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Zhao, Xian-Da,He, Yu-Yu,Gao, Jun,Zhao, Chen,Zhang, Ling-Lin,Tian, Jing-Yuan,Chen, Hong-Lei Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20
Background: The prognostic value of Bcl-2 protein expression in non-small cell lung cancer (NSCLC) is under debate. We therefore systematically reviewed the evidence for Bcl-2 protein effects on NSCLC survival to elucidate this issue. Materials and Methods: An electronic search in Pubmed and Embase complemented by manual searches in article references were conducted to identify eligible studies to evaluate the association between Bcl-2 protein expression and overall survival (OS) as well as disease free survival (DFS) of NSCLC patients. Combined hazard ratios (HRs) with corresponding 95% confidence intervals (95%CIs) were pooled using the random-effects model. Results: A total of 50 trials (including 52 cohorts) encompassing 7,765 patients were pooled in the meta-analysis regarding Bcl-2 expression and OS of NSCLC patients. High expression of Bcl-2 protein had a favorable impact (HR=0.76, 95%CI=0.67-0.86). In the group of Bcl-2 expression and DFS, 11 studies including 2,634 patients were included. The synthesized result indicated high expression of Bcl-2 protein might predict good DFS (HR=0.85, 95%CI=0.75-0.95). Conclusions: Our present meta-analysis demonstrated favorable prognostic values of Bcl-2 expression in patients with NSCLC. Further prospective trails are welcomed to validate the utility of assessing Bcl-2 in NSCLC patient management.
Advanced Application of Centralized Control for a Scanning Mirror System Based on EtherCAT Fieldbus
Ruei-Yu Huang,Yen-Jen Chen,Yu-Xian Chen,Chung-Wei Cheng,Mi-Ching Tsai,An-Chen Lee 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.3
Distributed control is the most popular control strategy for controlling numerous slave devices. However, the performance of slave devices is hard to improve because the control algorithm is handled by the commercial slave devices. Therefore, this paper proposes a hybrid control structure that follows the concept of centralized control strategy and handles part of the control loop on the master computer in a distributed control system through EtherCAT fieldbus. In this study, different advanced control methods such as robust control and learning control were applied to handle the position control loop of a scanning mirror system in a selective laser melting (SLM) system with stringent demand of position error around 40 µm based on EtherCAT fieldbus. By designing a proper controller, the experiment results showed that the tracking performance was significantly improved. The tracking error dropped by about 80% after the proposed hybrid control structure was applied. By applying the proposed hybrid control structure, one can improve the high-performance-requirement devices, while reducing the calculationburden of the master computer for other low-performance-requirement devices by retaining the benefit of distributed Control.
Wang, Xian-Yu,Wang, Songhu,Hinse, Tobias C.,Li, Kai,Wang, Yong-Hao,Laughlin, Gregory,Liu, Hui-Gen,Zhang, Hui,Wu, Zhen-Yu,Zhou, Xu,Zhou, Ji-Lin,Hu, Shao-Ming,Wu, Dong-Hong,Peng, Xi-Yan,Chen, Yuan-Yuan Astronomical Society of the Pacific 2018 Publications of the Astronomical Society of the Pa Vol.130 No.988
Gate-tunable phase transitions in thin flakes of 1T-TaS2.
Yu, Yijun,Yang, Fangyuan,Lu, Xiu Fang,Yan, Ya Jun,Cho, Yong-Heum,Ma, Liguo,Niu, Xiaohai,Kim, Sejoong,Son, Young-Woo,Feng, Donglai,Li, Shiyan,Cheong, Sang-Wook,Chen, Xian Hui,Zhang, Yuanbo Nature Pub. Group 2015 Nature nanotechnology Vol.10 No.3
<P>The ability to tune material properties using gating by electric fields is at the heart of modern electronic technology. It is also a driving force behind recent advances in two-dimensional systems, such as the observation of gate electric-field-induced superconductivity and metal-insulator transitions. Here, we describe an ionic field-effect transistor (termed an iFET), in which gate-controlled Li ion intercalation modulates the material properties of layered crystals of 1T-TaS2. The strong charge doping induced by the tunable ion intercalation alters the energetics of various charge-ordered states in 1T-TaS2 and produces a series of phase transitions in thin-flake samples with reduced dimensionality. We find that the charge-density wave states in 1T-TaS2 collapse in the two-dimensional limit at critical thicknesses. Meanwhile, at low temperatures, the ionic gating induces multiple phase transitions from Mott-insulator to metal in 1T-TaS2 thin flakes, with five orders of magnitude modulation in resistance, and superconductivity emerges in a textured charge-density wave state induced by ionic gating. Our method of gate-controlled intercalation opens up possibilities in searching for novel states of matter in the extreme charge-carrier-concentration limit.</P>
Modeling and Simulation of the Magnetic Method for High Voltage Direct Current Inspection Robot
Xian-jin Xu,Cheng-hui Liu,Yu Yan,Hao-da Chen,Lei Fang,Yun-long Wang,Long-hui Wu 한국자기학회 2018 Journal of Magnetics Vol.23 No.3
In order to solve the slipping problem of a two-arm-wheel combined inspection robot, a maglev system based on the magnetic field of a high voltage direct current (HVDC) is proposed. The magnetic system comprises of two parts: a magnetic levitation system and a magnetic drive system. The levitation component overcomes the gravity of the robot by the Ampere force generated by current-carrying coils in the magnetic field of HVDC. The drive component utilizes the Ampere force generated by current-carrying coils in the magnetic field of HVDC as the driving force. Simulation results of the model are compared with the calculated values. The results show that the magnetic levitation method and the magnetic drive method are theoretically feasible, and the model is accurate and effective, which is of great practical significance to the physical realization of the inspection robot.
