The effects of codon usage on the formation of secondary structures of nucleocapsid protein of peste des petits ruminants virus

Xiao‑xia Ma,Yi‑ning Wang,Xiao‑an Cao,Xue‑rui Li,Yong‑sheng Liu,Jian‑hua Zhou,Xue‑peng Cai 한국유전학회 2018 Genes & Genomics Vol.40 No.9

The nucleocapsid (N) protein of peste des petits ruminants virus (PPRV) with a conserved amino acid usage pattern plays an important role in viral replication. The primary objective of this study was to estimate roles of synonymous codon usages of PPRV N gene and tRNA abundances of host in the formation of secondary structure of N protein. The potential effects of synonymous codon usages of N gene and tRNA abundances of host on shaping different folding units (α-helix, β-strand and the coil) in N protein were estimated, based on the information about the modeling secondary structure of PPRV N protein. The synonymous codon usage bias was found in different folding units in PPRV N protein. To better understand the role of translation speed caused by variant tRNA abundances in shaping the specific folding unit in N protein, we modeled the changing trends of tRNA abundance at the transition boundaries from one folding unit to another folding unit (β-strand → coil, coil → β-strand, α-helix → coil, coil → α-helix). The obvious fluctuations of tRNA abundance were identified at the two transition boundaries (β-strand → coil and coil → β-strand) in PPRV N protein. Our findings suggested that viral synonymous codon usage bias and cellular tRNA abundance variation might have potential effects on the formation of secondary structure of PPRV N protein.

Effect of Different Cooling Rates in High Rheological Rate Forming Process on Mechanical Properties of Zr57Cu20Al10Ni8Ag5 Bulk Metallic Glass

Xiao‑Bo Mei,Bao‑Chuan Liu,Wei Jiang,Quan Xu,Qi‑Dong Zhang,Yu‑Bai Ma,Fang‑Qiu Zu 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.9

The influence of cooling rates on the mechanical properties of a Zr-based bulk metallic glass prepared with high rheologicalrate forming (HRRF) was investigated and compared with traditional suction cast methods. Amorphous samples of Zr57Cu-20Ni8Al10Ag5 were prepared in copper molds with different sizes in order to obtain different cooling rates for both HRRFand traditional cast methods. These specimens were subjected to compression experiments, including microhardness testing,X-ray diffraction testing and differential scanning calorimetry analysis. The results indicate that the plasticity of the samplesformed by HRRF are higher than that of the as-cast ones at the same cooling rates, while the microhardness manifests theopposite principle. As the cooling rate increases further, the difference in plasticity further increases between two methods,indicating that the plasticity of metallic glasses is more sensitive to cooling rates during the HRRF process. At the core ofthis phenomenon is the fact that HRRF methods can introduce more free volume into glasses than traditional cast methodswith an elevated cooling rate are able to.

Field-controllable injection of virtual magnetic domainwall in discrete magnetic nanodot chains

Xiao-Ping Ma,김선대,PIAO HONGGUANG,김동현 한국물리학회 2018 Current Applied Physics Vol.18 No.1

Periodic injection behaviors of virtual magnetic domain wall (VDW) have been systematically investigated in asymmetrically shaped nanodot chains by means of micromagnetic simulations. Systematic investigation on a controllable VDW injection has been carried out. We demonstrate that precise control of VDW injection is achievable by using different nanodot shapes as well as by changing alternating magnetic field (AC field) profiles. The VDW position can be tuned by adjusting AC field frequency and amplitude. Field-controllable periodic VDW injection phenomenon is found to be sustainable over wide ranges of phase diagram spanned by AC field frequency and amplitude.

