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16세기는 조선성리학이 크게 발전하고 학자들도 많이 배출된 시기였다. 호남의 河西 김인후 선생은 바로 조선성리학의 초창기에서 성장기로 넘어가는 과정 중의 인물로서, 그의 학술적 내용과 사상적 요지는 대체적으로 이 시기 조선성리학이 주목하고 있던 문제점과 이론적 특징을 잘 반영하고 있다. 이 글에서는 태극 음양 사단칠정 인심도심 등 조선성리학의 핵심적 내용에 착안하여 수직적으로는 이런 문제에 대한 河西의 관점을 파악하고 수평적으로는 河西가 다른 학자들과 이런 문제를 처리하는데 지니고 있던 같은 점과 다른 점을 비교해 보려하며, 더 나아가 조선중기성리학이 程朱理學을 발전시키고 풍부하게 한 이론적 대응 방식과 특징을 분석해보려 한다. In the 16th century, the Neo-confucianism of Chosun Dynasty had a tremendous development, many famous scholars emerged. KimHa-Shu is the watersheds in the period from the beginning to the maturity stage of the Neo-confuciansim of Chosun Dynasty. His acdemic content and thought`s orientation can reflect the core of the subjects and the characteristic of the thoeries concerned by the academic field of this period. This article bases on some important concepts and discussion, T` ai-chi and Yin Yang, Si-duan and Qi-ch`in, Jen-hsin and Dao-hsin, etc, then tends to horizontally grasp Kim Ha-Shu`s points about these question and vertically compare the similarities and differences between Kim Ha-Shu and other scholars. The final aim of this article is to analysis the new pattern and characteristic in the terms of thoery to develop and enrich the Neo-coufucianism by the scholars of Chosun Dynasty.
TDP-43 is a ubiquitously expressed DNA/RNA binding protein that has recently attracted attention for its involvement in neurodegenerative diseases. While TDP-43 has been found to participate in various important cellular activities including stress and apoptosis, little is known about its role in cancer cells. Here we report that staurosporine (STS) induced apoptosis in U87 glioma cells is associated with rapid downregulation of TDP-43 at both mRNA and protein levels. The latter is dependent on activation of caspase 3. More importantly, we have shown that knockdown of TDP-43 by specific siRNA dramatically enhanced cytotoxicity of STS. These results suggest that normal level of TDP-43 may be protective for cancer cells under apoptotic insult.
A method to predict the risk of lung cancer is proposed, based on two feature selection algorithms: Fisher and ReliefF, and BP Neural Networks. An appropriate quantity of risk factors was chosen for lung cancer risk prediction. The process featured two steps, firstly choosing the risk factors by combining two feature selection algorithms, then providing the predictive value by neural network. Based on the method framework, an algorithm LCRP (lung cancer risk prediction) is presented, to reduce the amount of risk factors collected in practical applications. The proposed method is suitable for health monitoring and self-testing. Experiments showed it can actually provide satisfactory accuracy under low dimensions of risk factors.
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在中国文化中,“师”作为一种社会身份是承载和传承传统的重要符号之一。师者不仅限于一种职业称谓,更以求道、载道为己任。师者作为传统的象征,与中国文化生命以“教”为核心的成长方式紧密相关。传统与师道是彼此需要、彼此激 荡的互动关系。师者是传统得以承续、发展之所依,传统是师者安身立命之所存。 In Chinese culture, TEACHERS as a social identity has been the vital role in and disseminating and inheriting our cultural tradition. THEACHERS is more than an occupational appellation, the teachers ought to take the responsibility of quest and transmission of Tao or Truth. Why TEACHERS plays such an important role in Chinese culture is closely to related to the significance of Teaching that is the core growth mode of Chinese cultural life. There is a indispensable and interactive relation between Tradition and Teachers' ethos. The cultural tradition can be inherited and developed depending on the teachers' working, meanwhile the cultural tradition is the spirit homeland of the teachers.
This paper discussed the cognitive system of Korean speakers and Chinese speakers by investigating the expressions of spatial relations between Korean and Chinese. The results are as follows: First, we pointed out the definition and characteristics of spatial relations and established their semantic types. Second, we compared expressions of spatial relation between Korean and Chinese through three types of spatial relations, namely relative static spatial relations, absolute static spatial relations and directional spatial relations. Third, we explained the universality and variety of the methods of conceptualization in terms of ‘figure-ground relationship', ‘iconicity', ‘perspective', ‘prominence', etc.
