심내막상 결손증 : 3예 보고 A Report of 3 Cases

황윤호,이양행,우종수,조광현 인제대학교 1986 仁濟醫學 Vol.7 No.4

심내막상 결손증(Endocardial cushion defect)은 선천성 심장기형의 약 3% 정도를 차지하는 비교적 드문 질환이며, 복잡한 동반 기형을 나타내고 있고, 그 수술 방법에 있어서도 많은 논란이 있으며, 사망율도 높은 질환인 바, 저자들은 지난 1년간에 3예의 본 증례에 대한 수술 치험에서 술후 3∼6개월간에 만족할만한 임상적 추적 결과를 얻었기에 보고하는 바이다. In Pusan Paik Hospital, Inje Medical College, there were two complete endocardial cushion defects (ECD) and a partial one, which were successfully repaired in 1986. In a patient of partial ECD, primum atrial septal defect was closed with pericardial patch. In a patient of complete ECD, associated with secundum ASD, pulmonary stenosis and Down's syndrome, the atrial and ventricular septal defects were closed separately with bovine pericardium and Dacron patches respectively, and then pulmonary stenosis was relieved by transannular patch widening in addition to valvotomy and infundibulectomy. In another patient with complete ECD, small interventricular communication was closed with simple suture with pledget, and primum ASD closed with pericardial patch. In all patient, the mitral clefts were closed with three or four 5-0 Prolene interrupted sutures. Transient A-V dissociation developed postoperatively in two patients, and heart failure in complete ECD with Down's syndrome was overcome with medical treatment.

다형홍반증에서 각질형성세포의 ICAM-1, TNF-α 및 IL-1α 발현에 관한 연구

황규왕,정현,이종석,박준홍,부태성,이성열 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The pathogenetic mechanisms involved in the developement of erythema multiforme(EM) are still largely unknown. The histologic and immunopathologic changes in erythema appear to be due in part to cellular immune mechanisms with the cytotoxic T cell. Especially cytotoxic T cell/ICAM-1 positive-keratinocyte adherence plays an important role in the pathogenesis of EM. In this study, we investigated the expression of TNF-a, IL-1 a by immunohistochemical stain and ELISA. In skin tissue of EM, strong basal cell expression of ICAM-1, TNF-a and IL-1 a was found, and we detected more TNF-a from supernatants of cultured human keratinocytes with serum of EM patient than normal control. Our results may suggest possible relationship between the pathogenesis of EM and cytokine from keratinocyte.

梓木이 腦血流 및 血壓에 미치는 影響

황경택,경은호,나한일,소응향,최병화,한종현 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

The purpose of this study is to measure the changes of regional cerebral blood flow (rCBF) and blood pressure (BP) in rats, following the intravenous injection of Catalpa Ovata Water Extract (COWE). The measurement was continually monitored by laser-doppler flowmeter (Transonic Instrument, USA) and pressure tranducer(Grass, USA) in anesthetized adult Sprague-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. The result of this experiment was as following : COWE increased the changes of rCBF and BP significantly. After pretreatment with propranolol and indomethacin, the changes of rCBF were inhibited significantly, but not by L-NNA and methylene blue. Also, after pretreatment with propranolol, the changes of BP were inhibited significantly, but not by L-NNA, methylene blue and indomethacin. According to above result, it is considered that Catalpa Ovata increased the rCBF and BP, related to adrenergic β-receptor.

