Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

대장에 발생한 샘암종에서 MUC1과 MUC2 점소 발현의 의의

이윤경,이주호,이용,심재영,박정훈,오수섭,박진실,기근홍 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.2

Background : Mucins possess the unique function of protecting and lubricating the epithelial surface and other important functions such as call growth, direct implication in the fetal development, the epithelial renewal and differentiation, the epithelial integrity, carcinogenesis, immune regulation, cellular adhesion and metastasis. Purpose : This study was done to provide the significance of alteration of MUC1 and MUC2 expression in colorectal adenocarcinoma, A series of 131 colorectal adenocarcinomas including 11 mucinous carcinomas were screened immunohistochemically for their expression of MUCI and MUC2, Materials and mehtods : Of 131 carcinomas, 76 (58,5%) were MUCI positive and 91 (68, 9%) were MUC2 positive, In normal colonic goblet cells, MUCl was not expressed but MUC2 was expressed in cytoplasm, Conclusion There were up-regulation of MUCI and down-regulation of MUC2 in colorectal carcinomas, The frequency of MUC2 positivity according to differentiation was statistically reliable. (p=0.0001)

A NOVEL FUNCTIONAL MATERIAL OF Ag-S$i_3N_4$ NANOSTRUCTURED COMPOSITE

Zhu, Zhu, Yi-Hun,Zhu, Zhu, Hong-Jie,Han, Han, Jin-Yi,Hu, Li-Ming 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.1 No.1

$Ag-Si_3N_4$ nanostrutured composite has been investigated. The results show that it exhibits some novel properties such as strong piezpelectricity and high dielectricity. It can be constituted a battery using graphite and aluminum as the positive and the negative electrodes, respectively. The origins of these properties have been discussed.

Synthesis and Antiproliferative Activity of 1,4-Bis(dimethylamino)- 9,10-anthraquinone Derivatives against P388 Mouse Leukemic Tumor Cells

Guang-Zhu Jin,Hai-Shan Jin,Li-Li Jin 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

A series of 2-substituted-1,4-bis(dimethylamino)-9,10-anthraquinone derivatives were synthesized and their in vitro antiproliferative activities against p388 mouse leukemic tumor cells were evaluated. In addition, the effect of substituents on the phenyl ring was investigated. Among the derivatives tested, seven showed a high antiproliferative effect and three showed a moderate effect. In addition, introduction of a series of substituted phenyl groups into 1,4-bis(dimethylamino)-9,10-anthraquinone at 2-position were shown to enhance its antiproliferative activity. The antiproliferative activity also increased upon substitution of the benzene ring by an electron donating group such as an amine or methoxyl group.

中日韓における形態素「~族」の比較研究

김금주(金錦珠)(Jin, Jin-Zhu) 한일일어일문학회 2012 한일어문논집 Vol.16 No.-

형태소 “족”은 “공통적인 특성을 가진 특정 사람”을 가리키는 의미에서 한중일 세 나라 언어로 공통된다. 본고에서는 형태소 “족”의 어의 “족”어의 중일한 비교 대조를 시도했다. 중국의 “족”어는 일본어와 한국어에 비해 외래어가 극소하고 그 95%가 한자로 표기되어 있다 특히“일족”라는 파생어를 생성하고있는 것도 한국어, 일본어와는 다르다. 일본어에 있어서 “족”어는 중국어와 한국어에 비해 당시의 인기 소설이나 잡지, 텔레비전 드라마의 제목에서 온 것이 많다. 또한 “족”어은 종종 마이너스의 어감을 띠고 있다. 일본에서는 “족”은 “계”로 대체되는 현상이 눈에 띄고, 일본어의 “족”어의 생성 메커니즘은 한중에 비해 쇠퇴의 길로 들어섰다 중국어와 일본어에 비해 한국어의 “족”어는 동물 이름으로 명명된 것이 많다. 또한 외래어 수용시“단축 + 합성” 형식의 다용, 한국산 영어가 범람함으로 말미암아 난해한 말이 많다. “족”어에는 한중일의 동의어가 많지만 그것은 인터넷의 보급이 “족”어의 전파에 박차를 가하고 있는 것이나 공통적인 생각, 행동 양식을 보이고 있는 이른바 “신·신 인류”가 세나라에 존재하는것에 기인하고 있다.

