심한 골병변으로 발현된 기능성 낭종성 부갑상선 선종

전숙,김영희,박지영,고관표,박철영,김덕윤,우정택,김성운,김진우,김영설,고석환 대한내분비학회 2003 Endocrinology and metabolism Vol.18 No.2

낭종성 부갑상선 선종과 심한 골병변을 동반한 부갑상선 기능항진증은 매우 드문 질환으로서, 저자들은 양측 고관절의 통증을 초기 주소로 내원한 환자에서 고칼슘혈증과 부갑상선 호르몬 증가, 골병변의 방사선적 소견을 통해 부갑상선 기능항진증을 진단하고, 경부 초음파와 컴퓨터 단층 촬영, 부갑상선 스캔검사 및 수술중 부갑상선 낭종액 검사 등을 통해 기능성 부갑상선 낭종의 한 종류인 낭종성 부갑상선 선종을 진단하고 수술적 제거를 통하여 정상화된 1예를 경험하였다. A cystic parathyroid adenoma is rare. A case of primary hyperparathyroidism, with the cystic formation of a parathyroid adenoma and a severe bony lesion, is reported. A 52-year-old male was admitted due to pain in both hips and for evaluation of hypercalcemia. The plasma level of the intact parathyroid hormone (iPTH) was elevated to 1424 pg/mL. Ultrasonography and the computed tomography revealed a parathyroid cyst on the left thyroid lower pole. Parathyroid scintigraphy detected a parathyroid adenoma. A radiograph showed a subperiosteal bone resorption on the phalanges, and a brown tumor (osteitis fibrosa cystica) on the femur shaft was noted. A surgical excision of the parathyroid adenoma was performed. The PTH level in the cystic fluid was increased. A histological examination confirmed a cystic parathyroid adenoma. The PTH level was normalized after the operation (J Kor SOC Endocrinol 18:214-220, 2003).

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이

남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.

Asphalt로 피복된 Portland Cement를 使用한 Concrete의 諸性質

尹錫天,李昌甲,洪元杓,鄭秀永,南宰鉉 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1

The construction works with concrete has the potential problems of water tightness. The conventional treatments for water-tight concrete are not satisfactory in terms of strength and water tightness. This study was to investigate the effects and application of the asphalt-coated portland cement on water-proof of the concrete and its influences on the physical properties of the concrete. The asphalt-coated portland cement, which is hereafter referred to as ACPC, was made by coating ordinary portland cement with asphalt in the rate of weight ranging from 0.5 to 1.0 percent. In this process, Calcium Chloride and Sodium Silicate were tried as the hardening time accelerator for producing ACPC, and carbon black, talc and other materials were tested for their effectiveness as pore filler. The specimens were prepared and tested with the various amounts of additives as a variable factor to find the optimum material. The analysis was mainly focused at water tightness, physical properties of the concrete and working conditions. The major findings of this experiment are as follows ; 1) Water-proof Test ① The specimens of ACPC and ordinary portland cement(OPC) were tested under the pressures of 3 and 9 kilograms per square centimeter per 24hours respectively and compared. The OPC specimens showed considerable amount of leakaged water while the ACPC specimens were rated lower permeabilities of 89%/28days, 40%/56days and21%/84days under the abovementioned pressure conditions. The most successful composition for water-proof was identified as ACPC added with Calcium Chloride and carbon black. ② The ACPC demonstrated its superiority in absorption test. The absorption amount of OPC for l hour was greater than that of ACPC for 24hours. 2) Compressive Strength Test Four kinds of specimens of ACPC aging 7, 28, 56 and 84days were tested and compared for their respective results of OPC. The ACPC added with carbon black was lower than OPC in compressive strength in the case of curing ages of 7 and 28days but ACPC was superior to the OPC in the specimens aging 56 and 84days. The ACPC added with others except carbon black exposed their lower compressive strength in all circumstances compared with the OPC specimens. 3) Slump Test The slump of ACPC with various additives such as carbon black, talc or clay was 21.6 centimeter which was higher than the OPC of 18.4centimeter slump. This result concluded that ACPC was much favorable in workability in comparison with that of the OPC. The conclusions are summarized as follows; 1) The optimum mixture for water tightness and compressive strength of concrete was found at 0.5% of SACPC, Calcium Chloride and carbon black respectively at the rate of the weight of cement.

