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Ru-Ting Liang,Tao Bo,Wan-Qiu Yin,Chang-Ming Nie,Lei Zhang,Zhi-Fang Chai,Wei-Qun Shi Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7
A first-principle approach within the framework of density functional theory was employed to study the effect of vacancy defects and fission products (FPs) doping on the mechanical, electronic, and thermodynamic properties of uranium monocarbide (UC). Firstly, the calculated vacancy formation energies confirm that the C vacancy is more stable than the U vacancy. The solution energies indicate that FPs prefer to occupying in U site rather than in C site. Zr, Mo, Th, and Pu atoms tend to directly replace U atom and dissolve into the UC lattice. Besides, the results of the mechanical properties show that U vacancy reduces the compressive and deformation resistance of UC while C vacancy has little effect. The doping of all FPs except He has a repairing effect on the mechanical properties of U<sub>1-x</sub>C. In addition, significant modifications are observed in the phonon dispersion curves and partial phonon density of states (PhDOS) of UC<sub>1-x</sub>, Zr<sub>x</sub>U<sub>1-x</sub>C, Mo<sub>x</sub>U<sub>1-x</sub>C, and Rh<sub>x</sub>U<sub>1-x</sub>C, including narrow frequency gaps and overlapping phonon modes, which increase the phonon scattering and lead to deterioration of thermal expansion coefficient (α<sub>V</sub>) and heat capacity (C<sub>p</sub>) of UC predicted by the quasi harmonic approximation (QHA) method.
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Non-Benzoquinone Geldanamycin Analog, WK-88-1, Induces Apoptosis in Human Breast Cancer Cell Lines
( Yu-ru Zhao ),( Hong-mei Li ),( Meilin Zhu ),( Jing Li ),( Tao Ma ),( Qiang Huo ),( Young-soo Hong ),( Cheng-zhu Wu ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.4
Heat shock protein 90 (Hsp90) is treated as a molecular therapeutic target for the prevention and treatment of cancer. Geldanamycin (GA) was the first identified natural Hsp90 inhibitor, but hepatotoxicity has limited its clinical application. Nevertheless, a new GA analog (WK-88- 1) with the non-benzoquinone skeleton, obtained from genetically engineered Streptomyces hygroscopicus, was found to have anticancer activity against two human breast cancer cell lines. WK-88-1 produced concentration-dependent inhibition of cell proliferation, cell cycle arrest, and apoptosis in estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 cell lines. Detailed analysis showed that WK-88-1 downregulated some key cell cycle molecules (CDK1 and cyclin B1) and lead to G2/M cell cycle arrest. Further studies also showed that WK- 88-1 could induce human breast cancer cell apoptosis by downregulating Hsp90 client proteins (Akt, p-Akt, IKK, c-Raf, and Bcl-2), decreasing the ATP level, increasing reactive oxygen species production, and lowering the mitochondrial membrane potential. Meanwhile, we discovered that WK-88-1 significantly decreased the levels of Her-2 and ER-α in MCF-7 cells but not in MDA-MB-231 cells. In addition, WK-88-1 significantly increased caspase-3, -8, and -9 activities and the cleavage of PARP in a concentration-dependent manner (with the exception of caspase-3 and PARP in MCF-7 cells). Taken together, our preliminary results suggest that WK-88-1 has the potential to play a role in breast cancer therapy.
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Chemical transformation and target preparation of saponins in stems and leaves of Panax notoginseng
Wang, Ru-Feng,Li, Juan,Hu, Hai-Jun,Li, Jia,Yang, Ying-Bo,Yang, Li,Wang, Zheng-Tao The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3
Background: Notoginsenoside Ft1 is a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultralow utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1. Methods: Chemical profiles were identified by ultraperformance liquid chromatography coupled with quadruple-time-of-flight and electrospray ionization mass spectrometry (UPLC-Q/TOF-ESI-MS). The acid hydrolyzing dynamic changes of chemical compositions and the possible transformation pathways of saponins were monitored by ultrahigh-performance LC coupled with tandem MS (UHPLC-MS/ MS). Results and conclusion: Notoginsenoside Ft1 was epimerized from notoginsenoside ST4, which was generated through cleaving the carbohydrate side chains at C-20 of notoginsenosides Fa and Fc, and vinaginsenoside R7, and further converted to other compounds via hydroxylation at C-25 or hydrolysis of the carbohydrate side chains at C-3 under the acid conditions. High temperature contributed to the hydroxylation reaction at C-25 and 25% acetic acid concentration was conducive to the preparation of notoginsenoside Ft1. C-20 epimers of notoginsenoside Ft1 and ST4 were successfully separated utilizing solvent method of acetic acid solution. The theoretical preparation yield rate of notoginsenoside Ft1 was about 1.8%, which would be beneficial to further study on its bioactivities and clinical application.