Thermostable Alkalophilic Protease 생산균주의 효소학적 특성 및 분류동정

황경숙,이종화 목원대학교 자연과학연구소 2002 自然科學 硏究論文集 Vol.11 No.2

충남 홍성군 광천지역의 사문암 토양은 pH 9.2 이상을 나타내어 초염기성 토양임이 확인되었다. 알칼리성 세균 분리에 사용되는 alkaline 배지(AL 배지)를 이용하여 초염기성 사문암토양으로부터 알칼리성 세균 76균주를 분리하였다. 분리균주 중 49균주가 알칼리성단백질 분해효소 생산균주로 약 65%의 높은 분포율을 나타내었다. 이들 세균 중 알칼리성 단백질 분해효소의 활성이 가장 큰 KSIA-9균주를 선발하여 효소학적 특성을 검토한 결과, 분리균주 KSIA-9는 최적 온도가 60℃이며 70℃에서도 최대 활성의 90% 이상을 유지하여 열에대해 안정한 특징을 나타내었다. 그람양성, 유포자세균으로 165 rDNA 염기서열 분석결과 Bacillus thuringinesis와 99%의 상동성을 나타내어 Bacillus thuringinesis로 동정되었다. Seventy-six alkalophilic bactena were isolated from serpentinite soil(>pH9.2). About 65% of the isolates among them was found to produce alkalophilic protease. Especially because KS1A-9 strain among them appeared to be finally selected. The apparent characteristics of these isolates based on the phenotypic, chemotaxonomic, and phylogenetic analysis are as follows. KS1A-9 which produced alkalophilic and thermostable protease was gram-positive, sporeforming, regular rods. Respiratory quinone is MK-7 and MK-8, and major cellular fatty acids are iso-C_15^-0, iso-C_14 0 and anteiso-C_13^-0. When determining the relationship of this strain was closely (99%) related to Bacillus thuringiensis.

18Cr-8Ni 및 17Cr Stainless鋼의 硅素에 의한 脫酸擧動에 관한 硏究

李鍾文,黃龍吉 釜産工業大學校 1984 論文集 Vol.25 No.-

The phenomena of decreasing chromium contents, the effect of deoxidation by adding silicon and the floating mechanism of slags, the crystal structure of inclusions for 18Cr-8Ni and 17Cr stainless steel respectively have been investigated. The scraps are melted by a high frequency induction furnace. The results are as follows; 1) The chromium contents in 17Cr stainless steel exhibits a remarkable decrease more than 1 hour is required for melting the scraps. The chromium contents in 18Cr-iNi stainless steel exhibits a small decrease, as 1.67% until holding for 2 hours. The required melting time is 1 hour. 2) The floating rate of spheroidal inclusions is greater than the floating rate of dispersed inclusions form molten bath. 3) The slags of 17Cr stainless steel before deoxidation and after deoxidation by adding silicon are FeO·Cr??O₃ and SiO₂, the slags of 18Cr-8Ni stainless steel is FeO·Cr??O₃, which can be seen by X-ray diffraction method. 4) The inclusions in 18Cr-8Ni and 17Cr stainless steel (containing less than 0.8% Si and less than 1.0% Mn, as cast) are Cr??O₃and Fe??O₄as can be seen by X-ray diffraction method.

중력가속도가 2차 자녀 성비에 미치는 영향

박종관,황명순 공군본부 의무감실 1991 항공의학 Vol.39 No.1-2

인체 두피 모낭 외측모근초 각질형성 세포의 배양

이종석,이성열,박영립,서용원,황규왕 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

Follicular stem cell was assumed as a hair matrix cell. But, recently it was suggested that follicular stem cells were in the bulge portion of outer root sheath of hair follicles, and its proofs were reported. We tried to culture outer root sheath keratinocytes in the bulge portion of human hair follicles, and it would be experimental base for many factors and drugs realated with hair growth and differentiation. The outer root sheath keratinocytes were isolated from plucked human hair follicles, and could be serially passaged for up to 2 times on used biologic feeder cell layer.

성인에서 Haemophilus influenzae 감염증의 임상양상과 미생물학적 특성

이종섭,황병연,정희진,김우주,박승철,이도현,이창규,신종희,황규잠,이영희 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.2

