가에 대한 연속 웨이브릿(Wavelet)의 적용

추진호,조성호,강태호 中央大學校 建設環境硏究所 2002 環境科學硏究 Vol.13 No.2

터널 라이닝의 두께와 강성(stiffness)의 평가에 웨이브릿(wavelet)을 이용하여 신호 해석의 극대화와 터널의 건전도 평가에 있어서 직접적인 수직 균열의 유무, 위치, 다양한 반사면의 탐지에 관한 웨이브릿해석의 적용성을 평가하였다. 기존의 탄성파 해석은 시간 혹은 주파수의 한 영역에서만 해석이 이루어져 왔으나, Wavelet 해석은 신호처리에 있어서 시간-주파수 영역을 동시에 살펴보면서 해석을 할 수 있다. 본 연구에서는 콘크리트의 두께와 강성 균열을 평가하기 위하여 탄성파 기법의 하나인 충격반향 시험법에 대하여 Wavelet 해석을 시행하였다. 유한요소법의 하나인 ABAQUS를 이용한 수치해석과 실규모 현장시험체에서 시행한 실측 데이터 해석에 연속 Wavelet을 적용하여 보았으며, 그 결과 구조물 내에 존재하는 균열의 존재 여부와 균열의 위치를 확인하는데 Wavelet 기법이 매우 효과적이며, 향상된 신뢰성을 제공함을 확인하였다. The feasibility of the continuous wavelet analysis was evaluated for the nondestructive assessment of the structural integrity of a tunnel concrete liner. The conventional approach to analyze the signal of the wave propagation is focused on just one domain of time or frequency, while the wavelet analysis analyzes both domains of time and frequency. This study introduced the continuous wavelet analysis to interpret and analyze the stress-wave signal in both frequency and time domains for the better identification of the vertical cracks in the tunnel concrete liner. The synthetic stress-wave signals from ABAQUS were used to establish the methodology to employ the wavelet analysis, and later the real measurements at the real-scale tunnel concrete liner were analyzed. As a result, it was concluded that the continuous wavelet analysis is a reliable and effective tool to identify the vertical cracks in the tunnel concrete liner.

有·無機質肥料가 水稻의 生育 및 收量에 미치는 影響

金鎭雨,安元燮,崔周鎬 진주산업대학교 1984 論文集 Vol.22 No.-

本 試驗은 有機質 및 無機質肥料가 水稻의 生育 및 收量에 미치는 影響을 알기 爲하여 施行되었으며 그 結果를 要約하면 다음과 같다. 1) N 18㎏, K_2O_5 9㎏, K_2O 12㎏, 施用區가 收量이 가장 높았다. 2) 有機質肥料만 施用한 區보다 無機質肥料만 使用한 區보다 無機質肥料만 使用한 區가 收量이 增加되었고 有機質 및 無機質肥料를 混用한 區의 收量이 가장 높았다. 3) N 21㎏, P_2O_5 9㎏, K_2O 12㎏ 施肥區가 初期生育이 가장 旺盛하였으나 千粒重 및 登熟率이 낮은 것으로 나타나 相對的으로 收量이 떨어졌다. The experiment was carried out to find the effect of growth and yield of the paddy depend upon the source of application fertilizers like inorganic, organic and the mixture of organic and inorganic with varying levels. In this experiment, fertilizer(inorganic) applied at the rate of 18, 9 and 12㎏ per.10 a (N:P:k) showed the most productive seed yield of all treatments. In the yield experiment, plants which received inorganic fertilizer alone was hisher than that of organic fertilizer alone, and plants which received the mixture of organic and inorganic fertilizer was the highest of all. The initial growth of the plants which received 21­9­12㎏/10 a (N­P­k) was the highest As results of that 1000 grains weight(g) and filled grain(%) was dereased, the yield was decreased.

SECKEL 증후군 환자의 증례보고

김추성,김재곤,백병주,양연미,정진우 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

Seckel 증후군은 상염색체 열성 유전질환으로 태내에서의 성장지연에 따른 출생 후의 소인증, 심한 소두증을 나타내며, 큰눈과 돌출된 코, 후퇴된 하악을 동반한 새 모양의 안모가 특징적이다. 다른 임상증상으로는 관절의 결함, 내반족, 드문드문 난 모발, 비뇨생식기의 이형성, 정신지체, 혈액학적 이상 등이 나타날 수 있다. Seckel 증후군의 구강 내 소견으로는 부정교합, 법랑질 저형성증, 일부 치아의 선천적 결손, 우상치 등이 나타날 수 있다. 본 증례는 Seckel 증후군을 보이는 두 증례에서 발육부전, 새 모양의 안모, 비뇨기과적 기형, 치아의 저형성과 부정교합 등 다양한 전신증상과 구강 내 증상들을 보였기에 이를 보고하는 바이다. Seckel syndrome is an autosomal recessive disorder characterized by intrauterine growth retardation and post-natally by dwarfism, severe microcephaly, bird-headed profile with receding chin, prominent nose, joint defects, clubfoot, sparse hair, malformation of genitourinary tract and rectum, mental retardation and hematological disorders. There is also a reduction in the number of blood cells. Dental anomalies of Seckel syndrome are crowded teeth with malocclusion, enamel hypoplasia, absence of some teeth and taurodontism. This report described the oral and maxillofacial manifestations of children associated with Seckel syndrome. Children with Seckel syndrome have several dental and skeletal irregularities. The purpose of this study was to report the dental and medical characteristics of the patient and review the literatures of Seckel syndrome.

