The impact of lymph node dissection on survival in patients with clinical early-stage ovarian cancer

Ting Deng,Qidan Huang,Ting Wan,Xiaoling Luo,Yanling Feng,He Huang,Jihong Liu 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.3

Objective: To estimate the impact of lymph node dissection on survival in patients withapparent early-stage epithelial ovarian cancer (EOC). Methods: We conducted a retrospective review of patients with clinical stage I–II EOC. Allpatients underwent primary surgery at Sun Yat-sen University Cancer Center between January2003 and December 2015. Demographic features and clinicopathological information as wellas perioperative adverse events were investigated, and survival analyses were performed. Results: A total of 400 ovarian cancer patients were enrolled, and patients were divided into2 groups: 81 patients did not undergo lymph node resection (group A), and 319 patientsunderwent lymph node dissection (group B). In group B, the median number of removednodes per patient was 25 (21 pelvic and 4 para-aortic nodes). In groups A and B, respectively,the 5-year progression-free survival (PFS) rates were 83.3% and 82.1% (p=0.305), and the5-year overall survival (OS) rates were 93.1% and 90.9% (p=0.645). The recurrence rate inthe retroperitoneal lymph nodes was not associated with lymph node dissection (p=0.121). The median operating time was markedly longer in group B than in group A (220 minutesvs. 155 minutes, p<0.001), and group B had a significantly higher incidence of lymph cysts atdischarge (32.9% vs. 0.0%, p<0.001). Conclusion: In patients with early-stage ovarian cancer, lymph node dissection was notassociated with a gain in OS or PFS and was associated with an increased incidence ofperioperative adverse events.

Scaling up the in-hospital hepatitis C virus care cascade in Taiwan

( Chung-feng Huang ),( Pey-fang Wu ),( Ming-lun Yeh ),( Ching-i Huang ),( Po-cheng Liang ),( Cheng-ting Hsu ),( Po-yao Hsu ),( Hung-yin Liu ),( Ying-chou Huang ),( Zu-yau Lin ),( Shinn-cherng Chen ),( 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1

Background/Aims: Obstacles exist in facilitating hepatitis C virus (HCV) care cascade. To increase timely and accurate diagnosis, disease awareness and accessibility, in-hospital HCV reflex testing followed by automatic appointments and a late call-back strategy (R.N.A. model) was applied. We aimed to compare the HCV treatment rate of patients treated with this strategy compared to those without. Methods: One hundred and twenty-five anti-HCV seropositive patients who adopted the R.N.A. model in 2020 and another 1,396 controls treated in 2019 were enrolled to compare the gaps in accurate HCV RNA diagnosis to final treatment allocation. Results: The HCV RNA testing rate was significantly higher in patients who received reflex testing than in those without reflex testing (100% vs. 84.8%, P<0.001). When patients were stratified according to the referring outpatient department, a significant improvement in the HCV RNA testing rate was particularly noted in patients from non-hepatology departments (100% vs. 23.3%, P<0.001). The treatment rate in HCV RNA seropositive patients was 83% (83/100) after the adoption of the R.N.A. model, among whom 96.1% and 73.9% of patients were from the hepatology and non-hepatology departments, respectively. Compared to subjects without R.N.A. model application, a significant improvement in the treatment rate was observed for patients from non-hepatology departments (73.9% vs. 27.8%, P=0.001). The application of the R.N.A. model significantly increased the in-hospital HCV treatment uptake from 6.4% to 73.9% for patients from non-hepatology departments (P<0.001). Conclusions: The care cascade increased the treatment uptake and set up a model for enhancing in-hospital HCV elimination. (Clin Mol Hepatol 2021;27:136-143)

Low initial human papillomavirus viral load may indicate worse prognosis in patients with cervical carcinoma treated with surgery

Ting Deng,Yanling Feng,Junsheng Zheng,Qidan Huang,Jihong Liu 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.2

Objective: To evaluate the prognostic implication of human papillomavirus (HPV) viral load in cervical cancer patients whounderwent radical hysterectomy. Methods: We conducted a retrospective review of patients with stage IA2 through stage IIIA cervical carcinoma who underwentradical hysterectomy at Sun Yat-sen University Cancer Center between January 2005 and December 2009. Patients who hadundergone preoperative hybrid capture 2 testing to detect HPV DNA were included. A total of 346 patients positive for HPVDNA were enrolled and stratified into two groups according to the median HPV viral load. Results: HPV viral load was significantly correlated with lymphovascular space invasion (p=0.026) and deep stromal invasion(p=0.024). However, other factors, such as age, stage, histologic grade, histologic type, lymph node metastasis, and tumor size,were not significantly associated with viral load. Low HPV viral load was correlated with poor disease-free survival in univariateanalysis (p=0.037) and multivariate analysis (p=0.027). There was no significant difference in overall survival with regard to initialHPV viral load. Conclusion: Low initial HPV viral load may be a poor prognostic factor for cervical cancer patients who have undergone radicalhysterectomy.

