A National Consensus Survey for Current Practice in Brain Tumor Management III: Brain Metastasis and Primary Central Nervous System Lymphoma

Sung Kwon Kim,Ji Eun Park,Kyung Hwan Kim,Jin Mo Cho,문장섭,Wan-Soo Yoon,김세훈,김영일,김영준,Ho Sung Kim,도윤식,박재성,윤홍인,서영범,Kyoung-Su Sung,송진호,Chan Woo Wee,Se-Hoon Lee,임도훈,임정호,장종희,한명훈,홍제범,Kihwan Hwang,Chul-Kee Park 대한뇌종양학회 2020 Brain Tumor Research and Treatment Vol.8 No.1

Background: The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted the nationwide questionnaire survey for diverse queries facing to treat patients with brain tumor. As part III of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with brain metastasis and primary central nervous system lymphoma (PCNSL). Methods: A web-based survey was sent to all members of the KSNO by email. The survey included 7 questions of brain metastasis and 5 questions of PCNSL, focused on the management strategies in specific situations. All questions were developed by consensus of the Guideline Working Group. Results: In the survey about brain metastasis, respondents preferred surgical resection with adjuvant treatment for patients with a surgically accessible single brain metastatic lesion less than 3 cm in size without extracranial systemic lesions. However, most respondents considered radiosurgery for surgically inaccessible lesions. As the preferred treatment of multiple brain metastases according to the number of brain lesions, respondents tended to choose radiotherapy with increasing number of lesions Radiosurgery was mostly chosen for the brain metastases of less than or equal to 4. In the survey about PCNSL, a half of respondents choose high-dose methotrexate-based polychemotherapy as the first-line induction therapy for PCNSL. The consolidation and salvage therapy showed a little variation among respondents. For PCNSL patients with cerebrospinal fluid dissemination, intrathecal chemotherapy was most preferred. Conclusion: The survey demonstrates the prevailing clinical practice patterns for patients with brain metastasis and PCNSL among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of brain metastasis and PCNSL.

Analysis of Phylogenetic Relationship of 30 Cultivars of Korean Mulberry (Rosales: Moraceae) in Korea

Kwon, O-Chul,Kim, Hyun-Bok,Sung, Gyoo-Byung,Kim, Yong-Soon,Ju, Wan-Taek Korean Society of Sericultural Science 2018 International Journal of Industrial Entomology Vol.37 No.2

This study was carried out to understand phylogenetic relationships of the 30 mulberry cultivars converved in Korea based on the ITS rDNA region, and they were compared to 40 reference sequences from GenBank. The size and the G+C content of the ITS rDNA gene regions from the 30 Korean mulberry cultivars and 40 reference sequences varied from 612-630 bp and 58.19-61.62%, respectively. Based on the results of the comparative phylogenetic analysis of the ITS rDNA regions of the 30 Korean mulberry cultivars and 40 reference sequences, they were divided into three groups (Group 1, 2, and 3) and two subgroups (Group 1A and 1B within Group 1). The sequence lengths of the Korean mulberry cultivar numbers 1-26 and 27-30 were 615 bp and 616 bp, respectively. At 205 bp location of ITS1 rDNA region, the cultivar numbers 1-26 contain the nucleotide thymine but the cultivar numbers 27-30 contain the nucleotide adenine. In addition, the insertion of the nucleotide adenine at 206 bp location was found only in the four Korean mulberry cultivars (numbers 27-30). Based on these sequence information and phylogenetic result, the 30 Korean mulberry cultivars were identified as M. alba and M. australis. This study will contribute to the construction of genetic database constructions and accurate variety identifications for unidentified mulberry varieties in Korea.