목적 : H. influenzae는 성인에서 흔히 호흡기 감염을 일으키는 균주로, 최근 ampicillin 내성 β-lactamase 생성 균주들이 지속적인 증가를 보이고 있어, 이에 국내 성인에서 H. influenzae에 의한 감염의 임상양상과 분리된 균주들의 미생물학적 특성을 조사하고자 하였다. 방법 : 1998년 3월부터 1999년 9월까지 고려대 구로병원에 내원한 환자중에서 H. influenzae가 분리된 68명을 대상으로 임상양상을 조사하고 항균제 감수성 검사를 시행하였다. 분리된 33주에 대해서 혈청형, 생물형, 세포외막 단백분석을 시행하였고, β-lactamase 생성여부에 따른 감염 환자군간 임상상 및 예후의 차이를 비교하였다. 결과 : 환자의 평균연령은 68세였고, 지역사회 획득감염이 전체의 85%를 차지하였다. 폐렴과 기관지염과 같은 하기도 감염이 전체환자의 75%를 차지하였고 분리 검체 역시 객담이 84%로 가장 많았다. 환자의 71%가 기저질환을 가지고 있었으며, 그 중에 만성 폐쇄성 폐질환, 심혈관 질환, 악성종양, 당뇨병이 대부분이었다. 혈청형으로는 nontypeable 형이 68%로 가장 많았고 b형은 한 예도 없었다. β-lactamase 생성율은 63.2%였고, β-lactamase 양성균주의 항균제 내성율이 음성균주에 비하여 높았으나 β-lactamase 생성 여부에 관계없이 cefotaxime, azithromycin, ciprofloxacin에 대하여 100%의 감수성을 나타내었고 cefaclor, cefuroxime에 대해서는 10% 이하의 낮은 내성율을 보여 이들 항균제들이 치료에 효과적일 것으로 사료된다. 세포외막 단백분석에서는 C형과 D형이 전체의 64%로 가장 많았으며, 혈청형과의 유의한 연관성은 보이지 않았다. 결론 : 성인에서 H. influenzae는 주로 만성 기저질환자에서 급성 호흡기감염 또는 만성 폐쇄성 폐질환의 급성 악화를 유발한다. 기존의 보고에 비해 β-lactamase 양성율이 증가하였고, 이에 따른 항균제 내성율도 증가하여 항균제의 선택에 유의하여야 할 것으로 생각된다. 세포외막 단백분석상 특정한 유형의 균주에 의해 감염이 집중적으로 발생하고 있어 향후 역학 조사의 도구로 이용할 수 있겠다. Purpose : H. influenzae is one of the common causative microorganisms of respiratory tract infections in adults. Recently. β-lactamase producing, ampicillin-resistant H. infiuenzae has become worldwide problem as well as in Korea. We studied to investigate the clinical features and microbiologic characteristics of H. infiuenzae infections in adults. Materials & Methods : From March 1998 to September 1999, 68 patients were enrolled in this study. Clinical features of H. infiuenzae infections were investigated, 68 isolates were subjected to the β-lactamase test, and 33 isolates were used for serotyping. biotyping, antibiotic susceptibility and outer membrane protein (OMP) analysis. Results : Mean age of study patients was 68 years-old and the acquisition rate in community was 85%. Pneumonia and bronchitis were the most common type of infection such as 80%, sputum was the most common clinical specimen for H. mQuenzae isolation. 70% of patients had chronic underlying diseases. Non-typeable strains were 68% and β-lactamase producing rate was 63%. There was no difference in the clinical features and prognosis of H. influenzae infection between the β-lactamase positivie and -negative groups. The susceptibility of cefotaxime, azithromycin, and ciprofloxacin was 100% and that of cefaclor, cefuroxime was under 10% in spite of β-lactamase positivity. In OMP analysis, C and D types were dominant (64%). Conclusion : H. influenzae caused acute respiratory infections in adults with chronic underlying disorders. This study shows higher β-lactamase producing rate and antibiotic-resistance rate than that were reported previously. OMP analysis shows that two major types of strains cause clinical infections intensively.

