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Guo-Hua Feng,Fu-Sheng Wang,Ji-Yuan Zhang,Qing-Lei Zeng,Lei Jin,Junliang Fu,Bin Yang,Ying Sun,Tianjun Jiang,Xiangsheng Xu,Zheng Zhang,Jinhong Yuan,Liyuan Wu 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.4
Interleukin-21 (IL-21)+CD4+ T cells are involved in the immune response against hepatitis B virus (HBV) by secreting IL-21. However, the role of IL-21+CD4+ T cells in the immune response against chronic hepatitis C (CHC) virus infection is poorly understood. This study aimed to investigate the role of IL-21+CD4+ T cells in CHC patients and the potential mechanisms. The study subjects in-cluded nineteen CHC patients who were grouped by viral load (low, < 106 RNA copies/ml, n = 8; high, > 106 RNA copies/ml, n = 11). The peripheral frequency of HCV-specific IL-21+CD4+ T cells was higher in the low viral load group and was negatively correlated with the serum HCV RNA viral load in all CHC patients. Meanwhile, IL-21+ cells accumulated in the liver in the low viral load group. In vitro, IL-21 treatment increased the expression of proliferation markers and cytolytic molecules on HCV-specific CD8+ T cells. In summary, these findings suggest that HCV-specific IL-21+CD4+ T cells might contribute to HCV control by rescuing HCV-specific CD8+ T cells in CHC patients.
A Convenient Dual-Side Anionic Initiator Based on 2,6-Luditine/s-Butyl Lithium
Wu Bin Ying,고나영,Chen Kai Yao,곽노훈,Ruoyu Zhang,이경진,이범재 한국고분자학회 2019 Macromolecular Research Vol.27 No.6
A novel convenient dual-side initiator of lutidine dianion for anionic polymerization has been investigated in terms of their initiation and propagation kinetics. This lutidine dianion could be synthesized in quantitative yields reacting commercial products of 2,6-lutidine with sec-butyl lithium without any complex organic synthesis, and could be used effectively as the dual-side initiator to synthesize polyisoprene with various molecular weights via living anionic polymerization. In addition, this lutidine dianion can produce 50% of 1.4-microstructure contents in polyisoprene which is very important for elastomeric property of polydienes. All experimental evidences showed the living property and were consistent with quantitative yields without any side reactions when the anionic living polymerization proceeded using lutidine dianion as the initiator.
Wu Bin Ying,배기현,고나영,김수희,류삼곤,Jin Zhu,Ruoyu Zhang,이범재,이경진 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
Polymer-based catalysts have been of special interest because of their several advantages such as easyprocessibility. Inorganic catalyst generally have been introduced into polymer-based media to endowcatalytic activity. Surface decoration or sol–gel reaction have been performed so far, but inherent lowaffinity between organic/inorganic causes low efficiency in loading amount, resulting in low catalyticactivity. Herein, we synthesized easily processible and highly functionalizable polyoxazoline as polymernonwovenfiber-based catalytic supporter. Zr(OH)4 was grown on surface offiber-web via sol–gelreaction. The Zr(OH)4 grownfiber exhibited not only excellent mechanical properties but also effectivedecontamination efficiency against organophosphate-based toxic agents.
Wu Bin Ying,장지욱,이민우,황택성,이경진,이범재 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.47 No.-
The sulfonated phenyl functionalized polystyrene-butadiene random copolymer was synthesized forapplication asflexible ion-exchange material. The polymer was prepared through phenyl functionalizationvia thiol-ene reaction and sulfonation of the base polystyrene-butadiene copolymer with differentvinyl contents and phenyl contents. Sulfonation on phenyl functionalized polystyrene-butadienecopolymer was carried out in 1,2-dichloroethane at room temperature using the acetyl sulfonate as thesulfonation agent which was prepared from the reaction of acetyl acetate with sulfuric acid. Thesulfonation degrees were adjusted from 7.3 mol% to 24.3 mol% determined by elemental analysis (EA)with great ion exchange capacity (0.60–2.26 meq/g), conductivity (0.47–6.1 mS/cm) and lower wateruptake (5.1–12.8 wt.%). These excellent characteristics lead to great potential using as theflexibleion-exchange material.