Quali-Quantitative Analysis of Flavonoids for Mulberry Leaf and Fruit of ‘Suhyang’

( Wan-taek Ju ),( O-chul Kwon ),( Min-ki Lee ),( Hyun-bok Kim ),( Gyoo-byung Sung ),( Yong-soon Kim ) 한국환경농학회 2017 한국환경농학회지 Vol.36 No.4

BACKGROUND: Globally, mulberry (Morus sp.) is exploited for feeding leaf to silkworms in order to obtain silk fiber or for animal feedstock production. Also, mulberry fruit is known to a by-product that was produced from mulberry tree after harvesting leaves for silkworm rearing, as a yield and consumption of mulberry fruit was increased, it has been fixing to a new income crop .Mulberry leaves and fruits are used for the health benefits of human beings. Mulberry contains various bioactive components, such as alkaloids and flavonoids. Mulberry flavonoids are an important part of the diet because of their effects on human nutrition. The flavonoids in mulberry leaf and fruit of ‘Suhyang’ (Morus alba L.) were determined. METHODSANDRESULTS: Flavonoids form ulberry leaf and fruit of ‘Suhyang’ were analysed using ultrahigh performance liquid chromatography coupled with diode array detection and quadrupole time-of-flight mass spectrometry (UPLC-DAD-QTOF/MS) technique. An UPLCDAD- QTOF/MS system was used, and identification of mulberry leaves constituents was carried out on the basis of the complementary information obtained from LC spectra, MS ions, and MS/MS fragments. The mulberry leaf (16 flavonoids) and fruit (9 flavonoids) were isolated and analyzed from Suhyang using UPLC-DAD-QTOF/MS chromatogram. To the best of our knowledge, Quercetin 3-O-(6''-O-malonyl) glucoside and quercetin 3-O-rutinoside (rutin) was detected on the highest content in leaf and fruit, respectively and further research will be devoted to evaluate their biological activity. CONCLUSION: Obtaining information about the concentration of functional materials in mulberry leaves could contribute to the development and promotion of processed, functional products and offer possible industrial use of ‘Suhyang’, holding promises to enhance the overall profitability of sericulture.

Nematicidal Activity of Bikaverin and Fusaric Acid Isolated from Fusarium oxysporum against Pine Wood Nematode, Bursaphelenchus xylophilus

Kwon, Hyeok-Ran,Son, Seung-Wan,Han, Hye-Rim,Choi, Gyung-Ja,Jang, Kyoung-Soo,Choi, Yong-Ho,Lee, Sunog,Sung, Nack-Do,Kim, Jin-Cheol The Korean Society of Plant Pathology 2007 Plant Pathology Journal Vol.23 No.4

Pine wood nematode, Bursaphelenchus xylophilus, causes pine wilt disease in a number of Pinus species, which is one of the most serious plant diseases in forest, Korea. In the course of a search for nematicidal substances from endophytic fungi, Fusarium oxysporum EF119 out of the 23 fungal strains tested showed the strongest activity to B. xylophilus. Two nematicidal substances were isolated and identified as bikaverin and fusaric acid. Fusaric acid showed somewhat higher nematicidal activity against B. xylophilus than bikaverin; fusaric acid and bikaverin, at $100{\mu}g/ml$, killed B. xylophilus with mortality values of 50% and 43%, respectively. In addition, both compounds acted synergistically. This is the first report on the nematicidal activity of bikaverin and fusaric acid.

A National Consensus Survey for Current Practice in Brain Tumor Management I: Antiepileptic Drug and Steroid Usage

Sung Kwon Kim,Jangsup Moon,Jin Mo Cho,Kyung Hwan Kim,김세훈,김영일,김영준,Ho Sung Kim,도윤식,박재성,Ji Eun Park,서영범,Kyoung-Su Sung,송진호,Chan Woo Wee,Wan-Soo Yoon,윤홍인,Se-Hoon Lee,임도훈,임정호,장종희,한명훈,홍제범,Kihwan Hwang,박철기,이 대한뇌종양학회 2020 Brain Tumor Research and Treatment Vol.8 No.1

