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- 저자 : Wenjing Zhou (검색결과 24 건)
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Wenjing Wang,Biao Wu,Zhihong Liu,Liqing Zhou,Xiujun Sun,Jiteng Tian,Aiguo Yang 한국유전학회 2021 Genes & Genomics Vol.43 No.6
Background The ark shell (Scapharca broughtonii) is one of the most economically important mollusks in the Bohai Sea and Yellow Sea of China. In recent years, ark shells from the Korean population were introduced to China for seed propagation and culture. Objective To explore the impact of the introduction of Korean ark shell on the genetic diversity of native population in China. Methods Simple sequence repeat (SSR) is efective and widely used tool for genetic analysis. In this study, 180 EST-SSRs were selected and verifed by polymerase chain reaction and polyacrylamide gel electrophoresis. Subsequently, fve polymorphic EST-SSRs were screened and their primers were modifed by fuorescein for use in the genetic analysis of four populations. Results Genetic analysis showed that 361 alleles amplifed by fve SSR loci were detected in the four populations. The number of alleles for the fve SSRs ranged from 8 to 30, with a mean of 18.05 (standard deviation, SD=6.492). The efective number of alleles varied from 2.253 to 22.222, with a mean of 10.596 (SD=4.713). Observed heterozygosity and expected heterozygosity were 0.167–0.833 and 0.566–0.971, with average values of 0.520 (SD=0.177) and 0.891 (SD =0.062), respectively. Polymorphic information content ranged from 0.521 to 0.953, with a mean of 0.865 (SD=0.070). The pairwise genetic diferentiation coefcient (FST) of the four populations ranged from 0.0267 to 0.0477, showing low genetic diferentiation. The phylogenetic tree constructed by neighbor-joining method showed that the genetic distance between the Chinese Dalian native population and three Korean populations was relatively more far than that among those Korean populations. Conclusion The results indicated that the genetic structure of the Dalian wild population was less afected by the introduced Korean wild populations.
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Jing Zhou,Xin Feng,Wenjing Wu,Xingyu Li,Xiaowei Zhang 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.15 No.2
A methodology based on distributed fiber optic sensors is proposed to detect the lateral buckling for subsea pipelines in this study. Uncontrolled buckling may lead to serious consequences for the structural integrity of a pipeline. A simple solution to this problem is to control the formation of lateral buckles among the pipeline. This firms the importance of monitoring the occurrence and evolution of pipeline buckling during the installation stage and long-term service cycle. This study reports the experimental investigations on a method for distributed detection of lateral buckling in subsea pipelines with Brillouin fiber optic sensor. The sensing scheme possesses the capability for monitoring the pipeline over the entire structure. The longitudinal strains are monitored by mounting the Brillouin optical time domain analysis (BOTDA) distributed sensors on the outer surface of the pipeline. Then the bending-induced strain is extracted to detect the occurrence and evolution of lateral buckling. Feasibility of the method was validated by using an experimental program on a small scale model pipe. The results demonstrate that the proposed approach is able to detect, in a distributed manner, the onset and progress of lateral buckling in pipelines. The methodology developed in this study provides a promising tool for assessing the structural integrity of subsea pipelines
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Local Buckling of Steel Equal Angle Members with Normal and High Strengths
Gang Shi,Wenjing Zhou,Yu Bai,Zhao Liu 한국강구조학회 2014 International Journal of Steel Structures Vol.14 No.3
Steel angle sections have been widely accepted with the development of steel structures, and such members made by highstrength steel (HSS) sections are also increasingly used in buildings and bridges, and especially in transmission towers and longspan trusses. Compared to normal strength steels, HSS exhibits different mechanical properties, which can cause different localbuckling behavior. A finite element analysis (FEA) was performed in this paper to investigate the local buckling of steel equalangle members with different strengths under axial compression, where the residual stresses and the initial geometricimperfections of specimens were accurately described. Through this work, the relationship of the ultimate local buckling stressof steel equal angle members under axial compression as a function of steel strength and width-to-thickness ratio wasestablished. By comparing the FEA results with the international design specifications (ANSI/AISC 360-10 and Eurocode 3),a modified design formula was developed and corresponding design suggestions were proposed, to take into account the effectsof steel strength.
