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Design, Synthesis and Biological Evaluation of Novel Analogs of Bortezomib
Rao, R. Janaki Rama,Rao, A.K.S. Bhujanga,Swapna, K.,Rani, B. Baby,Kumar, S. Prasanna,Awantika, S.,Murthy, Y.L.N. Korean Chemical Society 2011 대한화학회지 Vol.55 No.5
Novel analogs of bortezomib were designed, synthesized and in vitro biological evaluation was carried out using human tumor cell lines A549 and PC3. Docking studies of these analogs of bortezomib was discussed. According to biological investigations, the inhibitors 4, 6, and 8 were found to be more potent than reference drug candidate bortezomib. A549 cell line showed significant sensitivity towards 4, 6, and 8 with $IC_{50}$ values 14.03, 18.5, and 12.4 nM, respectively, and PC3 cell line showed IC50 values 26.1, 37.0, and 21.2 nM, respectively. The $IC_{50}$ values of bortezomib in these cell lines are 27.3 nM and 42.0 nM.
Sreekantha Reddy, D.,Kang, B.,Yu, S.C.,Dwarakanadha Reddy, Y.,Sharma, S.K.,Gunasekhar, K.R.,Rao, K.N.,Sreedhara Reddy, P. Elsevier 2009 Current Applied Physics Vol.9 No.2
Nanostructured Zn<SUB>1-x</SUB>Mn<SUB>x</SUB>S films (0=<x=<0.25) were deposited on glass substrates by simple resistive thermal evaporation technique. All the films were deposited at 300K in a vacuum of 2x10<SUP>-6</SUP>m bar. All the films temperature dependence of resistivity revealed semiconducting behaviour of the samples. Hot probe test revealed that all the samples exhibited n-type conductivity. The nanohardness of the films ranges from 4.7 to 9.9GPa, Young's modulus value ranging 69.7-94.2GPa.
LAMC2 enhances the metastatic potential of lung adenocarcinoma
Moon, Y W,Rao, G,Kim, J J,Shim, H-S,Park, K-S,An, S S,Kim, B,Steeg, P S,Sarfaraz, S,Changwoo Lee, L,Voeller, Donna,Choi, E Y,Luo, Ji,Palmieri, D,Chung, H C,Kim, J-H,Wang, Y,Giaccone, G Macmillan Publishers Limited 2015 Cell death and differentiation Vol.22 No.8
Lung cancer is the number one cancer killer, and metastasis is the main cause of high mortality in lung cancer patients. However, mechanisms underlying the development of lung cancer metastasis remain unknown. Using genome-wide transcriptional analysis in an experimental metastasis model, we identified laminin γ2 (LAMC2), an epithelial basement membrane protein, to be significantly upregulated in lung adenocarcinoma metastatic cells. Elevated LAMC2 increased traction force, migration, and invasion of lung adenocarcinoma cells accompanied by the induction of epithelial–mesenchymal transition (EMT). LAMC2 knockdown decreased traction force, migration, and invasion accompanied by EMT reduction in vitro, and attenuated metastasis in mice. LAMC2 promoted migration and invasion via EMT that was integrin β1- and ZEB1-dependent. High LAMC2 was significantly correlated with the mesenchymal marker vimentin expression in lung adenocarcinomas, and with higher risk of recurrence or death in patients with lung adenocarcinoma. We suggest that LAMC2 promotes metastasis in lung adenocarcinoma via EMT and may be a potential therapeutic target.
Lee, Y.S.,Gopi, C.V.V.M.,Venkata-Haritha, M.,Rao, S.S.,Kim, H.J. Elsevier Sequoia 2017 Journal of photochemistry and photobiology Chemist Vol. No.
The high stability and superior electrocatalytic activity of counter electrodes (CEs) are crucial but important issues in high performance quantum dot-sensitized solar cells (QDSSCs). To address the above issues, nanoparticle-structured nickel sulfide (NiS) thin film electrodes were prepared on F-doped SnO<SUB>2</SUB> glass (FTO glass) substrates using a facile chemical bath deposition method at different growth times and used directly as the CEs for CdS/CdSe/ZnS QDSSCs. The surface morphology and thickness of the resulting NiS films are greatly affected by the deposition time. By optimizing the growth time of the NiS CE materials, a power conversion efficiency up to 3.25% was achieved for CdS/CdSe/ZnS based QDSSCs, which was much higher than that of the Pt CE (0.79%). In addition, a preliminary durability test of the CE in QDSSCs reveals that the NiS CE exhibited good stability than the Pt CE. The improved performance of the QDSSC was attributed to the resulting electrochemical catalytic activity of the NiS CE with efficient charge transfer at the CE/electrolyte interface, which was verified by the electrochemical impedance spectroscopy and the Tafel polarization measurement results. Therefore, the excellent electrochemical performance of NiS highlights its promising application as a CE for high performance QDSSCs.