디지털회로의 효율적인 지연결함시험을 위한 경계면 스캔 구조

윤태진,장주석 경운대학교 산업기술연구소 1999 産業技術硏究論文誌 Vol.1 No.1(B)

In this paper, we analyze the problems of conventional and previous method on delay fault test architecture and test procedure on boundary scan. To solve them, we propose new delay fault test architecture, and one common test procedure. Previous method has an inefficient test procedure, and hardware overheads on the rate of the number of CUT(Circuit Under Test)s signal lines. The DFTArch(Delay Fault Test Architecture), we proposed, is to detect the delay defect of 0.5 Ttck size, and have a fixed small amount of hardware overhead. And The method is to test as 2 times faster than previous. The simulation results ascertain the correct operation and effectiveness of the proposed architecture and test procedure.

水稻葉處理가 登熟에 미치는 影響

金鎭雨,安元燮,崔周鎬 진주산업대학교 1982 論文集 Vol.20 No.-

水稻에 있어 葉處理가 登熟에 어떠한 影響을 미치는가를 “密陽23號”를 使用하여 3處理(완절, 반절, 꺽기)하고, 다시 處理日子別(8月6日, 8月16日, 8月26日)로 3反覆한 試驗結果를 要約하면 다음과 같다. 1. 本 品種은 直立性이고 오목型의 잎모양을 갖추고 있으며 滴定分葉開度를 이루고 있어 紋枯病의 發生이 比較的 적으면서 受光態勢가 良好하고 光合成能力이 높은 편이다. 2. 處理日子別 稈長, 穗長을 보면 稈長, 穗長 공히 완절이 가장 짧았고, 꺾기가 가장 길었다. 3. 葉處理가 登熟에 미치는 影響을 보면 반절과 꺾기는 비슷한 水準이었으나 완절의 경우는 收量, 千粒重, 登熟率 모두가 타處理에 比해 낮은 傾向을 나타내었다. 4. 완절의 경우 登熟比率이 낮은 것은 止葉의 除去로 인해 光合成能力이 낮아진 것으로 생각 되어진다. In order to investigate the effect of ripeness by the different treatment of rices leaves, this experiment was carried. The applied variety in this experiment was Milyang 23, the treatment of paddy's leaves were three methods (full cutting, half cutting, bending), and the treated dates were Aug.6, Aut. 16 and Aug. 26 in 1982. This results obtained in present experiment were follows: 1. Milyang 23 has an erect plant type, slightly rolling leaves, medium culm lenght, optimal tiller angle and good photosynthetic capacity. 2. The culm length and paniele length by the different treated dat in full cutting plot of the paddy's leaves were the shortest, besides those of in bending plot of the paddy's leaves were the logest. 3. In the effects of ripeness by the leaves, treatment, the level of half cutting plot and bending plot were a similiar, but the total yield, thousand grain weight and ripened grain ratio were tended the lower in with other treated plots. 4. In full cutting plot of the paddy's leaves, the ripened grain ration was show a low. But I think that the photosynthetic capacity was made lower by the cutting of the fallen leaves.

Zeolite시용으로 옥수수 生育時期에 處理區間別 土壤內 양이온 吸着에 관한 硏究

金鎭雨,李宗玉,崔周鎬 진주산업대학교 농업기술연구소 2000 農業技術硏究所報 Vol.13 No.-

Finding out chemical fertilizer and orangic fertilizer of Mixtures of zeolite treatments the changes of corn growth and soil physico-chemical properties were investigated in the sandy clay soil. pH of soil was increased and the treatments in organic fertilizer and zeolite of Mixtures. Cation exchange capacity was increased treatments of organic fertilizer, zeolite of mixture. Especially content of NH_4-N was high increased. The nutrent content(K, Ca, Mg, SiO_2) in the corn plant increased on the Zeolite treatment soils were higher than non-fertilizer treatment. The final results showed increased yield of organic fertilizer treatments for 151.7% less than No-fertilizer for 100%.

인공제오라이트 제립화에 의한 토양의 질산태질소 억제효과에 관한 연구

김진우,이 협,이종옥,최주호 진주산업대학교 농업기술연구소 2003 農業技術硏究所報 Vol.16 No.-

The effects of alkali treatment to fly ash powder coming in to being artificial zeolite were soil chemical investigated by amount of treat and during on days There was no significant difference in chemical properties between artificial zeolite and particle artificial zeolite. pH and EC value in treatments soils were high known by application with fly ash and artificial zeolite of amount increased. The amount of Av.P_(2)O_(5) adsorption capacity with artificial zeolite known higher than fly ash. In the case of amount of Ex-K, Ca, Mg were detect range between artificial zeolite and particle artificial zeolite. Artificial zeolite application with treatments in soils showed being contrary to each NH_(4)-N other NO_(3)-N for content therefore it is clear that application of particle artificial zeolite product should be more effective than of the artificial zeolite powder for soil condition.