마이크로 프로세서에 의한 自己制御형 永久磁石 同期 電動機의 驅動 및 運轉 特性의 改善

윤병도,김윤호,김일환,이용석 중앙대학교 기술과학연구소 1989 기술과학연구소 논문집 Vol.19 No.-

전력 전자 공학의 발달에 의해 영구자석 동기전동기의 운전 분야가 대단히 진보되고 있음이 최근 논문을 통해서 보고 되고 있다. 영구자석 동기전동기는 크기와 중량의 감소로 인한 장점, 회전자의 동손이 없으므로 효율이 높다는 장점이 있어 각종 분야의 응용에 유리하다. 본 연구는 마이크로프로세서와 전압원 인버터를 사용한 자기제어형 영구자석 동기전동기의 구동장치를 제안한다. 영구자석 동기전동기의 운전은 고정자 전류와 역기전력을 동기화 시킴으로서 가능하게 한다. 고 분해능의 인크리멘탈 엔코더를 사용하여 영구자석 동기전동기에 적합한 자기제어형 PWM. 인버터 설계를 가능하게 하였다. 저속 영역에서 토오크 리플을 감소 시키기 위해 펄스 수를 제어하였으며 운전중 최적 부하각의 제어는 토오크-속도 특성을 개선시킴을 검토 하였다. Recent research has indicated that the permanent magnet synchronous motor(PMSM) drives are considerably improved by the development of power electronics. The PMSMs are favoured in many applications as there are advantages in size and weight reduction, and in efficiency due to elimination of the field copper losses. This paper presents a Self-Controlled PMSM, fed by voltage suource inverter based on the microprocessor. The proper operation of the PMSM can be ensured only if the stator current is always synchronized with is Back-EMF. The use of incremantal encoder with high resolution makes it possible to design a Self-Controlled PWM inverter for a PMSM. The pulse ratios are controlled to reduce the torque ripple in the low-speed drive region. In addition, torque-speed characteristics are improved by the control of optimal load angle.

丹溪의 學術思想이 韓方婦人科學에 미친 影響의 考察

윤종원,오규석,홍영욱,이태균 동국대학교 한의학연구소 1997 東國韓醫學硏究所論文集 Vol.6 No.1

金元四大家 중의 한 사람인 朱震亨은 主火論의 영향을 받았지만 독창적인 "相火論"과 "陰不足而陽有餘"하다는 견해를 밝히면서 補驗精而抑相火를 위주로한 治法을 제창하여 後代에 "滋陰派"라고 불리운다. 이러한 丹溪의 醫學思想과 韓方婦人科學과 관련된 이론을 개괄하여 丹溪의 이론과 처방이 우리나라 韓方 婦人科學의 발전과정에 미친 영향을 고찰하였다. 그 결과 첫째, 丹溪의 證治思想의 특징은 祛濕痰, 調氣, 滋陰淸熱의 治法 運用과 禁慾的 攝生을 통한 養生論이었으며, 둘째로 丹溪의 理論과 處方들은 《醫方類聚》와 《東醫寶鑑》에서 《丹溪心法》과 《丹溪心法附餘》의 내용을 대폭 수용함으로써 우리나라 韓方婦人料學 理論의 주요한 부분을 형성하는 계기가 되었으며, 셋째로, 부인과 질환과 관련하여 月經病에 調氣 및 祛濕痰을, 不姙症에는 月經不調와의 關聯性은 물론 體型ㆍ體質別 病機와 治法을 구분하였으며, "産前當淸熱養血" 이론에 의한 黃芩·白朮을 위주로 한 安胎論, "從痰論治"한 惡阻治法, 難産豫防, 産後의 "大補氣血"등의 이론을 제시하여 丹溪의 학술사상이 우리나라 한방부인과학에 미친 영향은 많았던 것으로 사료된다. JuJinHyoung(朱需亨) is a well-known physcian of the four schools in the Jin(金) and Yuan(元) Dynasties. He lived in ZhejiangSheng(浙江省) which located in the southeast region of China. There was humid and heatful climate, this kinds of environments influenced to his medical thoughts. He persisted in the theory that Yang is ever in excess while Yin is ever deficient(陽常有餘陰不足論) and exhorted the therapy of subduing excessive Yang and making up deficient Yin by nourishing it, and he said about the theory of ministerial fire(相火論). So he was regarded as a representative of the nourishing Yin school(濫陰派). And he said that the method of "Clearing away heat and nourishing blood" is suitable in pregnanoy. So Scutellaria Baicalensis GEORGI and Atractylodes macrocephala KOIDZ. Can be apply in case of treatment on Anti-abortion. Thus these theories have influenced on Obstetric & Gynecology in Korea.

ZrO₂- 8m/ oY₂O₃- Bi₂O₃3성분계의 분말특성 및 소결체특성

윤종석,이희수,오영제 연세대학교 산업기술연구소 1990 논문집 Vol.22 No.2

The properties of the powder and the sintered body of ZrO₂- 8m/ oY₂O₃- Bi₂O₃prepared by copreciptitation method were investigated. The crystallization temperatures of the powder were increased with increasing of amount of bismuth, and the agglomeration was developed by the increasing of calcination temperatures. The sinterability was increased with the amount of Bi₂O₃added which caused liquid phase, and the deterioration of the thermal expansions and the electrical properties were happened. The electrical properties of 8YZB system were that the electrical conductivity was from ?? and the oxygen ion transference number was from 0.75 to 0.92.