A phase II trial of cytoreductive surgery combined with niraparib maintenance in platinum-sensitive, secondary recurrent ovarian cancer: SGOG SOC-3 study

Ting-Yan Shi,Sheng Yin,Jianqing Zhu,Ping Zhang,Jihong Liu,Libing Xiang,Yaping Zhu,Sufang Wu,Xiaojun Chen,Xipeng Wang,Yin-Cheng Teng,Tao Zhu,Aijun Yu,Yingli Zhang,Yanling Feng,He Huang,Wei Bao,Yanli Li 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.3

Background: In China, secondary cytoreductive surgery (SCR) has been widely used in ovarian cancer (OC) over the past two decades. Although Gynecologic Oncology Group-0213 trial did not show its overall survival benefit in first relapsed patients, the questions on patient selection and effect of subsequent targeting therapy are still open. The preliminary data from our pre-SOC1 phase II study showed that selected patients with second relapse who never received SCR at recurrence may still benefit from surgery. Moreover, poly(ADP-ribose) polymerase inhibitors (PARPi) maintenance now has been a standard care for platinum sensitive relapsed OC. To our knowledge, no published or ongoing trial is trying to answer the question if patient can benefit from a potentially complete resection combined with PARPi maintenance in OC patients with secondary recurrence. Methods: SOC-3 is a multi-center, open, randomized, controlled, phase II trial of SCR followed by chemotherapy and niraparib maintenance vs chemotherapy and niraparib maintenance in patients with platinum-sensitive second relapsed OC who never received SCR at recurrence. To guarantee surgical quality, if the sites had no experience of participating in any OC-related surgical trials, the number of recurrent lesions evaluated by central-reviewed positron emission tomography–computed tomography image shouldn't be more than 3. Eligible patients are randomly assigned in a 1:1 ratio to receive either SCR followed by 6 cycles of platinum-based chemotherapy and niraparib maintenance or 6 cycles of platinum-based chemotherapy and niraparib maintenance alone. Patients who undergo at least 4 cycles of chemotherapy and must be, in the opinion of the investigator, without disease progression, will be assigned niraparib maintenance. Major inclusion criteria are secondary relapsed OC with a platinum-free interval of no less than 6 months and a possibly complete resection. Major exclusion criteria are borderline tumors and non-epithelial ovarian malignancies, received debulking surgery at recurrence and impossible to complete resection. The sample size is 96 patients. Primary endpoint is 12-month non-progression rate. Trial Registration: ClinicalTrials.gov Identifier: NCT03983226

Fabrication of PVDF-blended ultrafiltration membranes incorporated by chiral mesoporous silica for enantioseparation

Ting Wang,Xiao-xing Huang,Li-guang Wu,Chun-juan Li,Dong-feng Zhu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.109 No.-

Novel poly(vinylidene fluoride) (PVDF) ultrafiltration membranes blending with chiral mesoporous SiO2materials were constructed to improve the anti-fouling and separation performance of PVDF-blendedmembranes. The formation of asymmetric mesoporous structure of chiral mesoporous SiO2 caused theirlarge hydrophilic surface and significant chiral features, which enhanced the hydrophilicity and polarityof the resulting PVDF membranes blended with chiral mesoporous SiO2. So, the PVDF-blended membranescontaining chiral mesoporous SiO2 had a high permeation performance and anti-fouling property. After blending with chiral mesoporous SiO2, the maximum flux of membranes exceeded 500 Lm2h1and was 6.5-fold higher than that of neat PVDF. Due to the stereo-specific interaction between enantiomersand chiral recognition sites introduced by chiral mesoporous SiO2 in the membranes, allPVDF-blended membranes had evident enantioseparation performance for DL-racemic tryptophan. TheC-SiO2-20/PVDF-blended membranes had the highest enantioseparation performance under the sameaddition content and the maximum enantiomeric excess (e.e.%) was more than 20 %. Given the strongstereo-specific interaction and hydrogen bonding between d-tryptophan and b-cyclodextrin (b-CD), theaddition of more b-CD would introduce more chiral recognition sites into the membranes, therebyenhancing the enantioseparation performance of the membranes for d-tryptophan. The maximum e.e. % of C-SiO2-20/b-CD/PVDF-blended membranes for the tryptophan enantiomer reached 55%.

Magnetization Processes in Permalloy Rings with Different Arrangements of Notches

Mei-Feng Lai,Chiun-Peng Lee,Hao-Ting Huang,Tzong-Rong Ger,Zung-Hang Wei 한국자기학회 2010 한국자기학회 학술연구발표회 논문개요집 Vol.2010 No.12

Home Energy Management System for Interconnecting and Sensing of Electric Appliances

( Wei-ting Cho ),( Chin-feng Lai ),( Yueh-min Huang ),( Wei-tsong Lee ),( Sing-wei Huang ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.7

Due to the variety of household electric devices and different power consumption habits of consumers at present, general home energy management (HEM) systems suffer from the lack of dynamic identification of various household appliances and a unidirectional information display. This study presented a set of intelligent interconnection network systems for electric appliances, which can measure the power consumption of household appliances through a current sensing device based on OSGi platform. The system establishes the characteristics and categories of related electric appliances, and searches the corresponding cluster data and eliminates noise for recognition functionality and error detection mechanism of electric appliances by applying the clustering algorithm. The system also integrates household appliance control network services so as to control them according to users` power consumption plans or through mobile devices, thus realizing a bidirectional monitoring service. When the system detects an abnormal operating state, it can automatically shut off electric appliances to avoid accidents. In practical tests, the system reached a recognition rate of 95%, and could successfully control general household appliances through the ZigBee network.

