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Xing Fu Yin,전영은,정희철,정세영,심재훈,강일준 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.1
The efficacy of Aster sphathulifolius (AS) for evaluation of preventive potencies against diabetes and diabetic complications was analyzed by assessment of inhibitory effects against advanced glycation end-products (AGEs) formation, rat lens aldose reductase (RLAR), α- glucosidase activity, and scavenging effects against DPPH. The 50% ethanol extract showed the highest DPPH radical scavenging activity (82.38%) at a concentration of 100 μg/ mL, exhibited the most potent AGEs formation inhibitory effect (93.88%) at a concentration of 200 μg/mL, showed the most potent RLAR inhibitory effect (86.44%) at a concentration of 11.11 μg/mL. The 95% ethanol extract showed a potent α-glucosidase inhibitory activity (19.16%) at a concentration of 1 mg/mL. The 50% ethanol extract value was 16.79%. The 50% ethanol extract exhibited the most potent antioxidant and preventive actions against diabetes and diabetic complications and can, thus, be a source of valuable compounds for prevention of diabetes and diabetic complications.
윤성복(Xing Fu Yin),전영은(Young Eun Jeon),김태근(Tae-Keun Kim),심재훈(Jae-Hoon Shim),강일준(Il-Jun Kang) 한국식품영양과학회 2012 한국식품영양과학회지 Vol.41 No.11
본 연구는 타락죽의 안전성을 확보하기 위해서 30 kGy 감마선 조사된 타락죽을 ICR 마우스에 3개월간 섭취시킨 다음 독성평가를 수행하였다. 비조사 타락죽 및 30 kGy 조사 타락죽을 암수 마우스에 투여를 한 결과 시험기간 동안 시험 물질에 의한 임상증상이나 폐사 동물을 나타나지 않았으며, 체중변화, 사료섭취량 및 주요 장기 무게도 대조군에 비해 차이를 보이지 않았다. 혈액학적 검사 및 혈청학적 검사 모두 정상범위 내의 수치를 나타내었으며, 병리조직학적 검사 역시 간 및 신장 모두 염증, 괴사 등의 유의할 만한 병적 변화 없는 정상적인 구조를 유지하고 있었다. 따라서 30 kGy로 감마선 조사된 타락죽을 암수 마우스에 3개월간 섭취시켜도 본 시험조건에서는 독성이 없는 것으로 나타났다. This study was conducted to evaluate the possible subacute toxicity of gamma-irradiated Tarakjuk. Tarakjuk was irradiated at a dose of 30 kGy at room temperature. For the animal study, AIN-93G as a control diet and 30 kGy irradiated and non-irradiated Tarakjuk diets were administered to male and female ICR mice (10 mice per group) for 3 months. During the experimental period, the group fed 30 kGy irradiated Tarakjuk did not show any changes in appearance, behavior, mortality, body weight, organ weight, or food consumption compared to control. Further, all biochemical parameters were in normal ranges. In the histopathological examination of liver and kidney tissues of ICR mice, there were no significant differences between the control and 30 kGy irradiated Tarakjuk groups. These results indicate that Tarakjuk irradiated at 30 kGy did not cause any toxic effects under these experimental conditions.
전영은,Xing Fu Yin,최단비,임순성,강일준,심재훈 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.5
Prickly pear (Opuntia ficus-indica) is a longdomesticated crop plant of arid and semiarid parts of the world. The efficacy of extracts of prickly pear root for managing diabetes and diabetes complications was evaluated using a variety of in vitro bioassays. The ethyl acetate-soluble fraction was most effective in the prevention of diabetes and its complications via the inhibition of rat lens aldose reductase activity, the formation of advanced glycation end products, and α-glucosidase activity. MS and NMR were used to identify the bioactive compound from the ethyl acetate-soluble fraction as 3,5,7,4'-tetrahydroxyflavanone (aromadendrin).
노유헌,김도희,이승아,Xing Fu Yin,박지애,이무열,이원복,이상형,김재광,김성수,정윤화,명순철,김태진,강일준 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.3
Many natural substances were screened to develop nutraceuticals that reduce menopausal symptoms. A complex of Cirsium japonicum var. maackii and Thymus vulgaris extracts, named MS-10, had significant positive effects. Under a low concentration of estrogen, which represents postmenopausal physiological conditions, MS-10 had beneficial effects on estrogen receptor-expressing MCF-7 cells by reversibly enhancing estrogen activity. In addition, in the ovariectomized rat model, changes in bone-specific alkaline phosphatase activity and osteocalcin, as well as low-density lipoprotein cholesterol and triglyceride levels were significantly decreased by MS-10. These results show that MS-10 protected bone health and reduced metabolic disturbances. Furthermore, in a clinical study, all menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, vertigo, fatigue, rheumatic pain, palpitations, formication, and headache, as well as colpoxerosis, were significantly improved by taking MS-10 for 90 days. Therefore, the evidence supports that MS-10 is an effective natural substance that can safely improve menopausal symptoms, including colpoxerosis.