Significance of Caveolin-1 Regulators in Pancreatic Cancer
Chen, Tao,Liu, Liang,Xu, Hua-Xiang,Wang, Wen-Quan,Wu, Chun-Tao,Yao, Wan-Tong,Yu, Xian-Jun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Caveolin-1 is a scaffold protein on the cell membrane. As the main component of caveolae, caveolin-1 is involved in many biological processes that include substance uptake and transmembrane signaling. Many of these processes and thus caveolin-1 contribute to cell transformation, tumorigenesis, and metastasis. Of particular interest are the dual rolesof tumor suppressor and oncogene that caveolin-1 appear to play in different malignancies, including pancreatic cancer. Therefore, analyzing caveolin-1 regulators and understanding their mechanisms of actionis key to identifying novel diagnostic and therapeutic tools for pancreatic cancer. This review details the mechanisms of action of caveolin-1 regulators and the potential significance for pancreatic cancer treatment.
Chen, Tao,Zhang, Min-Gui,Yu, Xian-Jun,Liu, Liang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: Postoperative carbohydrate antigen 19-9 (CA19-9) is an independent predictor of survival for pancreatic ductal adenocarcinoma (PDAC), and more powerful than preoperative CA19-9. However, making decisions just dependent on postoperative CA19-9 may result in necessary treatments not being performed. Materials and Methods: A total of 178 patients with resected PDAC were eligible for this retrospective study, classified into two corresponding subgroups according to postoperative CA19-9. Prognostic significance of all clinicopathologic factors was evaluated by univariate and multivariate analyses. Results: Postoperative CA19-9, preoperative CA125 and lymph node status were independent predictors. Better predictive performances for overall survival (OS) and recurrence-free survival (RFS) were achieved by postoperative CA19-9 compared to preoperative CA125 and lymph node status. Particularly, preoperative CA125 was associated with poor OS (p<0.001 for the normalized CA19-9 patients, p=0.012 for the elevated) and RFS (p=0.005 for the normalized, p=0.004 for the elevated). Moreover, preoperative CA125 levels related with survival in double-negative patients. Conclusions: Normalization of CA19-9 is not tantamount to be cured. Preoperative CA125 is a critical predictor for PDAC patients, especially in double-negative patients.
Zhong-Xian Lu,Xiao-Ping Yu,Jian-Ming Chen,Xu-Song Zheng,Hong-Xing Xu,Jue-Feng Zhang Zhang,Lie-Zhong Chen 한국응용곤충학회 2004 Journal of Asia-Pacific Entomology Vol.7 No.3
Abundance of the yeast-like symbiote (YLS) in brown planthopper (BPH), Nilaparvata lugens Stl, collected from rice fields in China and obtained from International Rice Research Institute (IRRI), was monitored. The role of YLS in nymph survival rate, development and adult reproduction, and activities of transaminases in BPH on different resistant rice varieties were examined. Also, the relationship between YLS and virulence shifts of BPH to resistant rice varieties was discussed. The results indicated that the virulence of BPH populations to resistant rice varieties was strongly related to the abundance of YLS in 5th instar nymphs and brachypterous females of BPH field populations at Nanning in South China and Hangzhou in East China, showing the more abundance of YLS in BPH, the higher virulence of BPH to resistant rice varieties, while no obvious differences in YLS abundance were monitored between three BPH biotypes. Numbers of YLS reduced significantly in female adult of BPH biotype 1 fed on resistant rice varieties IR26, Mudgo and ASD7, compared with that fed on susceptible rice variety TN1. The lowest YLS abundance of BPH from field population was found in 2nd generation successively fed on resistant varieties, and the number of YLS was resumed at 4th generation when the BPH has adapted the resistant varieties. The markedly lower nymphal survival rate, adult fecundity and activities of alanine and aspartic transminase, and significantly longer nymph duration in the three aposymbiotic biotypes than in the symbiotic ones were recorded on both susceptible and resistant rice varieties. However, the much greater differences between aposymbiotic and symbiotic BPH were found on the inadaptable resistant rice varieties than that on the fitness resistant rice varieties. Those results implied that YLS in BPH should play a crucial role in the virulent shift of BPH populations to resistant rice varieties.
( Hui Yu Chen ),( Sung Min Park ),( Jong Hak Lee ),( Xian Hui Meng ),( Dong Wook Shin ),( Ji Beom Yoo ) 대한금속재료학회 ( 구 대한금속학회 ) 2008 ELECTRONIC MATERIALS LETTERS Vol.4 No.4
This paper reports the large scale production of CuO nanoplatelets with smooth surface using a simple hydrothermal method in a water and ethanol solution without any templates or additives. The micro-structure and morphology of the CuO nanoplatelets were examined by X-ray diffraction, Raman spectra, field emission scanning electron microscopy and transmission electron microscopy. The CuO nanoplatelets were monoclinic, and their length and width ranged from 100 to 300 nm and 80 to 120 nm, respectively. A possible growth mechanism for the formation of CuO nanoplatelets was proposed. The volume ratio of ethanol in the solution was found to be a critical effect on the CuO morphology during the hydrothermal stage. The band gap of the CuO nanoplatelets was estimated to be 2.13 eV from the UV-vis spectra.