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봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향
이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.
New Pyrimidine Derivatives possessing ALK Inhibitory Activities
Yang, Eun Hye,Yun, Jeong In,Latif, Muhammad,Lee, Hyeon Ji,Yun, Chang-Soo,Lee, Kwangho,Park, Chi Hoon,Cho, Sung Yun,Jung, Hee Jung,Kim, Pilho,Ha, Jae Du,Kim, Hyoung Rae Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.10
Novel 2,4-dianilino-5-fluoropyrimidine derivatives possessing ALK inhibitory activities
Yun, Jeong In,Yang, Eun Hye,Latif, Muhammad,Lee, Hyeon Ji,Lee, Kwangho,Yun, Chang-Soo,Park, Chi Hoon,Lee, Chong Ock,Chae, Chong Hak,Cho, Sung Yun,Jung, Hee Jung,Kim, Pilho,Choi, Sang Un,Kim, Hyoung Ra 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
A new series of 2,4-dianilino-5-fluoropyrimidine derivatives were designed and synthesized and their anaplastic lymphoma kinase (ALK) inhibitory activities were evaluated by biochemical and cell-based assays in order to discover a new ALK inhibitor. Most compounds synthesized showed good inhibitory activities against ALK and good cytotoxic activities in H3122 cell line. The best compound 6f showed good activity against wild-type ALK along with crizotinib-resistant mutant ALK, and it showed 6 times better activity in cell-based assay than crizotinib. Some SAR studies were performed by the comparisons of the activities between 6 and the designed-synthesized compounds.
Cloning and Molecular Characterization of β-1,3-Glucan Synthase from Sparassis crispa
( Yun Hui Yang ),( Hyeon Woo Kang ),( Hyeon Su Ro ) 한국균학회 2014 韓國菌學會誌 Vol.42 No.2
A β-glucan synthase gene was isolated from the genomic DNA of polypore mushroom Sparassis crispa, which reportedly produces unusually high amount of soluble β-1,3-glucan (β-glucan). Sequencing and subsequent open reading frame analysis of the isolated gene revealed that the gene (5,502 bp) consisted of 10 exons separated by nine introns. The predicted mRNA encoded a β-glucan synthase protein, consisting of 1,576 amino acid residues. Comparison of the predicted protein sequence with multiple fungal β-glucan synthases estimated that the isolated gene contained a complete N-terminus but was lacking approximately 70 amino acid residues in the C-terminus. Fungal β-glucan synthases are integral membrane proteins, containing the two catalytic and two transmembrane domains. The lacking C-terminal part of S. crispa β-glucan synthase was estimated to include catalytically insignificant transmembrane α-helices and loops. Sequence analysis of 101 fungal β-glucan synthases, obtained from public databases, revealed that the β-glucan synthases with various fungal origins were categorized into corresponding fungal groups in the classification system. Interestingly, mushrooms belonging to the class Agaricomycetes were found to contain two distinct types (Type I and II) of β-glucan synthases with the type-specific sequence signatures in the loop regions. S. crispa β-glucan synthase in this study belonged to Type II family, meaning Type I β-glucan synthase is expected to be discovered in S. crispa. The high productivity of soluble β-glucan was not explained but detailed biochemical studies on the catalytic loop domain in the S. crispa β-glucan synthase will provide better explanations.
Process Optimization for Preparing High Performance PAN-based Carbon Fibers
Yun, Jeong-Hyeon,Kim, Bo-Hye,Yang, Kap-Seung,Bang, Yun-Hyuk,Kim, Sung-Ryong,Woo, Hee-Gweon Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
wet spun polyacrylonitrile (PAN) fiber precursors. The process variables chosen were treatment temperature, applied tension in stabilization process. The temperature profile of the stabilization was set on the basis of exothermic peaks of the differential scanning calorimetry (DSC) result. Both tensile strength and modulus increased with holding at onset temperatures of the exothermic peaks for extended duration, and with a higher heating rate up to the onset temperatures at a given applied tension among the experimental conditions. The increase in load monotonously increased the tensile modulus, on the other hand, the tensile strength was maximum at the load of 15 mg/filament (T15). The load 20 mg/ filament (T20) was considered to be exceeded to form oriented crystalline structure, possibly introducing more defects in the fiber than under load of T15. The sample CP3-T15 O5 H30 showed the best tensile properties among the samples experimented whose tensile properties are compatible with the commercialized grade of general purpose carbon fibers even at low carbonization temperature such as $800\;{^{\circ}C}$ (the carbonization temperature in the commercial process. 1300∼$1500\;{^{\circ}C}$).
