Effects of Chicory Inulin on Serum Metabolites of Uric Acid, Lipids, Glucose, and Abdominal Fat Deposition in Quails Induced by Purine-Rich Diets

Zhijian Lin,Bing Zhang,Xiaoqing Liu,Rui Jin,Wenjing Zhu 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.11

Inulin, a group of dietary fibers, is reported to improve the metabolic disorders. In the present study, we investigated the effects of chicory inulin on serum metabolites of uric acid (UA), lipids, glucose, and abdominal fat deposition in quail model induced by a purine-rich diet. In this study, 60 male French quails were randomly allocated to five groups: CON (control group), MOD (model group), BEN (benzbromarone-treated group), CHI-H (high-dosage chicory inulin-treated group), and CHI-L (low-dosage chicory inulin-treated group). The serum UA level was significantly increased in the model group from days 7 to 28, as well as triglyceride (TG) and free fatty acid (FFA) increased later in the experimental period. The abdominal fat ratio was increased on day 28. Benzbromarone can decrease UA levels on days 14 and 28. The high and low dosage of chicory inulin also decreased serum UA levels on days 7, 14, and 28. The abdominal fat ratio, activity, and protein of acetyl-CoA carboxylase (ACC) were decreased in chicory inulin-treated groups. The activities of xanthine oxidase (XOD) and fatty acid synthase (FAS) were increased in the model group and decreased in the benzbromarone and chicory inulin groups. This study evaluated a quail model of induced hyperuricemia with other metabolic disorders caused by a high-purine diet. The results indicated that a purine-rich diet might contribute to the development of hyperuricemia, hypertriglyceridemia, and abdominal obesity. Chicory inulin decreased serum UA, TG, and abdominal fat deposition in a quail model of hyperuricemia by altering the ACC protein expression and FAS and XOD activities.

Discovery and validation of PURA as a transcription target of 20(S)-protopanaxadiol: Implications for the treatment of cognitive dysfunction

Feiyan Chen,Wenjing Zhang,Shuyi Xu,Hantao Zhang,Lin Chen,Cuihua Chen,Zhu Zhu,Yunan Zhao 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.5

Background: 20(S)-protopanaxadiol (PPD), a ginsenoside metabolite, has prominent benefits for thecentral nervous system, especially in improving learning and memory. However, its transcriptionaltargets in brain tissue remain unknown. Methods: In this study, we first used mass spectrometry-based drug affinity responsive target stability(DARTS) to identify the potential proteins of ginsenosides and intersected them with the transcriptionfactor library. Second, the transcription factor PURA was confirmed as a target of PPD by biolayerinterferometry (BLI) and molecular docking. Next, the effect of PPD on the transcriptional levels of targetgenes of PURA in brain tissues was determined by qRT-PCR. Finally, bioinformatics analysis was used toanalyze the potential biological features of these target proteins. Results: The results showed three overlapping transcription factors between the proteomics of DARTSand transcription factor library. BLI analysis further showed that PPD had a higher direct interaction withPURA than parent ginsenosides. Subsequently, BLI kinetic analysis, molecular docking, and mutations inkey amino acids of PURA indicated that PPD specifically bound to PURA. The results of qRT-PCR showedthat PPD could increase the transcription levels of PURA target genes in brain. Finally, bioinformaticsanalysis showed that these target proteins were involved in learning and memory function. Conclusion: The above-mentioned findings indicate that PURA is a transcription target of PPD in brain,and PPD upregulate the transcription levels of target genes related to cognitive dysfunction by bindingPURA, which could provide a chemical and biological basis for the study of treating cognitive impairmentby targeting PURA.

The Role of Polarization Coulomb Field Scattering in the Electron Mobility of AlGaN/AlN/GaN Heterostructure Field-effect Transistors

Yan Liu,Zhaojun Lin,Jingtao Zhao,Ming Yang,Wenjing Shi,Yuanjie Lv,Zhihong Feng 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.7

The electron mobility for the prepared AlGaN/AlN/GaN heterostructure field-effect transistor (HFET) with the ratio of the gate length to the drain-to-source distance being less than 1/2 has been studied by comparing the measured electron mobility with the theoretical value. The measured electron mobility is derived from the measured capacitance-voltage (C-V) and current-voltage (I-V) characteristics, and the theoretical mobility is determined by using Matthiessen’s law, involving six kinds of important scattering mechanisms. For the prepared device at room temperature, longitudinal optical phonon scattering (LO scattering) was found to have a remarkable effect on the value of the electron mobility, and polarization Coulomb field scattering (PCF scattering ) was found to be important to the changing trend of the electron mobility versus the two-dimensional electron gas (2DEG) density.