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Juan Li,Ru-Feng Wang,Yue Zhou,Hai-Jun Hu,Ying-Bo Yang,Li Yang,Zheng-Tao Wang 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.3
Background: Inflammation is widespread in the clinical pathology and closely associated to the progressof many diseases. Triterpenoid saponins as a key group of active ingredients in Panax notoginseng (Burk.)F.H. Chen were demonstrated to show antiinflammatory effects. However, the chemical structures ofsaponins in the leaves and stems of Panax notoginseng (PNLS) are still not fully clear. Herein, the isolation,purification and further evaluation of the antiinflammatory activity of dammarane-type triterpenoidsaponins from PNLS were conducted. Methods: Silica gel and reversed-phase C8 column chromatography were used. Furthermore, preparativeHPLC was used as a final purification technique to obtain minor saponins with high purities. MS, NMRexperiments, and chemical methods were used in the structural identifications. The antiinflammatoryactivities of the isolated saponins were assessed by measuring the nitric oxide production in RAW 264.7cells stimulated by lipopolysaccharides. Real-time reverse transcription polymerase chain reaction wasused to measure the gene expressions of inflammation-related gene. Results: Eight new minor dammarane-type triterpene oligoglycosides, namely notoginsenosides LK1-LK8 (1e8) were obtained from PNLS, along with seven known ones. Among the isolated saponins,gypenoside IX significantly suppressed the nitric oxide production and inflammatory cytokines includingtumor necrosis factor-a, interleukin 10, interferon-inducible protein 10 and interleukin-1b. Conclusion: The eight saponins may enrich and expand the chemical library of saponins in Panax genus. Moreover, it is reported for the first time that gypenoside IX showed moderate antiinflammatory activity.
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Li, Juan,Wang, Ru-Feng,Zhou, Yue,Hu, Hai-Jun,Yang, Ying-Bo,Yang, Li,Wang, Zheng-Tao The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.3
Background: Inflammation is widespread in the clinical pathology and closely associated to the progress of many diseases. Triterpenoid saponins as a key group of active ingredients in Panax notoginseng (Burk.) F.H. Chen were demonstrated to show antiinflammatory effects. However, the chemical structures of saponins in the leaves and stems of Panax notoginseng (PNLS) are still not fully clear. Herein, the isolation, purification and further evaluation of the antiinflammatory activity of dammarane-type triterpenoid saponins from PNLS were conducted. Methods: Silica gel and reversed-phase C8 column chromatography were used. Furthermore, preparative HPLC was used as a final purification technique to obtain minor saponins with high purities. MS, NMR experiments, and chemical methods were used in the structural identifications. The antiinflammatory activities of the isolated saponins were assessed by measuring the nitric oxide production in RAW 264.7 cells stimulated by lipopolysaccharides. Real-time reverse transcription polymerase chain reaction was used to measure the gene expressions of inflammation-related gene. Results: Eight new minor dammarane-type triterpene oligoglycosides, namely notoginsenosides LK1-LK8 (1-8) were obtained from PNLS, along with seven known ones. Among the isolated saponins, gypenoside IX significantly suppressed the nitric oxide production and inflammatory cytokines including tumor necrosis $factor-{\alpha}$, interleukin 10, interferon-inducible protein 10 and $interleukin-1{\beta}$. Conclusion: The eight saponins may enrich and expand the chemical library of saponins in Panax genus. Moreover, it is reported for the first time that gypenoside IX showed moderate antiinflammatory activity.
