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- 저자 : Wenjie Lu (검색결과 10 건)
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Generative Artificial Intelligence for Structural Design of Tall Buildings
Wenjie Liao,Xinzheng Lu,Yifan Fei Council on Tall Building and Urban Habitat Korea 2023 International journal of high-rise buildings Vol.12 No.3
The implementation of artificial intelligence (AI) design for tall building structures is an essential solution for addressing critical challenges in the current structural design industry. Generative AI technology is a crucial technical aid because it can acquire knowledge of design principles from multiple sources, such as architectural and structural design data, empirical knowledge, and mechanical principles. This paper presents a set of AI design techniques for building structures based on two types of generative AI: generative adversarial networks and graph neural networks. Specifically, these techniques effectively master the design of vertical and horizontal component layouts as well as the cross-sectional size of components in reinforced concrete shear walls and frame structures of tall buildings. Consequently, these approaches enable the development of high-quality and high-efficiency AI designs for building structures.
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MXene/PVA Fiber-based Supercapacitor with Stretchability for Wearable Energy Storage
Wenjie Yu,Yu Li,Binjie Xin,Zan Lu 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11
MXene fiber-based supercapacitor exhibits a great potential for wearable energy storage devices with a largesurface area, good conductive, and higher power density. However, MXene flakes are difficult to spin independently due tothe non-liquid crystal structure. In the report, we fabricated freestanding MXene/PVA fibers with good stretchability andimpressive electrochemical properties for fiber-based supercapacitors by a simple wet spinning method. The tensile strengthof the MXene/PVA fibers is significantly enhanced compared with pure PVA fibers for the concentration of MXene foraround 5-20 wt.%. The elongation of the MXene/PVA fiber can reach 48 %, even if the MXene concentration increase to25 wt.%. MXene flakes also increase the thermal stability of hybrid fibers compared with pure PVA fibers. MXene/PVAfiber-based supercapacitors act as efficient energy storage devices, which display high gravimetric capacitance (119.3 F g-1),and areal capacitance (130.9 mF cm-2), strong durability in multiple mechanical states, and steady electrochemical behaviorafter stretching.
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Wenjie Ge,Ashraf F. Ashour,Weigang Lu,Dafu Cao 한국콘크리트학회 2020 International Journal of Concrete Structures and M Vol.14 No.2
Experimental and theoretical investigations on the flexural performance of steel reinforced ECC-concrete composite beams subjected to freeze-thaw cycles are presented in this paper. Four groups of reinforced composite beams with different ECC height replacement ratios subject to 0, 50, 100 and 150 cycles of freeze-thaw were physically tested to failure. Experimental results show that the bending capacity decreases with the increase of freeze-thaw cycles regardless of ECC height replacement ratios. However, the ultimate moment, stiffness and durability of ECC specimens and ECC-concrete composite specimens are greater than those of traditional concrete specimens, owing to the excellent tensile performance of ECC materials. With the increase of ECC height, the crack width and average crack spacing gradually decrease. According to materials’ constitutive models, compatibility and equilibrium conditions, three failure modes with two boundary failure conditions are proposed. Simplified formulas for the moment capacity are also developed. The results predicted by the simplified formulas show good agreement with the experimental moment capacity and failure modes. A parametric analysis is conducted to study the influence of strength and height of ECC, amount of reinforcement, concrete strength and cycles of freeze-thaw on moment capacity and curvature ductility of ECC-concrete composite beams.
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Lu Yi,Wu Jiachuan,Hu Minhui,Zhong Qinghua,Er Limian,Shi Huihui,Cheng Weihui,Chen Ke,Liu Yuan,Qiu Bingfeng,Xu Qiancheng,Lai Guangshun,Wang Yufeng,Luo Yuxuan,Mu Jinbao,Zhang Wenjie,Zhi Min,Sun Jiachen 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.6
Background/Aims: The accuracy of endosonographers in diagnosing gastric subepithelial lesions (SELs) using endoscopic ultrasonography (EUS) is influenced by experience and subjectivity. Artificial intelligence (AI) has achieved remarkable development in this field. This study aimed to develop an AI-based EUS diagnostic model for the diagnosis of SELs, and evaluated its efficacy with external validation. Methods: We developed the EUS-AI model with ResNeSt50 using EUS images from two hospitals to predict the histopathology of the gastric SELs originating from muscularis propria. The diagnostic performance of the model was also validated using EUS images obtained from four other hospitals. Results: A total of 2,057 images from 367 patients (375 SELs) were chosen to build the models, and 914 images from 106 patients (108 SELs) were chosen for external validation. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the model for differentiating gastrointestinal stromal tumors (GISTs) and non-GISTs in the external validation sets by images were 82.01%, 68.22%, 86.77%, 59.86%, and 78.12%, respectively. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy in the external validation set by tumors were 83.75%, 71.43%, 89.33%, 60.61%, and 80.56%, respectively. The EUS-AI model showed better performance (especially specificity) than some endosonographers. The model helped improve the sensitivity, specificity, and accuracy of certain endosonographers. Conclusions: We developed an EUS-AI model to classify gastric SELs originating from muscularis propria into GISTs and non-GISTs with good accuracy. The model may help improve the diagnostic performance of endosonographers. Further work is required to develop a multi-modal EUS-AI system.
