http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Isolation and Structural Elucidation of Related Impurities in Canrenone
Ya-Xi Yang,Guo-Rong Chen 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
Ten steroidal compounds as impurities in canrenone were isolated from the enriched mother liquor by using various chromatographic methods. Their structures were elucidated by spectrometric analysis, among which three new compounds were characterized as 3-(3-oxo-7α-(ethoxycarbonyl)methyl-17β-hydroxy-4-androsten-17α-yl) propionic acid γ-lactone (1), 3-(3-oxo-7α-ethoxy-17β-hydroxy-4-androsten-17α-yl) propionic acid γ-lactone (2) and 3-(3-oxo-5β-propionic acid-γ-lactone-6β,17β-hydroxy-4-androstan-17α-yl) propionic acid γ-lactone (3).
Xi-Yang Li,Qian-Lin Chen,Min Yang,Ya-Nan Li,Jing-Bo Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.3
The lithium titanium spinel Li4Ti5O12 has attracted more and more attention as anode materials applied in lithium ion batteries. Li4Ti5O12 material has been found to be able to intercalate lithium ions without deformation of the lattice. However, compared with graphite and other anode materials, the low conductivity of Li4Ti5O12 restricts its charging and discharging rate. Doping is deemed to be a businesslike method to enhance ionic and electronic conductivity of Li4Ti5O12. This paper reviews the effects of Li4Ti5O12 with different doping ions on different crystal lattice states. And it has been found by a summary that the doping objective of doping ions at Li4Ti5O12 is also different. Moreover, the applications of ion doping in different fields of Li4Ti5O12 are prospected.
Isolation and Structural Elucidation of Related Impurities in Canrenone
Yang, Ya-Xi,Chen, Guo-Rong Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.10
Ten steroidal compounds as impurities in canrenone were isolated from the enriched mother liquor by using various chromatographic methods. Their structures were elucidated by spectrometric analysis, among which three new compounds were characterized as 3-(3-oxo-7$\alpha$-(ethoxycarbonyl)methyl-17$\beta$-hydroxy-4-androsten-17$\alpha$-yl) propionic acid $\gamma$-lactone (1), 3-(3-oxo-7$\alpha$-ethoxy-17$\beta$-hydroxy-4-androsten-17$\alpha$-yl) propionic acid $\gamma$-lactone (2) and 3-(3-oxo- 5$\beta$-propionic acid-$\gamma$-lactone-6$\beta$,17$\beta$-hydroxy-4-androstan-17$\alpha$-yl) propionic acid $\gamma$-lactone (3).
Yang, Xue-Xi,Li, Fen-Xia,Zhou, Cui-Ping,Hu, Ni-Ya,Wu, Ying-Shong,Li, Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6
Objective: Data from a recent genome-wide association studiesy of gastric cancer (GC) and oesophageal squamous cell carcinoma in Chinese living in the Taihang Mountains of north-central China suggest that 1q22 and 10q23 are susceptibility-associated regions for GC. However, this has not been confirmed in southern Chinese populations. The aim of this study was to investigate whether these polymorphisms at 1q22 and 10q23 are associated with the risk of GC in a southern Chinese population. Methods: We selected seven top significant associated single nucleotide polymorphisms (SNPs) at 1q22 and 10q23 and conducted a population-based case-control study in a southern Chinese population. Genotypes were determined using MassARRAYTM system (Sequenome, San Diego, CA). Results: Two SNPs at 1q22, rs4072037 and rs4460629, were significantly associated with a reduced risk of GC, best fitting the dominant genetic model. Logistic regression models adjusted for age and sex showed that rs4072037 AG and GG (OR=0.64, P=0.017, compared with AA) and rs4460629 CT and TT (OR=0.54, P=0.0016, compared with TT) significantly reduced the risk of GC. However, no significant results for the five SNPs at 10q23 were obtained in this study. Conclusion: These outcomes indicate that 1q22 is associated with GC susceptibility in this southern Chinese population, while an association for the locus at 10q23 was not confirmed.