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Deqing Ruan,Wenjing Liu,Yanhong Shi,Menghui Tan,Li Yang,Zhengtao Wang,Yue Zhou,Rui Wang 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.1
Endotoxic shock exhibits a considerably high mortality risk. It is defined as a systemic inflammatory response syndrome caused by a microbial infection. Radix Isatidis has anti-inflammatory, antiviral, and antipyretic effects and is used worldwide. This study investigated the antiendotoxin sepsis effects of an aqueous R. Isatidis extract (RIE) and explored the possible pharmacological molecular mechanisms. Male C57BL/6J mice were intravenously injected with 15 mg/kg lipopolysaccharide (LPS) to induce endotoxic shock. The results demonstrated that the survival rate of mice pretreated with RIE increased, and LPS-induced liver and lung damage were reduced by inhibiting inflammation. For elucidating detailed molecular mechanisms, we focused on LPS-induced transcription factors: nuclear factor-κB (NF-κB) and interferon regulatory factor 3 (IRF3). Our results demonstrated that the protective effects of RIE were strongly dependent on IRF3-induced interferon-β, not on NF-κB-induced tumor necrosis factor-α and interleukin-1β. In addition, RIE suppressed the phosphorylation of IRF3, not NF-κB. In conclusion, this study revealed the antiendotoxic properties of RIE on LPS-induced sepsis and provided mechanistic evidence for the beneficial effects of RIE.
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Dynamic responses of a freestanding bridge tower under wave and wave-current loads
Chengxun Wei,Wenjing Wang,Daocheng Zhou 국제구조공학회 2022 Structural Engineering and Mechanics, An Int'l Jou Vol.82 No.4
A model experiment with a scale of 1:150 has been conducted to investigate the dynamic responses of a freestanding four-column bridge tower subjected to regular wave, random wave and coupled wave-current actions. The base shear forces of the caisson foundation and the dynamic behaviors of the superstructure were measured and analyzed. The comparisons of the test values with the theoretical values shows that wave-induced base shear forces on the bridge caisson foundation can be approximated by using a wave force calculation method in which the structure is assumed to be fixed and rigid. Although the mean square errors of the base shear forces excited by joint random wave and current actions are approximately equal to those excited by pure random waves, the existence of a forward current increases the forward base shear forces and decreases the backward base shear forces. The tower top displacements excited by wave-currents are similar to those excited by waves, suggesting that a current does not significantly affect the dynamic responses of the superstructure of the bridge tower. The experiment results can be used as a reference for similar engineering design.
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Passive control of railway vehicle car body flexural vibration by means of underframe dampers
Dao Gong,Jinsong Zhou,Wenjing Sun 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.2
To suppress vertical flexural vibration of a railway vehicle car body, a new passive control method by mounting dampers on the longitudinal beams of the car body underframe is proposed. The method is firstly studied by an Euler-Bernoulli beam model using Green’s functions, then it is further verified by a nonlinear dynamic model of the vehicle. Results show that the car body flexural vibration can be noticeably reduced by this method. It is better to mount the damper near the car body centre. The higher damping coefficient of the damper, the more effective in decreasing the car body first vertical bending vibration. The higher the rigidity of the damper bracket and rubber bush, the better performance of the damper. It is found that when mounting six dampers at proper positions, the damping coefficient of each damper is 1.33×10 7 N·s/m, even if the first vertical bending frequency of the studied car body is only 7.2 Hz, a very good ride quality will be achieved when the vehicle runs at 250 km/h.
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Yu Sun,Jinsong Zhou,Dao Gong,Wenjing Sun,Zhanghui Xia 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.1
To minimize the self-excitation effects of the equipment on the carbody, a high static and low dynamic stiffness (HSLDS) vibration isolator is proposed by connecting a negative stiffness unit and a positive linear stiffness spring in parallel. The nonlinear stiffness of the HSLDS isolator can be designed according to the needs of any target stiffness curve. A vibration test is applied to obtain the vibration acceleration of the under-chassis equipment. A rigid-flexible coupling multi-body dynamic model of a high-speed train is established which considers the elastic vibration of the carbody and the self-excitation of the under-chassis equipment based on the tested result. Different connection methods of the under-chassis equipment including rigid hanging, vibration isolation theory (VIT) hanging, dynamic vibration absorber (DVA) hanging and HSLDS hanging are applied and their effects on the carbody vibration and ride quality are investigated. The simulation results reveal that the proposed HSLDS vibration isolator can effectively isolate the self-excitation of the under-chassis equipment from the carbody and enhance the ride quality of the high-speed train.
