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Won Gun Lee,In Sik Kim,Sang Sun Kang,Sunghee Hyun 대한의생명과학회 2012 Biomedical Science Letters Vol.18 No.1
This study was performed to investigate the urinary methyl hippuric acid (UMHA) excretion among aircraft maintenance workers exposed to xylene by examination of blood test, urine test and biochemical tests. Study subjects (301) were divided into 2 groups; non-exposed group (n=123, who were not exposed to xylene), and exposed group (n=178, who were exposed to xylene). The average of blood level and MHA level was normal. The γ-GTP level was 35.5 IU/L (45.7%) in the exposed group and 27.9 IU/L (44.7%) in the non-exposed (control) group. The proportion of total cholesterol (TG) level higher than 150 mg/dl were 34.3% in the exposed group and 21.1% in the non-exposed group. These results were showed statistically significant difference (x2 = 6.10, P<0.05). Other items showed no statistically significant differences. The results of urine tests were no statistically significant differences in protein, occult blood and glucose level.
Damage Assessment of Free-fall Dropped Object on Sub-seabed in Offshore Operation
Won, Jonghwa,Kim, Youngho,Park, Jong-Sik,Kang, Hyo-dong,Joo, YoungSeok,Ryu, Mincheol Korean Society of Ocean Engineers 2015 Journal of advanced research in ocean engineering Vol.1 No.4
This paper presents the damage assessment of a free-fall dropped object on the seabed. The damage to a dropped object totally depends on the relationship between the impact energy and the soil strength at the mudline. In this study, unexpected dropping scenarios were first assumed by varying the relevant range of the impact velocity, structure geometry at the moment of impact, and soil strength profile along the penetration depth. Theoretical damage assessments were then undertaken for a free-fall dropping event with a fixed final embedment depth for the structure. This paper also describes the results of a three-dimensional large deformation finite element analysis undertaken for the purpose of validation. The analyses were carried out using the coupled Eulerian-Lagrangian approach, modifying the simple elastic-perfectly plastic Tresca soil model. The validation exercises for each dropping scenario showed good agreement, and the present numerical approach was capable of predicting the behavior of a free-fall dropped object.
( Sik-won Choi ),( Kwang-sik Lee ),( Jin Hwan Lee ),( Hyeon Jung Kang ),( Mi Ja Lee ),( Hyun Young Kim ),( Kie-in Park ),( Sun-lim Kim ),( Hye Kyoung Shin ),( Woo Duck Seo ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.9
Hypoxia-inducible factor (HIF)-1α is a key regulator associated with tumorigenesis, angiogenesis, and metastasis. HIF-1α regulation under hypoxia has been highlighted as a promising therapeutic target in angiogenesis-related diseases. Here, we demonstrate that diacetyl atractylodiol (DAA) from Atractylodes japonica (A. japonica) is a potent HIF-1α inhibitor that inhibits the Akt signaling pathway. DAA dose-dependently inhibited hypoxia-induced HIF-1α and downregulated Akt signaling without affecting the stability of HIF-1α protein. Furthermore, DAA prevented hypoxia-mediated angiogenesis based on in vitro tube formation and in vivo chorioallantoic membrane (CAM) assays. Therefore, DAA might be useful for treatment of hypoxia-related tumorigenesis, including angiogenesis. [BMB Reports 2016; 49(9): 508-513]
Kang, Sung-Sik,Kim, Ui-Hyung,Ahn, Jun Sang,Won, Jeong Il,Cho, Sang-Rae The Korean Society of Animal Reproduction and Biot 2021 한국동물생명공학회지 Vol.36 No.2
In the present study, we examined if deep uterine artificial insemination (DUAI) can improve the pregnancy rate of artificial insemination (AI) using epididymal spermatozoa (ES) in Hanwoo cattle. The estrus cycles of 88 Hanwoo cows were synchronized, and 17 cows were artificially inseminated using the DUAI method with ES, 20 cows were artificially inseminated via the uterine body (BUAI) method with ES, and as a control, 51 cows were inseminated by using the BUAI method with ejaculated spermatozoa from 1 proven bull after frozen thawing. The pregnancy rate of the DUAI method (58.8%) was higher than that of the BUAI method (25.0%, p = 0.0498). The motility of ES was examined immediately after thawing and after 3 and 6 h of incubation. The rapid progressive sperm motility of the control group was significantly higher than that of the ES group immediately after thawing and after 3 and 6 h of incubation (p < 0.05). The straight line velocity and average path velocity of the ES group after 6 h of incubation were significantly lower than those in the control group (p < 0.05). The linearity and amplitude of lateral head of ES were lower than those at 6 h (p < 0.05). The flagellar beat cross frequency and hyperactivation of ES were lower than the control spermatozoa immediately after thawing and at 3 h (p < 0.05). These motility parameters suggested that ES had a low motility and fertilization ability compared to the control spermatozoa. After frozen-thawing and 3 h of incubation, the percentage of live spermatozoa with intact acrosomes in the ES was significantly lower than that in ejaculated spermatozoa (p < 0.05). Our findings suggested that the DUAI method can overcome the low pregnancy rate of ES, despite the low motility, viability, and fertilization ability of ES.
( Won Jung Hwang ),( Joon Pyo Jeon ),( Seung Hee Kang ),( Hyun Sik Chung ),( Ji Yong Kim ),( Chul Soo Park ) 대한마취과학회 2010 Korean Journal of Anesthesiology Vol.59 No.3
Background: The pre-transplant model for end-stage liver disease (pre-MELD) score is controversial regarding its ability to predict patient mortality after liver transplantation (LT). Prominent changes in physical conditions through the surgery may require a post-transplant indicator for better mortality prediction. We aimed to investigate whether the post-transplant MELD (post-MELD) score can be a predictor of 1-year mortality. Methods: Perioperative variables of 269 patients with living donor LT were retrospectively investigated on their association with 1-year mortality. Post-MELD scores until the 30th day and their respective declines from the 1st day post-MELD score were included along with pre-MELD, acute physiology and chronic health evaluation (APACHE) II, and sequential organ failure assessment (SOFA) scores on the 1st post-transplant day. The predictive model of mortality was established by multivariate Cox`s proportional hazards regression. Results: The 1-year mortality rate was 17% (n=44), and the leading cause of death was graft failure. Among prognostic indicators, only post-MELD scores after the 5th day and declines in post-MELD scores until the 5th and 30th day were associated with mortality in univariate analyses (P<0.05). After multivariate analyses, declines in post-MELD scores until the 5th day of less than 5 points (hazard ratio 2.35, P=0.007) and prolonged mechanical ventilation ≥24 hours were the earliest independent predictors of 1-year mortality. Conclusions: A sluggish decline in post-MELD scores during the early post-transplant period may be a meaningful prognostic indicator of 1-year mortality after LT. (Korean J Anesthesiol 2010; 59: 160-166)