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Chunxiao Li,Lu Chen,Min Song,Zhirui Fang,Lusha Zhang,Joel Wake Coffie,Liyuan Zhang,Lulu Ma,Qianyi Wang,Wenjie Yang,Leyu Fang,Shaoxia Wang,Xiumei Gao,Hong Wang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8
Acute myocardial infarction (AMI) resultsin irreversible cardiac cell damage or death because ofdecreased blood fl ow to the heart. Apoptosis plays an importantrole in the process of tissue damage after myocardialinfarction (MI), which has pathological and therapeuticimplications. Ferulic acid (FA) is a phenolic acid endowedwith strong antioxidative and cytoprotective activities. Thepresent study aimed to investigate whether FA protectscardiomyocytes from apoptosis by regulating autophagy,which is a cellular self-digestion process, and one of thefi rst lines of defense against oxidative stress. Apoptosis wasinduced by TNF-α (10 ng/mL) and cycloheximide (CHX,5 μg/mL) in rat H9c2 cardiomyocytes. FA-inhibited TNF-α/CHX-induced apoptosis was determined by the quantifi cationof TUNEL-positive cells, and the eff ect was associatedwith decreased ROS production and inhibited caspase3activation. FA treatment enhanced autophagy and increasedautophagy-associated protein expression, leading to an inhibitionof mTOR signaling. When co-treated with 3-methyladenine(3-MA), an autophagy inhibitor, the anti-apoptoticeff ect of FA was attenuated. In an in vivo mouse MI model,FA treatment decreased the apoptotic cell number, reducedinfarct size, and improved cardiac performance, as determinedby histological and echocardiographic assessments. Taken collectively, these results suggest that FA could protectcardiomyocytes from apoptosis by enhancing autophagy.
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Yuping Chen,Feng Lu,Wenjie Lu,Xianfeng Chen 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.55 No.3
Based on cascaded second harmonic generation and difference-frequency generation interactions and employing a type-I quasi-phase-matching technique in MgO-doped periodically poled lithium niobate, we realized wavelength conversion of a 70-femtosecond pulse without pulse broadening at the group-velocity-matching wavelength. Due to the 25 nm bandwidth of second harmonic generation obtained in a 20-mm-long crystal, we convert a 70-fs pulse centered at 1.56 μm by using a continuous-wave signal at 1.60 μm. No obvious distortion or broadening of the converted pulse was observed. Based on cascaded second harmonic generation and difference-frequency generation interactions and employing a type-I quasi-phase-matching technique in MgO-doped periodically poled lithium niobate, we realized wavelength conversion of a 70-femtosecond pulse without pulse broadening at the group-velocity-matching wavelength. Due to the 25 nm bandwidth of second harmonic generation obtained in a 20-mm-long crystal, we convert a 70-fs pulse centered at 1.56 μm by using a continuous-wave signal at 1.60 μm. No obvious distortion or broadening of the converted pulse was observed.
