Ferulic acid protects cardiomyocytes from TNF-a/cycloheximide-induced apoptosis by regulating autophagy

Chunxiao Li,Lu Chen,Min Song,Zhirui Fang,Lusha Zhang,Joel Wake Coffie,Liyuan Zhang,Lulu Ma,Qianyi Wang,Wenjie Yang,Leyu Fang,Shaoxia Wang,Xiumei Gao,Hong Wang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.8

Acute myocardial infarction (AMI) resultsin irreversible cardiac cell damage or death because ofdecreased blood fl ow to the heart. Apoptosis plays an importantrole in the process of tissue damage after myocardialinfarction (MI), which has pathological and therapeuticimplications. Ferulic acid (FA) is a phenolic acid endowedwith strong antioxidative and cytoprotective activities. Thepresent study aimed to investigate whether FA protectscardiomyocytes from apoptosis by regulating autophagy,which is a cellular self-digestion process, and one of thefi rst lines of defense against oxidative stress. Apoptosis wasinduced by TNF-α (10 ng/mL) and cycloheximide (CHX,5 μg/mL) in rat H9c2 cardiomyocytes. FA-inhibited TNF-α/CHX-induced apoptosis was determined by the quantifi cationof TUNEL-positive cells, and the eff ect was associatedwith decreased ROS production and inhibited caspase3activation. FA treatment enhanced autophagy and increasedautophagy-associated protein expression, leading to an inhibitionof mTOR signaling. When co-treated with 3-methyladenine(3-MA), an autophagy inhibitor, the anti-apoptoticeff ect of FA was attenuated. In an in vivo mouse MI model,FA treatment decreased the apoptotic cell number, reducedinfarct size, and improved cardiac performance, as determinedby histological and echocardiographic assessments. Taken collectively, these results suggest that FA could protectcardiomyocytes from apoptosis by enhancing autophagy.

Sketch-based 3D modeling by aligning outlines of an image

Li, Chunxiao,Lee, Hyowon,Zhang, Dongliang,Jiang, Hao Society for Computational Design and Engineering 2016 Journal of computational design and engineering Vol.3 No.3

In this paper we present an efficient technique for sketch-based 3D modeling using automatically extracted image features. Creating a 3D model often requires a drawing of irregular shapes composed of curved lines as a starting point but it is difficult to hand-draw such lines without introducing awkward bumps and edges along the lines. We propose an automatic alignment of a user's hand-drawn sketch lines to the contour lines of an image, facilitating a considerable level of ease with which the user can carelessly continue sketching while the system intelligently snaps the sketch lines to a background image contour, no longer requiring the strenuous effort and stress of trying to make a perfect line during the modeling task. This interactive technique seamlessly combines the efficiency and perception of the human user with the accuracy of computational power, applied to the domain of 3D modeling where the utmost precision of on-screen drawing has been one of the hurdles of the task hitherto considered a job requiring a highly skilled and careful manipulation by the user. We provide several examples to demonstrate the accuracy and efficiency of the method with which complex shapes were achieved easily and quickly in the interactive outline drawing task.

Prediction Model of Net Cutting Specific Energy Based on Energy Flow in Milling

Chunxiao Li,Guoyong Zhao,Yugang Zhao,Shuang Xu,Zhifu Zheng 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.5

Net cutting specific energy ( NCSE ) reflects the actual cutting energy efficiency. Establishing a NCSE prediction model is helpful to analyze the energy consumption characteristics of machine tools. As so far, few studies have focused on the NCSE prediction in the way of energy flow. Therefore, based on the flow direction of cutting energy, a mathematical model for predicting NCSE is proposed in this paper. During milling, the energy used for cutting can be divided into forming surface energy, material removing energy and additional load energy. Thus, the NCSE model is decomposed into three sub-models. Firstly, in the cutting process of AISI 304 stainless steel, the phase transition of austenite to martensite on the machined surface is induced by parts of cutting energy, and then work hardening occur. Furthermore, the forming surface specific energy prediction model is established based on surface hardness. Secondly, the models of material removing energy and additional load energy are developed respectively with the material removal rate and spindle speed. The above sub-models are integrated into the NCSE prediction model with the determination coefficient R 2 of 0.982, and average prediction accuracy of 96.77%. Finally, the influence of input variables on NCSE and the energy consumption proportion are revealed. Among them, the forming surface specific energy, material removing specific energy and additional load specific energy account for 8.26%, 32.63% and 59.11% on NCSE respectively. The proposed model can not only predict the overall cutting energy consumption, but also predict the energy consumption of each sub-model. The research provides a new idea for analyzing cutting energy characteristics and improving processing theory.