This paper discusses semantic aspects of autoantonym and its interpretation in order to define semantic properties of autoantonym which exists between Korean and Chinese in the perspective of cognitive linguistics. The results are as follows: First, it pointed out the similarities and differences between autoantonym and antonym, and limit the scope of autoantonym. Second, the semantic aspects of autoantonym are largely divided into ‘directional opposition', ‘scale opposition', and ‘complementary opposition'. Through the contrast between Korean and Chinese, it showed that there are some autoantonyms which correspond to each other, whereas there are most autoantonyms which cannot correspond to each other. Third, the creation of autoantonym is supported by internal causes of language such as ‘contagion', and external causes of language such as encyclopedic knowledge about reference, human's cognitive tendencies, cultural background of research language, etc. Fourth, the study of autoantonym is meaningful for dictionary compilation, language education, and clarifying the way of human conceptualization.
Han,Ying-Hao,Mao,Ying-Ying,Yu,Nan-Nan,Jin,Mei-Hua,Jin,Ying-Hua,Wang,Ai-Guo,Zhang,Yong-Qing,Shen,Gui-Nan,Cui,Yu-Dong,Yu,Li-Yun,Lee,Dong-Seok,Jo,Yu-Jin,Sun,Hu-Nan,Kwon,Jeongwoo,권태호 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
In this study, we used RNA sequencing (RNA-seq) to analyze and compare bulk cell samples from wild-type (WT) dermal mesenchymal stem cells (DMSCs) (n = 3) and Prx II knockout DMSCs (n = 3). The purpose of the study was to elucidate the role of Prx II on allogeneic immune rejection of transplanted DMSCs. The results revealed differential expression of 472 genes (176 up-regulated and 296 down-regulated; p ≤ 0.05) between the PrxII+/+ (WT) and PrxII−/− sample groups. When highly regulated genes were categorized according to the Gene Ontology (GO) molecular function classification and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, the PrxII−/− samples showed a robust downward trend in allograft rejection. The study identified 43 all immunologically rejected differentially expressed genes, of which 41 showed lower expression in the PrxII−/− vs. PrxII+/+ (WT) samples. These findings suggest that Prx II gene knockout may down-regulate the allograft rejection that occurs during DMSCs transplantation and improve the survival rate of DMSCs in the host. This study provides a new perspective on the clinical treatment of stem cell transplantation.
Under the context that SNS is turning to a commerce tool from a communicate tool, this study investigates the antecedents of value and attitude toward SINA Weibo advertising, and examines the role of social media advertising positive and negative attributes as determinants of perceived advertising value and user's positive attitude toward advertising. Moreover, this study explored the relationships between perceived advertising value, user's positive attitude toward advertising and users' ads adoption. A conceptual model and hypotheses are tested with a sample of 304 SINA Weibo users, and conducted AMOS 22.0 analysis. Overall, the findings provided support for the model of the study. First, more informativeness, more entertainment, and more credibility to create higher user's advertising adoption in the SINA Weibo environment. Second, user-defined customization directly affects the user's attitude without the indirect impact of perceived value. Third, irritation is not important attributes affecting user's perceived ad value and positive attitude toward SINA Weibo advertising. Fourth, privacy concerns also directly affects users' attitudes toward SINA Weibo advertising. The study adds to and expands our knowledge of the antecedents and consequences of SINA Weibo users behaviour regarding advertising and therefore act as a valuable base of social media advertising practitioners.
Over the past few years, the SNS has gradually become a part of mainstream culture, even changing people's lifestyles, and having a new influence on the development of society and culture. For entrepreneurs who need to grasp the consumer mentality, be able to appropriate profit-making model, and transfer concepts and flow into money, the trends in the SNS industry have become of crucial concern. This is what informs this study. In China, in addition to firms, marketers and advertisers use of microblogging platforms for product advertising, and the microblogging platform also have strengthened netizens awareness on safeguarding their rights. They have enabled common people to become the main force in propagating and promoting news events. Importantly, the value of SNS has become prominent in commerce and recreation. It is for this reason a study of commercial value of SINA Weibo has an essential significance. By selecting major factors influencing the user's adoption of SINA Weibo advertising, the paper studies the correlativity between these factors (informativeness, entertainment, credibility, personalization, customization, irritation, privacy concern) and perceived value and users' positive attitudes toward the advertisements on SINA Weibo. Based on the outcome of this study, recommendations are made which shall be suitable and helpful for domestic SNS' development and propagation.