A Study on the Impact of Transformational Leadership on ESG Performance in SMEs

Zhu Jin,Huang, Fei 대한경영정보학회 2023 경영과 정보연구 Vol.42 No.1

With recent economic and social developments and scientific and technological advances, human society has made tremendous strides. Alongside the accomplishments, however, people have gradually realized that severe environmental and social problems accompany economic development and that non-financial factors such as the environment and corporate governance have become moral risks that cannot be ignored. As the fundamental unit of human economic activity and the primary social organization, enterprises are the backbone of sustainable development. ESG is a sustainable development concept that integrates environmental, social, and corporate governance. It emphasizes that enterprise development activities should pursue not only economic indicators but also consider environmental, social, and governance dimensions to achieve sustainable development of human society. ESG is the concrete manifestation of the "sustainable development concept" in the business world, serving as a guide and instrument for corporations to practice sustainable development. This paper examines, from a strategic management perspective, whether transformational leadership influences the ESG performance of corporations, whether organizational innovation mediates the relationship between transformational leadership and ESG performance, and the moderating effect of organizational ethical culture on transformational leadership and organizational innovation. The results of an analysis of 350 Chinese businesses indicate that transformational leadership has a positive effect on ESG performance, and that organizational innovation partially mediates the relationship between transformational leadership and corporate ESG performance. Furthermore, organizational ethical culture moderates the direct relationship between transformational leadership and organizational innovation and moderates the role of organizational innovation as a mediator between transformational leadership and ESG performance. This study provides valuable research on the relationship between leadership and ESG performance.

CYCLIN-DEPENDENT KINASE8 Differentially Regulates Plant Immunity to Fungal Pathogens through Kinase-Dependent and -Independent Functions in <i>Arabidopsis</i>

Zhu, Yingfang,Schluttenhoffer, Craig M.,Wang, Pengcheng,Fu, Fuyou,Thimmapuram, Jyothi,Zhu, Jian-Kang,Lee, Sang Yeol,Yun, Dae-Jin,Mengiste, Tesfaye American Society of Plant Biologists 2014 The Plant cell Vol.26 No.10

<P>This work explores the intriguing roles of Mediator subunit CYCLIN-DEPENDENT KINASE8 (CDK8) in plant immune responses to fungal infection. CDK8 regulates jasmonate-responsive gene expression and cuticle development via interactions with MEDIATOR COMPLEX SUBUNIT25 and transcription factor WIN1, respectively, while other interactions suggest evolutionary conservation of the Mediator kinase module.</P><P>CYCLIN-DEPENDENT KINASE8 (CDK8) is a widely studied component of eukaryotic Mediator complexes. However, the biological and molecular functions of plant CDK8 are not well understood. Here, we provide evidence for regulatory functions of <I>Arabidopsis thaliana</I> CDK8 in defense and demonstrate its functional and molecular interactions with other Mediator and non-Mediator subunits. The <I>cdk8</I> mutant exhibits enhanced resistance to <I>Botrytis cinerea</I> but susceptibility to <I>Alternaria brassicicola</I>. The contributions of CDK8 to the transcriptional activation of defensin gene <I>PDF1.2</I> and its interaction with MEDIATOR COMPLEX SUBUNIT25 (MED25) implicate CDK8 in jasmonate-mediated defense. Moreover, CDK8 associates with the promoter of <I>AGMATINE COUMAROYLTRANSFERASE</I> to promote its transcription and regulate the biosynthesis of the defense-active secondary metabolites hydroxycinnamic acid amides. CDK8 also interacts with the transcription factor WAX INDUCER1, implying its additional role in cuticle development. In addition, overlapping functions of CDK8 with MED12 and MED13 and interactions between CDK8 and C-type cyclins suggest the conserved configuration of the plant Mediator kinase module. In summary, while CDK8’s positive transcriptional regulation of target genes and its phosphorylation activities underpin its defense functions, the impaired defense responses in the mutant are masked by its altered cuticle, resulting in specific resistance to <I>B. cinerea</I>.</P>

An Enhancer Mutant of Arabidopsis salt overly sensitive 3 Mediates both Ion Homeostasis and the Oxidative Stress Response

Zhu, Jianhua,Fu, Xinmiao,Koo, Yoon Duck,Zhu, Jian-Kang,Jenney Jr., Francis E.,Adams, Michael W. W.,Zhu, Yanmei,Shi, Huazhong,Yun, Dae-Jin,Hasegawa, Paul M.,Bressan, Ray A. American Society for Microbiology 2007 Molecular and cellular biology Vol.27 No.14