Effect of Combined Manual Acupuncture and Massage on Body Weight and Body Mass Index Reduction in Obese and Overweight Women: A Randomized, Short-term Clinical Trial

Huiyong Huang,Jun-Feng He,Xing Zhang,Ya-Ting Qu,Xia Liu,Jia Du,Shengtong Guo 사단법인약침학회 2015 Journal of Acupuncture & Meridian Studies Vol.8 No.2

Obesity is one of the leading health risk factors worldwide and is associated with several other risk factors and health problems. Acupuncture is utilized to treat a variety of health problems, one of which is obesity. Fifty-six obese women with body mass index (BMI) ≥25 kg/m2 were recruited for this trial and were randomly divided into two groups, one with combined manual acupuncture and massage therapy (MAMT), and the other with only manual acupuncture therapy (MAT). In addition, 40 overweight women with BMI 23–25 kg/m2 were randomly divided into two groups, one with MAMT and the other with MAT. Therapy was carried out once per day for 21 days, and the body weights and the BMIs were recorded every day. The results showed that both MAMT and MAT could reduce body weight and BMI significantly, compared with the pretreatment values, for all the participants (p < 0.001); however, the differences in body weight and BMI reductions between pre- and posttreatment for the MAMT and the MAT groups were not statistically significant. The optimal periods for reductions in both body weight and in BMI were the first 4 days. Accounting for the economic strategy (time and money) in alternative therapy, MAT alone may present a reasonable option in the treatment of overweight and obesity in adults.

Mechanism of the simultaneous removal of nitrate and Ni(II) by Enterobacter sp. CC76 through mixotrophic denitrification processes

Jun Feng Su,Shu Yang,Ting Lin Huang,Xue Chen Bai,Jin Suo Lu,Lei He,Min Li 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.7

We studied the mechanism for the simultaneous removal of nitrate and Ni(II) by Enterobacter sp. CC76. Response surface methodology results showed that the maximum removal ratios of nitrate and Ni(II) were 95.02% and 75.99% under the following conditions: pH 7.37, 54.31mg·L1 Fe(II), and 10.00mg·L1 Ni(II). The mechanism of Ni(II) removal involved Fe-oxide adsorption and the increase of pH. In addition, meteorological chromatography analysis indicated that Ni(II) affected gas composition during denitrification. Scanning electron microscopy and X-ray photoelectron spectroscopy confirmed that Fe-oxide adsorption was the main contributor to Ni(II) removal. This study shows that Enterobacter sp. CC76 can enhance the adsorption of Ni(II) onto Fe-oxides while removing nitrate.

MRI T2-Weighted Imaging and Fat-Suppressed T2-Weighted Imaging Image Fusion Technology Improves Image Discriminability for the Evaluation of Anal Fistulas

Shi-Ting Feng,Mengqi Huang,Zhi Dong,Ling Xu,Yin Li,Yingmei Jia,Huasong Cai,Bingqi Shen,Zi-Ping Li 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.3

Objective: To explore whether MRI fusion technology (combined T2-weighted imaging [T2WI] and fat-suppressed T2WI [T2WI-FS]) improves signal differences between anal fistulas and surrounding structures. Materials and Methods: A total of 32 patients with confirmed diagnoses of anal fistula were retrospectively studied. All available T2WI and T2WI-FS images for each patient were used to generate fusion image (T2WI-Fusion) based on the addition of gray values obtained from each pixel via an MR post-processing work station. The discriminability of fistula, perianal sphincter, and perianal fat in T2WI, T2WI-FS, and T2WI-Fusion images was quantified with Fisher’s scoring algorithm. For subjective visual image assessment by researchers, five-point scale scores were determined using a modified double-stimulus continuous qualityscale test to evaluate T2WI-FS, T2WI, enhanced axial three-dimensional-volumetric interpolated breath-hold examination (3D-VIBE), and T2WI-Fusion sequence images. The differences were subsequently compared. Results: Mean Fisher scores for fistulas vs. sphincters obtained from T2WI-Fusion (FFusion-fistula = 6.56) were significantly higher than those from T2WI (FT2WI-fistula = 3.35) (p = 0.001). Mean Fisher scores for sphincters vs. fat from T2WI-Fusion (FFusion-sphincter = 10.84) were significantly higher than those from T2WI-FS (FSFS-sphincter = 2.57) (p = 0.001). In human assessment, T2WI-Fusion showed the same fistula discriminability as T2WI-FS, and better sphincter discriminability than T2WI. Overall, T2WI-Fusion showed better discriminability than T2WI, T2WI-FS, and enhanced 3D-VIBE images. Conclusion: T2WI and T2WI-FS fusion technology improves signal differences between anal fistulas and surrounding structures, and may facilitate better evaluation of anal fistulas and sphincters.