Ethanol을 전처치한 흰쥐의 간 및 혈청 Xanthine Oxidase 활성에 미치는 Bromobenzene의 영향

윤종국,임영숙 동아시아식생활학회 1997 동아시아식생활학회지 Vol.7 No.1

To evaluate the effect of ethanol pretreatment on the liver and serum xanthine oxidase(XO) actively, the bromobenzene(400㎎/㎏ body wt., i.p.) was orally given 3 times daily to the Sprague-Dawley male rats pretreated with 5% ethanol throughout 2 months. Bromobenzene treated rats pretreated with ethanol showed the more decreased activity of serum and liver XO. and lower value of V_(max) than those of only bromobenzene treated rats. By the bromobenzene treatment, ethanol pretreated rats showed the more decreased levels of serum alanine aminotransferase activity and liver weight/body weight(%), and decreased degree of liver damage on histopathological observation than the control group.

흰쥐 경동맥 풍선손상 모델에서 리포좀 전달체를 이용한 에스트로겐의 국소전달 효과

윤영섭,장양수,정광회,박요석,김형관,강웅철,권진욱,정보영,조상호,김성순 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

首都圈 衛星都市의 住民福祉向上을 위한 市議會와 行政機關의 役割에 관한 硏究 : Centering Around Koyang-Shi Kyung Ki-Do Area. (京畿道 高揚市를 中心으로)

윤석달,박오화,함영훈,황정룡,허희영 한국항공대학교 1993 論文集 Vol.31 No.-

地方化時代의 到來로 高揚市는 많은 變化가 豫想되고 있다. 1980年부터 繼續的으로 論議되던 地方自治의 問題가 지금은 現實化되어 1991年 4月에는 基礎地方自治의 議會를 構成하고 6月에는 廣域自治團體의 議會를 構成하였고 머지않은 將來 에 地方自治團體의 長을 選出할 豫定이다. 앞으로 많은 施行錯誤가 있을 수 있겠으나 地方自治時代에 돌입한 것은 누구 도 否認 할 수 없는 사실이다. 1997年경의 住民構成은 1990年代初期의 高揚市에 居住하고 있던 原住民과 一山을 포함한 新高揚 開發地域에 90萬의 新 入住者로 구성될 것이며, 이러한 高揚市 住民構成의 變化는 地方自治에 커다란 衝擊要因으로 작용될 것이다. 新.原住民의 要求를 調和하는 問題는 여러 形態로 나타날 수 있으나 住民福祉라는 側面이 매우 강하게 대두될 것이다. 高揚市의 福祉活動은 生活保護者들을 위한 특수한 경우를 제외하고는 거의 전무한 상태이다. 地方自治制度가 어느정도 安定的인 국면으로 접어들면, 地域的 次元에서 市民 모두를 위한 福祉活動이 深度있게 展開되어야 할 것이다. 市行政機 關과 市議會는 兒童福祉, 婦女福祉, 老人福祉및 醫療福祉에 대한 現況울 把握하고 이에 대한 해결의 優先順位를 결정하 여 다가오는 人口의 增加에 따른 福祉需要를 충족시켜 나가야 할 것이다. 福祉需要에 대한 優先順位를 硏究者들이 제시하여 보면 託兒施設과 더불어 綜合病院施設을 擴充하여 市民들에게 奉仕 하는 태세를 體系化하여야 할 것이며 그밖에는 施設을 擴充하는 方式보다는 年齡과 性別 및 職業 등의 基準에 맞게 "프 로그램"을 積極的으로 開發하는 努力이 경주되어야 할 것이다. 그러으로써 量的인 意味에서 뿐만이 아니라 質的인 意味 에서 福祉活動을 展開할 수 있는 基盤을 造成할 수 있을 것이다. It is expected that Koyang City have lots of changes according to the emergence of Decentralization era. Nowdays local self-government has been realized since its disscussion in 1980. On april, 1991, the assembly of basic self-government was established, and the assembly of extensive self-government constructed on june, 1991. The chairman of local-government assembly is supposed to be elected in the new future. None can deny the beginning of local-government era inspite of potential trial and errors. Population structure in 1997 is expected to be composed of the existing civilians of Koyang City in early 1990's and about 0.90millions of new comers in new cities including llsan area, and he change of the city population will significant impacts on the self-government scheme of Koyang City. The problem to coordinate desires of existing civilians and that of new comers might be embodied in many kinds of aspects, but welfare-raising will be strengthed first of all. Existing welfare programme of Koyang City dosen't show any signigicant activities except the case of Green Card programme. It is desirable that whole-sideed welfare programme be perfomed by local levels in the stage of staionary self-government systems. Administrative institutions and assembly of city should survey and research the present situations of children welfare, female welfare, the old age welfare, and medical welfare, and decide their priorities to meet increasing desires coming from rapid increase of city-population. We, researchers, propose several outstanding problems by priority as follows; to expand medical institutions and public nursery schools accompanies by strenthening the attitude of government employees for public service, to develop various programmes in order to activate many exiting institutions more efficiently rather than to build new institutions needed, in consideration of ages, sex and occupations of their users. If these propositions accomplished the welfare programme will have cornerstone to enrich its activities as well as activities as well as enlarge it bounderies.