Yang, Seo Young,Tai, Bui Huu,Song, Seok Bean,Li, Wei,Yan, Xi Tao,Sun, Ya Nan,Nguyen, Phuong Thao,Kim, Young Ho Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.8
A new aliphatic acid amide, ZP-amide F (1), and eight known compounds, including bungeanumamide A (2), tumuramide C (3), ZP-amide A (4), ZP-amide B (5), ZP-amide D (6), hyperin (7), quercitrin (8), and (-)-sesamin (9), were isolated from pericarps of Zanthoxylum piperitum. The effects of these compounds on $TNF{\alpha}$-induced NF-${\kappa}B$ activation and transactivational activity of PPARs, including $PPAR{\alpha}$, $PPAR{\beta}({\delta})$ and $PPAR{\gamma}$ subtypes, were evaluated. Compounds 7 and 9 exhibited potent inhibitory effects on $TNF{\alpha}$-induced NF-${\kappa}B$ activation with $IC_{50}$ values of 5.50 and $8.10{\mu}M$, respectively. Aliphatic acid amide compounds 3, 4 and 6 displayed enhanced effects on PPAR transactivational activity with $EC_{50}$ values of 47.12, 19.13 and $12.02{\mu}M$, respectively. Among them, compound 4 demonstrated an increase in $PPAR{\alpha}$ transactivational activity, compound 3 showed a moderate increase on all PPAR subtypes, whereas compound 6 displayed weak PPAR transactivational activity.
Characteristics of registered studies for Coronavirus disease 2019 (COVID-19): a systematic review
Ming Yang,Ya-xi Shang,Zi-yu Tian,Min Xiong,Chun-li Lu,Jiang Yue,Zhang Yao,Zhang Ying-ying,Jin Xin-yan,Jin Qiu-bai,Zhang Ying-ying,Willcox Merlin L.,Liu Jian-ping 한국한의학연구원 2020 Integrative Medicine Research Vol.9 No.3
Background: The World Health Organization characterized the Coronavirus disease 2019 (COVID-19) as a pandemic on March 11th. Many clinical trials on COVID-19 have been registered, and we aim to review the study characteristics and provide guidance for future trials to avoid duplicated effort. Methods: Studies on COVID-19 registered before March 3rd, 2020 on eight registry platforms worldwide were searched and the data of design, participants, interventions, and outcomes were extracted and analyzed. Results: Three hundred and ninety-three studies were identified and 380 (96.7%) were from mainland China, while 3 in Japan, 3 in France, 2 in the US, and 3 were international collaborative studies. Two hundred and sixty-six (67.7%) aimed at therapeutic effect, others were for prevention, diagnosis, prognosis, etc. Two hundred and two studies (51.4%) were randomized controlled trials. Two third of therapeutic studies tested Western medicines including antiviral drugs (17.7%), stem cell and cord blood therapy (10.2%), chloroquine and derivatives (8.3%), 16 (6.0%) on Chinese medicines, and 73 (27.4%) on integrated therapy of Western and Chinese medicines. Thirty-one studies among 266 therapeutic studies (11.7%) used mortality as primary outcome, while the most designed secondary outcomes were symptoms and signs (47.0%). Half of the studies (45.5%) had not started recruiting till March 3rd. Conclusion: Inappropriate outcome setting, delayed recruitment and insufficient numbers of new cases in China implied many studies may fail to complete. Strategies and protocols of the studies with robust and rapid data sharing are warranted for emergency public health events, helping the timely evidence-based decision-making.