<B>ABSTRACT</B><P>The myristoylated calcium sensor SOS3 and its interacting protein kinase, SOS2, play critical regulatory roles in salt tolerance. Mutations in either of these proteins render <I>Arabidopsis thaliana</I> plants hypersensitive to salt stress. We report here the isolation and characterization of a mutant called <I>enh1-1</I> that enhances the salt sensitivity of <I>sos3-1</I> and also causes increased salt sensitivity by itself. <I>ENH1</I> encodes a chloroplast-localized protein with a PDZ domain at the N-terminal region and a rubredoxin domain in the C-terminal part. Rubredoxins are known to be involved in the reduction of superoxide in some anaerobic bacteria. The <I>enh1-1</I> mutation causes enhanced accumulation of reactive oxygen species (ROS), particularly under salt stress. ROS also accumulate to higher levels in <I>sos2-1</I> but not in <I>sos3-1</I> mutants. The <I>enh1-1</I> mutation does not enhance <I>sos2-1</I> phenotypes. Also, <I>enh1-1</I> and <I>sos2-1</I> mutants, but not <I>sos3-1</I> mutants, show increased sensitivity to oxidative stress. These results indicate that ENH1 functions in the detoxification of reactive oxygen species resulting from salt stress by participating in a new salt tolerance pathway that may involve SOS2 but not SOS3.</P>

Switching Controller Design for a Class of Markovian Jump Nonlinear Systems Using Stochastic Small-Gain Theorem

Zhu, Jin,Park, Junhong,Lee, Kwan-Soo,Spiryagin, Maksym Hindawi Publishing Corporation 2009 Advances in Difference Equations Vol. No.

<P>Switching controller design for a class of Markovian jump nonlinear systems with unmodeled dynamics is considered in this paper. Based on the differential equation and infinitesimal generator of jump systems, the concept of Jump Input-to-State practical Stability (JISpS) in probability and stochastic Lyapunov stability criterion are put forward. By using backsetpping technology and stochastic small-gain theorem, a switching controller is proposed which ensures JISpS in probability for the jump nonlinear system. A simulation example illustrates the validity of this design.</P>

Efficient Promotion of Autophagy and Angiogenesis Using Mesenchymal Stem Cell Therapy Enhanced by the Low-Energy Shock Waves in the Treatment of Erectile Dysfunction

Zhu, Guan Qun,Jeon, Seung Hwan,Bae, Woong Jin,Choi, Sae Woong,Jeong, Hyun Cheol,Kim, Kang Sup,Kim, Su Jin,Cho, Hyuk Jin,Ha, U. Syn,Hong, Sung Hoo,Lee, Ji Youl,Kwon, Eun Bi,Kim, Sae Woong Hindawi 2018 Stem cells international Vol.2018 No.-

<P><B>Background</B></P><P> Mesenchymal stem cell therapy (MSCT) and defocused low-energy shock wave therapy (ESWT) has been shown to ameliorate erectile dysfunction (ED). However, the interactions and effects of action between MSCT and ESWT remain poorly understood. In this study, we investigated the mechanisms of combination therapy with MSCT and ESWT in a rat model of diabetic ED. </P><P><B>Materials and Methods</B></P><P> Eight-week-old male Sprague-Dawley rats were randomly divided into 2 parts. Diabetic rats induced by streptozotocin (65 mg/kg) were randomly divided into 4 groups: (1) DM control group, (2) DM + ESWT group, (3) DM + MSCT group, and (4) DM + ESWT + MSCT group. The sham group was a normal control group (without streptozotocin). MSCT and (or) ESWT were, respectively, administered to each group according to the proposal for 8 weeks. Immediately after recording of intracavernous pressure (ICP), the penis was then harvested for histologic analysis, ELISA, and Western blotting. </P><P><B>Results</B></P><P> The ratio of ICP/MAP was significantly higher in the DM + ESWT + MSCT group than in ESWT or MSCT treated group (<I>P</I> < 0.05). Also, the treatment stimulated angiogenesis and vasodilatation in the corpus cavernosum (<I>P</I> < 0.05). ESWT increased the quantity of MSCs in the corpus cavernosum and also induced MSCs to express more VEGF in vitro and vivo (<I>P</I> < 0.05) which activated the PI3K/AKT/mTOR and NO/cGMP signaling pathways in the corpus cavernosum. The combination approach stimulated autophagy and decreased apoptosis in the corpus cavernosum. NGF and BDNF expressions were higher in the DM + ESWT + MSCT group than in the DM control group (<I>P</I> < 0.01). Furthermore, the treatment promoted the MSC recruitment by inducing penile tissues to express more PECAM and SDF-1. </P><P><B>Conclusions</B></P><P> Combination of LI-ESWT and MSCT can get a better result than a single treatment by expressing more VEGF which can take part in autophagy by triggering the PI3K/AKT/mTOR signaling pathway. This cooperative therapy would provide a new research direction in ED treatment for the future.</P>