Cloning and Molecular Characterization of ${\beta}$-1,3-Glucan Synthase from Sparassis crispa
Yang, Yun Hui,Kang, Hyeon-Woo,Ro, Hyeon-Su The Korean Society of Mycology 2014 Mycobiology Vol.42 No.2
A ${\beta}$-glucan synthase gene was isolated from the genomic DNA of polypore mushroom Sparassis crispa, which reportedly produces unusually high amount of soluble ${\beta}$-1,3-glucan (${\beta}$-glucan). Sequencing and subsequent open reading frame analysis of the isolated gene revealed that the gene (5,502 bp) consisted of 10 exons separated by nine introns. The predicted mRNA encoded a ${\beta}$-glucan synthase protein, consisting of 1,576 amino acid residues. Comparison of the predicted protein sequence with multiple fungal ${\beta}$-glucan synthases estimated that the isolated gene contained a complete N-terminus but was lacking approximately 70 amino acid residues in the C-terminus. Fungal ${\beta}$-glucan synthases are integral membrane proteins, containing the two catalytic and two transmembrane domains. The lacking C-terminal part of S. crispa ${\beta}$-glucan synthase was estimated to include catalytically insignificant transmembrane ${\alpha}$-helices and loops. Sequence analysis of 101 fungal ${\beta}$-glucan synthases, obtained from public databases, revealed that the ${\beta}$-glucan synthases with various fungal origins were categorized into corresponding fungal groups in the classification system. Interestingly, mushrooms belonging to the class Agaricomycetes were found to contain two distinct types (Type I and II) of ${\beta}$-glucan synthases with the type-specific sequence signatures in the loop regions. S. crispa ${\beta}$-glucan synthase in this study belonged to Type II family, meaning Type I ${\beta}$-glucan synthase is expected to be discovered in S. crispa. The high productivity of soluble ${\beta}$-glucan was not explained but detailed biochemical studies on the catalytic loop domain in the S. crispa ${\beta}$-glucan synthase will provide better explanations.
Blended Grain Extracts Ameliorate Hyperglycemia in Streptozotocin-Nicotinamide Induced Diabetic Rats
Yun Sun Yang,Eun Woo Jeong,Damin Yun,Gi Su Han,Hyun Joo Kim,Hyeon Gyu Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The anti-diabetic effects of blended grain ethanol extracts (BGE) were evaluated in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats. The two types of BGE were prepared by mixing oat, sorghum, adzuki bean, finger millet, or proso millet in different ratios (BGE-1 and BGE-2). A group of normal and four groups of diabetic rats were administered with saline (DM), 200 mg/kg of metformin (MET), 500 mg/kg of BGE-1, and 500 mg/kg of BGE-2. After six weeks of administration, the fasting blood glucose level (FBG) and the area under curve of oral glucose tolerance test significantly (p<0.05) decreased in MET, BGE-1, and BGE-2 compared with DM. In particular, the FBG in BGE-2 was significantly (p<0.05) lower than BGE-1. Total cholesterol level in BGE-1 and triglyceride and alanine transaminase levels in BGE-1 and BGE-2 significantly (p<0.05) decreased compared with DM. In addition, BGE-1 and BGE-2 ameliorated pathological changes and increased insulin immunoreactivities in pancreatic β-cells. Thus, both BGE-1 and BGE-2 may exhibit anti-hyperglycemic effects, and BGE-2 especially may be more effective than BGE-1 in lowering FBG in STZ-NA induced diabetic rats.
Process Optimization for Preparing High Performance PAN-based Carbon Fibers
Jeong-Hyeon Yun,Bo-Hye Kim,Kap Seung Yang,Yun Hyuk Bang,Sung Ryong Kim,Hee-Gweon Woo 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
Optimum process conditions were investigated for maximizing the mechanical properties of the carbon fiber by from wet spun polyacrylonitrile (PAN) fiber precursors. The process variables chosen were treatment temperature, applied tension in stabilization process. The temperature profile of the stabilization was set on the basis of exothermic peaks of the differential scanning calorimetry (DSC) result. Both tensile strength and modulus increased with holding at onset temperatures of the exothermic peaks for extended duration, and with a higher heating rate up to the onset temperatures at a given applied tension among the experimental conditions. The increase in load monotonously increased the tensile modulus, on the other hand, the tensile strength was maximum at the load of 15 mg/filament (T15). The load 20 mg/filament (T20) was considered to be exceeded to form oriented crystalline structure, possibly introducing more defects in the fiber than under load of T15. The sample CP3-T15 O5 H30 showed the best tensile properties among the samples experimented whose tensile properties are compatible with the commercialized grade of general purpose carbon fibers even at low carbonization temperature such as 800 °C (the carbonization temperature in the commercial process. 1300∼1500°C ).