Energy-Aware Virtual Data Center Embedding

( Xiao Ma ),( Zhongbao Zhang ),( Sen Su ) 한국정보처리학회 2020 Journal of information processing systems Vol.16 No.2

As one of the most significant challenges in the virtual data center, the virtual data center embedding has attracted extensive attention from researchers. The existing research works mainly focus on how to design algorithms to increase operating revenue. However, they ignore the energy consumption issue of the physical data center in virtual data center embedding. In this paper, we focus on studying the energy-aware virtual data center embedding problem. Specifically, we first propose an energy consumption model. It includes the energy consumption models of the virtual machine node and the virtual switch node, aiming to quantitatively measure the energy consumption in virtual data center embedding. Based on such a model, we propose two algorithms regarding virtual data center embedding: one is heuristic, and the other is based on particle swarm optimization. The second algorithm provides a better solution to virtual data center embedding by leveraging the evolution process of particle swarm optimization. Finally, experiment results show that our proposed algorithms can effectively save energy while guaranteeing the embedding success rate.

중국 공익연계 라이브커머스 BJ 정보원천 특성이 구매의도에 미치는 영향

Xiao-Li Ma,김시내,조현준 한중사회과학학회 2023 한중사회과학연구 Vol.21 No.2

This study, based on a questionnaire, using S-O-R model, analyzed how BJ (broadcast jockey)’s information source characteristics affect purchase intention through the shopping value of consumers in China’s public interest live commerce. In addition, the moderating effect of congruence between BJ’s characteristics and corporate image was examined. To test the conceptual model, we collected survey data from those who had ever watched public interest live commerce in China (422 valid cases). The test results show that BJ’s characteristics such as trustworthiness, expertise, attractiveness, and interactivity have a positive effect on consumers’ perception of the shopping value which is composed of practical and social values. And the practical value shows a significant effect on consumers purchase intention, and the social value also shows a positive effect. And it is confirmed that the higher the congruence of BJ’s interactivity and attractiveness with the corporate image, the greater the influence on the purchase intention through consumers shopping value. On the other hand, it shows that BJ’s trustworthiness and expertise have no significant effect on the shopping value. This study differs from previous studies in that it adds interactivity to the characteristics of BJ information sources, analyzes the moderating effect of congruence with corporate image, and deals with the public interest linkage area among live commerce. 본 연구는 설문조사와 S-O-R 모형을 이용하여 중국 공익연계 라이브커머스에서BJ(broadcast jockey)의 정보원천 특성이 소비자의 쇼핑가치를 통해 구매의도에 어떠한영향을 미치는지를 분석하였다. 또한 BJ의 특성과 기업 이미지 간의 일치성(congruency)이 소비자의 쇼핑가치에 미치는 조절효과를 살펴보았다. 연구모형 및 가설을 검정하기 위해 중국에서 공익연계 라이브커머스를 시청한 적이 있는 사람들을 대상으로 설문 조사하여 총 422부의 유효 설문지를 얻었다. 실증분석 결과, BJ의 특성인신뢰성, 전문성, 매력성, 상호작용성은 실용적 가치와 사회적 가치로 구성된 쇼핑가치에 대한 소비자의 인식에 긍정적인 영향을 미치는 것으로 나타났다. 그리고 실용적 가치는 소비자의 구매의도에 매우 큰 영향을 미치며 사회적 가치 또한 긍정적인 영향을미치는 것으로 나타났다. 그리고 BJ의 특성 중 상호작용성과 매력성 두 요인에서 기업이미지와의 일치성이 높아질수록 소비자의 쇼핑가치를 통해 구매의도에 더욱 큰 영향을 미치는 것으로 나타났다. 그러나 BJ의 신뢰성와 전문성은 소비자의 쇼핑가치에 유의한 영향을 미치지 않는 것으로 나타났다. 본 연구는 BJ 정보원천 특성에 상호작용성을 추가한 점, 기업 이미지와의 일치성의 조절효과를 분석한 점, 라이브커머스 가운데공익연계 영역을 다룬 점 등에서 선행연구와의 차별성을 지닌다.

