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Chen-Ming Chen,Ming-Hua Chung,Tsung-Eong Hsieh,Bohr-Ran Huang,Huai-En Hsieh,Fuh-Shyang Juang,Yu-Sheng Tsai,Mark O. Liu,Jen-Lien Lin 한국물리학회 2009 Current Applied Physics Vol.9 No.4
The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation. The lifetimes of organic light emitting diodes (OLEDs) have been successfully enhanced with the modulation of LiF thickness and the utilization of encapsulating adhesives, which have been successfully and quickly synthesized with UV irradiation. Experimental results demonstrate that LiF and lab-made encapsulating adhesives can block the invasion of moisture as well as oxygen in the atmosphere into the OLEDs so that the lifetimes of devices with their encapsulation are 18-folds longer than those without encapsulation.
Tsai Yu-Chen,Cheng Tai-Shan,Liao Hsiu-Jung,Chuang Ming-Hsi,Chen Hui-Ting,Chen Chun-Hung,Zhang Kai-Ling,Chang Chih-Hung,Lin Po-Cheng,Huang Chi-Ying F. 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6
BACKGROUND: Extracellular vesicles (EVs) are derived from internal cellular compartments, and have potential as a diagnostic and therapeutic tool in degenerative disease associated with aging. Mesenchymal stem cells (MSCs) have become a promising tool for functional EVs production. This study investigated the efficacy of EVs and its effect on differentiation capacity. METHODS: The characteristics of MSCs were evaluated by flow cytometry and stem cell differentiation analysis, and a production mode of functional EVs was scaled from MSCs. The concentration and size of EVs were quantitated by Nanoparticle Tracking Analysis (NTA). Western blot analysis was used to assess the protein expression of exosomespecific markers. The effects of MSC-derived EVs were assessed by chondrogenic and adipogenic differentiation analyses and histological observation. RESULTS: The range of the particle size of adipose-derived stem cells (ADSCs)- and Wharton’s jelly -MSCs-derived EVs were from 130 to 150 nm as measured by NTA, which showed positive expression of exosomal markers. The chondrogenic induction ability was weakened in the absence of EVs in vitro. Interestingly, after EV administration, type II collagen, a major component in the cartilage extracellular matrix, was upregulated compared to the EV-free condition. Moreover, EVs decreased the lipid accumulation rate during adipogenic induction. CONCLUSION: The results indicated that the production model could facilitate production of effective EVs and further demonstrated the role of MSC-derived EVs in cell differentiation. MSC-derived EVs could be successfully used in cell-free therapy to guide chondrogenic differentiation of ADSC for future clinical applications in cartilage regeneration.
An Automatic Environmental Monitoring and Cooling System to Reduce Heat Stress in Dairy Cows
( Yu-chi Tsai ),( Chen-yu Cheng ),( Jih-tay Hsu ),( Shih-torng Dnig ),( Ta-te Lin ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
In tropical and subtropical regions with high temperature and humidity conditions, one of the problems in dairy farm management is the effect of heat stress on animal productivity. Due to this problem, the utilization of an automatic environmental monitoring system for cooling, labor-saving and heat stress reduction is necessary. In this study, an environmental monitoring and automatic cooling system based on an embedded system for dairy farms was designed. The system aims to regulate the environmental condition by means of direct feedback depending on the monitoring of heat stress index (HSI) augmented by dairy cow drinking behavior. The system is composed of two sub-systems: data acquisition and environmental control. The data acquisition module collects images, temperature and humidity data. The cooling system is controlled based on the real-time environmental data, and the historical data are recorded and uploaded to the server for display and analysis. The data are analyzed on the environmental monitoring panel on the farm and on the website, which can be remotely accessed. The control parameters are adjusted using the image results from the dairy cow drinking behavior with a fixed time interval. The results of the conducted experiments show that there is labor saving improvement and an increment in milk production compared to the same period in the previous year when the system was not installed. The automatic environmental monitoring cooling system exhibits high efficiency and can perform real-time control and self-adjustment. The system can be used for fully automated dairy cow system application, as well as dairy cow behavior analysis through both environmental and image information.
On The Security of RFID-based Monitoring Mechanism for Retail Inventory Management
( Yu Yi Chen ),( Jinn Ke Jan ),( Meng Lin Tsai ),( Chun Ching Ku ),( Der Chen Huang ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.2
The aim of this article is to provide a study on the issue of inventory inaccuracy and to show the manner in which RFID technology can improve the inventory management performance. The objective of inventory control is to monitor the stock flow of merchandises in order to understand the operating profit and loss. A proper mechanism of inventory control could be made to help the profitability. As RFID is applied to inventory control, it can improve efficiency, enhance accuracy and achieve security. In this paper, we introduce the evolution of different mechanisms of inventory control with RFID system - counting method, collect-all method, and continuous monitoring method. As for improving the accuracy of inventory check during business hours, continuous monitoring is the solution. We introduce the infrastructure of the RFID inventory management system based on M2M architecture can make the inventory be efficiently monitored with instant warnings.
Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
An Imaging System for Monitoring the Feeding Behavior of Dairy Cows
( Cheng-yu Kuan ),( Yu-chi Tsai ),( Chen-yu Cheng ),( Jih-tay Hsu ),( Shih-torng Dnig ),( Ta-te Lin ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
In sub-tropical countries, dairy cows tend to experience heat stress problems. This phenomenon may lead to declines in feed intake, milk production, and fertility. Under normal conditions, the dairy cows have a regular feeding and drinking time. For this reason, changes in feeding behavior can be a possible indicator to detect heat stress phenomena that can help farm owners monitor dairy cow health. In order to monitor and record the feeding behavior of dairy cows, an imaging system is proposed herein. The imaging system uses Raspberry Pi 3, as the embedded system, and a camera module to acquire images for dairy cow face detection in front of the feeding area to confirm if the dairy cow is eating. The dairy cow faces are detected through cascade-AdaBoost algorithms which can automatically select weak classifiers to form a strong classifier with fast processing speed in an embedded system. The factors affecting the performance of the dairy cow face detection algorithm have been tested and optimized. The system has been tested in a feeding area in National Taiwan University’s dairy farm, which has 25 dairy cows in total. By converting the frequency of dairy cow face detection into feeding time, the feeding behavior of grouped dairy cows can be analyzed. Furthermore, combining the temperature humidity index (THI) and feeding behavior can provide the farm owners with an index to evaluate the level heat stress of dairy cows.
Hui-Chen Tsai,Julia Yu-Fong Chang,Chia-Chun Tu,Chung-Chen Jane Yao 대한치과교정학회 2023 대한치과교정학회지 Vol.53 No.2
Before progress was recently made in the application of temporary anchorage devices (TADs) in bio-mechanical design, orthodontists were rarely able to intrude molars to reduce upper posterior dental height (UPDH). However, TADs are now widely used to intrude molars to flatten the occlusal plane or induce counterclockwise rotation of the mandible. Previous studies involving clinical or animal histological evaluation on changes in periodontal conditions after molar intrusion have been reported, however, studies involving human histology are scarce. This case was a Class I malocclusion with a high mandibular plane angle. Upper molar intrusion with TADs was performed to reduce UPDH, which led to counterclockwise rotation of the mandible. After 5 months of upper molar intrusion, shortened clinical crowns were noticed, which caused difficulties in oral hygiene and hindered orthodontic tooth movement. The mid-treatment cone-beam computed tomography revealed redundant bone physically interfering with buccal attachment and osseous resective surgeries were followed. During the surgeries, bilateral mini screws were removed and bulging alveolar bone and gingiva were harvested for biopsy. Histological examination revealed bacterial colonies at the bottom of the sulcus. Infiltration of chronic inflammatory cells underneath the non-keratinized sulcular epithelium was noted, with abundant capillaries being filled with red blood cells. Proximal alveolar bone facing the bottom of the gingival sulcus exhibited active bone remodeling and woven bone formation with plump osteocytes in the lacunae. On the other hand, buccal alveolar bone exhibited lamination, indicating slow bone turnover in the lateral region.
Advanced Application of Centralized Control for a Scanning Mirror System Based on EtherCAT Fieldbus
Ruei-Yu Huang,Yen-Jen Chen,Yu-Xian Chen,Chung-Wei Cheng,Mi-Ching Tsai,An-Chen Lee 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.3
Distributed control is the most popular control strategy for controlling numerous slave devices. However, the performance of slave devices is hard to improve because the control algorithm is handled by the commercial slave devices. Therefore, this paper proposes a hybrid control structure that follows the concept of centralized control strategy and handles part of the control loop on the master computer in a distributed control system through EtherCAT fieldbus. In this study, different advanced control methods such as robust control and learning control were applied to handle the position control loop of a scanning mirror system in a selective laser melting (SLM) system with stringent demand of position error around 40 µm based on EtherCAT fieldbus. By designing a proper controller, the experiment results showed that the tracking performance was significantly improved. The tracking error dropped by about 80% after the proposed hybrid control structure was applied. By applying the proposed hybrid control structure, one can improve the high-performance-requirement devices, while reducing the calculationburden of the master computer for other low-performance-requirement devices by retaining the benefit of distributed Control.