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( Won Jun Song ),( Jung Seop Eom ),( Hong Seok Yoo ),( Byeong Ho Jeong ),( Ho Yun Lee ),( Won Jung Koh ),( Kyeong Man Jeon ),( Hye Yun Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, various factors could be associated with the severity of pneumonia in patients with COPD. Therefore, we examined the risk factors associated with severe pneumonia in a COPD population. Methods: A retrospective observational study with a prospectively collected database of community-acquired pneumonia (CAP) was conducted between 2008 and 2012. Patients with hospital-acquired pneumonia, immunocompromised patients, and those without a baseline computed tomography (CT) scan were excluded. As a result, 150 patients with COPD and CAP were included. Results: Of the 150 patients, 106 (70.7%) and 44 (29.3%) were classified with non-severe and severe pneumonia, respectively. A multivariate logistic regression analysis revealed that the presence of pulmonary emphysema on a CT scan (odds ratio, 2.933; 95% confi dence interval, 1.144 7.516; P = 0.025) was independently associated with severe pneumonia in patients with COPD. However, no signifi cant difference in severity of the air ow limitation, presence of bronchiectasis, previous COPD medicationincluding inhaled corticosteroids, or pathogens was identifi ed between those with non-severe and severe pneumonia. Conclusions: The presence of pulmonary emphysema on a CT scan at the time of admission to the hospital of a patient with COPD was independently associated with severe pneumonia in a COPD population.
Won-Jun Koh,Jeong-Hyeon Cho,Ji-Hyun Lee,Won-Sik Kang,Min-Kyung Lee,Jun-Hyoung Kim,Deok-kyu Cho 영남대학교 의과대학 2012 Yeungnam University Journal of Medicine Vol.29 No.2
A 70-year-old male came to the emergency room of the authors’ hospital because of sudden cardiac arrest due to inferior wall ST elevation myocardial infarction. His coronary angiography revealed multiple severe coronary spasms in his very long left anterior descending artery. After an injection of intracoronary nitroglycerine, his stenosis improved. The cardiac arrest relapsed, however, accompanied by ST elevation of the inferior leads, while the patient was on diltiazem and nitrate medication to prevent coronary spasm. Recovery was not achieved even with cardiac massage, intravenous injection of epinephrine and atropine, and intravenous infusion of nitroglycerine. The patient eventually recovered through high-dose nicorandil intravenous infusion without ST elevation of his inferior leads. Therefore, intravenous infusion of a high dose of nicorandil must be considered a treatment option for cardiac arrest caused by refractory coronary vasospasm.
( Won Jun Song ),( Jung Seop Eom ),( Hong Seok Yoo ),( Byeong Ho Jeong ),( Ho Yun Lee ),( Won Jung Koh ),( Kyeong Man Jeon ),( Hye Yun Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, various factors could be associated with the severity of pneumonia in patients with COPD. Therefore, we examined the risk factors associated with severe pneumonia in a COPD population. Methods: A retrospective observational study with a prospectively collected database of community-acquired pneumonia (CAP) was conducted between 2008 and 2012. Patients with hospital-acquired pneumonia, immunocompromised patients, and those without a baseline computed tomography (CT) scan were excluded. As a result, 150 patients with COPD and CAP were included. Results: Of the 150 patients, 106 (70.7%) and 44 (29.3%) were classified with non-severe and severe pneumonia, respectively. A multivariate logistic regression analysis revealed that the presence of pulmonary emphysema on a CT scan (odds ratio, 2.933; 95% confidence interval, 1.144-7.516; P = 0.025) was independently associated with severe pneumonia in patients with COPD. However, no significant difference in severity of the airflow limitation, presence of bronchiectasis, previous COPD medication including inhaled corticosteroids, or pathogens was identified between those with non-severe and severe pneumonia. Conclusions: The presence of pulmonary emphysema on a CT scan at the time of admission to the hospital of a patient with COPD was independently associated with severe pneumonia in a COPD population.
Fenretinide Ameliorates Insulin Resistance and Fatty Liver in Obese Mice
Koh, In-uk,Jun, Hye-Seung,Choi, Joo Sun,Lim, Joo Hyun,Kim, Won Ho,Yoon, Jong Bok,Song, Jihyun Pharmaceutical Society of Japan 2012 Biological & pharmaceutical bulletin Vol.35 No.3
<P>Fenretinide (FEN), a ligand of retinol binding protein 4 (RBP4), has been suggested as a measure to reduce insulin resistance and its associated disorders such as obesity, and fatty liver by reducing serum RBP4. We investigated whether there is another possible mechanism by which fenretinide reduces insulin resistance and fatty liver in genetically obese (ob/ob) mice. Male obese mice fed a high-fat diet (45% of calories from fat) were divided into two groups (<I>n</I>=13 each). One (FEN) received fenretinide (20 mg/kg body weight, intraperitoneally) and the other (O) received vehicle three times weekly for 24 d. C57BL/6J mice fed a normal-fat diet (16% of calories from fat) were used as a control (C; <I>n</I>=13). No changes in fat weight and serum leptin level could be observed in FEN mice. Lower plasma RBP4 was observed in FEN mice compared with O mice. Fenretinide improved whole-body insulin sensitivity based on glucose and insulin tolerance tests and the homeostasis model assessment of insulin resistance. Fenretinide decreased the plasma lipid (triglyceride, cholesterol, and free-fatty acid) levels, hepatic TG level, and histological steatosis score. The mechanism by which fenretinide prevents fatty liver may be explained by an increased plasma adiponectin level, increased activation of hepatic AMP-activated protein kinase, and the expression of peroxisome proliferator-activated protein-α and peroxisomal acyl-CoA oxidase, which promote fat oxidation. FEN alleviated insulin resistance and fatty liver in obese mice and thus may act as an anti-lipidemic and anti-diabetic drug.</P>
Koh, Young Jun,Koh, Bong Ihn,Kim, Honsoul,Joo, Hyung Joon,Jin, Ho Kyoung,Jeon, Jongwook,Choi, Chulhee,Lee, Dong Hun,Chung, Jin Ho,Cho, Chung-Hyun,Park, Won Seok,Ryu, Ji-Kan,Suh, Jun Kyu,Koh, Gou Young Ovid Technologies Wolters Kluwer -American Heart A 2011 Arteriosclerosis, thrombosis, and vascular biology Vol.31 No.5
Optimization of Reverse Engineering Processes for Cu Interconnected Devices
Koh, Jin Won,Yang, Jun Mo,Lee, Hyung Gyoo,Park, Keun Hyung The Korean Institute of Electrical and Electronic 2013 Transactions on Electrical and Electronic Material Vol.14 No.6
Reverse engineering of semiconductor devices utilizes delayering processes, in order to identify how the interconnection lines are stacked over transistor gates. Cu metal has been used in recent fabrication technologies, and de-processes becomes more difficult with the shrinking device dimensions. In this article, reverse engineering technologies to reveal the Cu interconnection lines and Cu via-plugs embedded in dielectric layers are investigated. Stacked dielectric layers are removed by $CF_4$ plasma etching, then the exposed planar Cu metal lines and via-plugs are selectively delineated by wet chemical solution, instead of the commonly used plasma-based dry etch. As a result, we have been successful in extracting the layouts of multiple layers within a system IC, and this technique can be applicable to other logic IC, analog IC, and CMOS IC, etc.