Bacterial and Fungal Diversity in the Starter Production Process of Fen Liquor, a Traditional Chinese Liquor

Xiao-Ran Li,En-Bo Ma,Liang-Zhen Yan,Han Meng,Xiao-Wei Du,Zhe-Xue Quan 한국미생물학회 2013 The journal of microbiology Vol.51 No.4

Fermented foods and beverages are important parts of human diet. Fen liquor, a Chinese liquor is a fermented beverage that uses a traditional fermentation process. Starters are the main microbial source and also provide nutrients for microorganisms during fermentation. In this study, starters of Fen liquor were produced through a complex traditional fermentation process. To investigate the community structure and the composition of microorganisms in the starter production process, bacterial 16S rRNA and fungal internal transcribed spacer (ITS) regions were sequenced using clone libraries and pyrosequencing, respectively. There was much higher diversity among the bacteria than among the fungi in the starter production process. Bacteria on the surface of the starters belonged mostly to the Lactobacillaceae family,while members of the Bacillacae family were dominant in the interior of the samples that lacked access to air and water. In the fungi population, diversity was high only in the raw material. In all other samples, nearly all of the fungal sequences were from Pichia kudriavzevii, a member of the Saccharomycetaceae family. Nearly all samples showed similar fungal community structures, indicating that there was little change in the fungal community. To the best of our knowledge, this is the first report to reveal the whole process of the starter production of Chinese traditional liquor. The findings obtained in this study provide new insights into understanding the composition of the microbial community during the traditional Chinese liquor starter production process and information about the production process control and monitoring.

Clinical Evaluation of Tumor Markers for Diagnosis in Patients with Non-small Cell Lung Cancer in China

Ma, Li,Xie, Xiao-Wei,Wang, Hai-Yan,Ma, Ling-Yun,Wen, Zhong-Guang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: To evaluate the value of combined detection of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), and carbohydrateantigen 125 (CA125) for the clinical diagnosis of nonsmall cell lung cancer (NSCLC). Materials and Methods: Serum CEA, CYFRA21-1 and CA125 were assessed in 140 patients with NSCLC, 90 patients with benign lung disease and 90 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of NSCLC were analyzed. Results: Serum CEA, CYFRA21-1 and CA125 in patients with NSCLC were significantly higher than those with benign lung disease and normal controls (P<0.05). The sensitivity of CEA, CYFRA21-1 and CA125 were 49.45%, 59.67%, and 44.87% respectively. As expected, combinations of these tumor markers improved their sensitivity for NSCLC. The combined detection of CEA + CYFRA21-1 was the most cost-effective combination which had higher sensitivity and specificity in NSCLC. Elevation of serum CEA and CYFRA21-1 was significantly associated with pathological types (P<0.05) and elevation of serum CEA, CYFRA21-1 and CA125 was significantly associated with TNM staging (P<0.05). Conclusions: Single measurement of CEA, CYFRA21-1 and CA125 is of diagnostic value in the diagnosis of lung cancer, and a joint detection of these three tumor markers, could greatly improve the sensitivity of diagnosis on NSCLC. Combined detection of CEA + CYFRA21-1 proved to be the most economic and practical strategy in diagnosis of NSCLC, which can be used to screen the high-risk group.

A newly characterized exopolysaccharide from Sanghuangporus sanghuang

Xiao-kui Ma,Xu She,Eric Charles Peterson,Yu Zhen Wang,Peng Zheng,Hongyan Ma,Kexin Zhang,Jian Liang 한국미생물학회 2019 The journal of microbiology Vol.57 No.9