Barrier Lyapunov Function Based Adaptive Cross Backstepping Control for Nonlinear Systems with Time-varying Partial State Constraints

Chunxiao Wang,Lu Qi,Jia-yun Liu,Jia-li Yu 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.7

This paper focuses on an adaptive cross-backstepping control for a class of nonstrict-feedback nonlinear systems affected by time-varying partial state constraints. The nonstrict-feedback nonlinear systems considered in this paper are divided into two strict-feedback nonlinear subsystems. One constrained subsystems and another unconstrained subsystems. In view of the normal backstepping method is only an effective method to control lowertriangular systems, cross-backstepping control is introduced which successfully solves the problem of alternatetime-varying state constraints. For the constrained subsystems, novel time-varying tan-type barrier Lyapunov function (TBLF) is employed in each step of backstepping design to guarantee the boundedness of the fictitious or actual state tracking errors. Besides, proper adaptive laws are designed for the upper bound of uncertain parameters, which successfully neutralize the influence of parametric uncertainties. Based on the stability analysis, it is concluded that the states of the closed-loop system maintain in the predefined time-varying compact sets and the output can be guaranteed to be as close to the desired trajectory as possible. The effectiveness of the proposed technique is illustrated by a constrained hyperchaotic system in two cases.

Experimental and numerical simulation investigation on vortex-induced vibration test system based on bare fiber Bragg grating sensor technology for vertical riser

Wang Chunxiao,Wang Yu,Liu Yu,Li Peng,Zhang Xiantang,Wang Fei 대한조선학회 2021 International Journal of Naval Architecture and Oc Vol.13 No.1

The Vortex-Induced Vibration (VIV) test system on deepwater riser based on Bare Fiber Bragg Grating (BFBG) sensor technology was designed. Meanwhile, a riser VIV response numerical model was established based on the work-energy principle. The results show that the first-order vibration frequency dominates the vibration of the riser, and as the velocity increases, the dominant frequency of the riser gradually increases under the effect of different top tensions. At the same velocity, as the top tension increases step by step, the dominant frequency and fatigue damage at the same position along the axial length of the riser both gradually decreases. The model test and numerical simulation show a relatively consistent change, maintaining a high degree of agreement. The process control system based on BFBG of model test has excellent performance, and FBG sensors have great advantages in VIV test of a vertical riser in water.

Preparation and properties of coated silica/aluminum cermet materials via powder metallurgy method

Jieguang Song,Yue Liu,Chunxiao Wu,Xueqing Yang,Huihui Luo,Chunyan He,Chengbin Li,Haizhen Yang 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.2

Cermet is a combination of metal and ceramic, it exhibits some special properties, so it is one of the most widely usedengineering materials. In this paper, the properties of encapsulated SiO2/Al cermet were prepared by powder metallurgymethod. Results showed that the density of SiO2/Al cermet is increased with an increasing Al content. When the Al contentis high, and the high temperature is sintered, the liquid phase can fully bond the surrounding SiO2 particles to form a relativelycontinuous and dense structure, thereby obtaining a high microstructure density. When the SiO2:Al ratio is increased from 1:1to 1:3, the hardness is gradually increased. The hardness and density of the sample are gradually increased with an increasingmolding pressure. The surface hardness of the cermet is increased first and then decreased with an increasing sinteringtemperature. When the SiO2:Al ratio is 1:3, the holding time is 10 min under molding pressure of 15 MPa, and the sinteringtemperature is 900 °C for 1 h, the surface hardness of the obtained coated SiO2/Al cermet is high, the value is 175.2 HV.

