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Study on the Closure Time in Healthy Small-Breed Dogs by Platelet Function Analyzer-200
Ul Soo Choi 한국임상수의학회 2023 한국임상수의학회지 Vol.40 No.5
Platelet function evaluation by PFA-100 or -200 has been known to be objective and sensitive for assessing platelet function and dysfunction of Von Wil- lebrand Factor in humans and dogs. However, using the C/EPI cartridge in dogs is controversial. This study aimed to establish a reference range for PFA closure time in healthy small breed dogs (body weight < 10 kg) and to evaluate the effective- ness of both C/ADP and C/EPI cartridges for these dogs. Citrated blood samples were collected from 50 clinically healthy small breed dogs that were admitted for presurgical procedures or health checkups, and closure times were measured using the PFA-200. Reference ranges were determined as 42-144 s (median 67 s, mean 71.2 s, SD ± 21.2 s, 95% RI 43-140 s) , for CT-C/ADP and 41-200 s (median 87, mean 91.2 s, SD ± 31.8 s, 95% RI 44-195 s) for CT-C/EPI. The present study demonstrated that the reference ranges for PFA closure times in small breed dogs are in line with existing reference ranges. The utilization of C/ADP cartridg- es is the preferred choice for evaluating platelet function in small breed dogs. However, due to variable responses of epinephrine to platelet aggregation in dogs, caution should be exercised when using C/EPI cartridges.
Choi, Ul Soo,Labelle, Philippe,Kim, Sehoon,Kim, Jury,Cha, Jaegwan,Lee, Ki Chang,Lee, Hae-Beom,Kim, Nam-Soo,Kim, Min-Su Blackwell Publishing Ltd 2010 Veterinary ophthalmology Vol.13 No.2
<P>Abstract</P><P>A 10-year-old intact male Yorkshire Terrier was referred for investigation of a large raised and nonpainful corneal lesion oculus dexter. Clinical examination revealed a pale, translucent corneal mass, which occupied half of the corneal surface and measured 11 mm × 11 mm × 13 mm. The mass was removed by superficial keratectomy and equine amniotic membrane (AM) was transplanted into the large corneal defect to cover the wound and provide tectonic support for the remaining cornea. The mass was histologically confirmed as a corneal epithelial inclusion cyst. There was no evidence of recurrence or complication at the surgical site 100 days postoperatively. Corneal epithelial inclusion cysts are uncommon in dogs. Although superficial keratectomy is the recommended treatment for corneal inclusion cyst, the combination of superficial keratectomy and AM transplantation had to be considered as an alternative for repair of large corneal defects. This is the first case report of the combined application of AM and superficial keratectomy to successfully treat a corneal inclusion cyst in a dog.</P>
Soo-Hee Choi,Seung Chan An,Ul Soon Lee,Je-Yeon Yun,Joon Hwan Jang,Do-Hyung Kang 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.4
Objective: Meditation can elicit trait-like changes in psychological and social styles, as well as enhancement of emotional regulatory capacity. We investigated the relation between personality traits and emotional intelligence in meditation practitioners. Methods: Seventy-two long-term practitioners of mind-body training (MBT) and 62 healthy comparative individuals participated in the study. The participants completed emotional intelligence questionnaires and the Myers-Briggs Type Indicator (MBTI). Results: The MBT group revealed higher scores on all five emotional intelligence factors than did those in the control group, such as emotional awareness and expression, empathy, emotional thinking, emotional application, and emotional regulation (all p≤0.001). MBT practitioners also had higher scores on the intuition of perceiving function (t =−2.635, p =0.010) and on the feeling of the judging function (t =−3.340, p =0.001) of the MBTI compared with those in the control group. Only the MBT group showed a robust relationship with every factor of emotional intelligence and MBTI-defined intuitive styles, indicating that higher scores of emotional intelligence were related to higher scores for intuition. Conclusion: Emotional intelligence of meditation practitioners showed notable relationships with some features of personality trait. In-depth associations between emotional intelligence and personality traits would help to foster psychological functions in meditation practitioners.