Facile Synthesis of MoS2 Hierarchical Nanostructures as Electrodes for Capacitor with Enhanced Pseudocapacitive Property

Shiting Luo,Limei Xu,Jinshan Li,Wenjing Yang,Minli Liu,Lin Ma 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2020 NANO Vol.15 No.02

In this work, the 3D porous hierarchical MoS2 nanostructures were prepared via a simple hydrothermal deposition method only utilizing titanium (Ti) mesh as a substrate. The as-synthesized uniform MoS2 flower-like nanostructures were assembled by nanosheets composed of several stacking layers. The curved and rough surface of cylindrical Ti wire was beneficial to assembly of MoS2 nanosheets into hierarchical architectures. Moreover, the electrochemical performance of the as-prepared MoS2 nanostructured electrodes for capacitors was also investigated. The structural advantages lead to a remarkably improved pseudocapacitive property including high capacitance and durable cycling ability.

중국 신용카드 사용자의 고객만족요인과 지속적 이용및 타인추천에 관한 연구

이사영(Lee, Sa-Young),이현종(Lee, Hyon-Jong),林文靜(Lin, Wenjing) 글로벌경영학회 2015 글로벌경영학회지 Vol.12 No.2

본 논문에서는 중국 산동지역의 신용카드 사용자를 대상으로 중요한 고객만족요인이 무엇인지를 분석하였다. 이와 더불어 본 논문에서는 고객만족요인이 직접적으로 지속적인 사용의도와 타인추천에 미치는 영향에 대해서도 연구하였다. 먼저 여러 고객만족요인 중 고객의 만족도에 영향을 미치는 중요한 요인으로는 회사/안전성과 비용 그리고 정보/부가서비스 3요인이 선정되었으며 카드사용에 대한 만족도는 지속적사용과 타인추천에 지대한 영향을 미쳤다. 신용카드 각각의 고객만족요인이 직접적으로 지속적 이용의도와 타인추천에 대하여 미치는 영향에 대한 분석에서는 지속적 이용의도의 경우에는 5개 고객만족요인 중 직원서비스와 정보/부가서비스 2요인만이 주요 요인으로 채택된 반면 타인추천의 경우에는 회사/안전성과 비용 그리고 정보/부가서비스의 3요인이 주요요인으로 채택되었다. 이것은 타인에게 추천할 때는 추천한 대상이 피해나 손실을 입지 않도록 추천하는 사람이 안정적인 면을 중요하게 여긴다는 것으로 해석할 수 있다. This paper studies on the customers’ satisfaction factors for credit card users in China. In addition, this paper also researches the influence of the customers’ satisfaction factors on the intention of continuous use and on the recommendation to others. From the research, company/security, fees and information/additional service are selected for more important satisfaction factors for credit card users. This paper also finds that staff service and information/additional service have an influence on the intention of continuous use, while company/security, fees, and information/additional service affect on the intention of recommendation to others. This results are interpreted that customers consider security and economic factors more important when they recommend credit cards to others.

Dual-Responsive Cross-Linked Micelles from Amphiphilic Four-Arm Star Copolymers with Different Block Ratios for Triggering DOX Release

Yunwei Huang,Yanzhe Li,Zilun Tang,Qiuping Su,Tingting Liao,Yuxin Gu,Xiaofeng Lin,Xihong Zu,Wenjing Lin,Guobin Yi 한국고분자학회 2020 Macromolecular Research Vol.28 No.8

The four-arm star copolymers poly(methacrylic acid)-poly(2-hydroxyethyl methacrylate-disulfide~)-poly(poly(ethylene glycol) methyl ether methacrylate) (4AS-PMAAx-(PHEMA-SS~)y-PPEGMAz) with four different block ratios were synthesized and could self-assembled into cross-linked polymer micelles for the exploration of the structure-property relationship. The cross-linked polymer micelles in aqueous solution had low critical micelle concentration (CMC) values (1.9-4.6 mg/L), which exhibited better stability than non-cross-linked micelles. The CMC value decreased with the increase of the length of inner PMAA core and hydrophobic PHEMA cross-linked middle layer. The blank and doxorubicin (DOX)- loaded micelles with different block ratios were prepared by dialysis with the particle sizes of 120-240 nm. The longer inner PMAA core and cross-linked middle layer enhanced the drug loading content (DLC) results and led to relatively bigger particle sizes of polymer micelles. The in vitro DOX release data revealed that DOX-loaded micelles had low DOX cumulative release percentages of 18-37% after 110 h at pH 7.4, but up to 83-90% when introducing reductant GSH at pH 5.0. The 4AS-PMAA21.2-(PHEMASS~) 13.1-PPEGMA5.1 micelles with the longest PMAA core had the largest cumulative release of 90.1%. The DOX release process and mechanism of the micelles at different conditions fitted well with the semi-empirical equation. Overall, the results demonstrated that the block ratios and pH/redox-responsiveness of these four-arm star copolymers could be well-controlled and their self-assembled cross-linked micelles as anticancer drug carrier system could be improved by optimizing the different ratios.