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Wenjia Li,Fengxian Wei,Bin Xu,Quanyou Sun,Wen Deng,Huihui Ma,Jie Bai,Shaoyu Li 아세아·태평양축산학회 2019 Animal Bioscience Vol.32 No.12
Objective: The study was conducted to evaluate the effect of stocking density and alpha-lipoic acid (ALA) on the growth performance, feed utilization, carcass traits, antioxidative ability and immune response of broilers. Methods: A total of 1,530 22-day-old male broilers (Arbor Acres) with comparable body weights (731.92±5.26) were placed into 18 cages (2.46×2.02 m) in groups of 75 birds (15 birds/m2, 37.5 kg/m2; low stocking density [LD]), 90 birds (18 birds/m2, 45.0 kg/m2; high stocking density [HD]) and 90 birds with 300 mg/kg ALA added to the basal diet (18 birds/m2, 45.0 kg/m2; HD+ALA, high stocking density+α-lipoic acid); each treatment was represented by 6 replicates. The experimental period was 3 weeks. Results: The results showed that the high stocking density regimen resulted in a decreased growth, feed conversion ratio, carcass weight, thigh yield and bursa weight relative to body weight (p<0.05) on d 42. The abdominal fat yield in the HD+ALA group was lower (p = 0.031) than that of the LD group at 42 d. The superoxide dismutase and glutathione peroxidase activities in serum were increased, and malondialdehyde content decreased after adding ALA product (p<0.05) on d 42. Additionally, the serum concentrations of immunoglobulin A (IgA) and IgG were decreased (p<0.05) and the level of diamine oxidase was higher (p< 0.01) in the HD group on d 42. Conclusion: The high stocking density significantly decreased broiler growth performance, feed utilization and carcass traits, increased physiological and oxidative stress and induced intestinal mucosal injury. The supplementation of ALA product in broiler diet at 300 mg/kg may reduce the adverse effects of high stocking density-mediated stress by maintaining the antioxidant system and humoral immune system.
In-Situ Distortion Prediction in Metal Additive Manufacturing Considering Boundary Conditions
Wenjia Wang,Jinqiang Ning,Steven Y. Liang 한국정밀공학회 2021 International Journal of Precision Engineering and Vol.22 No.5
Undesired distortion often occurs in metal additive manufacturing due to the high temperature gradient resulting from repeated thermal cycles. A good understanding and fast predictions of in-situ distortion are essential to achieve high dimensional accuracy and prevent delamination or failure of build parts. Experimental investigations and numerical methods have been employed to study the in-situ distortion. However, the complex measurement systems and high computational cost limit their applications. An analytical modeling method with closed-form solutions is proposed in this paper to predict the in-situ distortion of laser cladding process without using iteration-based numerical calculations. The effects of build edges and geometry are considered, which include thermal convection and radiation at boundaries. Heat input and heat sink solutions modified from the point moving heat source model are added together to predict the temperature profile of the build and substrate. The die-substrate assembly model is used to calculate the deflection during the manufacturing process. Alloy 625 is selected to test the predictive accuracy and computational efficiency of the presented analytical model. The predicted results are close to the experimental data of in-situ distortion in literature. The computational time is less than 30 s. The good predictive accuracy and low computational cost make the presented method a promising approach to study the full-field temperature and distortion of a geometrically complex part.
Function of Rhs proteins in porcine extraintestinal pathogenic Escherichia coli PCN033
Lu Wenjia,Tan Jia,Lu Hao,Wang Gaoyan,Dong Wenqi,Wang Chenchen,Li Xiaodan,Tan Chen 한국미생물학회 2021 The journal of microbiology Vol.59 No.9
Extraintestinal pathogenic Escherichia coli (ExPEC) is an important zoonotic pathogen that places severe burdens on public health and animal husbandry. There are many pathogenic factors in E. coli. The type VI secretion system (T6SS) is a nano-microbial weapon that can assemble quickly and inject toxic effectors into recipient cells when danger is encountered. T6SSs are encoded in the genomes of approximately 25% of sequenced Gram-negative bacteria. When these bacteria come into contact with eukaryotic cells or prokaryotic microbes, the T6SS assembles and secretes associated effectors. In the porcine ExPEC strain PCN033, we identified four classic rearrangement hotspot (Rhs) genes. We determined the functions of the four Rhs proteins through mutant construction and protein expression. Animal infection experiments showed that the Δrhs-1CT, Δrhs-2CT, Δrhs-3CT, and Δrhs-4CT caused a significant decrease in the multiplication ability of PCN033 in vivo. Cell infection experiments showed that the Rhs protein is involved in anti-phagocytosis activities and bacterial adhesion and invasion abilities. The results of this study demonstrated that rhs1, rhs3, and rh4 plays an important role in the interaction between PCN033 and host cell. Rhs2 has contribution to cell and mice infection. This study helps to elucidate the pathogenic mechanism governing PCN033 and may help to establish a foundation for further research seeking to identify potential T6SS effectors.