Seismic Performance of a New Type Concrete-Filled Precast Concrete Tubular Column

Chuang Du,Yanzhao Li,Chunxiao Zhang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.2

To investigate the seismic behaviour of a new type of concrete-filled precast concrete tubular column, five concrete-filled precast concrete tubular columns varying in concrete strength and stirrup ratio were tested under cyclic loading. The behaviours of the failure mode, hysteretic curve, skeleton curve, bearing capacity, deformability, displacement ductility and energy dissipation were studied to evaluate the seismic resistance performance of the columns. The results show that the failure mode of the concrete-filled precast concrete tubular columns was flexural failure, and the hysteretic curve had a plump shuttle shape, which indicates that the concrete-filled precast concrete tubular column has good energy dissipating capacity. The bearing capacity of the specimen was increased with increasing concrete strength of the precast tube. The stirrup ratio has little effect on its bearing capacity, whereas it has a significant effect on the deformation, ductility and energy dissipation. The story drift of the specimens can meet the requirements of the elastic plastic story drift limit value of 1/50 of the code in China, and the ductility coefficient is greater than 3, which demonstrates that the concrete-filled precast concrete tubular column has excellent seismic properties.

FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated cervical cancer by inactivating the LKB1/AMPK pathway

Gao Fuxian,Wang Chunxiao,Ji Jianghai,Li Wenjuan 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3

Background Cervix cancer (CC) is the most common gynecological malignancy and the leading cause of morbidity in women around the world. Objectives In this research, the eff ect of FBXO22 on HPV-associated CC was evaluated. Results The results fi rst illuminated that FBXO22 was highly expressed in HPV + CC patients. FBXO22 knockdown inhibited the proliferation of HPV + CC cells, and promoted autophagy in HPV + CC cells. Finally, FBXO22 regulates the LKB1/ AMPK pathway . Conclusion This research hinted that FBXO22 promotes cell proliferation and inhibits autophagy in HPV-associated CC by inactivating the LKB1/AMPK pathway.

Topology Modeling and Vulnerability Analysis of China Mine Power Grid Based on Complex Network Theory

Junji Wang,Caoyuan Ma,Chunxiao Li,Xinshang Zhu,Kang Zhao 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.10

A structural vulnerability analysis of China mine power grid, which considering the particular of topological structure and the increase gas power generation nodes, is proposed based on complex network theory. According to transmission capacity of weighted network model, this paper analyses the network characteristics, including degree distribution, clustering coefficient and average path length, to prove that the mine power grid is a scale -free network. The node importance, node betweenness, edge weight and edge betweenness are regarded as the index of identification and the remaining load capacity after attack is chosen as evaluation index to analyze the structural vulnerability of mine power grid to have a fault simulation of the mine power grid before and after adding gas power generation nodes. The results of fault simulation show that the model is in line with the actual situation of the China mine power grid, and can better identify and assess the vulnerability of the mine power grid.

An Efficient Indexing Structure for Multidimensional Categorical Range Aggregation Query

( Jian Yang ),( Chongchong Zhao ),( Chao Li ),( Chunxiao Xing ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.2

Categorical range aggregation, which is conceptually equivalent to running a range aggregation query separately on multiple datasets, returns the query result on each dataset. The challenge is when the number of dataset is as large as hundreds or thousands, it takes a lot of computation time and I/O. In previous work, only a single dimension of the range restriction has been solved, and in practice, more applications are being used to calculate multiple range restriction statistics. We proposed MCRI-Tree, an index structure designed to solve multi-dimensional categorical range aggregation queries, which can utilize main memory to maximize the efficiency of CRA queries. Specifically, the MCRI-Tree answers any query in O(nkn-1) I/Os (where n is the number of dimensions, and k denotes the maximum number of pages covered in one dimension among all the n dimensions during a query). The practical efficiency of our technique is demonstrated with extensive experiments.