국내 항만정책의 분석 연구

김성득,황종태 울산대학교 1998 공학연구논문집 Vol.29 No.2

우리나라는 지난 20여년 간 너무나 急速한 經濟成長을 거치면서 持續的인 對外 指向的 經濟成長을 推進해왔다. 이러한 急速한 經濟成長을 이루면서 그 배후에는 港灣施設이 가장 중요한 役割을 하였다고 할 수 있을 것이다. 그러나 고도의 經濟成長을 거치면서 港灣施設의 확보는 너무나도 미흡하였고 港灣施設의 확충을 위한 政府의 投資 또한 經濟成長에 비하여 미흡하였다. 그 실 예로 外國의 경우 GNP대비 投資率 면에서 일본이 0.34%, 대만이 0.5%인데 비해서 우리 나라는 92년 0.15%에 불과한 실태이다. 우리 나라의 施設부족을 보면 1991년 全國의 港灣 物動量은 4억 1,318만 1천톤이며 이중에서 施設所要貨物量(油類貨物量 제외)은 2억 7,663만 1천톤으로서 荷役能力 2억 5,635만 2천톤에 비해 1,927만 9천톤이다. 이러한 施設부족은 계속 增加하여 2001년에 釜山港의 경우 2,581만 8천톤 仁川港은 3,792만 7천톤 光陽港은 5,517만 4천톤, 그리고 蔚山港의 경우 2,438만 4천톤의 施設부족을 보일 것으로 예상이 된다. 따라서 本 論文에서는 外國의 投資實態 및 港灣施設, 荷役能力, 그리고 항만지원시설등을 살펴보고 政府의 港灣 開發 政策을 진단하고자 한다. 현재 우리 나라는 2001년까지 전구 主要港灣에서의 적체현상을 대폭완화하고 2011년까지 완전 해소한다는 목표를 가지고 있다. 그 대표적인 예가 新港灣 開發 計劃이다. 인천 북항, 보령 新港灣, 새만금 新港灣, 목포 신외항, 부산 가덕도 新港灣, 蔚山 新港灣, 포항영일만 新港 등 7개항이다. 항만의 개발은 막대한 투자를 요구하기 때문에 개발의 경제적 타당성이 우선적으로 고려되어야 하며, 정치적 고려에 의한 지역 안배나 Two Port System과 같은 단순 논리의 개념은 배제 되어야 한다. 또한 港灣은 단 순한 荷役 場所가 아닌 快適하고 親環境的인 綜合港灣空間으로 造成이 되어야 한다. 따라서 단순한 荷役만을 目的으로 하는 港灣이 아닌 친수공간, 종합물류단지, 금융 및 정보통신, 국제회의장, 무역센터기능 등을 부여하는 등 體系的이고 普遍的인 港灣開發이 요구된다. The reapid economic growth of Korea for the past few decades could not have been achieved without the promotion of international trades including export of commodity goods and oversea construction services. For the promotion of exports good harbor facilities must play an important role, but it is found that the investment on harbor facilities of Korea has been insufficient compared with those of competing countries, such as Japan and Taiwan. In 1991 the overall figure of loading/unloading volume was 413,181,000 tons, among which 276,631 ton needed loading/unloading facilities other than pipe lines for petrochemical products. Compared with the figure 256,352 ton, the total loading/unloading capacity at that time, lack of harbor facilities turned up 19,279 ton per annum. This work aims at examining the harbor development policies of the port authority of Korea and a brief investigation into the current status of harbor facilities of some other countries. The targets set by Korean government are 1) to reduce delay of loading/unloading substantially by 2001 and 2) to completely resolve the problem of delaying loading/unloading operation. For these purposes they have plans to build new ports all over the coasts including North-Inchon, Samangum, New-Mokpo, Gaduckdo, New-Ulsan and Youngilman.

정맥 유리 피판술을 이용한 수부 손상 재건술

윤성호,황종익 大韓成形外科學會 1991 Archives of Plastic Surgery Vol.18 No.1

In cases of severe crushing finger injury, skin defect with vascular loss was result in bone, tendon and joint exposures. In patients with certain cases, conventional treatments were vein graft, local flap and disrant flap. Exoposed vein grafred blood vesels were not suitable for graft because of high risk of thrombosis, tissue necrosis and skin graft will not survive on deep structure and local flap may be technically impossible at extensive finger damage. Furthermore distant flap was inappropriate due to postoperative immobilization bulkiness of grafted skin and many times of operations. Therefore in the cases of exposed deep structure, it has been studied about skin flap including subcutaneous vein for a long time. In 1984, Honda et al dad attempte das clinical application and in 1985, Nichtter and Harris et al reported three types of venous flap: 1) total venous perfusion flap 2) arterialized venous perfusion flap 3) total arterial venous perfusion flap. These venous free flaps(skin flaps with subcutaneous veins, flow through venous flap have advantage that can be done without bone shortening as one procedure. And authors did 13 cases of venous flaps, especially 3) and complete survival were 11 cases, partial necrosis were 2 cases.