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Qing-Fang Li,Ru-Yong Yao,Ke-wei Liu,Hong-Ying Lv,Tao Jiang,Jun Liang 대한의학회 2010 Journal of Korean medical science Vol.25 No.6
The aim of this study was to evaluate the predictive value of the polymorphism Glutathione S-transferase P1 (GSTP1) Ile105Val on oxaliplatin/5-FU-based chemotherapy in advanced gastric cancer. Patients with advanced gastric cancer accepted oxaliplatin/5-FU-based chemotherapy as first-line chemotherapy were investigated. GSTP1 Ile105Val polymorphism was detected by TaqMan-MGB probe allelic discrimination method. Response to treatment was assessed by disease controlled rate. Time to progression, overall survival and toxicities were recorded. Final patient outcomes were as follows: the allele frequencies of GSTP1 were 105Ile/105Ile 52%, 105Ile/105Val 41% and 105Val/105Val 7%. For patients with 105Ile/105Ile and those with at least one 105Val allele, disease control rate was 39% and 71% (P=0.026), respectively;median time to progression was 4.0 and 7.0 months (P=0.002); median overall survival time was 7.0 and 9.5 months (P=0.002). Neurological toxicity was more frequently occurred in patients with two 105Ile alleles (P=0.005). In conclusion, patients with at least one 105Val allele have better prognosis and response to oxaliplatin/5-FUbased regimen as first-line treatment for patients with advanced gastric cancer.
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( Kai Yuan Wan ),( Yong Tao ),( Ru Hai Li ),( Jun Feng Pan ),( Lei Lei Tang ),( Fang Chen ) 한국잡초학회 2012 Weed Biology and Management Vol.12 No.1
In order to provide a scientific basis for developing integrated weed management strategies in rice paddy fields, this study investigated the influences of different types of fertilization on weed biodiversity. The experiment was conducted at Long-term-located Monitoring Station for Soil Fertility, Agricultural Science Academy, of Jiangxi Province, China. Five fertilization treatments were set: no fertilization (NOF), PK, NP, NK, and NPK. The results showed that the influence of different fertilization treatments on weed community traits followed the models PK > NOF > NK > NP > NPK for species richness, PK > NOF > NK > NP > NPK for species diversity, NPK > NP > NK > NOF > PK for community dominance, and PK > NOF > NK > NP > NPK for community evenness. Under NPK (i.e. balanced fertilization), the weed species diversity and richness and weed community evenness were the lowest. The principal component analysis showed that the weed community was divided into three groups: (i) NK and a part of NOF; (ii) NP and NPK; and (iii) PK and NOF. The correlation analysis indicated that the influence of each macro-element on the weed community followed the model N > P > K. The organic content in the paddy soil might have played an equally important role with the amount of available N in determining the weed community`s characteristics. Regarding the way by which N, P, and K influenced the weed community, the amount of available P and K mainly influenced the organic content, while the amount of available N influenced both the organic content and light transmittance within the canopy, thereby enhancing the capacity of rice to compete with weeds.
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Guang-Xun Lin,Li-Ru He,Jin-Niang Nan,Wen-Bin Xu,Keyi Xiao,Zhiqiang Que,Shang-Wun Jhang,Chien-Min Chen,Ming-Tao Zhu,Gang Rui 대한척추신경외과학회 2024 Neurospine Vol.21 No.1
Objective: This meta-analysis aims to refine the understanding of the optimal choice between different cage shapes in transforaminal lumbar interbody fusion (TLIF) by systematically comparing perioperative data, radiological outcomes, clinical results, and complications associated with banana-shaped and straight bullet cages. Methods: A meticulous literature search encompassing PubMed, Embase, Scopus, Web of Science, China Knowledge Network, and Wanfang Data was executed up to October 5, 2023. Inclusion criteria focused on studies comparing banana-shaped and straight bullet cages in TLIF. The quality of included studies was assessed using appropriate tools such as the Newcastle-Ottawa Scale (NOS) for nonrandomized studies. Rigorous evaluations were performed for radiographic outcomes, including disc height (DH), segmental lordosis (SL), lumbar lordosis (LL), subsidence, and fusion rates. Clinical outcomes were meticulously evaluated using visual analogue scale (VAS), Oswestry Disability Index (ODI), and complications. Results: The analysis incorporated 7 studies, involving 573 patients (297 with banana-shaped cages, 276 with straight cages), all with NOS ratings exceeding 5 stars. No statistically significant differences were observed in operative time, blood loss, or hospitalization between the 2 cage shapes. Banana-shaped cages exhibited greater changes in DH (p = 0.001), SL (p = 0.02), and LL (p = 0.01). Despite statistically higher changes in ODI for straight cages (26.33, p < 0.0001), the actual value remained similar to banana-shaped cages (26.15). Both cage types demonstrated similar efficacy in VAS, complication rates, subsidence, and fusion rates. Conclusion: Although banana-shaped cages can excel in restoring DH, SL, and LL, straight bullet cages can provide comparable functional improvements, pain relief, and complication rates.
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