Laccase- and Peroxidase-Free Tyrosinase Production by Isolated Microbial Strain
( Sambasiva Rao K. R. S. ),( N. K. Tripathy ),( Y. Mahalaxmi ),( R. S. Prakasham ) 한국미생물 · 생명공학회 2012 Journal of microbiology and biotechnology Vol.22 No.2
Laccase- and peroxidase-free tyrosinase has commercial importance in the production of L-3, 4-dihydroxyphenylalanine (L-DOPA), which is mainly used in the treatment of Parkinson`s disease. In the present study, isolation of an actinomycetes microbial strain capable of producing only tyrosinase is reported. Among all soil isolates, three individual colonies revealed black color around the colony in the presence of tyrosine. Further screening for laccase and peroxidase activities using syringaldazine denoted that one of the isolates, designated as RSP-T1, is laccase and peroxidase negative and produces only tyrosinase. The microbe was authenticated as Streptomyces antibioticus based on 16S ribotyping. Effective growth of this isolate was noticed with the use of medium (pH 5.5) containing casein acid hydrolysate (10.0 g/l), K2HPO4 (5.0 g/l), MgSO4 (0.25 g/l), L-tyrosine (1.0 g/l), and agar (15 g/l). The scanning electron micrograph depicted that the microbe is highly branched and filamentous in nature. The enzyme production was positively regulated in the presence of copper sulfate. The impact of different fermentation parameters on tyrosinase production depicted that the maximized enzyme titer values were observed when this isolate was grown at 6.5 pH and at 30oC temperature under agitated conditions (220 rpm). Among all the studied physiological parameters, agitation played a significant role on tyrosinase production. Upon optimization of the parameters, the yield of tyrosinase was improved more than 100% compared with the initial yield.
Binder burnout and sintering kinetic study of alumina ceramics shaped using methylcellulose
K. Rajeswari,S. Chaitanya,P. Biswas,M. Buchi Suresh,Y.S. Rao,Roy Johnson 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.1
Ceramic components are generally processed by the techniques such as compaction, extrusion, injection molding, casting etc., and the selection of forming method is generally based on the complexity of the shapes. Additives such as binders, plasticizers, surfactants and lubricants, which are generally organic in nature, play a significant role to ensure the flowability of the mass which is critical in shaping of ceramics. Alumina (α-Al2O3) powder was subjected to torque rheometric studies to identify Critical Volume Binder Concentrations (CBVC) corresponding to specific processing regimes. An initial torque value of 3-4Nm for compaction followed by 6-7N-m for extrusion and 2-3N-m for casting regimes were observed. Viscosities of the pre-mixes prepared by the addition of methyl cellulose (C6H7O2 (OH)x(OCH3)y, (where x = 1.0-1.5 and y = 2-1.45) as a binder were also found to exhibit a similar trend in viscosity, corresponding to CBVC torque values and are shaped into green specimens. Green strength of the standard specimens (45 × 4 × 3 mm) was estimated through 3-point bend tests and exhibited a good correlation with the binder content. Binder burnout characteristics were also elucidated by TG/DSC technique and activation energy estimated is 75-110 kJ/mol for the thermal degradation of methylcellulose binder. Activation energy of 883 ± 45 kJ/mol was estimated through kinetic analysis of sintering by the construction of the Master Sintering Curves (MSC).
Development of the 3.7 GHz LHCD System on HL-2A
B. Lu,M. Huang,H. Zeng,X. Y. Bai,X. H. Mao,Z. H. Lu,J. Liang,Z. H. Kang,M. W. Wang,K. Feng,H. Wang,C. Wang,J. Q. Wang,S. Wei,T. Yao,Y. N. Bu,J. Feng,G. Y. Cheng,S. D. Song,D. H. Xia,J. Rao 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.65 No.8
A 2 MW-3.7 GHz lower hybrid current drive (LHCD) system is under development for physicsexperiments on the HL-2A device. The RF Power is generated by four TH2103A klystron amplifiersand propagates in the TE10 mode through WR284 waveguides. The transmission lines with a lengthof 20 m to 30 m are pressurized with 2 bars of nitrogen to decrease the possibility of arcing. Thelauncher, based on the passive-active multi-junction (PAM) concept, has been developed and iscurrently being realized. It was designed for a power spectrum peaked at Nk = 2.75 with goodcoupling properties over a wide range of plasma parameters. The four klystrons are fed by ahigh-voltage power supply (HVPS) based on the pulse step modulation (PSM) concept with a fastswitch-off time of less than ten μs. This system is expected to be in operation within 1 years and willexplore many international thermonuclear experimental reactor (ITER) related LH experiments inthe following years.