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- 저자 : Xiaoqian Wu (검색결과 5 건)
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Coat colour phenotype of Qingyu pig is associated with polymorphisms of melanocortin receptor 1 gene
Xiaoqian Wu,Zhendong Tan,Linyuan Shen,Qiong Yang,Xiao Cheng,Kun Liao,Lin Bai,Surong Shuai,Mingzhou Li,Xuewei Li,Shunhua Zhang,Li Zhu 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.7
Objective: Qingyu pig, a Chinese indigenous pig breed, exhibits two types of coat colour phenotypes, including pure black and white with black spotting respectively. Melanocortin receptor 1 (MC1R) and agouti signaling protein (ASIP) are two widely reported pivotal genes that significantly affect the regulation of coat colour. The objectives of this study were to investigate whether the polymorphisms of these two genes are associated with coat colour and analyze the molecular mechanism of the coat colour separation in Qingyu pig. Methods: We studied the phenotype segregation and used polymerase chain reaction amplification and Sanger sequencing to investigate the polymorphism of MC1R and ASIP in 121 Qingyu pigs, consisting of 115 black and 6 white with black spotted pigs. Results: Coat colour of Qingyu pig is associated with the polymorphisms of MC1R but not ASIP. We only found 2 haplotypes, EQY and Eqy, based on the 13 observed mutations from MC1R gene. Among which, Eqy presented a recessive inheritance mode in black spotted Qingyu pigs. Further analysis revealed a g.462-463CC insertion that caused a frameshift mutation and a premature stop codon, thus changed the first transmembrane domain completely and lost the remaining six transmembrane domains. Altogether, our results strongly support that the variety of Qingyu pig’s coat colour is related to MC1R. Conclusion: Our findings indicated that black coat colour in Qingyu pig was dominant to white with black spotted phenotype and MC1R gene polymorphism was associated with coat colour separation in Qingyu pig.
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Xiaoning Wu,Xiaoqian Xu,Jialing Zhou,Yameng Sun,Huiguo Ding,Wen Xie,Guofeng Chen,Anlin Ma,Hongxin Piao,Bingqiong Wang,Shuyan Chen,Tongtong Meng,Xiaojuan Ou,Hwai-I Yang,Jidong Jia,Yuanyuan Kong,Hong Yo 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.3
Background/Aims: Existing hepatocellular carcinoma (HCC) prediction models are derived mainly from pretreatment or early on-treatment parameters. We reassessed the dynamic changes in the performance of 17 HCC models in patients with chronic hepatitis B (CHB) during long-term antiviral therapy (AVT). Methods: Among 987 CHB patients administered long-term entecavir therapy, 660 patients had 8 years of follow-up data. Model scores were calculated using on-treatment values at 2.5, 3, 3.5, 4, 4.5, and 5 years of AVT to predict threeyear HCC occurrence. Model performance was assessed with the area under the receiver operating curve (AUROC). The original model cutoffs to distinguish different levels of HCC risk were evaluated by the log-rank test. Results: The AUROCs of the 17 HCC models varied from 0.51 to 0.78 when using on-treatment scores from years 2.5 to 5. Models with a cirrhosis variable showed numerically higher AUROCs (pooled at 0.65–0.73 for treated, untreated, or mixed treatment models) than models without (treated or mixed models: 0.61–0.68; untreated models: 0.51–0.59). Stratification into low, intermediate, and high-risk levels using the original cutoff values could no longer reflect the true HCC incidence using scores after 3.5 years of AVT for models without cirrhosis and after 4 years of AVT for models with cirrhosis. Conclusions: The performance of existing HCC prediction models, especially models without the cirrhosis variable, decreased in CHB patients on long-term AVT. The optimization of existing models or the development of novel models for better HCC prediction during long-term AVT is warranted.
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Sun Yanzhou,Han Wu,Liu Xiaoqian,Song Xiaoyan,Wei Yanfang 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.2
In order to solve the problem of limited frequency selection range and simplify calculations on the grounded capacitance measurement for the ungrounded distribution system, a high-frequency injecting method for the capacitive current measurement is proposed in the paper. The injecting frequency can be high enough to ignore capacitive reactance and leakage resistance comparing with leakage inductance. The leakage inductance value is obtained directly on the base of simplifi ed calculation. Then the resonant frequency of the power system needs to be obtained by the traditional resonant method. Finally, the grounded capacitance can be calculated through the equivalent circuit and the simultaneous equations. The simulation and experiments verify the feasibility of the high-frequency method. The experiment results prove that this method not only solves the problem of frequency selection, but also has advantages of convenience and high precision (the relative error is less than 5%), which is also suitable for the larger grounded capacitance system.
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Guoxu Wang,Jie Wu,Bifan Zeng,Zhibin Xu,Wanqiang Wu,Xiaoqian Ma 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.1
A well-performed core power control to track load changes is crucial in pressurized waterreactor (PWR) nuclear power stations. It is challenging to keep the core power stable at thedesired value within acceptable error bands for the safety demands of the PWR due to thesensitivity of nuclear reactors. In this paper, a state-space model predictive control (MPC)method was applied to the control of the core power. The model for core power control wasbased on mathematical models of the reactor core, the MPC model, and quadratic programming(QP). The mathematical models of the reactor core were based on neutron dynamicmodels, thermal hydraulic models, and reactivity models. The MPC model waspresented in state-space model form, and QP was introduced for optimization solutionunder system constraints. Simulations of the proposed state-space MPC control system inPWR were designed for control performance analysis, and the simulation results manifestthe effectiveness and the good performance of the proposed control method for core powercontrol.
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Chao Ma,Xing Duan,Xiaoqian Guo,Hua Qiao,Lianying Zhang,Xianbiao Mao,Peidong Wu 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.2
The deformation mechanisms of a rolled high-purity α-titanium plate under monotonic loading along the rolling direction(RD), transverse direction (TD), and normal direction (ND) are investigated by the Elastic Visco-Plastic Self-Consistent(EVPSC) model, which incorporates a Twinning and De-Twinning (TDT) scheme to describe twinning behavior duringstraining. In the EVPSC-TDT model, plastic deformation is assumed to be accommodated by prismatic, basal and pyramidal⟨c + a⟩ slip modes as well as the 10̄12 extension and 11̄22 contraction twin modes. Numerical results based on theEVPSC-TDT model are in good agreement with the corresponding experimental data. The tension–compression asymmetry,anisotropic initial yielding and strain hardening behavior are interpreted in terms of the predicted relative activities of variousdeformation modes, twin volume fractions and texture evolutions. It is demonstrated that twinning plays an important rolein tension–compression asymmetry and plastic anisotropy, which is closely related to the loading direction with respect tocrystal orientations in the initial texture. In addition, it can be concluded that the TDT scheme permits better performancein describing twinning-associated deformation behavior for the rolled high-purity α-titanium plate than the PredominantTwin Reorientation (PTR) model even when detwinning is not involved.
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