Regulation of PDGF signalling and vascular remodelling by peroxiredoxin II
Choi, Min Hee,Lee, In Kyung,Kim, Gyung Whan,Kim, Bang Ul,Han, Ying-Hao,Yu, Dae-Yeul,Park, Hye Sun,Kim, Kyung Yong,Lee, Jong Seo,Choi, Chulhee,Bae, Yun Soo,Lee, Byung In,Rhee, Sue Goo,Kang, Sang Won Nature Publishing Group 2005 Nature Vol.435 No.7040
Platelet-derived growth factor (PDGF) is a potent mitogenic and migratory factor that regulates the tyrosine phosphorylation of a variety of signalling proteins via intracellular production of H<SUB>2</SUB>O<SUB>2</SUB> (refs 1, 2–3). Mammalian 2-Cys peroxiredoxin type II (Prx II; gene symbol Prdx2) is a cellular peroxidase that eliminates endogenous H<SUB>2</SUB>O<SUB>2</SUB> produced in response to growth factors such as PDGF and epidermal growth factor; however, its involvement in growth factor signalling is largely unknown. Here we show that Prx II is a negative regulator of PDGF signalling. Prx II deficiency results in increased production of H<SUB>2</SUB>O<SUB>2</SUB>, enhanced activation of PDGF receptor (PDGFR) and phospholipase Cγ1, and subsequently increased cell proliferation and migration in response to PDGF. These responses are suppressed by expression of wild-type Prx II, but not an inactive mutant. Notably, Prx II is recruited to PDGFR upon PDGF stimulation, and suppresses protein tyrosine phosphatase inactivation. Prx II also leads to the suppression of PDGFR activation in primary culture and a murine restenosis model, including PDGF-dependent neointimal thickening of vascular smooth muscle cells. These results demonstrate a localized role for endogenous H<SUB>2</SUB>O<SUB>2</SUB> in PDGF signalling, and indicate a biological function of Prx II in cardiovascular disease.
Dosimetry of a new P-32 ophthalmic applicator.
Choi, Chang Heon,Han, Hyon Soo,Son, Kwang-Jae,Park, Ul Jae,Lee, Jun Sig,Wee, Won Ryang,Ha, Sung Whan,Kim, Il Han,Ye, Sung-Joon The American Association of Physicists in Medicine 2011 Medical physics Vol.38 No.11
<P>The potential of P-32 ophthalmic applicator irradiation after pterygium excision has been demonstrated as an alternative to Sr???Y-90 irradiation. This study aimed to provide the clinical dosimetry for this new applicator.</P>
Park, Surim,Choi, Ul Soo,Kim, Eun Ju,Lee, Jong Hyun,Lee, Hae Beom,Cho, Ho Seong,Kim, Wonil,Lim, Chae Woong,Kim, Bumseok WILDLIFE DISEASE ASSOCIATION 2016 Journal of wildlife diseases Vol.52 No.2
<P>We describe coinfection with Hepatozoon sp. and canine distemper virus (CDV) in a yellow-throated marten (Martes flavigula koreana). We found Hepatozoon cysts in muscular tissue and viral inclusion bodies in the brain. Hepatozoon sp., and CDV was confirmed in blood and brain, respectively, by PCR.</P>
Epitheliotropic cutaneous lymphoma (mycosis fungoides)in a dog
윤화영,방동하,Ul Soo Choi,김민규,Eun-Hwa Choi,Min-Soo kang,황철용,김대용,이창우 대한수의학회 2006 Journal of Veterinary Science Vol.7 No.1
A seven-year-old castrated male Yorkshire terrier dog was presented for a recurrent skin disease. Erythematous skin during the first visit progressed from multiple plaques to patch lesions and exudative erosion in the oral mucosa membrane. Biopsy samples were taken from erythematous skin and were diagnosed with epitheliotropic T cell cutaneous lymphoma by histopathology and immunochemical stain. In serum chemistry, the dog had a hypercalcemia (15.7 mg/dl) and mild increased alkaline phosphatase (417 U/l). Immunohistochemistry was performed to detect parathyroid hormone-related peptide (PTH-rP) in epitheliotropic cutaneous lymphoma tissues but the neoplastic cells were not labeled with anti-PTH-rP antibodies. The patient was treated with prednisolone and isotretinoin. However, the dog died unexpectedly.