Background: The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted a nationwide questionnaire survey for diverse queries faced in the treatment of brain tumors. As part I of the survey, the aim of this study is to evaluate national patterns of clinical practice about antiepileptic drug (AED) and steroid usage for management of brain tumors. Methods: A web-based survey was sent to all members of the KSNO by email. The survey included 9 questions of AED usage and 5 questions of steroid usage for brain tumor patients. All questions were developed by consensus of the Guideline Working Group. Results: The overall response rate was 12.8% (54/423). Regarding AED usage, the majority of respondents (95.2%) routinely prescribed prophylactic AEDs for patients with seizure at the peri/postoperative period. However, as many as 72.8% of respondents prescribed AED routinely for seizure-naive patients, and others prescribed AED as the case may be. The duration of AED prophylaxis showed wide variance according to the epilepsy status and the location of tumor. Levetiracetam (82.9%) was the most preferred AED for epilepsy prophylaxis. Regarding steroid usage, 90.5% of respondents use steroids in perioperative period, including 34.2% of them as a routine manner. Presence of peritumoral edema (90.9%) was considered as the most important factor determining steroid usage followed by degree of clinical symptoms (60.6%). More than half of respondents (51.2%) replied to discontinue the steroids within a week after surgery if there are no specific medical conditions, while 7.3% preferred slow tapering up to a month after surgery. Conclusion: The survey demonstrated the prevailing practice patterns on AED and steroid usage in neuro-oncologic field among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of brain tumor patients.

Views of Principals and General Education Teachers towards Inclusion for Kindergarteners with Disabilities

( Sang Bok Lee ),( Myung Ok Kwon ),( Wan Wo Lee ) 한국정서.행동장애아교육학회(구.한국정서학습장애아교육학회) 2005 정서ㆍ행동장애연구 Vol.21 No.4

본 연구는 B시에 소재하고 있는 사립유아교육기관의 운영자와 일반교사가 지니고 있는 장애(위험) 유아들의 통합교육에 대한 인식을 알아보고자 하였다. 현재 우리나라 유치원과정의 유아들에 대한 통합교육 필요사항들을 근거로 하여, 이전 연구에서 제시된 질문들을 재구성하여 그 타당도와 신뢰도를 점검한 설문지를 통하여 자료수집 되었다. 222명의 응답자들을 대상으로 수집된 자료분석의 결과, 유아교육기관의 운영자와 일반교사 대부분이 통합교육에 대해 긍정적인 인식을 나타내고 있음을 나타냈다. Inclusion is one of the more attention-getting issues on the current education. The current study was to examine the views of kindergarten principals and general education teachers towards inclusion for young children with disabilities. A sample of 222 participants(99 principals and 113 teachers) in B city of Korea were studied, using a survey questionnaire, their perception was analysed. The results showed positiveness towards inclusion in the respondents` views suggests practical readiness requires to be launched.

An InSb-based magnetoresistance biosensor for detecting liver cancer biomaker

Sung Jong Kim,Seung-Woo Lee,Young-Wan Kwon,Kyung-Jin Lee,Hyun Cheol Koo 한국자기학회 2019 한국자기학회 학술연구발표회 논문개요집 Vol.29 No.2

Evaluation of Mechanical Properties for Narrow-Gap Weld Zone in Reactor Coolant Loop

Kwon, Jae Do,Woo, Seung Wan,Lee, Choon Yeol,Kang, Suk Chull,Shin, Ho Sang Trans Tech Publications, Ltd. 2005 Key Engineering Materials Vol.297 No.-

<P>Conventionally, shield metal arc welding (SMAW) process was applied to join pipes of RCL, which caused lot of loss in time and cost due to excessive heat input and defects in joining section. Recently, narrow-gap welding (NGW) process was introduced to overcome the disadvantages of SMAW. However, the application of NGW to nuclear power plant is not yet common because safety of NGW process is not proven. In present paper, the welded coupons are manufactured under different welding processes in carbon steel. Then, microstructure observations and various mechanical tests are performed. It is verified that the mechanical properties of carbon steel are greatly changed after repair welding process due to applied heat flux, and that the effect of post-welding heat treatment is beneficial.</P>