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Hongwei Li,Xingzhuang Zhu,Wei Zhang,Wenjie Lu,Chuan Liu,Jinbo Ma,Rukun Zang,Yipeng Song 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.4
Mitochondrial fission regulator 2 (MTFR2) is associated with mitochondrial fission, while few studies have assessed the associations between MTFR2 expression and clinical characteristics or prognosis of esophageal squamous cell carcinoma (ESCC). In this study, we compared the expression of MTFR2 in 6 ESCC tumors and relative normal tissues by immunohistochemistry (IHC). To assess the effect of MTFR2 expression on clinicopathologic characteristics and survival, 115 paraffin embedded ESCC tissue samples were assessed by IHC staining. Furthermore, the association between clinicopathological properties and MTFR2 expression in patients with ESCC was examined. The survival analysis was performed using the Cox regression models. We found that MTFR2 expression was significantly increased in ESCC tumors compared with normal esophageal epithelial cells. IHC analysis of 115 paraffin embedded ESCC tumor specimens of the patients showed that the expression of MTFR2 was significantly associated with clinical stage (P < 0.001), tumor classification (P < 0.001), histological grade (P < 0.001), and other clinicopathological characteristics. Both univariate and multivariate analyses showed that MTFR2 expression was inversely correlated with the survival of ESCC patients. In conclusion, the expression of MTFR2 is significantly associated with clinicopathologic characteristics and prognosis of ESCC. Thus, MTFR2 expression could serve as a potentially important prognostic biomarker and clinical target for patients with ESCC. Key Words MTFR2, Esophageal squamous cell carcinoma, Immunohistochemistry, Prognosis
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Shugang Xi,Guihua Zhou,Xuexin Zhang,Wenjie Zhang,Lu Cai,Chunyan Zhao 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.8
Total aralosides of Aralia elata (Miq) Seem (TASAES) from Chinese traditional herb Longya Aralia chinensis L was found to improve cardiac function. The present study was to determine the protective effects of TASAES on diabetic cardiomyopathy, and the possible mechanisms. Therefore, a single dose of streptozotocin was used to induce diabetes in Wister rats. Diabetic rats were immediately treated with low, medium and high doses of TASAES at 4.9, 9.8 mg/kg and 19.6 mg/kg body weight by gavage, respectively, for eight weeks. Cardiac function was evaluated by in situ hemodynamic measurements, and patch clamp for the L-type Ca2+ channel current (ICa2+-L) and transient outward K+ channel current (Ito). Histopathological changes were observed under light and electron microscope. The expression of pro-fibrotic factor, connective tissue growth factor (CTGF) was monitored using immunohistochemistry staining. Compared with diabetic group, medium and high doses, but not low dose, of TASAES showed a significant protection against diabetes-induced cardiac dysfunction, shown by increased absolute value of left ventricular systolic pressure (LVSP) and maximum rates of pressure development (±dp/dtmax), and enhanced amplitude of ICa2+-L (P < 0.05). Histological staining indicated a significant inhibition of diabetes-caused pathological changes and up-regulation of CTGF expression (P < 0.05). The results suggest that TASAES prevents diabetes- induced cardiac dysfunction and pathological damage through up-regulating ICa2+-L in cardiac cells and decreasing CTGF expression. Total aralosides of Aralia elata (Miq) Seem (TASAES) from Chinese traditional herb Longya Aralia chinensis L was found to improve cardiac function. The present study was to determine the protective effects of TASAES on diabetic cardiomyopathy, and the possible mechanisms. Therefore, a single dose of streptozotocin was used to induce diabetes in Wister rats. Diabetic rats were immediately treated with low, medium and high doses of TASAES at 4.9, 9.8 mg/kg and 19.6 mg/kg body weight by gavage, respectively, for eight weeks. Cardiac function was evaluated by in situ hemodynamic measurements, and patch clamp for the L-type Ca2+ channel current (ICa2+-L) and transient outward K+ channel current (Ito). Histopathological changes were observed under light and electron microscope. The expression of pro-fibrotic factor, connective tissue growth factor (CTGF) was monitored using immunohistochemistry staining. Compared with diabetic group, medium and high doses, but not low dose, of TASAES showed a significant protection against diabetes-induced cardiac dysfunction, shown by increased absolute value of left ventricular systolic pressure (LVSP) and maximum rates of pressure development (±dp/dtmax), and enhanced amplitude of ICa2+-L (P < 0.05). Histological staining indicated a significant inhibition of diabetes-caused pathological changes and up-regulation of CTGF expression (P < 0.05). The results suggest that TASAES prevents diabetes- induced cardiac dysfunction and pathological damage through up-regulating ICa2+-L in cardiac cells and decreasing CTGF expression.
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Ferroelectrically tunable magnetic skyrmions in ultrathin oxide heterostructures
Wang, Lingfei,Feng, Qiyuan,Kim, Yoonkoo,Kim, Rokyeon,Lee, Ki Hoon,Pollard, Shawn D.,Shin, Yeong Jae,Zhou, Haibiao,Peng, Wei,Lee, Daesu,Meng, Wenjie,Yang, Hyunsoo,Han, Jung Hoon,Kim, Miyoung,Lu, Qingyo Springer Science and Business Media LLC 2018 NATURE MATERIALS Vol.17 No.12
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