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Neurological diseases such as Alzheimer, Parkinson, and ischemic stroke have increased in occurrence and become important health issues throughout the world. There is currently no effective therapeutic strategy for addressing neurological deficits after the development of these major neurological disorders. In recent years, it has become accepted that adult neural stem cells located in the subventricular and subgranular zones have the ability to proliferate and differentiate in order to replace lost or damaged neural cells. There have been many limitations in the clinical application of both endogenous and exogenous neurogenesis for neurological disorders. However, many studies have investigated novel mechanisms in neurogenesis and have shown that these limitations can potentially be overcome with appropriate stimulation and various approaches. We will review concepts related to possible therapeutic strategies focused on the perspective of neurogenesis for the treatment of patients diagnosed with Alzheimer disease, Parkinson disease, and ischemic stroke based on current reports.
Background: Recently, as an independent fracture factor from Bone mineral density (BMD), muscle weakness due to the fatty degeneration of thigh muscles have been attracting attentions as causes of hip fracture. The purpose of this study is to investigate the correlation between the body composition and BMD and fatty degeneration of thigh muscles of the female patients over 65 years old with osteoporotic hip fracture. Methods: This study was conducted with 178 female osteoporotic hip fracture patients. Total hip BMD was measured using dual energy X-ray absorptiometry. Cross-sectional area (CSA), cross-sectional muscle area (CSmA), muscle attenuation coefficient (MAC), and intramuscular adipose tissue (IMAT) of gluteus maximus, hip abductors, quadriceps and hamstring muscle were measured with computed tomography. Normalized IMAT (nI- MAT) was calculated by dividing the fat area in the muscle into the size of each muscle. The correlation between each measurement is examined then the differences between the intertrochanteric fracture group and the femoral neck fracture group were analyzed. Results: CSmA and MAC of quadriceps were the largest and nIMAT was the lowest. CSA and CSmA of the four muscles showed a statistically significant positive correlation with weight, height, body mass index (BMI), and BMD. MAC of 2 gluteal muscles was positively correlated with weight, BMI and BMD. nIMAT of all four muscles was positively correlation with weight and BMI but nIMAT of 2 mid-thigh muscles was positively correlation with BMD. Conclusions: Muscle size and fatty degeneration in the thigh muscles were most positively correlated with the body weight. BMD was positively correlation with CSA and CSmA of all thigh muscles, and MAC of 2 gluteal muscles and fatty degeneration of 2 mid-thigh muscles. There was no statistically significant difference in the size of the femoral muscle and the degree of fatty degeneration between the two fracture groups.
This study analyzed the effect of housing price changes on the performance of Korean regional banks using DOLS model. The analysis shows that housing price changes does not have a statistically significant effect on the loan growth, profitability and soundness of regional banks. Among macroeconomic variables, only short-term interest rates have a significant positive effect on any model. This means that a rise in short-term interest rates significantly increases loans by regional banks, which leads to a significant increase in profitability, but has a significant negative impact on soundness. On the other hand, bank characteristics variables are found to have a significant negative effect on the loan growth, profitability and soundness of Korean regional banks. 본 연구는 주택가격의 변화가 우리나라 지방은행의 경영성과에 미치는 영향을 DOLS 모형을 이용하여 분석하였다. 분석 결과, 주택가격변동률은 지방은행의 성장성, 수익성 및 건전성에 모두 통계적으로 유의한 영향을 미치지 못하는 것으로 나타났다. 거시경제변수 중에서 단기금리만이 어떠한 모형에서도 유의한 양(+)의 영향을 미치는 것으로 나타났다. 이는 단기금리가 상승하면 지방은행이 대출을 유의하게 증가시키고 이는 수익성의 유의한 증가를 가져오지만 건전성에는 유의한 부정적 영향을 미치는 것을 의미한다. 반면에 은행특성변수들은 대부분 지방은행의 성장성, 수익성 및 건전성에 유의한 음(-)의 영향을 미치는 것으로 나타났다.
Recently, traffic congestion is intensifying as tourists, who use a rental car, increase in a tourist city such as Jeju Island. To alleviate this issue, it is necessary to make tourism easier using public transportation. To achieve this purpose, it is crucial to understand the detailed characteristics of the previous tourists, who used public transportation, through the analysis of public traffic card data. However, since the traffic card data is encrypted, there is no attribute to identify tourists among passengers. To tackle this problem, this work proposes a method for recognizing tourists from the encrypted transportation card data. Specifically, our proposed approach shows that considering types of access to the tourist city improves the tourist identification accuracy. Extensive experiments were conducted with the public transportation card data of Jeju island. As a result, we confirmed that the proposed method achieves higher accuracy of tourist identification, compared with the previously related research. 최근 제주와 같은 관광도시에서 렌터카를 이용한 관광객이 증가함에 따라, 교통 체증 문제가 더욱 가속화되고 있다. 이러한 문제의 완화를 위해, 대중교통 기반의 관광 활성화가 중요하다. 우선 교통카드 데이터 분석을 통해 기존 대중교통 관광객의 특성을 이해하는 것이 필요하다. 다만, 교통카드 데이터는 암호화되어 있어 승객 중에서 관광객을 식별하기 위한 속성을 제공하지 않는다. 이를 해결하기 위해 본 논문은 이러한 암호화된 교통카드 데이터에서 승객의 관광객 여부를 식별하는 알고리즘을 제안한다. 특히, 본 연구에서는 관광도시 출입 유형을 고려하여 교통카드 데이터에서 관광객의 식별 정확도를 향상할 수 있음을 보여준다. 제안 방법은 2019년 제주지역 교통카드 데이터를 이용하여 검증하였다. 그 결과, 제안하는 방식이 기존의 방식에 비해 더 나은 관광객 식별이 가능한 것을 확인하였다.
The problem of Self is most crucial in understanding of Whitman's poetry. The purpose of this paper is to study Whitman's concept of good and evil on the basis of his Self in the light of Vedantic philosophy. Both Whitman and Vedantic mystics believe that there are two selves in them, Me(the real self) and not-Me. The real self, atman in Vedantic philosophy, is impregnable, immortal, immutable, non-dual, free and pure and is identical with the Absolute. When man realizes that the real self is identified with the Absolute, he liberates. After this realization, he is free from all the dualism, such as good and evil, matter and spirit, subject and object, and sensible and suprasensible. Whitman makes contradictory statements regarding evil in his poems. In one and the same breath he denies evil and insists that evil is not delusion. Like Vedantists, Whitman seems to recognize two distinct planes of existence―the one phenomenal, the other metaphysical. The former is the point of view of "the developed soul" and the latter is that of the undeveloped individual. While to the developed soul evil has no reality and is only maya, to the undeveloped evil has reality. Whitman, the developed soul, denies evil only from the point of view of knowlege, though from the point of view of ignorance he concedes that there is evil. While evil is invalid with reference to Whitman and his soul is unaffected by moral distinctions and suffering in the world around him, evil has a reality to ordinary men. Whitman expresses both points of view in his poems. This is why Whitman accepts and denies evil at the same time and he stands indifferent to both good and evil.