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Xiangling Wang,Xiaofeng Guo,Masoud Babaei,Rasoul Fili,Hossein Farahani Techno-Press 2023 Advances in nano research Vol.15 No.4
Natural frequency behavior of graphene platelets reinforced composite (GPL-RC) joined truncated conical-cylindrical- conical shells resting on Winkler-type elastic foundation is presented in this paper for the first time. The rule of mixture and the modified Halpin-Tsai approach are applied to achieve the mechanical properties of the structure. Four different graphene platelets patterns are considered along the thickness of the structure such as GPLA, GPLO, GPLX, GPLUD. Finite element procedure according to Rayleigh-Ritz formulation has been used to solve 2D-axisymmetric elasticity equations. Application of 2D axisymmetric elasticity theory allows thickness stretching unlike simple shell theories, and this gives more accurate results, especially for thick shells. An efficient parametric investigation is also presented to show the effects of various geometric variables, three different boundary conditions, stiffness of elastic foundation, dispersion pattern and weight fraction of GPLs nanofillers on the natural frequencies of the joined shell. Results show that GPLO and BC3 provide the most rigidity that cause the most natural frequencies among different BCs and GPL patterns. Also, by increasing the weigh fraction of nanofillers, the natural frequencies will increase up to 200%.
Jia, Xiangling,Zhang, Chen,Liu, Juanjuan,Lv, Wei,Wang, Da-Wei,Tao, Ying,Li, Zhengjie,Zheng, Xiaoyu,Yu, Jong-Sung,Yang, Quan-Hong The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.8
<P>A controllable drying strategy is proposed for the precise and non-destructive control over the structure of a 3D graphene assembly. Such an assembly is used as a model carbon material to investigate the pore structure-dependent shuttle effect and cycling performance of the cathode of a Li-S battery.</P>
JunCheng Guo,YiJun Yang,Min Guo,XiaoDan Wang,Yang Juan,YunSuo Gao,LinQiu Fu,XiangLing Jiang,LinMei Fu,Tao Huang 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.4
Objective-To investigate the correlations of four genetic single nucleotide polymorphisms (SNPs) of brain-derived neurotrophic factor (BDNF) with posttraumatic stress disorder (PTSD). Methods-A total of 300 patients with sporadic PTSD and 150 healthy subjects (the control group) were selected according to the diagnostic criteria of PTSD (DSM-IV), and the genotypes of the BDNF SNPs G-712A, C270T, rs6265, and rs7103411 were detected by polymerase chain reaction and direct DNA sequencing to determine intergroup differences in the genotypes and allele frequencies; the pvalues were corrected with the permutation test. Results-The genotypes and allele frequencies of the SNPs G-712A, rs6265, and rs7103411 of BDNF showed no significant intergroup differences (p>0.05). However, the genotype and allele frequencies of C270T showed significant differences between the PTSD group and the control group (p<0.05). Conclusion-The SNP C270T of BDNF may be associated with PTSD. Individuals carrying the polymorphic T allele of C270T may be more likely to suffer from PTSD.
PDEA-coated Magnetic Nanoparticles for Gene Delivery to Hep G2 Cells
Hanwen Sun,Xin-jun Zhu,Lian-ying Zhang,Xiangling Gu,Jinghe Wang,Jing Li,Yancong Zhang 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.4
Poly(2-(diethylamino)ethyl methacrylate) coated magnetic nanoparticles (PDEA-MNPs) were synthesized as a new gene nanocarrier to delivery plasmids (pEGFPN1and pRL-TK) into human hepatoma (Hep G2) cells. The PDEA-MNPs shows the pH-sensitive property. These nanoparticles are positively charged at acidic pH and negatively charged at neutral or alkaline pH. The PDEAMNPs exhibited a low cytotoxicity in Hep G2 cells. PDEA-MNPs could bind and protect DNA from DNase I degradation. The transfection study demonstrated that the PDEA-MNPs could carry plasmid into Hep G2 cells and exhibited a high gene transfection efficiency. These results indicated that the novel magnetic nanoparticles could enhance gene transfection in vitro and hold the potential to be a promising non-viral nanodevice.
Caspase-3 inhibitor inhibits enterovirus D68 production
Wenbo Huo,Jinghua Yu,Chunyu Liu,Ting Wu,Yue Wang,Xiangling Meng,Fengmei Song,Shuxia Zhang,Ying Su,Yumeng Liu,Jinming Liu,Xiaoyan Yu,Shucheng Hua 한국미생물학회 2020 The journal of microbiology Vol.58 No.9
Enterovirus D68 (EVD68) is an emerging pathogen that recently caused a large worldwide outbreak of severe respiratory disease in children. However, the relationship between EVD68 and host cells remains unclear. Caspases are involved in cell death, immune response, and even viral production. We found that caspase-3 was activated during EVD68 replication to induce apoptosis. Caspase-3 inhibitor (Z-DEVDFMK) inhibited viral production, protected host cells from the cytopathic effects of EVD68 infection, and prevented EVD68 from regulating the host cell cycle at G0/G1. Meanwhile, caspase-3 activator (PAC-1) increased EVD68 production. EVD68 infection therefore activates caspase-3 for virus production. This knowledge provides a potential direction for the prevention and treatment of disease related to EVD68.
Effects of a chitosan nanoparticles encapsulation on the properties of litchi polyphenols
Xingan Cheng,Qiwen Zou,Hanhui Zhang,Jianwei Zhu,Murtaza Hasan,Fangyun Dong,Xin Liu,Junjie Li,Yuehua Wu,Xiaojing Lv,Keqiang Wang,Xiangling Deng,Zhanmei Liu,Xuhong Jiang 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.13
Litchi polyphenols have very specific biological activities. Nevertheless, the low and inconsistent oral bioavailability and instability hinder the further application of litchi polyphenols in food systems. This work prepared litchi polyphenols loaded chitosan nanoparticles (LP-CSNPs) by ionic gelation method to enhance the encapsulation on the properties of litchi polyphenols. The optimum conditions of formation via single factors and the Box–Behnken design were chitosan (CS) concentration 1.065 mg/mL, sodium tripolyphosphate (TPP) concentration 0.975 mg/mL, and the mass ratios of polyphenols and CS 1:1 with encapsulation efficiency (EE%) of 45.53%. LP-CSNPs presented the nanosized range of particle size (mean 170 nm), excellent polydispersity index (PDI) (0.156 ± 0.025), and zeta potential values (+ 35.44 ± 0.59). The in vitro release in simulated gastric fluid (pH 1.2) and intestinal fluid (pH 6.8) during 100 h was 58.34% and 81.68%, respectively. LP-CSNPs could effectively improve the storage stability and had great antibacterial activity compared with unencapsulated litchi polyphenols.