Chen Wenjia,Ma Zhaochen,Yu Lingxiang,MAO Xia,Ma Nan,Guo Xiaodong,Yin Xiaoli,Jiang Funeng,Wang Qian,Wang Jigang,Fang Mingliang,Lin Na,Zhang Yanqiong 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Artesunate (ART) has been indicated as a candidate drug for hepatocellular carcinoma (HCC). Glucosylceramidase (GBA) is required for autophagic degradation. Whether ART regulates autophagic flux by targeting GBA in HCC remains to be defined. Herein, our data demonstrated that the dramatic overexpression of GBA was significantly associated with aggressive progression and short overall survival times in HCC. Subsequent experiments revealed an association between autophagic activity and GBA expression in clinical HCC samples, tumor tissues from a rat model of inflammation-induced HCC and an orthotopic mouse model, and human HCC cell lines. Interestingly, probe labeling identified GBA as an ART target, which was further verified by both a glutathione-S-transferase pulldown assay and surface plasmon resonance analysis. The elevated protein expression of LC3B, the increased numbers of GFP-LC3B puncta and double-membrane vacuoles, and the enhanced expression of SQSTM1/p62 indicated that the degradation of autophagosomes in HCC cells was inhibited by ART treatment. Both the in vitro and in vivo data revealed that autophagosome accumulation through targeting of GBA was responsible for the anti-HCC effects of ART. In summary, this preclinical study identified GBA as one of the direct targets of ART, which may have promising potential to inhibit lysosomal autophagy for HCC therapy.
胡文嘉(Hu, Wenjia),?林?(Zheng, linxiao) 한국중어중문학회 2015 中語中文學 Vol.61 No.-
A Dictionary of the Chinese Language in Three Parts, complied by the British missionary Robert Morrison from 1815 to 1823, is the first Chinese-English dictionary in history which has made great contributions to the communication between China and West. What this paper focuses on is Woo-chay-yun-foo, the second part of Morrison’s great dictionary. In Woo-chay-yun-foo, Morrison developed romanizations for 12680 Chinese characters, which shed light on the pronunciation of Mandarin at that time. Presently, the research on Woo-chay-yun-foo is very limited, most of which is about the phonology recorded in this dictionary. This paper aims to continue the discussion of phonology by analyzing the pronunciation of the initial groups Zhi, Zhuang and Zhang in Woo-chay-yun-foo. It is found that in Woo-chay-yun-foo, the initials in group Zhi and Zhang are mainly pronounced as [tⓒ, tⓒ‘,ⓒ], while some of them are turned into [ts, ts‘,s] when combined with Geng She. The initials in group Zhuang, however, develops in two directions according to the finals following them: 1) ts, ts‘ and s before final group Yu; 2) tⓒ, tⓒ‘ and ⓒ before final group Jia. The pronunciation of group Zhi, Zhuang and Zhang in this dictionary is similar to what Xiong Zhenghui (1990) names “Nanjing type” when classifying modern Mandarin Chinese. In this sense, it is likely that what Woo-chay-yun-foo records is Mid-Q?ng Mandarin based on Nanjing Dialect.
체험마케팅을 이용한 상업공간의 디지털미디어 디자인 사례연구
조문가(CAO WENJIA),이샘(Lee Seam),안세윤(An, Sei-Yun) 한국실내디자인학회 2015 한국실내디자인학회 학술대회논문집 Vol.2015 No.10
Digital media has become a major means of communication in modern society. And the popularization of digital media technology presented more varied forms. In the Space Marketing design strategy of commercial spaces. The application of digital media has become a trend. 《Experiential Marketing》by Bernd H. Schmitt in reference to three trends for future marketing, intelligence technology, brand and communication. This is further proof of the importance of digital applications in commercial spaces. In this study, focused on interior spaces. by studying advance researches, to find out the design elements contained Space design, Experiential Marketing and Digital Media, Then analysis the cases of digital media application in commercial space. The result shows there are four types by different identities. And the result will be the reference material for Design and development of digital media for the marketing of commercial spaces.