Sanghuangporus sanghuang is a well-known pharmacodynamic and economically important edible fungus associated with mulberry (Morus spp.). A distinctly new exopolysaccharide (EPS), designated SHP-2 was obtained from S. sanghuang P0988 broth, and its structure and anti-aging prosperity were characterized. SHP-2 was found to be composed of a backbone of 4)-β-Manp-(1 4)-α-Araf-(1 3,4)-α-Glcp(1 3,4)-α-Glcp-(1 3,4)-α-Glcp-(1 3,4)-α-Glcp-(1 3,4)-α- Glcp-(1 6)-α-Galp-(1 4)-β-Manp-(1 and five branches, including four α-D-Glcp-(1 and one α-D-Manp-(1 SHP-2 was shown to increase antioxidant enzyme activities including catalase (CAT) and superoxide dismutase (SOD) activities, as well as trolox equivalent antioxidant (TEAC) capacity in serum of mice pre-treated with D-Gal, while reducing lipofuscin levels. SHP-2 exerted a favorable influence on immune organ coefficients and ameliorated the histopathological hepatic lesions and apoptosis in hepatocytes of Dgalactose- aged mice almost in a dose-dependent manner. Using the same analytical methods, on comparison with previously studied EPS compounds (i.e. SHP-1), SHP-2 was found to have more complex structure, larger molecule weight, and different anti-aging properties. The results presented here suggest that not only does EPS bioactivity vary with respect to molecular structures and molecule weight, but that multiple structures with different activity can be expressed by a single fungal strain. These results may help understanding the antiaging prosperity of these polysaccharides for use in health foods or dietary supplements.

TERM LIMITS AND AUTHORITARIAN POWER SHARING: THEORY AND EVIDENCE FROM CHINA

Xiao Ma 동아시아연구원 2016 Journal of East Asian Studies Vol.16 No.1

Term limits that effectively govern leadership transition play an important role in authoritarian power sharing. A fixed term and a pre-appointed successor – two crucial components of term limits – credibly commit the incumbent ruler to share power with other elites, and also allow the elites to monitor and coordinate against the ruler's transgression of the power-sharing agreement. While the successful adoption of term limits often requires an even balance of power among the ruling elites in the first place, once adopted it initiates an evolving bargain over allocation of political power among multiple generations of leaders that further keeps any one faction from dominating the others. I corroborate this argument using a biographical dataset of elite members of the Chinese Communist Party from 1982 to 2012. The findings suggest that the Party's incumbent leaders and their rivals (i.e., predecessor and heir-apparent) shared equal chances in promoting their associates—which proxy their political influence—and this pattern has become more salient since the 16th party congress, when the term limits that currently govern China's leadership transition became fully fledged. This result also sheds light on the role of informal, patronage-based promotion in the institutionalization of authoritarian politics.

Structural and Optical Properties of RF Magnetron Reactively Sputtered Ag2O Film

Xiao-Yong Gao,Jiao-Min Ma,Chao Chen,Meng-Ke Zhao,Jin-Hua Gu,Jing-Xiao Lu 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.5

A series of <111> oriented Ag2O films was deposited onto glass substrates by using RF magnetron reactive sputtering at different flow ratios (FRs) of oxygen to argon. The Ag2O film deposited at FR = 0.667 was the best <111> oriented film due to dual contributions from both lattice strain and film stress. The films’ transmissivity of over 70% in the near-infrared region indicated that Ag2O films are not suitable for applications as transparent conductive films in the visible region. Ag2O films deposited at FRs from 0.467 to 0.800 had optical band gaps ranging from 3.266 eV to 3.107 eV. The redshift in the films’ absorption edge may be attributed to the decrease in the lattice strain with increasing in FR. A series of <111> oriented Ag2O films was deposited onto glass substrates by using RF magnetron reactive sputtering at different flow ratios (FRs) of oxygen to argon. The Ag2O film deposited at FR = 0.667 was the best <111> oriented film due to dual contributions from both lattice strain and film stress. The films’ transmissivity of over 70% in the near-infrared region indicated that Ag2O films are not suitable for applications as transparent conductive films in the visible region. Ag2O films deposited at FRs from 0.467 to 0.800 had optical band gaps ranging from 3.266 eV to 3.107 eV. The redshift in the films’ absorption edge may be attributed to the decrease in the lattice strain with increasing in FR.