Sun, Ya Nan,Li, Wei,Yan, Xi Tao,Yang, Seo Young,Song, Seok Bean,Kim, Young Ho Japan Society for Bioscience, Biotechnology, and A 2014 Bioscience, Biotechnology, and Biochemistry Vol.78 No.3
<P>Two novel phenolic glucosides (1-2), as well as seven known compounds (3-9), were isolated from the stem of Acanthopanax koreanum; their chemical structures were determined by chemical and spectroscopic methods and subsequently compared with previously reported data. Their inhibition of nuclear factor kappa B (NF-κB) was measured in human embryonic kidney (293T) cells by using an NF-κB luciferase assay.</P>
Two New Phenolic Compounds from <i>Artemisia iwayomogi</i>
Yan, Xi‐,Tao,Ding, Yan,Li, Wei,Sun, Ya‐,Nan,Yang, Seo‐,Young,Koh, Young‐,Sang,Kim, Young‐,Ho WILEY‐VCH Verlag 2014 Helvetica chimica acta Vol.97 No.2
<P><B>Abstract</B></P><P>Two new phenolic compounds, (<I>Z</I>)‐5′‐hydroxyjasmone 5′‐<I>O</I>‐{6″‐<I>O</I>‐[(<I>E</I>)‐caffeoyl]‐<I>β</I>‐<SMALL>D</SMALL>‐glucopyranoside} (<B>1</B>) and quercetin‐7‐<I>O</I>‐<I>β</I>‐<SMALL>D</SMALL>‐glucuronide methyl ester (<B>2</B>), along with ten known phenolic compounds, <B>3</B>–<B>12</B>, were isolated from the aerial parts of <I>Artemisia iwayomogi.</I> Their structures were elucidated by spectroscopic methods, including 1D‐ and 2D‐NMR, and HR‐ESI‐TOF‐MS techniques. The inhibitory effects of compounds <B>1</B>–<B>12</B> on the LPS‐stimulated production of IL‐12 p40, IL‐6, and TNF‐<I>α</I> in bone marrow‐derived dendritic cells were evaluated.</P>
Sun, Ya Nan,Li, Wei,Song, Seok Bean,Yan, Xi Tao,Yang, Seo Young,Kim, Young Ho Medknow PublicationsMedia Pvt Ltd 2016 Pharmacognosy magazine Vol.12 No.45
<P><B>Background:</B></P><P><I>Polygonum multiflorum</I> is well-known as “Heshouwu” in traditional Chinese herbal medicine. In Northeast Asia, it is often used as a tonic to prevent premature aging of the kidney and liver, tendons, and bones and strengthening of the lower back and knees.</P><P><B>Objective:</B></P><P>To research the anti-inflammatory activities of components from <I>P. multiflorum</I>.</P><P><B>Materials and Methods:</B></P><P>The compounds were isolated by a combination of silica gel and YMC R-18 column chromatography, and their structures were identified by analysis of spectroscopic data (1D, 2D-nuclear magnetic resonance, and mass spectrometry). The anti-inflammatory activities of the isolated compounds 1−15 were evaluated by luciferase reporter gene assays.</P><P><B>Results:</B></P><P>Fifteen compounds (1–15) were isolated from the roots of <I>P. multiflorum</I>. Compounds 1−5 and 14−15 significantly inhibited tumor necrosis factor-α-induced nuclear factor kappa B-luciferase activity, with IC<SUB>50</SUB> values of 24.16-37.56 μM. Compounds 1−5 also greatly enhanced peroxisome proliferator-activated receptors transcriptional activity with EC<SUB>50</SUB> values of 18.26−31.45 μM.</P><P><B>Conclusion:</B></P><P>The anthraquinone derivatives were the active components from the roots of <I>P. multiflorum</I> as an inhibitor on inflammation-related factors in human hepatoma cells. Therefore, we suggest that the roots of <I>P. multiflorum</I> can be used to treat natural inflammatory diseases.</P><P><B>SUMMARY</B></P><P><P>This study presented that fifteen compounds (1-15) isolated from the roots of Polygonum multiflrum exert signifiant anti inflmmatory effects by inhibiting TNF α induced NF κB activation and PPARs transcription.</P></P> >[FIG OMISSION]</BR><P>Abbreviation used: NF κB: Nuclear factor kappa B, PPARs: Peroxisome proliferator activated receptors, PPREs: Peroxisome proliferator response elements, TNF α: Tumor necrosis factor α, ESI-MS: Electrospray ionization mass spectrometry, HepG2: Human hepatoma cells</P>