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Xiaoyan Zhang,Jie Xia,Wenjing Zhang,Yao Luo,Wenbo Sun,Wei Zhou 한국한의학연구원 2017 Integrative Medicine Research Vol.6 No.3
Background: Tryptanthrin is a major active constituent of several Chinese herbal plants, such as Isatidis radix. Tryptanthrin had been demonstrated to have several beneficial pharmacological effects in vitro for human diseases, including antitumor, anti-inflammatory and antibacteria activities. In contrast to the extensive in vitro investigations, the in vivo disposition process of tryptanthrin was explored limitedly. Methods: In this study, the pharmacokinetics (PK) and tissue distribution of tryptanthrin in Kunming mice following a single oral dose of 80 mg/kg tryptanthrin were investigated for the first time. Mouse plasma, liver, heart, spleen, lung, kidney and brain were collected and analyzed using a validated reversed-phase high-performance liquid chromatography with ultraviolet detection (RP-HPLC–UV) method after biological sample preparation by a simple liquid–liquid extraction. Results: The chromatographic analysis was performed on a Diamonsil C18 column (5 μm, 250 mm × 4.6 mm) and ultraviolet detection was set at a wavelength of 251 nm. The analysis was achieved with a mobile phase of methanol (A) and water (B) (60:40, v/v) at a flow rate of 1.0 mL/min. The method was linear over the concentration range of 4.0–400.0 μg/mL with a lower limit of quantification of 0.10–0.30 μg/mL. Inter- and intraday precisions (relative standard deviations %) were all within 2.93%. Recoveries of tryptanthrin were more than 86.44%. Maximal tryptanthrin concentrations in plasma and tissues of mice were reached within 2.5 hours. The actual highest concentration (Cmax) in mouse plasma was 3.13 μg/mL, the area under the curve (AUC0–t) was 9.38 h μg/mL, and the terminal half-life was 2.27 hours. The volume of distribution was 343.89 mL, the clearance rate was 204.58 mL/h, and the PK of tryptanthrin in mice after oral administration was fit to 2 compartment 1 st Order. After oral dosing of tryptanthrin to Kunming mice, the analyte was well distributed to the plasma and main tissues. Cmax was found in the liver with a mean value of 3.54 μg/g, followed by that in the kidney, lung, spleen, heart, and brain. Conclusion: In this study, a validated RP-HPLC–UV method was developed and successfully applied to PK and tissue distribution of oral tryptanthrin in mice. We confirmed that tryptanthrin was closely related and targeted to plasma, liver, kidney, and lung. These results indicate that tryptanthrin will have a good clinical application in the liver, kidney, or lung. The clinical use of tryptanthrin should focus on its pharmacodynamics and safety study in these tissues.
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Effects of density on flow in a nano channel using a molecular-continuum hybrid method
Kim, Youngjin,Jeong, Myunggeun,Zhou, Wenjing,Tao, Wen Quan,Ambrosia, Matthew Stanley,Ha, Man Yeong Elsevier 2017 Computers & fluids Vol.156 No.-
<P><B>Abstract</B></P> <P>A molecular-continuum hybrid method was developed to simulate micro- and nano-scale fluid flows that cannot be predicted using continuum fluidics. Molecular dynamics simulation was used near stationary solid surfaces, and Navier-Stokes equations were used in other regions. We carried out Couette flow simulation using this hybrid method and validated the results by comparing them with the analytical solution. We also studied the dependence of the velocity slip and slip length on the surface energy, liquid density, and roughness for a liquid channel flow with and without nano-structures on the solid surface. The behavior of the liquid near the solid wall changed with the surface energy as well as the liquid density. The variation of the velocity slip and slip length according to the surface energy also depended on the liquid density as well as the surface roughness. We compared the required computational time obtained from the molecular-continuum hybrid method with that obtained from full molecular dynamics simulation under the same computational condition, giving much shorter computational time for the case using the molecular-continuum hybrid method than that for full molecular dynamics simulation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The velocity slip and slip length decrease with increasing the surface energy. </LI> <LI> The locking boundary condition is enhanced with the structure. </LI> <LI> The trends of <I>u<SUB>s</SUB> </I> and <I>L<SUB>s</SUB> </I> at each liquid density are changed on the smooth surface. </LI> <LI> The trends at each liquid density differ between the rough and smooth surface. </LI> </UL> </P>
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