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- 저자 : Xiaoguang Cheng (검색결과 5 건)
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Wang Xiaoguang,Yin Hao,Liu Cheng,Li Xiaofeng,Zhang Guoguang,Liu Yi,Xu Wei 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.5
The rotor leakage flux will cause a lot of eddy current losses in the windings of coreless axial flux permanent magnet synchronous machine (CAFPMSM). This article presents a rotor leakage flux adjustment method for the CAFPMSM based on U-shaped iron, which can also achieve the optimization of the rotor flux field. The U-shaped iron can reduce the leakage flux crosses the winding and improve the spatial harmonic distribution of the air gap field at the same time. Firstly, the basic topology and its operating principle are investigated by using an equivalent magnetic circuit model. And then, the characteristics of the flux field distribution in the winding area are analyzed, and the parameters of the U-shaped iron on the leakage flux path regulation are elaborated and optimized by the three-dimensional finite-element method (3D FEM) analysis. Finally, the comprehensive experimental results show that the leakage flux path of the rotor passes through the U-shaped magnetically conductive block rather than through the windings, the total harmonic distortion (THD) of the air gap flux density waveform can be significantly decreased, and the THD of the back EMF and the eddy current losses are lower than before.
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Intracellular trafficking of TREM2 is regulated by presenilin 1
Yingjun Zhao,Xiaoguang Li,Timothy Huang,Lu-lin Jiang,Zhenqiu Tan,Muxian Zhang,Irene Han-Juo Cheng,Xin Wang,Guojun Bu,Yun-wu Zhang,Qi Wang,Huaxi Xu 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Genetic mutations in triggering receptor expressed on myeloid cells 2 (TREM2) have been linked to a variety of neurodegenerative diseases including Alzheimer’s disease, amyotrophic lateral sclerosis, frontotemporal dementia and Parkinson’s disease. In the brain, TREM2 is highly expressed on the cell surface of microglia, where it can transduce signals to regulate microglial functions such as phagocytosis. To date, mechanisms underlying intracellular trafficking of TREM2 remain elusive. Mutations in the presenilin 1 (PS1) catalytic subunit of the γ-secretase complex have been associated with increased generation of the amyloidogenic Aβ (amyloid-β) 42 peptide through cleavage of the Aβ precursor amyloid precursor protein. Here we found that TREM2 interacts with PS1 in a manner independent of γ-secretase activity. Mutations in TREM2 alter its subcellular localization and affects its interaction with PS1. Upregulation of PS1 reduces, whereas downregulation of PS1 increases, steady-state levels of cell surface TREM2. Furthermore, PS1 overexpression results in attenuated phagocytic uptake of Aβ by microglia, which is reversed by TREM2 overexpression. Our data indicate a novel role for PS1 in regulating TREM2 intracellular trafficking and pathophysiological function.
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Jianfeng Zhang,Xiaodan Xie,Cheng Liang,Weihuang Zhu,Xiaoguang Meng 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.73 No.-
Compared with graphene oxide (GO), r-GO (the reduced form) has a lower adsorption capacity for heavymetal ions and, therefore, generates concern over the release of adsorbed contaminants when GOadsorbent is discharged into a reducing environment. This study reveals that the maximum adsorptioncapacity of Pb(II) on GO and r-GO was 937.65 and 92.99 mg g 1 respectively. GO was reduced to r-GO bysulfide, causing 2.59–6.46% of the adsorbed Pb(II) to be released and was stably dispersed as a Pb(II)-oxidative debris (OD) complex. Our results provide valuable information about heavy metaltransportation in environments containing GO under different redox conditions.
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Yong Zhang,Zhuang Zhou,Cheng’ai Wu,Danhui Zhao,Chao Wang,Xiaoguang Cheng,Wei Cai,Ling Wang,Yangyang Duanmu,Chenxin Zhang,Wei Tian 대한영상의학회 2016 Korean Journal of Radiology Vol.17 No.5
Objective: To investigate the bone mineral density (BMD) of cervical vertebrae in a population-stratified manner and correlate with that of the lumbar vertebrae. Materials and Methods: Five hundred and ninety-eight healthy volunteers (254 males, 344 females), ranging from 20 to 64 years of age, were recruited for volumetric BMD (vBMD) measurements by quantitative computed tomography. Basic information (age, height, weight, waistline, and hipline), and vBMD of the cervical and lumbar vertebrae (C2–7 and L2–4) were recorded. Comparisons among sex, age groups and different levels of vertebrae were analyzed using analysis of variance. Linear regression was performed for relevance of different vertebral levels. Results: The vBMD of cervical and lumbar vertebrae was higher in females than males in each age group. The vBMD of the cervical and lumbar vertebrae in males and the vBMD of lumbar vertebrae in females decreased with aging. In each age group, the vBMD of the cervical vertebrae was higher than that of the lumbar vertebrae with gradual decreases from C2 to C7 except for C3; moreover, the vBMD of C6 and C7 was significantly different from that of C2–5. Correlations of vBMD among different cervical vertebrae (females: r = 0.62–0.94; males: r = 0.63–0.94) and lumbar vertebrae (males: r = 0.93–0.98; females: r = 0.82–0.97) were statistically significant at each age group. Conclusion: The present study provided normative data of cervical vertebrae in an age- and sex-stratified manner. Sex differences in vBMD prominently vary with age, which can be helpful to design a more comprehensive pre-operative surgical plan.
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Xuejin Fan,Qi Peng,Yanhua Chen,Zeke Ma,Xiaoguang He,Biying Deng,Hui Huang,Juan Zeng,Chuyun Cheng,Shaoji Liu,Xiaomei Lu 한국유전학회 2015 Genes & Genomics Vol.37 No.12
The aim of this study was to test the impact of variants rs900400 (located near LEKR1 and CCNL1) and rs9883204 (located in ADCY5) on birth weight in a Chinese population. We conducted a case–control study including 156 low-birth- weight infants as the case group and 100 normal-birth-weight infants as the control group. The rs900400 and rs9883204 variants were analyzed by gene sequencing in all the participants. Our results revealed a significant difference in the genotype distribution (v2 = 10.449, p = 0.005) and allele distribution (v2 = 9.277, p = 0.002) of rs900400 between the case group and the control group. The C allele of rs900400 was associated with lower birth weight (OR 1.771 [95 % CI 1.237–2.535]) in the Chinese population. However, the rs9883204 polymorphism was not informative in the Chinese population. Our study shows that the ‘‘birth weightlowering’’ variant rs900400 located near LEKR1 and CCNL1, which is strongly associated with birth weight in European cohorts, appears to have a similar association in Chinese cohorts. However, the rs9883204 variant located in ADCY5 does not appear to be correlated with low birth weight in the same population. Moreover, we found that the variant rs900400 may also be associated with premature birth, thereby supporting the need for further research in this area.
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