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유능수,남윤수,이정완,이명재 강원대학교 산업기술연구소 2005 産業技術硏究 Vol.25 No.B
Two methods, the bin averaging method and least square method, are often used in calibrating wind turbine test sites. The objective of this work was to determine a better method to predict the wind speed at wind turbine installing point. The calibration was done at the test site on a complex terrain located in Daegwallyeong, Korea. It was performed for two different cases based on the IEC 61400-12 power performance measurement standard. The wind speeds averaged for 10 minutes ranged between 4 m/s and 16 m/s. The wind-direction bins of each meteorological mast were 10 degrees apart, and only the bins having data measured for more than 24 hours were employed for the test site calibration. For both cases, the two methods were found to yield almost same results which estimated real wind speed very closely.
Engineered iron oxide nanoparticles to improve regenerative effects of mesenchymal stem cells
Wan Su Yun,Susmita Aryal,Ye Ji Ahn,서영준,Jaehong Key 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.2
Mesenchymal stem cells (MSCs) based therapies are a major fi eld of regenerative medicine. However, the success of MSCtherapy relies on the effi ciency of its delivery and retention, diff erentiation, and secreting paracrine factors at the targetsites. Recent studies show that superparamagnetic iron oxide nanoparticles (SPIONs) modulate the regenerative eff ects ofMSCs. After interacting with the cell membrane of MSCs, SPIONs can enter the cells via the endocytic pathway. The physicochemicalproperties of nanoparticles, including size, surface charge (zeta-potential), and surface ligand, infl uence theirinteractions with MSC, such as cellular uptake, cytotoxicity, homing factors, and regenerative related factors (VEGF, TGF-β1). Therefore, in-depth knowledge of the physicochemical properties of SPIONs might be a promising lead in regenerativeand anti-infl ammation research using SPIONs mediated MSCs. In this review, recent research on SPIONs with MSCs andthe various designs of SPIONs are examined and summarized.
Yun, Wan Su,Choi, Jin Sil,Ju, Hyun Mi,Kim, Min Hee,Choi, Seong Jin,Oh, Eun Seol,Seo, Young Joon,Key, Jaehong MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.5
<P>Intranasal delivery of mesenchymal stem cells (MSCs) to the olfactory bulb is a promising approach for treating olfactory injury. Additionally, using the homing phenomenon of MSCs may be clinically applicable for developing therapeutic cell carriers. Herein, using superparamagnetic iron oxide nanoparticles (SPIONs) and a permanent magnet, we demonstrated an enhanced homing effect in an olfactory model. Superparamagnetic iron oxide nanoparticles with rhodamine B (IRBs) had a diameter of 5.22 ± 0.9 nm and ζ-potential of +15.2 ± 0.3 mV. IRB concentration of 15 µg/mL was injected with SPIONs into MSCs, as cell viability significantly decreased when 20 μg/mL was used (<I>p</I> ≤ 0.005) compared to in controls. The cells exhibited magnetic attraction in vitro. SPIONs also stimulated CXCR4 (C-X-C chemokine receptor type 4) expression and CXCR4-SDF-1 (Stromal cell-derived factor 1) signaling in MSCs. After injecting magnetized MSCs, these cells were detected in the damaged olfactory bulb one week after injury on one side, and there was a significant increase compared to when non-magnetized MSCs were injected. Our results suggest that SPIONs-labeled MSCs migrated to injured olfactory tissue through guidance with a permanent magnet, resulting in better homing effects of MSCs in vivo, and that iron oxide nanoparticles can be used for internalization, various biological applications, and regenerative studies.</P>
Virus Isolation from the First Patient with SARS-CoV-2 in Korea
Wan Beom Park,권낙중,Su Jin Choi,강창경,Pyoeng Gyun Choe,Jin Yong Kim,Jiyoung Yun,Gir-Won Lee,성문우,Nam Joong Kim,서정선,Myoung-don Oh 대한의학회 2020 Journal of Korean medical science Vol.35 No.7
Novel coronavirus (SARS-CoV-2) is found to cause a large outbreak started from Wuhan since December 2019 in China and SARS-CoV-2 infections have been reported with epidemiological linkage to China in 25 countries until now. We isolated SARS-CoV-2 from the oropharyngeal sample obtained from the patient with the first laboratory-confirmed SARS- CoV-2 infection in Korea. Cytopathic effects of SARS-CoV-2 in the Vero cell cultures were confluent 3 days after the first blind passage of the sample. Coronavirus was confirmed with spherical particle having a fringe reminiscent of crown on transmission electron microscopy. Phylogenetic analyses of whole genome sequences showed that it clustered with other SARS- CoV-2 reported from Wuhan.
Vaginal sling implant misdiagnosed as rectal subepithelial tumor
( Su-mi Kim ),( Ji-suk Han ),( Jin-wan Park ),( Jong-soo Kim ),( Hwan Namgung ),( Yun-dan Kang ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.4
As cosmetic procedures receive increasing attention from the media, female genital cosmetic surgery (FGCS) has become quite popular in Korea. The safety and efficacy of these surgeries and procedures have yet to be thoroughly documented. We report a case of a 47-year-old woman who underwent a vaginal sling implantation, which resulted in the misdiagnosis of a rectal subepithelial tumor during endoscopic mucosal resection (EMR). This patient suffered an iatrogenic rectal perforation during the EMR, which necessitated an exploratory operation. The sling implant was removed via the vaginal approach, and a primary repair of the vaginal and rectal walls was performed. The patient subsequently showed no sign of complication at her 6-month follow-up. Patients need to be educated about the importance of reporting a history of FGCS prior to undergoing surgical or endoscopic procedures. Also, physicians have to check the medical history of patient thoroughly to avoid misdiagnoses and unnecessary treatment.
( Su Mi Kim ),( Yun Dan Kang ),( Jin Wan Park ),( Choong Hak Park ),( Jong Soo Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: We investigated the effect of radachlorin-mediated PDT on invasion, vascular formation as well as apoptosis by targeting EGFR/VEGFR2 signaling pathways in HEC-1-A endometrial adenocarcinoma cell line. 방법: To investigate the apoptotic pathway, we performed the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay, TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay, and Western blot analysis. Also, we evaluated the effects of PDT on tubular capillary formation and invasion in HEC-1-A cells with a tube formation assay, invasion assay, prostaglandin E2 (PGE2) assay, and Western blot analysis. 결과: PDT had anti-cancer effects on HEC-1-A through activation of the intrinsic pathway of apoptosis via caspase- 9 and PARP. PDT also inhibited tubular capillary formation and invasion of HEC-1-A under VEGF pretreatment, which resulted from down-regulation of VEGFR2, EGFR, RhoA and PGE2. Interestingly, tube formation, invasion assay, and Western blot analysis of caspase-9 and PARP results showed strong anti-cancer effects on VEGF pretreatment, indicative of the specificity of radachlorin-mediated PDT to VEGF. 결론: PDT had anti-cancer effects on HEC-1-A human endometrial adenocarcinoma cell line, through activation of the intrinsic pathway of apoptosis via caspase-9 and PARP. PDT also inhibited tubular capillary formation and invasion of HEC-1-A under VEGF pretreatment, which resulted from down-regulation of VEGFR2, EGFR, RhoA, and PGE2. different signaling pathways were modulated in radachlorin-mediated PDT. Firstly, the angiogenic pathway was suppressed by inhibition of VEGFR2, EGFR, PGE2, and RhoA. Secondly, intrinsic apoptosis was activated via caspase- 9 and PARP.