Ying, Wu Bin,Jang, Ji Uk,Lee, Min Woo,Hwang, Taek Sung,Lee, Kyung Jin,Lee, Bumjae Elsevier 2017 Journal of industrial and engineering chemistry Vol.47 No.-
<P><B>Abstract</B></P> <P>The sulfonated phenyl functionalized polystyrene-butadiene random copolymer was synthesized for application as flexible ion-exchange material. The polymer was prepared through phenyl functionalization via thiol-ene reaction and sulfonation of the base polystyrene-butadiene copolymer with different vinyl contents and phenyl contents. Sulfonation on phenyl functionalized polystyrene-butadiene copolymer was carried out in 1,2-dichloroethane at room temperature using the acetyl sulfonate as the sulfonation agent which was prepared from the reaction of acetyl acetate with sulfuric acid. The sulfonation degrees were adjusted from 7.3mol% to 24.3mol% determined by elemental analysis (EA) with great ion exchange capacity (0.60–2.26meq/g), conductivity (0.47–6.1mS/cm) and lower water uptake (5.1–12.8wt.%). These excellent characteristics lead to great potential using as the flexible ion-exchange material.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Wu, Chunxia,Zhao, Bin,Li, Yingli,Wu, Qiuhua,Wang, Chun,Wang, Zhi Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.3
A dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFO) has been developed as a new approach for the extraction of trace copper in water and beverage samples followed by the determination with flame atomic absorption spectrometry. In the DLLME-SFO, 8-hydroxy quinoline, 1-dodecanol, and methanol were used as chelating agent, extraction solvent and dispersive solvent, respectively. The experimental parameters related to the DLLME-SFO such as the type and volume of the extraction and dispersive solvent, extraction time, sample volume, the concentration of chelating agent and salt addition were investigated and optimized. Under the optimum conditions, the enrichment factor for copper was 122. The method was linear in the range from 0.5 to $300\;ng\;mL^{-1}$ of copper in the samples with a correlation coefficient (r) of 0.9996 and a limit of detection of $0.1\;ng\;mL^{-1}$. The method was applied to the determination of copper in water and beverage samples. The recoveries for the spiked water and beverage samples at the copper concentration levels of 5.0 and $10.0\;ng\;mL^{-1}$ were in the range between 92.0% and 108.0%. The relative standard deviations (RSD) varied from 3.0% to 5.6%.
( Bin Xiao ),( Dan-dan Li ),( Ying Wang ),( Eun La Kim ),( Na Zhao ),( Shang-wu Jin ),( Dong-hao Bai ),( Li-dong Sun ),( Jee H. Jung ) 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.5
In a search for effective PPAR-γ agonists, 110 clinical drugs were screened via molecular docking, and 9 drugs, including parecoxib, were selected for subsequent biological evaluation. Molecular docking of parecoxib to the ligand-binding domain of PPAR-γ showed high binding affinity and relevant binding conformation compared with the PPAR-γ ligand/antidiabetic drug rosiglitazone. Per the docking result, parecoxib showed the best PPAR-γ transactivation in Ac2F rat liver cells. Further docking simulation and a luciferase assay suggested parecoxib would be a selective (and partial) PPAR-γ agonist. PPAR-γ activation by parecoxib induced adipocyte differentiation in 3T3-L1 murine preadipocytes. Parecoxib promoted adipogenesis in a dose-dependent manner and enhanced the expression of adipogenesis transcription factors PPAR-γ, C/EBPα, and C/EBPβ. These data indicated that parecoxib might be utilized as a partial PPAR-γ agonist for drug repositioning study.
Wei Bin,Guo Ying,Ou Xiaoqi,Lin Liyan,Su Zhenzhen,Li Lixin,Wu XiaoJuan,Cai Bei 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.5
Background: There is no standard cut-off value of serum IgG4 concentration and serum IgG4/total IgG ratio for the diagnosis of IgG4-related disease (IgG4-RD) or as a marker of treatment responses. We aimed to explore this issue through a retrospective cohort analysis of adults in southwest China. Methods: The diagnostic performance of serum IgG4 concentration and IgG4/IgG ratio for IgG4-RD was evaluated in a retrospective analysis of 177 adults newly diagnosed as having IgG4-RD and 877 adults without IgG4-RD. Dynamic analysis was performed to evaluate the significance of serum IgG4 concentration on IgG4-RD treatment responses. Results: The serum IgG4 concentration differed according to sex. The optimal cut-off values of serum IgG4 concentration and IgG4/IgG ratio for IgG4-RD diagnosis were 1.92 g/L and 0.12 in males and 1.83 g/L and 0.11 in females, respectively. For patients with serum IgG4 concentration >2.01 g/L, the cut-off values in the total population were >3.00 g/L and 0.19, respectively. The median serum IgG4 concentration decreased over time, and the decrease rate increased over time. The serum IgG4 concentration significantly decreased at >1 week post-treatment (P=0.004), and the median decrease rate was close to 50% at >4 weeks post-treatment. Conclusions: Serum IgG4 can be a good indicator for IgG4-RD diagnosis; however, different diagnostic cut-off values should be determined according to sex. The decreasing rate is more conducive than the serum IgG4 concentration to monitor treatment efficacy. The IgG4/IgG ratio did not improve the diagnostic efficacy for IgG4-RD.
Chunxia Wu,Bin Zhao,Qiuhua Wu,Chun Wang,Zhi Wang,Yingli Li 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.3
A dispersive liquid-liquid microextraction based on solidification of floating organic droplet (DLLME-SFO)has been developed as a new approach for the extraction of trace copper in water and beverage samples followed by the determination with flame atomic absorption spectrometry. In the DLLME-SFO, 8-hydroxy quinoline, 1-dodecanol, and methanol were used as chelating agent, extraction solvent and dispersive solvent,respectively. The experimental parameters related to the DLLME-SFO such as the type and volume of the extraction and dispersive solvent, extraction time, sample volume, the concentration of chelating agent and salt addition were investigated and optimized. Under the optimum conditions, the enrichment factor for copper was 122. The method was linear in the range from 0.5 to 300 ng mL^(−1) of copper in the samples with a correlation coefficient (r) of 0.9996 and a limit of detection of 0.1 ng mL^(−1). The method was applied to the determination of copper in water and beverage samples. The recoveries for the spiked water and beverage samples at the copper concentration levels of 5.0 and 10.0 ng mL^(−1) were in the range between 92.0% and 108.0%. The relative standard deviations (RSD) varied from 3.0% to 5.6%.