A National Consensus Survey for Current Practice in Brain Tumor Management II: Diffuse Midline Glioma and Meningioma

Sung Kwon Kim,윤홍인,Wan-Soo Yoon,Jin Mo Cho,Jangsup Moon,Kyung Hwan Kim,김세훈,김영일,김영준,Ho Sung Kim,도윤식,박재성,Ji Eun Park,서영범,Kyoung-Su Sung,송진호,Chan Woo Wee,Se-Hoon Lee,임도훈,Jung Ho Im,장종희,한명훈,홍제범,Kihwan Hwan 대한뇌종양학회 2020 Brain Tumor Research and Treatment Vol.8 No.1

Background The Guideline Working Group of the Korean Society for Neuro-Oncology (KSNO) conducted a nationwide questionnaire survey for diverse queries faced in the treatment of brain tumors. As part II of the survey, the aim of this study is to evaluate the national patterns of clinical practice for patients with diffuse midline glioma and meningioma. Methods A web-based survey was sent to all members of the KSNO by email. The survey included 4 questions of diffuse midline glioma and 6 questions of meningioma (including 2 case scenarios). All questions were developed by consensus of the Guideline Working Group. Results In the survey about diffuse midline glioma, 76% respondents performed histologic confirmation to identify H3K27M mutation on immunohistochemical staining or sequencing methods. For treatment of diffuse midline glioma, respondents preferred concurrent chemoradiotherapy with temozolomide (TMZ) and adjuvant TMZ (63.8%) than radiotherapy alone (34.0%). In the survey about meningioma, respondents prefer wait-and-see policy for the asymptomatic small meningioma without peritumoral edema. However, a greater number of respondents had chosen surgical resection as the first choice for all large size meningiomas without exception, and small size meningiomas with either peritumoral edema or eloquent location. There was no single opinion with major consensus on long-term follow-up plans for asymptomatic meningioma with observation policy. As many as 68.1% of respondents answered that they would not add any adjuvant therapies for World Health Organization grade II meningiomas if the tumor was totally resected including dura. Conclusion The survey demonstrates the prevailing clinical practice patterns for patients with diffuse midline glioma and meningioma among members of the KSNO. This information provides a point of reference for establishing a practical guideline in the management of diffuse midline glioma and meningioma.

Effects of Gait Training Using Functional Electrical Stimulation on Stroke Patients' Balance and Gait Velocity

Kwon Young Kang,Wan Suk Choi,Ho Jung An,Ja Pung Koo,Joon Hee Lee,Young Dae Yun,Jung Sook Lee,Joung Youl Ju,Sang Bin Lee 국제물리치료학회 2011 Journal of International Academy of Physical Ther Vol.2 No.2

The purpose of this study is to examine the effects of gait training using functional electrical stimulation on the improvement of hemiplegic patients' functions for balance and gait velocity. The subjects of the experiment were determined to be 10 each hemiplegic patients who had been diagnosed with stroke or brain damage six months or longer earlier assigned to an experimental group and a control group respectively. The subjects were evaluated before the experiment using Tetrax and 10M gait tests, received gait training five times a week for four weeks using functional electrical stimulation and were evaluated after the experiment in the same method as used in the evaluation before the experiment. In order to examine differences between the experimental group that received gait training using functional electrical stimulation and the control group that was treated by functional electrical stimulation and received gait training thereafter, differences between before and after the experiment were analyzed using paired sample t-tests and differences in changes after the experiment between the experimental group and the control group were analyzed using independent sample t-tests in order to compare the two groups with each other. Experimental results showed significant differences in weight bearing, balance and gait velocity between before and after the experiment in the experimental group(p<.05). In the control group, whereas weight bearing and gait velocity did not show any significant difference between before and after the experiment(p>.05), balance showed significant differences(p<.05). Weight bearing, balance and gait velocity change rates showed significant differences between the experimental group and the control group(p<.05). In conclusion, it was indicated that gait training using functional electrical stimulation is effective for enhancing stroke patients' weight bearing rates, balance abilities and gait velocity.